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HALOGENATED 2-OXETANONES APPROVED: Graduate Committee: tiJ. Major Profe f " Committee Member Committee pember ^Cdmmittee Member m Director of the Department of Chemistry Dean' of the Graduate School

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Page 1: tiJ. - Digital Library/67531/metadc... · cycloadditions ultimately lead to an important method for the synthesis of methylenecycloalkanes. ... pounds (20)^ such as dibenzalacetone,

HALOGENATED 2-OXETANONES

APPROVED:

Graduate Committee:

tiJ. Major Profe

f " Committee Member

Committee pember

^Cdmmittee Member

m

Director of the Department of Chemistry

Dean' of the Graduate School

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latel, Arvind D. , Halogenated 2-0xetanones. Doctor of

Philosophy (Chemistry), May, 1973, 68 pp., 4 tables,

bibliography, 44 titles.

The purpose of this investigation is threefold:

(1) to examine in detail the cycloaddition of halogenated

ketenes and carbonyl compounds, (2) to study the decarboxy-

lation of the resulting halogenated 2-oxetanones,and (3) to

investigate the effect of halogens in the halogenated

2-oxetanones on the nucleophilic addition reaction.

The generation of dichloroketene by the zinc dehalo-

genation of trichloroacetyl chloride in the presence of

simple ketones resulted in the formation of the corres-

ponding 2-oxetanones. Efforts to cycloadd dichloroketene

to -unsaturated carbonyl compounds were unsuccessful;

however, the zinc dehalogenation of trichloroacetyl chloride

in the presence of cyclic ketones resulted in the formation

of the corresponding 3,3-dichloro-spiro-2-oxetanones. These

cycloadditions ultimately lead to an important method for

the synthesis of methylenecycloalkanes.

Alkylhaloketenes also undergo in situ cycloadditions,

but only with activated carbonyl compounds. Cycloadditions

of alkylhaloketenes with aldehydes'produced both cis and

trans isomers in approximately equal amounts.

Any electronegative substituent on the 2-oxetanone ring

decreased the rate of decarboxylation. The presence of a

trichloromethyl substituent on the 4 position of the

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2-oxetanone ring severely Inhibited decarboxylation. This

is perhaps an indication of the mechanism of the elimination

reaction, and suggests some charge separation whereby the

4 carbon assumes some positive character. Decarboxylation

of the alkylchloroketene-chloral adducts over an electrically

heated wire provided a useful synthesis for the exotic

trichloromethylallenes.

Electronegative substituents on the 2-oxetanone ring

increased the reactivity of the 2-oxetanone towards the

nucleophilic addition, and only acyl-oxygen bond cleavage

occurred during the nucleophilic addition reaction.

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HALOGENATED 2-OXETANONES

DISSERTATION

Presented to the Graduate Council of the

North Texas State University in Partial

Fulfillment of the Requirements

For the Degree of

DOCTOR OF PHILOSOPHY

By

Arvind D. Patel, B. S., M. S.

Denton, Texas

May, 1973

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TABLE OP CONTENTS

Page

LIST OF TABLES iv

Chapter

I. INTRODUCTION 1

II. EXPERIMENTAL 16

III. RESULTS AND DISCUSSION 45

BIBLIOGRAPHY 66

iii

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LIST OF TABLES

Table Page

I. 2-Oxetanonea from Dichloroketene-Ketone

Cycloaddi tions 44

II. 2-0xetanones from Methylhaloketene-Carbonyl

Compound Cycloadditions 49

III. Effect of Chloro Substituent in 3 Position

on Rate of Decarboxylation 55

IV. Effect of Chloromethyl Substituent in 4

Position on Rate of Decarboxylation... 56

iv

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CHAPTER I

INTRODUCTION

The cycloaddition of ketenes and carbonyl compounds

yields 2-oxetanones (^-lactones).

C =C= 0 C = 0

;Staudinger first reported the cycloaddition of a ketene

to a carbonyl compound in 1908 (19). Most of the early work

was with diphenylketene and act -unsaturated carbonyl com-

pounds (20)^ such as dibenzalacetone, quinone and benzophenone.

The cycloadditions required temperatures of 130 to 140°C, and

at such temperatures the 2-oxetanones decarboxylated. Benzo-

phenone and diphenylketene undergo cycloaddition, to presumably

produce the corresponding 2-oxetanone, which decarboxylates

under the reaction conditions to yield tetraphenylethylene,

which is the only isolated product.

P h N Ph^ ^ C = C = 0 + > = 0

Ph Ph

Ph ^Ph

* c°2 Ph Ph

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Since the elevated temperatures, required for cyclo-

additions are sufficient to cause the dimerization and poly-

merization of lower molecular weight aldoketenes and keto-

ketenes (21), most of the early work was limited to diphenyl-

ketene.

Kung (13), Zaugg (23), Hagemeyer (11)?and Quadbeck (18)

reported that in the presence of a suitable catalyst, carbonyl

compounds will undergo cycloaddition with ketene, to yield

isolable 2-oxetanones. Ketene was found to undergo cycloaddition

with aldehydes smoothly in the presence of mild Friedel-Crafts

type catalysts, such as zinc chloride, but ketones required

stronger catalysts, such as boron trifluoride etherate.

H s c = c = 0 + R > = 0 C a t a l r s t > H" R

Aldehydes were also found to react with ketoketenes in

the presence of suitable catalysts, resulting in the formation

of the corresponding 2-oxetanones (12).

K R „ . , . J > C = C = 0 + c = 0 Catalyst ?

H R

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Oshe and coworkers have reported (17) the cycloadditlon

of ketene with chloral and hexachloroacetone in the absence

of a catalyst at 80°C.

H,

H

CC1, ,C = C = 0 :c = 0

H'

. 80° C

CCI3

It has "been recently reported by Bormann and Wegler (2, 3)

that the cycloaddition of ketenes to carbonyl compounds, to

produce 2-oxetanones occurs readily when the carbonyl function

is activated by electronegative substituents on the «<-carbon.

Thus the cycloaddition of several ketenes with activated car-

bonyl compounds, such as chloral, bromal, hexachloroacetone

and 1,1,3-trlchloro-1,3,3-trifluoroacetone have been

accomplished. The ketenes were generated in situ by the

triethylamine dehydrohalogenation of the appropriately sub-

stituted acyl chlorides.

R

R'

R .C AT C = 0

O it H

R - C - R ' " & + HN(Et).

I CI

More recently Bormann and Wegler (4) have reported that

dichloroketene undergoes cycloaddition with simple aldehydes,

to produce the corresponding 2-oxetanonee.

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CI

CI CH -§-01

CI

Lei

v, • C= C = 0

9 R-C-H

CI

CI

o II

H

Dichloroketene was also found to cycloadd with °C-keto-

esters under similar conditions, to produce the corresponding

2-oxetanones; however, simple ketones such as acetone, cyclo-

hexanone and acetophenone did not react with dichloroketene.

C1 N O O O u

CI • CH-0-C1 + R-6-C-0Et

N( E t^3

CI

Clw

+ «N(Et), H >

EtO-C.

Recently Brady and Smith (5) have reported on the

stereochemistry of the cycloaddition of some aldoketenes with

chloral, and found that both cis-. and trans-2-oxetanones were

produced in approximately equal amounts. The aldoketenes were

R, R CH-S-CI f ;c = c = o H ' LH

o CC1,-C-H^ — — 3—z

CC1_ Trans 3

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generated in situ "by the dehydrochlorination of the appro-

priately substituted acyl chlorides, and/or by dehalogenation

of appropriately substituted «C-haloacyl halides with zinc,

at room temperature.

The isomer distributions were approximately the same, reg-

ardless of the nature of the substituents on the ketene, or

the reaction solvent. A consideration of the principle of the

conservation of orbital symmetry, and the four possible ortho-

gonal approaches led to the conclusion that both isomers of

the 2-oxetanones would be expected to be formed in about equal

amounts, with perhaps a predominance of the cis isomer. A

concerted process was thus suggested for the cycloaddition.

During the course of this investigation, Brady and Smith

found that the generation of dichloroketene by the zinc de-

halogenation of trichloroacetyl chloride in the presence of

acetone and cyclohexanone producted the corresponding 2-oxetan-

ones.

c c l 3 - ^ 0 1 t U S ?

It was proposed that zinc was activating the carbonyl

group of the ketones. This was substantiated by the increased

yield of the cycloaddition of chloral and dimethylketene, in

the presence of activated zinc.

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A report (15) since the present investigation was

initiated has revealed that the dehydrohalogenation of cyclo-

heptatriene-7-carboxylic acid chloride in the presence of

benzophenone yields the cycloadduct, containing a conjugated

y-lactone formed by 8 + 2 cycloaddition of 8-oxoheptafulvene

and benzophenone. It was proposed that the y-lactone might

-CI

N(Et) 3-*

0

Ph-B-Ph. & be an isomerized product of the -lactone, the product of

2 + 2 cycloaddition of 8-oxoheptafulvene and benzophenone.

0 |i

Ph-C-Ph

Ph'

2 + 2

& •

Ph

Ph Ph © Ph

8-0xoheptafulvene was also found to react with tropone

to produce the unconjugated y-lactone, the result of a

concerted 8 + 2 cycloaddition.

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\]

&7T+ 21r

Recent reviews (23, 9) concerning the chemistry of

2-oxetanones reveal the general instability of this class of

compounds, and the variety of reactions which 2-oxetanones

undergo, such as polymerization, nucleophilic addition

reactions, and decarboxylation. ,

The thermal decarboxylation of 2-oxetanones yields the

expected olefin.

NC = 0 + /

CO,

In 1880 Erlenmeyer (8) proposed that in the preparation

of olefins from the salts of- (3-haloacids, $-lactones of

transitory existence are formed, and then decarboxylate

immediately into olefin and carbon dioxide.

-C-CHp-C-(? S l o w y

i Past \ /

C = C + / N CO,

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8

later, in 1883, Einhorn reported (7) that the (^-lactone

derived from f-bromo- $-(o-nitrophenyl) propionic acid

decomposes in boiling water to o-nitrostyrene and carbon

dioxide.

h2£. R.

H

.H '

, c=q CO, H

R = C6H4-o-N02

The thermal decarboxylation of the £-lactone from

5-hydroxy-6-carboxy ^-nor steroids occurs smoothly around

150°C (22).

vo

150° C + CO,

Pr.O

Gresham reported that isovalerolactone in water at

room temperature decomposes rapidly to carbon dioxide and

isobutylene (10), to the near exclusion of hydrolysis. It was

reported that this is probably due to a tendency for ionization

at the tertiary carbon-oxygen bond, with subsequent shift of

electrons, and expulsion of carbon dioxide occuring more

rapidly than attack of an ion at the tertiary carbon.

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_H20_ H.

H C—C

^ch3

SCH, CO,

It has "been reported (16) that 2-oxetanones undergo

decarboxylation in boiling water to yield stereoselectively

the corresponding olefins. A competing reaction was the

addition of water to yield the $-hydroxy acid.

Boiling

V *

H > = C

CH y R

75%

/ / H,

R = g6h4-£-ci

CH /

R

SH

80%

H 0 25%

3

00H

COOH

20%

Recently Adam and coworkers have reported (1) the direct

cyclization of f-hydroxy acids with benzenesulfonyl chloride

in pyridine at 0-5°C to tri- and tetrasubstituted £-lactones

in high yields. The $ -lactones obtained decarboxylated at

moderate temperatures of about 140-160°C, into the corres-

ponding olefins, with retention of the initial geometry of the

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10

•'C TO X V .thout double bond iso-

H^O-—OH

R ?S ^ R%

>n°o + CO,

r,'°-H4 3

-l comparison ol the relative stability of 2-oxeta.nones

i a v/-i-cn different aiJcyl groups are attached at the ^-carbon

iias sesn ::;ace (14). The rate of decarboxylation of ^-propio-,

P ~ OUXJTO- , and. j'-isovalerolactones in water increased with,

increasing the number of alkyl groups at the p-carbon. This

'VuJ projciDiy due to a greater tendency for ionization to occur

at the carbon and oxygen bond, with subsequent shift of

electrons, and expulsion of carbon dioxide. This would be

expected to occur more readily at tertiary carbon than either

secondary or primary.

CH„ 9 J

H

Cornfortn and coworkers have reported (6) that the

S -lactones obtained from ketene and 0-haloketone and

p -Ii&l0r.iii5ehyde cycloadditions are thermally stable, and

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11

do not decarboxylate in water as $-isovalerolactone does, but

gave good yield of corresponding olefin at 150-160°C.

R-CH

1500 0 , H > = o f , + C02

H pH-R

The unusual thermal stability of 4-trichloromethyl-2-

oxetanones have been reported by Oshe (17). It was found

that 4-trichloromethyl-2-oxetanones polymerized upon heating

at 200°C, rather than decarboxylation. However, the nucleophilic

addition such as hydrolysis, alcoholysis, and aminolysis was

200° C (n~0— U - ° ^ ) i i CC1,

n

CC1,

effected in usual manner to give corresponding £-hydroxy

acid, ester, and amide derivatives.

HNu H I 1

I • CC1,

Nu

Nu = OH, OCHj, HNR

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12

Brady and Smith havo recently reported (5) thnt attempts

to pyrolyse 3-chloro-4-trichloromethyl-2-oxetanone at 160°C

for 12 hours were unsuccessful; however, 3,3-dichloro-4 ,4-

dimethyl-2-oxetanone decarboxylated at 150°C in the expected

manner, to produce 1,1-dichloro-2-methylpropene.

No Reaction

CI CH_ 15° c > x0 = c'

• \ CI CH,

3

Few 2-oxetanones have "been reported with different

electronegative substituents in the 3- and 4- positions.

Therefore, the effect of such substituents on the ease of

decarboxylation is unknown, although there seems to "be a

very pronounced effect as just described.

In summary, the literature on ketene-carbonyl cyclo-

additions, and decarboxylation of the resulting 2-oxetanones

reveals that (a) the cycloaddition of dichloroketene to

simple ketones is tentative pending further investigation;

(b) very little work has been done with halogenated ketenes;

(c) activation of carbonyl function is necessary for cyclo-

additions in the absence of catalysts; (d) there are no

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13

reports on the relative stability of 2-oxetanones, when

different electronegative groups are attached to the -carbon;

(e) the effect of electronegative substituents in oO~P°sition

on decarboxylation of 2-oxetanone is unknown; (f) pyrolysis

of thermally stable 2-oxetanones at higher temperature is

relatively unknown.

Therefore, the purpose of this investigation is threefold;

(1) to examine in detail the cycloaddition of halogenated

ketenes and carbonyl compounds; (2) study the decarboxylation

of the resulting halogenated 2-oxetanones, thus determining

the effect of electronegative substituents at 3- and 4-positions

on the rate of decarboxylation; (3) investigate the effect of

halogens in the halogenated 2-oxetanones on the nucleophilic

addition reaction.

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CHAPTER BIBLIOGRAPHY

1. Adam, W. and Baeza, J.t J. Amer. Chem. Soc.. <U. 2000 (1972).

2. Bormann, D. and Wegler, R., Chem. Ber.. 99. 1245 (1966).

3. Bormann, D. and Wegler, R., Chem. Ber.. 100. 1575 (1967). ~

4. Bormann, D. and Wegler, R., Chem. Ber.. 102. 64 (1969). — -

5. Brady, W. T. and Smith, 1., J. Org. Chem.. 36. 1637 (1971). 6 ^

6. Cornforth, R. H., J. Chem. Soc.. 4052 (1959).

7. Einhorn, A., Chem. Ber.. 16, 2208 (1883).

8. Erlenmeyer, H., Chem. Ber.. 13, 303 (1880).

9. Etienne, Y. and Piascher, N., Heterocyclic Compounds Vol. XIX, Ed. Interscience Publishers, Inc., New York, pp. 729-880.

10. Gresham, T. L. and Jansen, J. E., J. Amer. Chem. Soc.. 76, 486 (1954).

11. Hagemeyer, H. J. Jr., Ind. Eng. Chem.. 41, 765 (1949).

12. Hasek, R. H. and Elam, E. U., U. S. Patent 3004989 (1961); Chem. Abstr.. 56, 4623 (1962).

13. F. ?•».?; S. Patent 2356459 (1944); Chem. Abstr. 39, 88 (1945). ; —

14* L i ^ ' Bartlett, P. D., J. Amer. Chem. S o n . . 80t 3885 (1958/•

15. Morita, N. and Kitahara, Y., Tetrahedron Lett.. Q. 872 (1972). ' U

16. f* %a n d Banitt, E. H., J. Org. Chem.. 31,

4043 (1966)*

14

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15

18. Quadbeck, G., Angew. Chem. , 68, 361 (1956).

19. Staudinger, H., Chem. Ber. 1355 (1908).

20. Staudinger, H., Chem. Ber. *

1493 (1908).

21. Staudinger, H., Chem. Ber. , 44, 533 (1911).

22. Tull, T. and Ourisson, G., Bull. Soc. Chem.

23. Zaugg, H. E., Organic Reactions, Vol. 8, R. Adams, Ed., Willey, New York, 1954, pp. 305 ff.

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n u ' R> rnj,\ R T Kj.i i x i X ,i~ J t J. l , L l

EXPERIMENTAL

Proton nuclear magnetic resonance spectra were obtained

using Jeolco ^iniroar (60 rnHZ) or Jeolco PS-100 (100 mHZ)

spectrophotometers. Chemical shifts are reported v/ith

respect to te tramethylsilane, w M c h was used as an internal

stand<urd. The nmr spectra were recorded at a sample concen-

tration of about twenty percent in carbon tetrachloride,

deuterated chloroform, or deuterated acetone solvents.

The infrared spectra were obtained using a Perkin-Elmer

Model ky7 Grating Infrared spectrometer. The cell used for

sample handling was 0,1 mm fixed pathlength cell with sodium

chloride optics.

Vapor phase chromatography was used for monitoring

reactions, determining the purity of products, and

purification of contaminated products by preparative

chromatographic separation techniques. The instrument used

for analytical purpose was F and K Scientific Model 700,

with a thermal conductivity detection system and a 3% SE.30

on chrornosorb W (AW-DMCS) 80/100-mesh, 5 feet x 0.25 inch

column. For preparative purpose a Varian Aerograph 1520

v/ith a 20 feet x 0,4— inch column v/ith similar column packing

materials was employed.

16

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17

Mass spectra were obtained using a Hitachi RMU-6E

mass spectrometer.

Analysis for carbon and hydrogen were conducted by

C.F. Geiger and Associates, Ontario, California.

Preparation of Reagents

All of the solvents employed in this study were

commercially available. The solvents were distilled over

sodium and stored over molecular sieves under nitrogen

atmosphere.

Commercially available triethylamine was distilled

over freshly cut sodium. Technical grade, commercially

available chloral was distilled at 40°C at 80 mm prior to

use. All the carbonyl compounds used in the investigation

were commercially available.

Most of the acid halides were prepared from the corres-

ponding commercially available acid by the following procedure.

One mole of acid was treated with 1.1 mole of thionyl

chloride^ and the reaction mixture refluxed at 100°C for

five to six hours. The acid halides prepared are tabulated

in table I.

cC-Chlorlnation of butanoyl and pentanoyl chloride;

The acid chloride (1.0 mole) and sulfuryl chloride

(1.25 mole) in the presence of 2.0 g of iodine were refluxed

overnight. The fractional distillation of the reaction

mixture gave a 50 per cent yield of 2-chlorobutanoyl chloride

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18

"bp 129-131°C (lit. bp 129-131°C (12)), and a 40 per cent

yield of 2-chloropentanoyl chloride, bp 154-155°C (lit. bp

154-155°C (14)).

TABLE I

ACID CHLORIDES PREPARED FROM COMMERCIALLY AVAILABLE ACIDS

Acid Chloride B.P.°C Reference

Butanoyl chloride 110-112 5

Pentanoyl chloride 126-128 5

2-Chloropropanoyl chloride 110-112 11

2-Bromopropanoyl chloride 131-132 8

Chloroacetyl chloride 105-106 17

Dichloroacetyl chloride 108-110 5

Preparation of Bromochloroacetyl chloride

Bromochloroacetyl chloride was prepared by the procedure

of Crompton and coworkers (6) .cc^jJ-Dichlorovinyl ethyl ether

was prepared by adding 650 g (5.0 mole) of trichloroethylene

to a previously prepared solution of 175 g (7.5 mole) of

sodium metal in 3 liters of absolute ethanol, in a flask

fitted with a large reflux condenser. Initially, only a

small portion (50 ml) of trichloroethylene was added, and

the reaction was initiated by heating the reaction flask

to 95°C with a water bath. After the reaction commenced,

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19

tile water oath was removed and triehloroethylene added

at sufficient rate to maintain vigorous reflux. After

addition was complete, the reaction mixture v/as allowed

to oxana at room temperature for 10 hours and then poured

into 10 1. of water. The organic layer was separated and

dried over CaCl^. Further drying was accomplished by re-

iluxirig with 1.5 1. of benzene removing the water by azeo-

tropic distillation. The benzene v/as evaporated on the

o

rotatory evaporator and the product distilled, bp 124-126 Cr

and stored over molecular sieves(Linde type 4A). The yield

v/as 400 g (SO per cent).

In a flask fitted with an addition funnel was placed

380 g (2.68 mule) of oc^-diciilorovinyl ethyl ether. A 430-g

(2.70 mole) portion of bromine was added dropwise over a

3-hour period. The bromine was rapidly absorbed as evidence

by the disappearance of the bromine color. After the bromine

addition, the reaction mixture v/as heated strongly under

a stream of nitrogen and the product distilled through a

6-inch Yigreaux column. After about 150 g of ethyl bromide

had been collected at 37-42°C, the temperature rose to 135°C,

and 300 g of bromochloroacetyl chloride were collected from

13S-140°C (lit. bp 138-139°C). This corresponds to a 56 per

cent yield; careful exclusion of atmospheric moisture is

necessary through out the reaction to prevent the formation

of ethyl broraochloroacetate.

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20

Activation of Zinc:

A 4-g (0.016 mole) portion of hydrated copper sulfate

was dissolved in 150 ml of water (3), and this solution was

added to 60 g (0.92 g atom) of zinc dust. This mixture was

stirred "by efficient magnetic stirrer for two hours. The

zinc dust was filtered "by suction filtration, washed several

times with acetone, and three times with dry ether. The zinc

was dried in a vacuum oven at 100°C prior to use in dehalo-

genation reactions.

Tri-n-butyltin hydride:

To a stirred slurry of LiAlH^ (4.75 g, 0.136 mole) in

300 ml of anhydrous ether was added 100 g (0.308 mole) of

tri-n-butyltin chloride at such a rate to keep gentle reflux

under nitrogen atmosphere. After addition of tri-n-butyltin

chloride, it was stirred for additional seven hours at 50-60°C.

The excess LiAlH^ was destroyed by addition of water, after

cooling by ice water bath. The reaction mixture was decanted

from lithium and aluminum salts. Distillation under reduced

pressure yielded 70 g (80 per cent yield) of tri-n-butyltin

hyride, bp 68-69°C at 0.3 mm (lit. bp 68-69°G at 0.3 mm (9)).

General procedure for dichloroketene-ketone cyclo-

addition by dehalogenation method:

To a stirred mixture of 3 moles of activated zinc,

200 ml of anhydrous ether and 2 moles of the ketone was

added dropwise an ether solution containing 1 mole of tri-

chlproacetyl chloride at room temperature. Cooling of the

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reaction vessel was usually necessary, and this was accom-

plished with an ice-water "bath. After the addition was

complete, stirring was continued for an additional hour.

The excess zinc was removed by filtration, and the filtrate

concentrated and extracted three times with dry hexane to

separate the 2-oxetanone from the zinc chloride etherate

and dichloroketene polymer. The hexane extracts were combined,

concentrated, and vacuum distilled to yield the 2-oxetanones.

3,3-Dichloro-4-ethyl-4-methyl-2-oxetanone:

The cycloadduct of dichloroketene and 2-butanone was

prepared in 35 per cent yield; bp 40°C at 0.5 mm; ir,

1875 cm*1 (C=0); nmr, $ 1.1 (t, 3H), 1.72 (s, 3H), 2.08 (q, 2H).

Analysis calculated for CgHgOlgOg! C, 39.3; H, 4.37.

Found: C, 39.08; H, 4.32.

3,3-Diehloro-4-methyl-4-n-propyl-2-oxetanone;

The cycloadduct of dichloroketene and 2-pentanone was

prepared in 35 per cent yield; bp 53°C at 0.5 mm; ir,

1875 cm"1 (C=0); nmr, J 1.1 (t, 3H), 1.78 (a, 3H), 1.5 (m, 2H),

2.0 (m, 2H).

Analysis calculated for C^H^QCO^Og: C, 42.6; H, 5.07.

Pound: C, 42.67; H, 4.96.

3.3-Dichloro-4-methyl-4-iso-propyl-2-oxetanone:

The cycloadduct of dichloroketene and 3-methyl-2-butanone

was prepared in 20 per cent yield; bp 43°C at 0.5 mm; ir,

1874 cm"1 (C=0); nmr, / 1.72 (s, 3H), 1.0 (d, 3H), 1.04

(d, 3H), 2.2 (m, 1H).

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Analysis calculated for C^H 1 0C1 20 2: C, 42.6; H, 5.07.

Found: C, 42.88; H, 4.88.

3,3-Dichloro-4-chloromethyl-4-methyl-2-oxetanone:

The cycloadduct of dichloroketene and chloroacetone

was prepared in 15 per cent yield; bp 43°C at 0.5 mm; ir,

1880 cm"1 (C=0); nmr, cf 2.0 (a, 3H), 4.25 (s, 2H).

Analysis calculated for C ^ H ^ C l ^ : C, 29.5; H, 2.48.

Found: C, 29.80; H, 2.25.

3* 3-Dichloro-4-benzyl-4-methyl-2-oxetanone :

The cycloadduct of dichloroketene and phenylacetone

was prepared in 40 per cent yield and obtained as a white

solid; mp 80°C; ir, 1870 cm"1 (C=0); nmr, cf 1.55 (s, 3H),

3.0 (d, 1H), 3.35 (d, 1H), 7.1 (a, 5H).

Analysis calculated for C^H^ClgOg: C, 53.88; H, 4.08.

Found: C, 53.67; H, 4.04.

3.3-Dichloro-4--chloroniethyl-4-Phenyl-2-oxetanone:

The cycloadduct of dichloroketene and CJ -chloro-

acetophenone was prepared in 20 per cent yield; bp 125-130°C

at 0.05 mm; ir, 1878 cm"1 (C=0); nmr, / 4.25 (s, 2H),

7.18 (s, 5H).

Analysis calculated for C 1 0H 7C1 50 2: C, 45.2, H, 2.65.

Found: C, 45.02; H, 2.43.

3,3-Dichloro-4.4-dichlororoethyl-2-oxetanone:

The cycloadduct of dichloroketene and sjm-dichloro-

acetone was prepared in 23 per cent yield; bp 85°C at 1.5 mm;

ir, 1882 cm"1 (0=0); nmr, <f 3.9 (s).

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Analysis calculated for C ^ C l ^ : C, 25.2; H, 1.68.

Found: C, 25.54; H, 1.65.

1,1-Dichloro-2-methyl-1-heptene:

The cycloadduct of dichloroketene and 2-heptanone was

prepared by. the general method indicated above. Prior to

vacuum distillation, the residue revealed a band in the

infrared spectrum at 1870 cm"1 (C=0), verifying the presence

of the 2-oxetanone. However, upon distillation decarboxylation

occurred and the corresponding olefin was isolated in an

over-all yield of 40 per cent; bp 78-80°C at 25 mm; ir,

1635 cm"1; nmr, cf 0.8 (m, 3H), 1.3 (m, 6H), 1.85 (s, 3H)

and 2.25 (m, 2H).

Analysis calculated for CgH^Clgj C, 53.3; H, 7.77.

Found: C, 52.99; H, 7.57.

General procedure for cycloaddition of dichloroketene

and cycloalkanones by dehalogenation method;

To a refluxing stirred mixture of 3 moles of activated

zinc, 200 ml of dry ether, and 1.5 mole of the cycloalkanone

was added dropwise an ether solution containing 1.0 mole of

trichloroacetyl chloride. After the addition was complete,

stirring was continued for four hours. The excess zinc was

removed by filtration and the filtrate concentrated and

extracted with hexane to separate the 2-oxetanone from zinc

chloride etherate and dichloroketene polymer. The hexane

extracts revealed a carbonyl stretching in the infrared at

1872 cm , verifying the presence of the 2-oxetanone. The

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hexane extracts were combined, concentrated, and vacuum

distilled. Decarboxylation of the 2-oxetanone usually

occurred upon distillation, and the corresponding dichloro-

methylenecycloalkanes were isolated in an overall yield of

40-50 per cent. In those cases where decarboxylation did

not occur, or was incomplete upon distillation, heating at

120-150°C for about one hour was sufficient for decarboxylation.

Dichloromethylenecyclopentane:

Cycloaddition of dichloroketene and cyclopentanone

yielded 3,3-dichloro-1-oxaspiro [3.4~] heptane-2-one in 30

per cent yield; bp 56-58°C at 0.5 mm; 1855 cm"1 (C=0). Upon

heating at 120-150°C for one hour decarboxylation occurred,

to yield dichloromethylenecyclopentane in quantitative

yield; bp 55-56°C at 1.5 mm; ir, 1635 cm"1 (C=C).

Dichloromethylenecyclohexane:

Cycloaddition of dichloroketene and cyclohexanone

yielded 3,3-dichloro-1-oxaspiro [^3.5j octane-2-one in 50

per cent yield; bp 62°C at 0.2 mm; ir, 1850 cm"1 (C=0).

Upon heating at 120-150°C for one hour decarboxylation

occurred to yield dichloromethylenecyclohexane in quantitative

yield; bp 62-65°C at 1.5 mm; ir, 1620 cm"1 (G=C).

3-Me thyldlchlorome thylenecyclohexane;

Cycloaddition of dichloroketene and 3-methylcyclohexanone

yielded 3,3-dichloro-1-oxaspiro [3.5] -5-methyloctane-2-one;

_ 1

ir, 1855 cm (C=0). Partial decarboxylation occurred upon

distillation, and was completed at 120-150°C to yield

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3-methyldichloromethylenecyclohexane in an overall yield of

45 per cent; "bp 72-75°C at 1.5 mm; ir, 1620 era""1 (C=C).

4-Methyldichloromethylenecyclohexane:

Cycloaddition of dichloroketene and 4-methylcyclohexanone

yielded 3,3-dichloro-1-oxaspiro [ 3.5] -6-methyloctane-2-one;

ir, 1855 cm (0=0). Partial decarboxylation occurred upon

distillation, and was completed at 120-150°C to yield

4-methyldichloromethylenecyclphexane in an overall yield of

50 per cent; bp 70-75°C at 1.5 mm; ir, 1620 cm*"1 (C=C).

Dichloromethylenecycloheptane: HI • inn mm N MI i f KI.I •n,.mi i i I A

Cycloaddition of dichloroketene and cycloheptanone

yielded 3,3-dichloro-1-oxaspiro [3.6] -nonane-2-one; ir,

1865 cm 1 (C=0). Upon distillation complete decarboxylation

occurred and dichloromethylenecycloheptane was isolated in

50 per cent yield; bp 70-72°C at 1.5 mm; ir, 1610 cm"1 (C=C).

Di chlorome thylene cyclo o ctane:

Cycloaddition of dichloroketene and cyclooctanone yielded

3,3-dichloro-1-oxaspiro decane-2-one; ir, 1870 cm"1

(C=0). Upon distillation complete decarboxylation occurred

and dichloromethylenecyclooctane was isolated in 45 per cent

yield; bp 75-78°C at 1.5 mm; ir, 1610 cm"1 (C=C).

Dechlorination of dichloromethylenecycloalkanes:

The dechlorination of dichloromethylenecycloalkanes

was easily accomplished with a slightly modified method of

Boorl and coworkers (1).

The dechlorination was carried out with a 10-12 g atom

solution of sodium in liquid ammonia at -78°C using a

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dry ice/acetone "bath, an efficient magnetic stirrer, and

dry ice/acetone cold finger.

The required amount of liquid ammonia was charged to the

reaction flask to dissolve the sodium (10-12 g atoms of sodium

per mole of chloride to he dechlorinated). The sodium was

added slowly in small pieces. When the sodium had dissolved,

the dichloromethylenecycloalkanes, diluted with one to five

volumes of dry pentane was added dropwise to the stirred

sodium solution in ammonia and dry pentane. After the addition

was complete, the reaction mixture was stirred for an add-

itional hour to ensure completion of the reaction.

The excess sodium amide was neutralized with slow

addition of solid ammonium chloride until the reaction mixture

became colorless. About 100 ml of water was added slowly and

the cooling hath was removed. The aqueous layer was separated/

and the organic layer was washed with dilute sodium bicarbonate

solution and finally with water. The solution was then dried

over anhydrous magnesium sulfate and the solvent evaporated.

The residue was fractionally distilled to give an 80-90

per cent yield of the methylenecycloalkanes.

Methylenecyclopentane:

Dechlorination of dichloromethylenecyclopentane yielded

methylenecyclopentane in 80 per cent yield? bp 77-78°C (lit.

77-78°C (15)).

Methylenecyclohexane:

Dechlorination of dichloromethylenecyclohexane yielded

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methylenecyclohexane in 90 per cent yield; bp 100-102°C

(lit. 100-102°C (15)).

3-Methylmethylenecyclohexane:

Dechlorination of 3-methyldichloromethylenecyclohexane

yielded 3-methylmethylenecyclohexane in 90 per cent yield;

bp 123-124°C (lit. 123-124°C (16)).

4-Methylmethylenecyclohexane:

Dechlorination of 4-methyldichloromethylenecyclohexane

yielded 4-methylmethylenecyclohexane in 95 per cent yield;

bp 122-123°C (lit. 122-123°C (16)).

Methylenecjcloheptane:

Dechlorination of dichloromethylenecycloheptane yielded

methylenecycloheptane in 90 per cent yield; bp 136-138°C

(lit. 136-138°C (15)).

Methylenecyclooctane:

Dechlorination of dichloromethylenecyclooctane yielded

methylenecyclooctane in 85 per cent yield; bp 154-156°C

(lit. 154-156°C (15)).

General procedure for cycloaddltlon of alkylhalo-

ketenes with chloral by dehydrohalogenation;

A solution of 2 moles of freshly distilled chloral

in 150 ml of hexane was stirred while 1 mole of oC -halo-

acid chloride and 1.5 mole of triethylamine were added

simultaneously at room temperature. After stirring for an

additional hour, the salt was removed by suction filtration,

and the filtrate concentrated. Distillation under reduced

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pressure afforded the corresponding 2-oxetanone in good yields.

3-Chloro-3-methyl-4-trichloromethyl-2-oxetanone '•

2-Chloropropanoyl chloride was dehydrochlorinated in

the presence of chloral to give 53 per cent yield of the

2-oxetanone. Both isomers were obtained in approximately

A 1

equal amounts; bp 70 C at 0.5 mm; ir, 1875 cm" (C=0); nmr,

S 2.05 (s, 3H), 4.95 and 5.18 (2 s of cis and trans isomer, 1H).

Analysis calculated for G^H^C1^02: 0, 25.21; H, 1.67.

Found: C, 25.53; H, 1.51.

3-Chloro-3-ethyl-4-trichloromethyl-2-oxetanone:

2-Chlorobutanoyl chloride was dehydrochlorinated in

the presence of chloral to give a 50 per cent yield of both

isomers of the 2-oxetanone; bp 72-75°C at 0.5 mm; ir,

1875 cm"1 (C=0); nmr,cf 1.23 (t, 3H), 2.5 (m, 2H) and 4.82

and 5.18 (2 s of cis and trans isomers, 1H).

Analysis calculated for CgHgCl^Ogi C, 28.57; H, 2.38. Found: C, 28.52; H, 2.33.

3-Chloro-3-n-propyl-4-trichloromethyl-2-oxetanone:

2-Chloropentanoyl chloride was dehydrochlorinated in

the presence of chloral to form a 45 per cent yield of the

2-oxetanone. Both isomers were formed in approximately

equal amounts; bp 72-78°C at 0.5 mm; ir, 1875 cm"1 (C=0);

nmr, cf 1.0 (m, 3H), 1.7 (m, 4H), 4.82 and 5.18 (2 s of cis

a n d "trans isomers, 1H).

Analysis calculated for O ^ H g C l ^ : C, 31.57; H, 3.00.

Found: C, 31.61; H, 3.05.

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3-Bromo-»3--niethyl~4-trichlorometh,yX-2-oxetanone:

2-Bromopropanoyl chloride was dehydrochlorinated in

the presence of chloral to give a 60 per cent yield of both

isomers of the 2-oxetanones; hp 75-80°C at 0.4 mm; ir,

1875 cm"1 (C=0); nmr, cf 2.2 (s, 3H), 4.8 and 5.22 (2 s of

els and trans isomers, 1H).

Analysis calculated for C^H^BrC1^02: C, 21.27; H, 1.52.

Pound: C, 21.26; H, 1.65.

Methylhaloketene cycloadditlons with o-chlorobenz-

aldehyde:

A one-mole portion of the 2-halopropanoyl chloride was

added dropwise at room temperature to a stirred solution

of 2 moles of triethylamine, 200 ml of hexane, and 1.5 mole

of o-chlorobenzaldehyde. After the addition, stirring was

continued at room temperature for four hours. The amine salt

was filtered, the filtrate concentrated, and the residue

vacuum distilled to yield the 2-oxetanones.

3-Ghloro-3-methyl-4-o-chlorophenyl-2-oxetanone:

2-Chloropropanoyl chloride was dehydrochlorinated in the

presence of o-chlorobenzaldehyde to yield two isomers of the

2-oxetanone in about equal amounts, yield 45 per cent; bp

50°C at 0.2 mm; ir, 1878 cm"1 (C=0); nmr, cf 2.2 and 2.38

(2 s of cis and trans isomers, 3H); 6.35 and 6.45 (2 s cis

a n d trans 1H); 7.0 (m, 4H).

Analysis calculated for C^HgClgOg: C, 51.95; H, 3.28.

Pound: C, 51.53; H, 3.34.

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3-Bromo-3-methyl-4-o-chlorophenyl-2-oxetanone:

2-Bromopropanoyl chloride was dehydrochlorinated in

the presence of o-chlorobenzaldehyde to yield two isomers

of 2-oxetanone in about equal amounts, yield 50 per cent;

bp 125-13O°0 at 0.1 mm; ir, 1878 cm"1 (C=0); nmr,/ 2.1

and 2.7 (2 s for cis and trans 3H); 7.0 (m, 4H).

Analysis calculated for C.jQHgBrC102: C, 43.6; H, 2.93.

Found: C, 43.91; H, 2.92.

Methylhaloketene cycloaddition with sym-dichloro-

tetrafluoroacetone:

A solution of 1 mole of triethylamine in 200 ml of hexane

was cooled to -78°C, and then 1 mole of 2-halopropanoyl

chloride was added dropwise. After the addition was complete,

the reaction mixture was stirred at this temperature for 15-20

minutes, and then 1.5 mole of sym-dichlorotetrafluoroacetone

was added..After warming to room temperature, the salt was

removed by filtration, the filtrate concentrated, and the j i;

residue vacuum distilled to yield the 2-oxetanones.

3-Chloro-3-methyl-4.4-bis(chlorodifluoromethyl)-ji

2-oxetanone:

2-Chloropropanoyl chloride was dehydrochlorinated in

the presence of sym-dichlorotetrafluoroacetone to give a

55 per cent yield of the 2-oxetanone; bp 48-50°C at 1.5 mm;

ir, 1885 cm"1 (C=0); nmr,<f 2.05 (s).

Analysis calculated for CgHjCl^F^OgJ 0, 24.82; H, 1.08.

Found: C, 24.94; H, 1.03.

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3-Bromo-3-methyl-4>4-bis(chlorodifluoromethyl)-2-oxetanone:

2-Bromopropanoyl chloride was dehydrochlorinated in

the presence of sym-dichlorotetrafluoroacetone to give a

60 per cent yield of the 2-oxetanone; bp 48-52°C at 0.5 mm;

ir, 1885 cm~1(C=0); nmr, 6 2.08 (s).

Analysis calculated for CgH^BrC^Og! C, 21.56; H, 0.99.

Found: C, 21.38; H, 0.96.

Cycloaddition of chloroketene with sym-dichloro-

tetrafluoroacetone:

The same procedure was employed for this cycloaddition

as described above for the methylhaloketenes with this

ketone, yield 50 per cent; bp 45-47°C at 1.5 mm; ir, 1895 cm

nmr, </ 5.25 (s).

Analysis calculated for C^HCl^F^Og: C, 21.81; H, 0.37.

Found: C, 21.79; H, 0.69.

3,3-Dichloro-4-trichloromethyl-2-oxetanone:

A solution of 2 moles of freshly distilled chlora.1 in

150 ml of hexane was stirred while 1 mole of dichloroacetyl

chloride and 1.5 moles of triethylamine were added simul-

taneously at room temperature. The salt was removed by

filtration, and the filtrate was concentrated. Distillation

at ,90°C at 12 mm afforded 60 per cent yield of 2-oxetanone:

ir, 1870 cm"1 (C=0) (2).

3,3-Dichloro-4-acetyl-4-meth.yl-2-oxetanone:

A solution of 1.5 mole of triethylamine in 300 ml of

hexane containing 1.5 mole of dimethylglyoxal was stirred

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while a solution of 1 mole of dichloroacetyl chloride in

hexane was added at room temperature. After completion of

the addition, the reaction mixture was stirred for four

hours and filtered. The solvent was removed under reduced pres-

sure and the 2-oxetanone distilled at 85°C at 3 mm in 40

per cent yield; ir, 1870 cm"*1 (C=0); nmr, & 1.85 (s, 3H)

and 2.4 (s, 3H).

Analysis calculated for C^HgClgO^: C, 36.58; H, 3.08.

Found: C, 36.33; H, 2.92.

Bromochloroketene-aldehyde cycloadditions:

The same procedure was employed as described for

3,3-dichloro-4-acetyl-4-methyl-2-oxetanone.

3-Bromo-3-ch.loro-4-phenyl-2-oxetanone:

Bromochloroacetyl chloride was added to a solution

containing henzaldehyde and triethylamine. Prior to vacuum

distillation the residue revealed a "band at 1870 cm"1 and

a singlet at <f 5.66 and a singlet at cf 6.0 in equal amounts

for the methinyl hydrogens for "both isomers. Upon distillation

decarboxylation occurred, and ^-"bromo-^-chlorostyrene was

isolated in 35 per cent yield at 80°C at 0.5 mm; ir,

1600 cm"*1; nmr, cf 6.95 and 7.05 (2 s of cis and trans

isomers, 1H) and 7.25 (m, 5H).

Analysis calculated for CgHgBrCl: C, 44.14; H, 2.75.

Pound: C, 44.18; H, 2.61.

3-Bromo-3-chloro-4-isopropyl-2-oxetanone:

Bromochloroacetyl chloride was dehydrochlorinated in

the presence of isobuytraldehyde. Vacuum distillation

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afforded a 20 per cent yield of two isomers in equal amounts

at 60°C at 0.5 mm; ir, 1872 cm-1 (C=0); nmr, 1.15 (d, 6H),

1.93 (m, 1H), 4.26 and 4.40 (2 d for cis and trans isomers, 1H).

Analysis calculated for CgHgBrC102: C, 31.63; H, 3.43.

Found: C, 31.23; H, 3.41.

3-Bromo-3-chloro-4-trichloromethyl-2-oxetanone:

Bromochloroa,cetyl chloride was dehydrochlorinated in

the presence of chloral to produce the 2-oxetanone in a 50

per cent yield of two isomers in equal amounts at 65-70°C

at 0.5 mm; ir, 1880 cm"1 (C=0); nmr, 5.42 and 5.61 (2s

for cis and trans isomers).

Analysis calculated for C HBrCl/jC>2: C, 23.52; H, 0.53.

Found: C, 23.38; H, 0.61.

trans~3-Chloro-4-trichloromethyl-2-oxetanone:

The in situ cycloaddition of chloroketene and chloral

at room temperature gave both cis and trans isomers of

2-oxetanone; cis isomer, pair of doublets centered at 5.18

and 5.58 (J=6 Hz); trans isomer, pair of doublets centered

at 5.04 and 5.25 (J=3 Hz). The cis/trans ratio in the

reaction mixture was 1.64 (4). The following prodedure

yielded only the trans isomer.

A solution of 1 mole of triethylamine in 200 ml of

hexane was cooled to -78°C in dry ice/acetone bath and then

1 mole of chloroacetyl chloride was added dropwise. After the

addition was complete, the reaction mixture was stirred at

this temperature for ten minutes and then 1.5 mole of chloral

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was added. After warming to room temperature, the salt was

removed by filtration, and the filtrate concentrated, and the

residue vacuum distilled to yield only trans-3-chloro-4-tri-

chloromethyl-2-oxetanone in 40 per cent yield; nmr, pair of

doublets centered at J 5.04 and 5.25 (J=3.0 Hz); ir, 1870

cm""1 (C=0).

Dechlorination of 3,3-dichloro-4-ethyl-»4-methyl-

2-oxetanone by tri-n-butyltin hyride:

A solution of 0.05 mole of freshly distilled tri-n-

butyltin hyride in hexane was slowly added to a stirred

solution of 0.05 mole of 3,3-dichloro-4-ethyl-4-methyl-2-

oxetanone in hexane. The reaction solution was kept cool by

cold water. After stirring for two hours, the hexane was

evaporated under reduced pressure, and the residue distilled

at 40-43°C at 1.5 mm to give 3-chloro-4-ethyl-4-methyl-2-

oxetanone in quantitative yield. Both cis and trans isomers

~ 1

were obtained in approximately equal amounts; ir, 1865 cm

(C=0); nmr, cT 1.0 (t, 3H), 1.5 (2 s of cis and trans isomers,

3H), 1.80 (m, 2H) and 4.92 (s, 1H).

Analysis calculated for CgH^ClO^ C, 48.48; H, 6.66.

Pound: C, 48.36; H, 6.53.

4-Ethyl-4-methyl-2-oxetanone:

A solution of 0.05 mole of tri-n-butyltin hydride in

hexane was added to a solution of 0.025 mole of 3,3-dichloro-

4-e thyl-4-methyl-2-oxetanone and 0.1 g of azobisisobutyro-

nitrile in hexane. The reaction solution was cooled by cold

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35

water. After stirring for two hours, the solvent was

removed under reduced pressure, and 4-ethyl-4-methyl-2-

oxetanone was distilled at 60-65°C at 10 mm in quantitative

yield, (lit. 60°C at 10 mm (10)).

Decarboxylation

Decarboxylation of 4-ethyl-4-methyl, 3-chloro-4-ethyl-

4-methyl and 3«3-dichloro-4-ethyl-4-methyl-2-oxetanones:

Three solutions of 1.5 g of 2-heptanone containing

1.5 g of each 2-oxetanone in three 10 ml flasks were decarbo-

xylated at 80°C in an oil bath. The rate of decarboxylation

was determined by observing the disappearance of the 2-oxe-

tanone carbonyl band in the ir at about 1865-70 cm~^. The

carbonyl band of 2-heptanone at 1735 cm was used as an

internal standard. The relative rates were determined from

the time required for 50 per cent decarboxylation. The

relative rates for 4-ethyl-4-methyl, 3-chloro and 3»3-dichloro-

4-ethyl-4-methyl-2-oxetanones were 100 ; 6 : 1 respectively.

Decarboxylation of 3,3-dichloro-4-ethyl-4-methyl, 3,3-

dichloro-4-chloromethyl-4-methyl and 3,3-dichloro-4,4-dichloro-

methyl-2-oxetanones;

A 3 g portion of each of the 2-oxetanones in three 10

ml flasks were thermally decarboxylated at 150°C in an oil

bath. The rate of decarboxylation was determined by vpc

analysis by observing the disappearance of 2-oxetanone and

appearance of the olefin. The time required for 50 per cent

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decarboxylation was found and the relative rates for

3,3-dichloro-4-ethyl-4-methyl, 3,3-dichloro-4-chloromethyl-

4-methyl and 3,3-dichloro-4,4-dichloromethyl-2-oxetanones

were 100 : 17 : 1 respectively.

Attempted decarboxylation of 3»3-dichloro-4-ethyl-4-

methyl-2-oxetanone in water:

A 5.0 g portion of the 2-oxetanone was mixed with 50

ml of water in a 100 ml flask. The flask was heated to 50°C

in an oil bath for about thirty minutes. No evidence of

olefin was detected on vpc.

Decarboxylation of 3.3-dichloro-4-acetyl-4-methyl-2-

oxetanone and 3.3-dlchloro-4-chloromethyl-4-methyl-2-oxetanone:

A 3.Q g portion of each of the 2-oxetanones were thermally

decarboxylated at 170°C in an oil bath. The rate of decarbo-

xylation was determined by vpc analysis by observing the

disappearance of 2-oxetanone, and' appearance of the olefin.

The relative rates were found to be approximately 1 ; 1.

Pyrolysis of 3-chloro-3-methyl-4-trichloromethyl-2-

oxetanone:

A 24 g (0.1 m) portion of the 2-oxetanone was pyrolyzed

in a ketene generator at 1.5-2 mm as the 2-oxetanone was

slowly refluxed over the electrically heated red hot filament.

After about 2 hours, trichloromethylallene was isolated from

a dry ice-acetone trap in the system. Distillation afforded

9.4 g (60 per cent) of the allene at 80-82°C; irf 1610 cm"1

(vs) and 1965 cm"1 (w); nmr, <f 5.36 (d, 2H) and 6.03 (s, 1H).

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Analysis calculated for O ^ C l ^ : C, 30.47; H, 1.94.

Found: C, 30.32; H, 1.99. (Mol. wt. 156 by mass spect#f

theory 156).

Pyrolysis of 3-chloro-3-ethyl-4-trichloromethyl-2-

oxetanone:

A 10-g portion of the 2-oxetanone was pyrolyzed in a

ketene generator as described above, 1,1,1-trichloro-2,3-

pentadiene was obtained in 50 per cent yield. Purification

was accomplished by preparative vpc; ir, 1600 cm"1; nmr,

S 1.75 (d, 3H), 6.12 (q, 1H) and 6.32 (s, 1H).

Analysis calculated for C^H^Cl^: C, 34.98; H, 2.90.

Found: C, 35.16; H, 2.79 (Mol. wt. 170 by mass spect.,

theory 170).

Pyrolysis of 3-chloro-3-propyl-4-trichloromethyl-2-

oxetanone:

A 9.0-g portion of the 2-oxetanone was pyrolyzed in a

ketene generator under the same conditions described above.

The 1»1»1-trichloro-2,3-hexadiene was obtained in 40 per

cent yield and purified by preparative vpc; ir, 1600 cm'1;

nmr,J 1.0 (t, 3H), 2.13 (m, 2H), 6.08 (t, 1H) and 6.22 (s, 1H).

Analysis calculated for C ^ C l ^ C, 38.81; H, 3.77.

Found: C, 38.66; H, 3.65. (Mol. wt. 184 by mass spect.,

theory 184).

Pyrolysis of 3,3-dichloro-4-trichloromethyl-2-oxetanone:

A 26-g (0.1 m) portion of the 2-oxetanone was pyrolyzed

under the same conditions as described above. The products

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of the pyrolysis were collected in a dry ice-acetone trap _ <4

at -78 C. There was a strong band in the ir at 1962 cm"

at low temperature, which disappeared upon warming to room

temperature. Distillation afforded 7.5 g (35 per cent) of

1,3,3,3-pentachloropropene, 1.7 g (13 per cent) of tri-

chloroethylene, and 1.8 g (11 per cent) of perchloroallene

dimer, which crystallized from the residue of the disti-

llation; mp 90-91°C (lit. 90-91°G (13)). The ir spectrum

was identical to that reported in the literature.

Pyrolysis of 1,1,3,3.3-pentachloropropene:

Pyrolysis of 5.0 g of 1,1,3>3»3-pentachloropropene

under the identical conditions as described above for

3,3-dichloro-4-trichloromethyl-2-oxetanone at 25 mm pressure

produced products in the dry ice-acetone trap, which gave _ -i

a band in the ir at 1962 cm at low temperature, which

disappeared upon warming to room temperature.

Decarboxylation of trans-3-chloro-4-trlchloromethyl-

2-oxetanone:

A 20-g (0.09 mole) portion of the 2-oxetanone was

pyrolyzed in a ketene generator under reduced pressure as

described above. A 13 g (80 per cent) portion of 1,3,3,3-

tetrachloropropene was isolated from the dry ice-acetone

trap. This olefin consisted of approximately equal amounts

of the els and trans isomers as evidenced by the nmr coupling

constants for the vinyl protons (7).

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39

Nucleophilic Addition

2.2-Dichloro-3-hydroxy-3-methylpentanoic acid:

3.3-Dichloro-4-ethyl-4-methyl-2-oxetanone (0.05 mole)

was stirred with 100 ml of water at 60-65°C. After 4 days,

the organic layer was separated from the aqueous layer.

Vpc analysis of the organic layer revealed some decarboxy-

lation product along with the starting 2-oxetanone. The

aqueous layer was slowly evaporated and the hydroxy acid

crystallized in a 15 per cent overall yield; mp 82°C; ir,

1722 cm"1; nmr (deuterated acetone), j 1.0 (t, 3H),

1.5 (s, 3H), 1.80 (m, 2H)» 2.2 (m, 1H).

This acid was converted to the corresponding methyl

ester.

Methyl 2,2-dichloro-3-hydroxy-3-methylpentanoate:

3,3-Dichloro-4-ethyl-4-methyl-2-oxetanone (0.05 mole)

was added to a stirred 50-ml portion of methanol at 50°C.

The progress of the reaction was followed "by vpc. After 48

hours, only 50 per cent of the starting 2-oxetanone had

disappeared and the corresponding ester formed. Fractional

distillation afforded the ester at 53-54°C at 0.25 mm; ir,

1720 cm"1; nmr (deuterated acetone), <f 1.0 (t, 3H), 1.45

(s, 3H), 1.85 (q, 2H), 3.8 (s, 4H).

Analysis calculated for C^H^ClgO^: C, 39.90; H, 5.59.

Pound: C, 39.72? H, 5.62.

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N,N-Dimeth.yl-2,2-dichloro-3-hydroxy-3-methylpentanamide:

3,3-Dichloro-4-ethyl-4-methyl-2-oxetanone (0.05 mole)

was added to a stirred solution of dimethylamine (0.06 mole)

in 100 ml of ether at 0-5°C. Upon warming to room temperature,

the ether was evaporated and the amide distilled in quanti-

tative yield at 70-75°C at 0.5 mm; ir, 1640 and 1670 cm*"^;

nmr (deuterated acetone), cf > 3H), 1.45 (s, 3H),

2.0 (q, 2H), 3.25 (m, 6H), 4.65 (s, 1H).

Analysis calculated for CQH15C12N02: C, 42.11; H, 6.58.

Found: 0, 42.61; H, 6.62.

2,2, 4.4» 4-Pentachloro-3-hydroxy"butanoic acid;

3,3-Dichloro-4-trichloromethyl-2-oxetanone (0.05 mole)

was stirred with 100 ml of water at 70°C. After 2 hours,

the organic layer had gone into solution. The water was

slowly evaporated and the acid crystallized from solution

in 80 per cent yield; mp 180°C; ir, 1725 cm"^; nmr (deuterated

acetone), <f , 2.2 (s, 1H), 5.2 (s, 1H).

Analysis calculated for C^H^Cl^O^: C, 17.36; H, 1.08.

Found: C, 17.31; H, 0.98.

Methyl 2,2,4,4.4-Pentachloro-3-'hydroxy"butanoate:

3,3-Dichloro-4-trichloromethyl-2-oxetanone (0.05 mole)

was slowly added to a stirred 50-ml portion of dry methanol

at room temperature. The reaction was exothermic and upon

evaporation of the solvent and distillation of the residue,

there was obtained a quantitative yield of the ester, bp

100°C at 0.05 mm; mp 72°C; ir, 1740 cm~^; nmr (deuterated

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acetone), / , 3.92 (s, 3H), 5.2 (m, 1H), 7.1 (m, 1H).

Analysis calculated for C ^ C l ^ : C, 20.65; H, 1.72.

Found: C, 20.23; H, 1.65.

N.N-Dimethyl-2,2,4,4,4-pentachloro-3-hydroxybutanamide:

3,3-Dichloro-4~trichloromethyl-2-oxetanone (0.05 mole)

was added to a stirred solution of dimethylamine in 100 ml

of ether at -78°C. Upon warming to room temperature, a

small amount of amine hydrochloride precipitated from

solution. The reaction mixture was filtered and the ether

evaporated to yield the crystalline amide, mp 123°C; ir,

1635 and 1670 cm**''; nmr (deuterated acetone), cf , 2.0 (s, 1H),

3.1 (s, 6H), 5.4 (s, 1H).

Analysis calculated for CgHgCl^NOg: C, 23.72; H, 2.63.

Pound: C, 23.53; H, 2.71.

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CHAPTER BIBLIOGRAPHY

1. Boord, C. E., Hoff, M. C. and Greenlee, K. W., J. Amer. Ghem. Soc., 73, 5329 (1951)/

2. Borrmann, D. and Wegler, R., Chem. Ber., 99, 1245 (1966). ~

3. Brady, W. T. and Liddell, H. G., J, Org. Chem., 31, 626 (1966).

4. Brady, W. T. and Smith, L., J. Org. Chem., 36_

1637 (1971). ^

5. Brown, H. C., J. Amer. Chem. Soc., 60^ 1325 (1938).

6. Crompton, H. and Vanderstichele, P., J. Chem. Soc., or UJ, 691 (1949).

7. Fields, R. and Hasteldine, R. J. Chem. Soc., (C) 165

0969).

8. Fischer, E. and Raske, K., Chem. Ber. 39, 3981 (1906).

9. Ghosez, L. and Montaigne, R.., Tetrahedron, 27, 615

(1971).

10. Hagemeyer, H. J. Jr., Ind. Eng. Chem., 41 , 765 (1949).

11. Michael, A., Chem. Ber. 34, 4028 (1901).

12. Paal, C. and Schiedewitz, H., Chem. Ber., 62, 1935 ( 1929 ) . ~

13. Roedig, A., Bischoff, F,, and Markl, G. Justus Liebigs Ann. Chem., 6^0, 8 (1963).

14. Servais, L., J. Chem. Soc. ,Ab3tr., 1_1J, 80 (1901).

15. Siegel, S. and Dunkel, M., J. Org. Chem., 31. 2802 (1966). - ~

16. Vilkas,,M. and Abraham, N., Bull. Soc. Chim. France.. 201, 1196 (1960).

17. Wilde, P., Justus Liebigs Ann. Chem.. 132, 171 (1864).

42

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CHAPTER III

RESULTS AND DISCUSSION

. The generation of dichloroketene "by the zinc dehalo-

genation of trichloroacetyl chloride in the presence of

simple ketones resulted in the formation of the corresponding

2-oxetanone. The cycloadducts were prepared in 15-40 per

cent yields, aa illustrated in Table I,

9 R

CCl,-b-Cl + ^ C = 0 3 R

Ether

Dichloroketene does not undergo cycloaddition with

simple ketones when the ketene is prepared "by the triethyl-

amine dehydrochlorination of dichloroacetyl chloride (1).

However, if zinc/zinc chloride are added to the dehydro-

halogenation mixture, cycloaddition occurs in about 15 per

cent yield. Thus the role of zinc/zinc chloride was activating

the carbonyl group of the ketone.

Unfortunately, this method cannot be used to effect the

cycloaddition of dichloroketene and simple aldehydes. The

aldehydes trimerize in the presence of the activated zinc

43

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TABLE I

2-0XETAN0NES PROM DICHIOROKETENE-KETONE

CYCLOADDITIONS

R R' % Yield

Me Et 35

Me n^Pr. 35

Me i-Pr 20

Me CH2CI 15

Me CH2-Ph 40

Ph CH2CI 20

CH2CI CH2CI 23

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and zinc chloride.

R—I—H ZS(?"C12—>• n u n _ Ether

Also, efforts to cycloadd dichloroketene to ^^-unsatu-

rated aldehydes and ketones, such as crotonaldehyde, cinnam-

aldehyde and methyl vinyl ketone were unsuccessful. Such

carbonyl compounds are deactivated "by the conjugated double

bond. However, the zinc dechlorination of trichloroacetyl

chloride in the presence of cyclic ketones resulted in the

formation of the corresponding 3,3-dichloro-spiro-2-oxetanones.

CI CI

(CH ) n \o + CCl3-?-Cl (CH2)n

n = 4, 5, 6, 7.

These cycloadditions ultimately lead to an important

method for the synthesis of dichloromethylenecycloalkanes

and methylenecycloalkanes.

The exocyclic olefins are generally prepared by the

Wittig reaction. Aside from this well known reaction, which

has its limitations, little information on other methods

is available in the literature.

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46

( C H2)n

Ph

CHL=P-Ph 2 i

Ph ^ C ^ n ^ ) ~ C s

H Ph

0=P-Ph i Ph

2-0xetanones are generally quite susceptible to decar-

boxylation to olefins when heated (10). The higher the

boiling points of these cycloadducts the more this decar-

boxylation becomes significant. The cycloadduct of dichloro-

ketene and 2-heptanone could not be isolated by vacuum

distillation because decarboxylation occurred. However, the

olefin was isolated in 40 per cent yield based on trichloro-

acetyl chloride.

CI

A ci

R = -(CH2)4-CH3.

C= C CH,

R CO,

Likewise, the spiro-2-oxetanones obtained from dichloro-

ketene and cycloalkanones are easily decarboxylated upon

distillation, or heating, yielding the dichloromethylene-

cycloalkanes in 40-50 per cent yields, based on the tri-

chloroacetyl chloride.

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47

CI CI

(cH2)n

A - ( o h a ~ ^ ) / C 1

=c + ecu CI *

The dechlorination of the dichloromethylenecycloalkanes

with sodium in liquid ammonia at -78°C afforded the methylene-

cycloalkanes in near quantitative yields.

"0" \

,C1

CI

Na/NH, -78° 5 >

These dichloroketene cycloadditions are accompanied

by the formation of an insoluble tar which is attributed

to polymerization of the ketene, hence the lower yields on

cycloadditions. This is characteristic of reactions involving

halogenated ketenes.

Halogenated ketene-olefin cycloadducts can be readily

dehalogenated with tri-n-butyltin hydride, or with zinc-

acetic acid to the parent ketones (4), (8).

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48

i n ^ 4 V 3 £ 2 l * o r

Zn/HOAc.

Similarly, cycloadducts of dichloroketene and simple

ketones can be dehalogenated. The removal of one chlorine

from 3,3-dichloro-4-ethyl-4-niethyl-2-oxetanone occurs

readily with a 1 : 1 mole ratio of tributyltin hydride and

cycloadduct, but the removal of both halogens requires the

addition of a free radical source such as azobisisobutyro-

nitrile in an excess of tri-n-butyltin hydride.

(n-C4H0)3SnH >

Et

The cycloaddition of alkylhaloketenes with chloral,

o-chlorobenzaldehyde and sym-dichlorotetrafluoroacetone

was investigated and the results are shown in Table II. The

ketenes were generated in situ by the triethylamine dehydro-

chlorination of the appropriate eC-haloacid chlorides.

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TABLE II

2-OXETANONES FROM METHYLHALOKETENE-CARBONYL

COMPOUND CYCLOADDITIONS

49

R-CH-ti-Cl- + ^C=0 R

R

Bf R R " X % Yield

cci3 H Me CI 53

coi3 H Et CI 50

CC1, H n-Pr CI 45

o-ClPh H Me CI 45

cf2CI cf2ci Me CI 55

cci3 H Me Br 60

o-ClPh H Me Br 50

cf2ci C P2 C 1 Me Br 60

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Ar. exacinati on of the car'oonyl compounds in Table II,

aloi".£ with the fact that propionaidehyde, her.zaldeh.jde, acetone,

oyclohexanone and ethyl methyl ketone did not enter into

cyclooedition vdth the niethylhaloka tenes under the conditions

employed, reveals that activation of the carbonyl group is

necessary for cycloadditicn.

Cycloadditions of the alkylhaloketenes with chloral

and o-cnlorobenzaldehyde can produce cis and trans isomers.

, o p , \ R-CH-C-Cl + )C=0 •• 5~>

H A

cis trans

Both c.ls and trans isomers were produced an approximately

equal amounts as previously reported, for the aldoketenes

and chloral. The isomer distributions were determined as

ratios of integrated peak areas on gas chromatograms of the

reaction solutions, and by nmr integration of the methinyl

.region.

Also, the cycloaddition of bromochloroketene with chloral,

henzaldehyde and isobutyraldehyde produced cis and trans

isomers of 2-oxetanones in approximately equal amounts.

"Bromochloroketene was generated in situ by the dehydro-

chlorination of bromochloroacetyl chloride with triethylamine.

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o R JtSr-CH-C-Cl + VC= 0

I '

CI H

G1

Br

H H cis trans

The isomer distributions obtained from the cycloaddition

of several different ketoketenes with different aldehydes

reveal that the reaction is not stereoselective. Like the

aldoketene-chloral cycloadditions (3)» this cycloaddition

is concerted and a consideration of the four possible

orthogonal approaches, leads to the conclusion that both

isomers would be expected to be formed in about equal amounts.

Since all the halogenated ketenes are not stable, they

are trapped by in situ methods of dehydrohalogenation of

appropriately substituted acid halides having «c-hydrogens.

Tertiary amines, notably triethylamine, have been used as

dehydrohalogenating agents.

^ \ ?« ^ ^CH-C-Cl + NCEt)^ * ' C " C — 0 + HN(Et),Cl

X X •>

The ketene-carbonyl cycloadditions are found to be

catalyzed by Lewis acid type catalyst (6). However, this

catalyst cannot be employed in the ketene-carbonyl compound

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52

cycloadditicm reactions when ketene is generated in situ

by the dehydrohalogenation method, since tertiary amines,

used to effect the dehydrohalogenation would neutralize the

Lewis acid catalyst. Thus the halogenated ketene-carbonyl

compound cycloaddition is limited to the activated carbonyl

compounds, which would condense in absence of catalyst.

The generation of ketenes by the triethylamine dehydro-

halogenation method can present serious competing reactions;

e.g., reaction of the amide with the activated carbonyl

compounds. Triethylamine was found to react with sym-dichloro-

tetrafluoroacetone. This problem was alleviated by a stoichio-

metric reaction of the amine and acid halide at low temperature

in the absence of the sym-dichlorotetrafluoroacetone. and

then this reactant was added as the reaction mixture warmed

to room temperature.

^CH-b-Cl + N(Et)3 • 7 8 ° C >

R = CF2C1

; 8 e X

„CH-ij-iHEt),

Cl e '

0

R-C-R

2 5°C R

R

The order of the addition of reagents is very important

as the addition of triethylamine to the oc-haloacid chlorides

results in the formation of ®c-halovinyl esters, (2) of the

acid chlorides. Furthermore, since triethylamine catalyzes

the polymerization of chloral, these cycloadditions were

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53

fIR- C~X K(nt; 0 - 0 . X X

I 0 i U

R-CH-C-X -> 0=0-0-0-014?,

X ! !

X X

aecompiisned oy separate out simultaneous addition of the

.nali.de ana amine xo chloral in the solvent.

The dehydr-ochlorination of chloroacetyl chloride in

the presence of £vm-dichlorotetrafluoroacetone at -78°0

.'ecru '"Ited in the formation of the adduct derived from chloro-

Ice ten e.

ch2CI-<3-CI _1) N(3t) 7 at -78° 2) R-C-R"' *

5 oi

+ HN(Et), i J 01

The in situ cycloaddition of chloroketene and chloral

at room temperature produces both cis and trans isomers as

previously described (3). However, if this reaction is

conducted at -78 0 and slowly allowed to warm to room

9 o , , CH9-C-C1 + 001v-0-K - l i M I ^ 25°c 01

3->

001

cj s

001.,

trnnn

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54

temperature, only the tram? isomer is produced.

Qu HI , at/"-CM-\ _0Clv~0-.fi 0 if

9C1-C-01 + N(Et),, ^ -78UC

H

However, this is not a general result as "both isomers

were obtained in ketoketene cycloadditions with chloral in

approximately equal amounts regardless of the temperature.

Also, other aldoketenes gave a mixture of isomers even when

prepared by this method.

Decarboxylation

The effect of halogen in the 3-position of 2-oxetanones

upon the rates of decarboxylation was easily determined by

comparing the rates of decarboxylation of the compounds in Table

III. The relative rates represent the time required for 50 per

cent decarboxylation. The decarboxylation was measured by

observing the disappearance of the carbonyl band of

- 1

2-oxexanone at 1870 cm in the infrared using the carbonyl

band of the solvent, 2-heptanone, as an internal standard.

A further comparison of the effect of chloro substituents

in the 3-position was observed; when 3,3-dichloro-4-ethyl-

4-methyl-2-oxetanone did not decarboxylate in water up to

50°C, whereas isovalerolactone (4,4-dimethyl-2-oxetanone)

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readily decarboxylated in water at room temperature (5).

2-Heptanone „ R V = < " e + 00

80 C R Et 2

TABLE III

R R' Relative Rate

CI CI 1

H CI 6

H H 100

Similarly, the effect of a chloromethyl substituent

in the 4-position on the rate of decarboxylation can he

seen by comparing the rate of decarboxylation of the compounds

in Table IV.

Again, the relative rates represent the time required

for completion of 50 per cent of the decarboxylation. The

rate of decarboxylation was measured by observing the

disappearance of 2-oxetanones and appearance of olefins

by vpc.

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15G°C 01N R

G=C ci' R

CO,

DA BIS IY

R

CH:2CI

c h 2 c i

CH-

R

CHgCl

CH-

CH0CH~ d 0

Relative Rate

1

17

100

The rate of decarboxylation of the 2-oxetanones derived

from dichloroketene and chloroacetone and dimethylglyoxal was

compared at 170°C, and the rates were approximately the same.

G H 2 G 1 Me-0=0

The attainment of a conjugated system in the transition state of

3,3-d ichloro-4-acetyl-4-methyl-2-oxetanone upon decarboxylation,

serves as a driving force for the decarboxylation. This ease

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of decarboxylation was also observed when the 2-oxetanone;

obtained from brorr.ochloroketene and benzaldehyde and iso-

buiyraldehyde were prepared.

?h isoPr.

3-3ror,o-3-ch 1 oro-4-pheny 1 -2-oxetanone could not be

distilled under reduced pressure, as decarboxylation occurred

at 100°C to yield the corresponding styrene derivative,

while 3-bromo-4-chloro-4-isopropyl--2-oxetanone could be

isolated, and did not appreciably decarboxylate prior to

160°C. Both isomers of 3-brouio-3-chloro-4-isopropyl-2-oxe-

tanone were produced in the cycloaddition reaction in

approximately equal amounts.

The decarboxylation of the 2-oxetanones derived from

methylch1oroketene and chloral, p-chlorobenzaldehyde and

sym-aichlorotetrafluoroacetone did not occur up to

250°C. Polymerization of these 2-oxetanones was observed

at higher temperature, as reported by Ohse and coworkers (7).

O

n H CEU 250 0 , _ • i 3

— > — c — G — c ~ ~ ) i i ji n CClv 0

3

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Thus, the halogen substituents on the 2-oxetanone ring

severely inhibits the decarboxylation. This is perhaps an

indication of the mechanism of the elimination reaction#

and suggests some charge separation in the transition state

between the carbon and oxygen bond, whereby the 4-carbon

assumes some positive character.

+ 00 0 / N C.

Decarboxylation of the cycloadducts of alkylchloroketene

and chloral did decarboxylate over an electrically heated

wire, but this decarboxylation was accompanied by a dehydro-

chlorination to yield trichloromethyallenes in 40-60 per

cent yields.

* , C = C = C + HC1 + CO, A H ^CC13

R = H, Me, Et.

No evidence of the halogenated olefin was found in any

of the systems. A consideration of the order of the two

elimination steps suggest that the dehydrochlorlnation

precedes the decarboxylation. Since the °C-chlorine is more

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i a ;> ilr, sirliyc! rorh'l o r.i na I i on o ,i" tiic i'-oxc lauonc j mo re

likely to lead to the 2-oxetanone intermediate, which would

be expected to decarboxylate more readily than the 2-oxetanone,

Furthermore, if decarboxylation occurred first, it is less

Ly to expect the olefin to undergo dehydrochlorination. 1 - Is* -J. J V - ^

HCl j R s

CGI.

•GO, /H c = c= c

H/ CC15

CC1.

The 2-oxetanone obtained from dichloroketene ana chloral

was likewise very resistant to decarboxylation. However,

refluxing 3,3-dichloro-4-trichloromethyl-2-oxetanone over

an electrically heated wire produced a mixture of products

including the expected olefin, 1,1,3,3,3-pentachloropropene,

perchloroallene, the allene dimer and trichloroethylene.

-CO

A 2->

CI v ,H -HCl

CI s CC15 A

CI ^C = CS

CI CI

C1S ,ci c = c = c

CI NC1

Cl-C

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The perchloroallene was observed in a dry ice acetone trap

- 1

as evidenced "by a "band in the infrared at 1962 cm . This

band disappeared upon warming to room temperature but the

allene dimer was isolated (9).

The olefin resulting from decarboxylation was isolated

in 40 per cent yield, and suggests that the decarboxylation

preceded the dehydrochlorination. This is substantiated by

the fact that the olefin, 1,1,3,3,3-pentachloropropene,

dehydrochlorinates under the reaction conditions to yield

perchloroallene^, which dimerizss upon warming to room tempera-

ture .

Cl s 01 s ,C1 C — C — c = C= C y dimer

CI xcci3 A c l ' V

C 1

The cycloadduct obtained from chloroketene and chloral,

was also quite resistant to decarboxylation. However, de-

carboxylation did not occur as above but the corresponding

olefin, 1,3,3,3-tetrachloropropene, was produced in 80 per

cent yield. A trace of allene (trichloroallene) was observed

in the cold trap at -78°C as evidenced by a band in the

infrared at 1962 cm . However, this was a much weaker band

than in the previous system. This decarboxylation was

conducted on the trans-2-oxetanone and an equal mixture of

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the two isomeric olefins was obtained.

01 x ,001- H v ,001-C — C v ^ + 0 = 0 3

w w / \ H H 01 H

cis trans

Thus it is very apparent that any electronegative

substituent on the 2-oxetanone ring decreases the rate of

decarboxylation. The presence of a trichloromethyl substi-

tuent on the 4-position of the 2-oxetanone ring severely

inhibits decarboxylation. Decarboxylation of the alkyl-

chloroketene-chloral adducts over an electrically heated

wire provides a useful synthesis for these exotic trichloro-

methylallenes.

Nucleophilic Addition

The reaction of 3,3-dichloro-4-ethyl-4-raethyl-2-oxe-

tanone with water, methanol and dimethylamine produced the

corresponding ^-hydroxy acid, ester and amide.

ch3 o

+ HNu * CH3-CH2-C—CC12-B-NU

OH

Nu a OH, OMe, NMe2

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The reactions paralleled the nucleophilicity of the

nucleophiles; e.g., dimethylamine gave a quantitative yield

at 0-5°C, methanol a 50 per cent yield after 48 hours at

50°C, and water a 15. per cent yield after 4 days at 60-65°C,

Some decarboxylation accompanied the hydrolysis reaction.

The reaction of 3,3-dichloro-4-trichloromethyl-2-oxe-

tanone with the same nucleophiles also occurres to yield

only the acyl-oxygen cleavage products as illustrated.

HNu CCl,-CH-CCl0-C-Nu 3 i 2 A '

OH

Nu = OH, OMe, NMe2

This 2-oxetanone is considerably more reactive than

3,3-dichloro-4-ethyl-4-methyl-2-oxetanone. 3,3-Dichloro-4-

trichloromethyl-2-oxetanone reacts with dimethylamine at

-78°C, and upon warming to room temperature a quantitative

amount of amide is produced. There is some indication of

nucleophilic displacement of a halogen as evidenced "by some

dimethylamine hydrochloride. 3,3-Dichloro-4-trichloromethyl-

2-oxetanone reacts with methanol at room temperature to

immediately produce a quantitative yield of ester, and with

water at 70°C in two hours to produce an 80 per cent yield

of hydroxy acid.

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63

The exclusive acyl-oxygen cleavage with the two halo-

genated 2-oxetanone investigated is probably the result of

the electronegative substituents increasing the electro-

philicity of the carbonyl carbon atom. The increased reactivity

of 3, 3-dichloro--4-trichloromethyl-2-oxetanone, and the exclusive

aeyl-oxygen cleavage of the trichloromethyl-2-oxetanones

studied by Ohse and coworkers (7) is probably due to the

trichloromethyl substituent stabilizing the negative charge

on oxygen in the transition state.

Conclusions

Dichloroketene cycloaddition to simple ketones provides

a useful synthesis of a series of halogenated 2-oxetanones

and methylenecycloalkanes. In the preparation of dichloro-

ketene by the zinc dehalogenation of trichloroacetyl chloride,

the zinc/zinc chloride are acting as catalyst for dichloro-

ketene-ketone cycloaddition. Cycloaddition of alkylhalo-

ketenes with unsymmetrical carbonyl compounds produce cis

ana trans isomer of 2-oxetanones in approximately equal

amounts. Activation of the carbonyl compounds is necessary

for cycloaddition.

Electronegative substituents on the 2-oxetanone ring

decrease the rate of decarboxylation. However, if conjugation

results from decarboxylation, this seems to serve as a

driving force for the elimination and decarboxylation occurs

more readily than expected. The presence of a trichloromethyl

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64

substituent on the 4-position of the 2-oxetanone ring

severely inhibits decarboxylation. This is perhaps an

indication of the mechanism of the elimination reaction and

suggests some charge separation in the transition state,

whereby the 4-carbon assumes some positive character. De-

carboxylation of the alkylchloroketene-"chloral adducts

over an electrically heated wire provides a useful synthesis

for these exotic trichloromethylallenes.

Electronegative substituents on the 2-oxetanone ring

increase the reactivity of the 2-oxetanone towards nucleo-

philic addition, and only acyl-oxygen bond cleavage occurs

during the nucleophilic addition reaction.

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CHAPTER BIBLIOGRAPHY

1. Bormann, D. and Wegler, R., Chem. Ber.f 102, 64 (1969).

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65

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Erlenmeyer, H., Chem. Ber.. 13, 303 (1880). 66

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67

Fields, R. and Hasteldine, R. J. Chem. Soc., (C) 165 (1969).

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Hagemeyer, H. J. Jr., Ind. Eng. Chem., 41, 765 (1949).

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Brady, W. T. and Patel, A. D., Synthesis, 565 (1972).