tissue engineering & xenotransplantation
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The development andmanipulation of laboratory-grownmolecules, cells,tissues, and organs toreplace or supportthe function of defective or injuredbody parts
Represent applicationsthat repair or replacestructural tissues (i.e.
bone, cartilage, bloodvessels, bladder, etc.),tissues that function byvirtue of theirmechanical properties
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Also applied to efforts to performspecific biochemical functions usingcells within an artificially-createdsupport system (e.g. an artificialpancreas, or a bioartificial liver)
Where cells areimplanted orseeded into an
artificialstructure capableof supportingthree-dimensionaltissue formation
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Allow cell attachment and migrationDeliver and retain cells and biochemicalfactorsEnable diffusion of vital cell nutrientsand expressed products
Exert certain mechanical and biologicalinfluences to modify the behaviour of the cell phase
Providing cellular replacement partsThe living skin equivalent that consisted of adermal component with a fully developed
epidermis
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Providing formed acellular replacementparts capable of inducing regeneration
Demineralized bones can induceregeneration of cartilage and bone tissue
Providing tissue or organ-like modelsystems populated with cells for basicresearch and for many applied uses such
as toxicity testing with normal cells andthe study of disease states usingaberrant cells
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Providing vehicles for deliveringengineered cells to the organism
Bioartificial liver deviceArtificial pancreasArtificial bladdersCartilageDoris Taylor's heart in a jarTissue-engineered airwayArtificial skinArtificial bone marrow
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The ultimate goal is to develop powerfulnew therapies biological substitutes for structural and functional disordersof the human health that have provendifficult or impossible to addresssuccessfully with the existing tools of medicine.
Bi-layered skinsubstitute fromhuman neonatal
foreskin tissue
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A two-layerwound dressingthat contains livehuman skin cellscombined withbovine collagen
1998 approvedfor treatment of leg ulcers
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TimeImmunogenicityPreservationTissue cultureVascularization
OrganogenesisEthics
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Chimeric Immune System
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What can it offer?
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