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Tissue Hypoxia: Cell Swells – 1 st sign [ No ATP No Na/K ATPas ] [Na/water enters cell excess] Irreversible Cell injury dt: Hypoxia: How Damage to Cell Membrane: o Free Radicals Lipid Peroxidation [reverse w. Vitamin E !!] o Calcium activates Cell Mem. Phospholipase [bad] Lipid Peroxidation Calcium Enters Mitochondria: Electron Dense Deposits = destroys mitoch. Mitochondria damage: Caspases released [bad] Case: Acetaminophen – [converted by Liver P450 into FR….acts on Sulfhydryl groups in hepatocyte cell membranes] MCC: Fulminant Liver Necrosis Antidote: N-Acetylcysteine ……MoA: Replenish GSH [Glutathione – inactivates FR] [GSH made by HMP shunt]

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Page 1: Tissue Hypoxia

Tissue Hypoxia: Cell Swells – 1st sign [ No ATP No Na/K ATPas] [Na/water enters cell excess]

Irreversible Cell injury dt: Hypoxia: HowDamage to Cell Membrane:

o Free Radicals Lipid Peroxidation [reverse w. Vitamin E!!]o Calcium activates Cell Mem. Phospholipase [bad] Lipid Peroxidation

Calcium Enters Mitochondria: Electron Dense Deposits = destroys mitoch.Mitochondria damage: Caspases released [bad]

Case: Acetaminophen – [converted by Liver P450 into FR….acts on Sulfhydryl groups in hepatocyte cell membranes] MCC: Fulminant Liver Necrosis

Antidote: N-Acetylcysteine……MoA: Replenish GSH [Glutathione – inactivates FR] [GSH made by HMP shunt]

Journal Hypoxia

Altitude hypoxia

Matthew Boland MD, FCCP Pulmonary/CCM. A definition of SHOCK Global tissue hypoxia “global” implying systemically while “tissue hypoxia” implies inadequate

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Hypoxia Hypoxia is defined as a deficiency in either the delivery or the utilization of oxygen at the tissue level, which can lead to changes in function,

Hypoxia and tissue destruction in pulmonary tuberculosis

Hypoxia 2012ppt

2. HYPOXIA

Tissue Stiffness and Hypoxia Modulate the Integrin-Linked ...cmngroup/104_Pang_CancerRes_2016.pdf · Microenvironment and Immunology Tissue Stiffness and Hypoxia Modulate the Integrin-Linked

INFARCTION - WordPress.com  · Web viewThe susceptibility of a tissue to hypoxia influences the likelihood of infarction. Neurons undergo irreversible damage when deprived of their

Tissue Hypoxia and Oxygen Therapy - Prince of Songkla ...medinfo2.psu.ac.th/surgery/Edu_be_document/document4/Tissue_hypoxia... · Tissue Hypoxia and Oxygen Therapy ˘ˇˆ˙˝˛˚˜

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Review Article OzoneandOzonatedOilsinSkinDiseases:AReviewozonewithoutborders.ngo/wp-content/uploads/2017/06/ozona... · 2017-07-04 · with tissue hypoxia, other patients are immunosuppressed

Anemias. Definition Reduction of total RBC MASS below average levels Reduction of oxygen carrying capacity of the blood Leads to tissue hypoxia Practically,

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Hypoxia-inducible factor-1 alpha dependent induction of ... · supply-and-demand ratios during inflammation, a process result-ing in localized tissue hypoxia within inflammatory

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Hypoxia and tissue destruction in pulmonary tuberculosisof MMP secretion in primary human cell culture model systems in normoxia, hypoxia, chemical hypoxia and by siRNA inhibition

Ian Cook July 2013Ian Cook1. Hypoxia What is hypoxia and what can happen with prolonged hypoxia? Hypoxia is the physical condition induced by an inadequate

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Hypoxia in Soft-Tissue Sarcomas on [ 18 F]- Fluoroazomycin Arabinoside Positron Emission Tomography (FAZA-PET) Powerfully Predicts Response to Radiotherapy

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Hypoxia Tolerance in Animals: Biology and Applicationfaculty.bennington.edu/~sherman/comp. anim. physiol./hypoxia... · 733 Hypoxia Tolerance in Animals: Biology and Application*

Hypoxia-inducible Factor -1 (HIF-1)-independent hypoxia ... · HIF-1-independent hypoxia response in C. elegans 1 Hypoxia-inducible Factor -1 (HIF-1)-independent hypoxia response

HYPOXIA Maroun Matta, M.D.. Plan I. Dyspnea v/s Hypoxia II. Mechanisms of hypoxia III. Evaluation of hypoxia ▫A. Questions to ask over the phone ▫B. Looking

Microarray Gene Expression Analyses in - United States ...yosemite.epa.gov/sab/sabhap.nsf...Overview of Experimental Plan hypoxia treatment tissue collection protein RNA Real-time

Shock Amr Mohsen. What is shock? Acute circulatory failure leading to Inadequate tissue perfusion that results in Generalized organ hypoxia

ALTITUDE PHYSIOLOGY OUTLINE Classifications of Hypoxia Signs and symptoms of Hypoxia Stages of Hypoxia Prevention of Hypoxia Provisions of AR 95-1 Provisions

และ การพยาบาลผู้ป่วยบาดเจ็บ ...pws.npru.ac.th/poopitukkul/data/files/ภาวะ...พยาธ สร รภาพ Tissue hypoxia

Transport of Gases - WordPress.com · –Reduced capacity of muscles for work 12. Hypoxia Features Hypoxic hypoxia Anemic hypoxia Stagnant hypoxia Histotoxic hypoxia 1. PO2 in arterial

TISSUE PO AND THE EFFECTS OF HYPOXIA ON THE … · 2 at various tissue depths in the isolated mouse spinal cord, before and after the onset of drug-induced locomotion. To the best

Editorial Role of Tissue and Systemic Hypoxia in Obesity ...downloads.hindawi.com/journals/jdr/2016/1527852.pdf · Journal of Diabetes Research hypoxia in the pathogenesis and treatment

06 hypoxia