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I. THROMBOSIS

A. DEFINITION

1. THROMBUS

2. BLOOD CLOT

3. COMPARE

B. VIRCHOW TRIAD

1. ENDOTHELIAL INJURY

2. CHANGES IN BLOOD FLOW3. HYPERCOAGULABILITY

C. CHARACTERISTIC OF THROMBI

1. ARTERIAL THROMBOSIS

2. CARDIAC AND AORTIC THROMBOSIS

3. VENOUS THROMBI

a. SVT

b. DVT

D. FATE OF THROMBUS

1. DISSOLUTION

2. PROPAGATION

3. ORGANIZATION/RECANALIZATION

4. EMBOLIZATION

II. DISSEMINATED INTRAVASCULAR COAGULATION (DIC)

A. DESCRIPTION

B. Cause

C. Pathogenesis

D. Clinical effects

E. Lab findings

III. EMBOLISM

A. SOURCES OF EMBOLI

B. THROMBOEMBOLIC1. Systemic (arterial)

2. Pulmonary (venous)

C. PARADOXICAL EMBOLI

D. FAT EMBOLI

E. ATHEROMA EMBOLI

F. Amniotic fluid emboli

G. Gas emboli

IV. Ischemia

A. General characteristics

1. Definition

2. CauseB. 5 factors governing potential tissue changes

1. Availability and integrity of collateral circulation

2. Rate of development of obstruction

3. Tissue susceptibility to ischemia/tissue metabolic rate

C. Ischemia caused by venous obstruction

V. Infarction

A. Morphology of infarctions

1. Arterial

2. Venous

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VI. Shock

A. Definition

B. 3 main types

1. Hypovolemic

2. Cardiogenic

a. Intrinsic

b. Compressive

c. Obstructive3. Shock by generalized vasodilation

a. Anaphylactic shock

b. Neurogenic shock

c. Septic / inflammatory shock

C. Stages of shock

1. Compensation (non-progressive)

2. Impaired tissue perfusion (progressive)

3. Decompensation (irreversible)_