TNINTecnologie Non Invasive per le

Neuroscienze:Risonanza Magnetica

Federico Giovefederico.giove@roma1.infn.it

Mission

• To develop and exploit NMR approaches for the neurosciences• Visual system, Neuroenergetics• BOLD, MRS, multimodal approaches, neurocurrents• Structural (pathologies)

BOLD

… OR NEURONAL CURRENTS?

FUNCTIONAL CONNECTIVITY

MD Fox et al., PNAS 102:9673 (2005)

FUNCTIONAL CONNECTIVITY

GM atrophy

HS MCI AD

PCC

ADHS MCI

Hippocampus

Functional connectivity

HS MCI AD

L -Hippocampus

From PPC seed-region

NK Logothetis, Nature 453:869 (2008)

• To complement BOLD findings• 1H MRS drawbacks

– Limited temporal resolution– Low spatial resolution

• CREATE STATIONARY “DISENTAGLED” CONDITIONS

• Add other modalities

ASSESSING THE NEUROMETABOLIC COUPLING

VISUAL PERCEPTION

• V1 responds to invisible stimuli• Activation of V1 per se is insufficient for awareness

Viswanathan and Freeman, Nat Neurosci 10:1308 (2007)

Sign

al in

crea

se %

-0.5

0.0

0.5

1.0

1.5

2.0

2.5

3.0

BOLD@7.5Hz BOLD@30Hz

fMRI RESULTS

MRS RESULTS

MRS RESULTS

Marco CarnìAntonino M. CassaràMauro Di NuzzoMichela FratiniGirolamo Garreffa,Marta Moraschiand Bruno Maraviglia (Fermi Center)

Silvia Mangia (U Minnesota)Tommaso Gili (U Cardiff)Silvia Capuani, Giulia Di Pietro, Marco Palombo (U Sapienza)

EXTERNAL COLLABORATORSNEUROPHYSIOLOGY, NEUROSCIENCES:NK Logothetis, GE Hagberg, Y Murayama (MPI Tuebingen), Emiliano Macaluso (Santa Lucia IRCCS) , Richard G Wise, Silvia De Santis (U Cardiff)

CLINICAL RESEARCHM Bozzali, G Spalletta (Santa Lucia IRCCS)

MODELLING:S Vannucci (Columbia), I Simpson (U Penn) , A Carruthers (U Massachusetts),A De Martino, E Marinari (U Sapienza)

PAST COLLABORATORSM Bianciardi, S Peca, G Giulietti, M Rebuzzi, P Porcari, F Di Salle