toronto, 2015 alpha-lipoic acid s effects on the ... · int j clin pract. 2005 jun;59(6):645-50....
TRANSCRIPT
![Page 1: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/1.jpg)
Toronto, 2015 Alpha-Lipoic Acid�s Effects on the Mitochondrion
and Human Disease Modification
Burton M. Berkson MD MS PhD The Integrative Medical Center of NM
Las Cruces, NM 88011
![Page 2: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/2.jpg)
Alpha-lipoic acid, (ALA), Thioctic Acid
![Page 3: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/3.jpg)
ACTIONS OF ALA
![Page 4: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/4.jpg)
Glycolysis: anaerobic
Occurs in the cytoplasm Glucose is converted to pyruvate Cancer cells typically
just go this far and convert pyruvate to lactate even in the presence of O2.
![Page 5: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/5.jpg)
Tricarboxylic acid cycle
• ALA
Occurs in the mitochondrion
In the presence of oxygen aerobic
Glycolysis anaerobic
![Page 6: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/6.jpg)
Pyruvate Dehydrogenase Complex
Alpha lipoic acid is fundamental,
for the conversion of food to energy. It is my hypothesis that ALA is the rate-limiting agent in the
production of energy from food in aerobic cells
![Page 7: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/7.jpg)
ALA pushes anaerobic cell metabolism into aerobic cell metabolism
ALA accelerates this process and it�s more than just a co-factor.
GLYCOLYSIS Anaerobic
Kreb�s cycle Aerobic
PDH ALA
![Page 8: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/8.jpg)
Alpha Lipoic Acid inhibits Pyruvate Dehyrogenase Kinase (PDK) PDK inhibits the enzyme that converts
Pyruvate into Acetyl CoA
Korotchkina LG, Sidhu S, Patel MS. Lipoic acid inhibits mammalian pyruvate dehydrogenase kinase.
Free Radic Res. 2004 Oct;38(10):1083-92.
![Page 9: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/9.jpg)
Pyruvate dehydrogenase kinase inhibits Pyruvate Dehydrogenase More available Pyruvate Dehyrogenase results in increased Pyruvate being directed into the Krebs Cycle over the conversion of Pyruvate to Lactate
![Page 10: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/10.jpg)
ALPHA-LIPOIC ACID
FATS CARBS PROTEINS GLYCEROL PYRUVATE PDH ALPHA-LIPOIC ACID ACETYL CO A
Pyruvate Dehydrogenase Complex PDH
Glycolysis
![Page 11: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/11.jpg)
Since a young person produces enormous amounts of ALA,
what happens when you feed a Thanksgiving dinner
to a 2 year old child;
or a 80 year old man?
![Page 12: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/12.jpg)
What if a mitochondrion receives too much ALA? Lipoic acid LD50 Studies by Drs Vigil and Couch.
Couch RC, Vigil M. et al. A dose escalation toxicity study of DL-6-8 thioctic acid (lipoic acid) in Rhesus monkeys. 1997.
Poster display. Annual Meeting Society of Toxicology.
LOE B
![Page 13: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/13.jpg)
• Following these studies I was asked to observe the necropsies and help with the electron microscopy work on the damaged tissues at NMSU.
• I observed extensive necrotic lesions in the liver, kidneys, heart, and the large muscles of the extremities.
![Page 14: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/14.jpg)
Healthy primate mitochondrion (hepatocyte)
![Page 15: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/15.jpg)
Mitochondria from animals who had received excessively high doses of ALA became extremely edematous, and demonstrated a disruption of all the crucial structures. These mitochondria did not exhibit the regular double membrane wall structure, but showed a coalescence of these structures with a deliquescence of membranes thus exhibiting a complete disruption of normal ultrastructure.
![Page 16: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/16.jpg)
Primate hepatocyte mitochondria following a LD50 IV lipoic acid dose of
about 90mg/kg
![Page 17: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/17.jpg)
LIVER MITOCHONDRIA SUFFERED SEVERE STRUCTUAL
DAMAGE BY EXTREMELY HIGH DOSES OF INTRAVENOUS ALPHA LIPOIC ACID
Global Advances in Health and Medicine January,2014, volume 3 number 1
Michael Vigil MD Adjunct Associate Research Professor, Department of Biochemistry NMSU Burton M. Berkson MD MS PhD Former Assistant Professor, Rutgers University Former Associate Professor, Chicago State University President, The Integrative Medical Center of New Mexico Adjunct Professor, NMSU [email protected] (corresponding author) Ana Patricia Garcia DVM MS PhD Associate Research Professor and Veterinary Pathologist Yerkes Assistant Professor, Department of Pathology and Laboratory Medicine
Emory University School of Medicine
![Page 18: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/18.jpg)
• In reality, much lower doses of IV lipoic acid may cause serious bouts of hypoglycemia and the doctor and nurse must all times watch carefully for possible problems.
![Page 19: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/19.jpg)
With appropriate ALA levels, the mitochondrion functions normally. If the mitochondrion does not obtain sufficient ALA, it suffers, and the organism dies.
![Page 20: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/20.jpg)
If the mitochondrion is supplied with excessive amounts of ALA, it accelerates aerobic respiration and the process runs ahead of the other necessary constituents. The mitochondrion heats up, free radicals accumulate, and its membranous components break down. Severe damage to the mitochondrion is first seen by gross swelling and then severe damage to the cristae and matrix material.
![Page 21: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/21.jpg)
It is interesting to note that therapeutic doses of intravenous ALA helps a liver regenerate but extremely high doses of the same agent causes liver necrosis. Of course, excessive and unreasonable amounts of any substance given intravenously can be lethal, including water and salt.
![Page 22: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/22.jpg)
Does ALA helps regenerate livers?
1st large scale clinical trial with IV alpha-lipoic acid at NIH.
(Bartter, Berkson, et. al. 1977-1980)
B
![Page 23: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/23.jpg)
Bartter FC, Barry Rumack, and Berkson B 1978 As visiting scientists at the Max Planck Institute in Heidelberg
![Page 24: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/24.jpg)
We reported in 3 publications that we treated 79 people with acute hepatic necrosis and 75 regenerated their livers with the just the administration of intravenous Alpha-lipoic acid.
I was appointed FDA principal investigator 1983. That
lasted 23 years.
![Page 25: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/25.jpg)
B Our first paper. Should have been titled ALA reverses Acute Hepatic Necrosis
![Page 26: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/26.jpg)
Amanita virosa
Destroying angel
![Page 27: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/27.jpg)
![Page 28: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/28.jpg)
If IV ALA reverses acute liver disease, will it reverse chronic liver disease, for example
hepatitis C?
![Page 29: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/29.jpg)
CIRRHOTIC LIVER
![Page 30: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/30.jpg)
GERMAN JOURNAL OF INTERNAL MEDICINE ARTICLE
Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium.Med Klin (Munich). 1999 Oct 15;94 Suppl 3:84-9.
I took 3 cirrhotic hepatitis C patients in the process of liver transplant evaluation at University Hospital and
administered ALA, silymarin and selenium (inhibition of replication).
The 3 recovered normal liver function within 6 months.
B
![Page 31: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/31.jpg)
Most important laboratory tests for the evaluation of liver disease.
Albumin
Prothrombin Time Platelet count ALT
![Page 32: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/32.jpg)
MR EA (hepatitis C) ALBUMIN LEVELS
0
1
2
3
4
5
6
2001 JUNE 2001 AUG 2002 JAN
![Page 33: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/33.jpg)
MR EA PROTIMES
0
2
4
6
8
10
12
14
16
18
20
2001 JUNE 2001 AUG 2002 JAN
![Page 34: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/34.jpg)
MR. EA-HEPATITIS C SECONDARY TO BLOOD TRANSFUSION PLATELET COUNT
0
20,000
40,000
60,000
80,000
100,000
120,000
140,000
160,000
180,000
200,000
JUNE O1 AUG O1 JAN O2
![Page 35: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/35.jpg)
MR. EA ALT (SGPT) RESULTS
0
20
40
60
80
100
120
140
1-Jun AUGUST O1 2-Jan
![Page 36: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/36.jpg)
Conclusion of my 1999 paper. The author offered a more conservative approach to the treatment of hepatitis C, that is exceedingly less expensive. One year of the triple ant-oxidant therapy described in this paper costs less than $ 3,000, as compared to more than $ 400,000 a year for liver transplant surgery. B
![Page 37: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/37.jpg)
Are there other diseases that ALA might help? Smith AR, Shenvi SV, Widlansky M, et al. Curr Med Chem. 2004 May;11(9):1135-46.)
Lipoic acid is a potential therapy for chronic diseases associated with oxidative stress.
Most chronic diseases are associated with OS.
B
![Page 38: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/38.jpg)
Baur, et al., Klin Wochenschr 69 (1991): 722-4.
Alpha lipoic acid has been shown to be an effective inhibitor of human immuno-deficiency virus (HIV-1)
replication.
B
![Page 39: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/39.jpg)
Lipoic Acid prevents ischemia-reperfusion injury Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath V. Brain Res. 1996;717(1-2):184-188. - Alpha-Lipoic acid protects against ischemia reperfusion injury following cerebral ischemia.
B
![Page 40: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/40.jpg)
Suh JH, Shigeno ET, Morrow JD, et al. Faseb J. 2001;15(3):700-706. Oxidative stress in the aging rat heart is reversed by supplementation with alpha-lipoic acid.
B
![Page 41: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/41.jpg)
What about ALA and diabetes?
Jacob S, Henriksen E, Schiemann A. et al. Enhancement of glucose disposal in patients with type 2 diabetes
by alpha-lipoic acid. Arzneimittel-Forschung 1995, 45(8):872-874.
Henriksen et al. published the first human study to show
that ALA increases insulin stimulated glucose movement into the cell, and out of the blood stream, in
diabetes.
B
![Page 42: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/42.jpg)
Singh U, Jialal l Alpha-lipoic acid supplementation and diabetes.
Nutr.Rev. 2008 Nov;66(11):646-57.
ALA improves insulin sensitivity, reduces oxidative stress,
and improves neuropathy in diabetic patients.
B
![Page 43: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/43.jpg)
Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, Augustin HJ, Dietze GJ, Rett K. Free Radic Biol Med. 1999;27:309-14. Administration of alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial.
A
![Page 44: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/44.jpg)
Tankova T, Cherninkova S, and Koev D. Treatment for diabetic neuropathy with IV alpha-lipoic acid.
Int J Clin Pract. 2005 Jun;59(6):645-50.
This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral and autonomic
diabetic neuropathy and also diabetic neuropathy of the cranial nerves leading to full recovery of the
patients.
At the Integrative Medical Center of New Mexico, we treat diabetic neuropathies with IV ALA every day.
B
![Page 45: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/45.jpg)
What about ALA and cancer? Cancer cells hate oxygen.
Warburg O. The chemical constitution of respiration
ferment. Science. 1928;68:437–443.
Science.68.1767.437.
B
![Page 46: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/46.jpg)
Thomas Seyfried Cancer As a Metabolic Disease (Wiley, 2012) "All hallmarks of cancer including the Warburg effect can be linked to impaired respiration and energy metabolism,� These are "downstream effects of damaged mitochondrial function."
![Page 47: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/47.jpg)
Wenzel U, Nickel A, and Daniel H. .Alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing
mitochondrial respiration which results in O2-*-generation. Apoptosis. 2005 Mar;10(2):359-68
This study provided evidence that ALA and its
reduced form can induce cancer cell death by a prooxidant mechanism that is initiated by an
increased uptake of oxygen into the mitochondrion.
B
![Page 48: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/48.jpg)
Shi DY, Liu HL, Stern JS, Yu PZ, Liu SL. FEBS Lett. 2008 May 28;582(12):1667-71.
Alpha-lipoic acid induces apoptosis and necrosis in hepatocellular carcinoma cells.
B
![Page 49: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/49.jpg)
Kisurina-Evgen'eva OP, Onishchenko GE. Alpha-lipoic acid triggers elimination of cells with abnormal nuclei in human
carcinoma epidermoid cell line Tsitologiia. 2010;52(3):225-34.
Alpha-lipoic acid not only triggered apoptosis of carcinoma cells, but it also activated the mechanism of elimination of other cells with abnormal chromosome
number.
![Page 50: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/50.jpg)
Zachar Z, Marecek J, Maturo C, et al. ALA disrupts cancer cell mitochondrial metabolism and is a potent
anticancer agent in vivo J Mol Med (Berl). 2011 Nov;89(11):1137-48. Epub 2011 Jul 19.
Lipoic Acid causes disruption of tumor metabolism
and this is followed by cell death by multiple, pathways, including apoptosis and necrosis.
B
![Page 51: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/51.jpg)
Na MH, Seo EY, Kim WK Nutr Res Pract. 2009 Winter;3(4):265-71. Alpha-lipoic acid stimulates apoptosis in human
breast cancer cells.
and
Choi SY, Yu JH, Kim H. Ann N Y Acad Sci. 2009 Aug;1171:149-55. Alpha-lipoic acid induces apoptosis of lung cancer
cells.
B
![Page 52: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/52.jpg)
From Cancer metabolic plan from Signaling And Metabolism In Cancer, Maurice Israël, Cancer Therapy, 2014
![Page 53: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/53.jpg)
Non-Standard Cancer Protocol at IMCNM
• Intravenous Alpha Lipoic Acid (ALA) (Bartter and Berkson).
• Intravenous Vitamin C. • Low Dose Naltrexone (LDN) (after Zagon and Bihari.) • Hydroxycitrate (HCA) (after Schwartz L.). • Healthy diet and life style. • Supplements (artemesinin, curcumin, etc) • Prescription drugs (metformin, xanax, cimetidine, etc.)
![Page 54: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/54.jpg)
Low Dose Naltrexone (LDN)
• 1.5 to 4.5 mg. LDN at hs • Fools the brain. Not enough endogenous opiates
in blood stream. • In AM, flood of endogenous opiates released. • At least one of the opiates, met-enkephalin
binds to cancer cell receptors and promotes apoptosis.
Several papers by Ian Zagon and associates.
![Page 55: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/55.jpg)
Transforming growth factor beta
From LDN website Inflammation
![Page 56: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/56.jpg)
T helper 17 cell (Th17) is a type of T helper cells that produce interleukin 17 (IL 17). These cells produce tissue injury by inflammatory processes Crohn�s disease, juvenile diabetes, MS, rheumatoid arthritis, SLE, etc. Normally, Th17 cells provide epithelial and mucosal anti-microbial immunity by producing interleukin 22, etc. which stimulates epithelial cells to produce Inflammatory proteins to kill microbes.
![Page 57: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/57.jpg)
Berkson BM, Rubin DM, and Berkson AJ Integrative Cancer Therapies
Volume 5, Number 1, March 2006
�The long-term survival of a patient with pancreatic cancer and metastases to the liver�
We published the first human study that demonstrated the therapeutic
effects of ALA combined with LDN for cancer
B
![Page 58: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/58.jpg)
Berkson BM, Rubin DM, Berkson AJ. Integr Cancer Ther. 2007 Sep;6(3):293-6.
Reversal of signs and symptoms of a B-cell lymphoma
in a patient using low-dose naltrexone. (Patient was on IV ALA for 2 weeks)
B
![Page 59: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/59.jpg)
Burton M. Berkson, Daniel M. Rubin, and Arthur J. Berkson Integr Cancer Ther. 2009 Mar;5(1):83-9.
Revisiting the ALA/N (α-Lipoic Acid/Low-Dose Naltrexone) Protocol for People With Metastatic
Pancreatic Cancer: A Report of 3 New Cases
B
![Page 60: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/60.jpg)
Schwartz L, Guais A, Israël M, et al.
Invest New Drugs. 2013 Apr;31(2):256-64. doi: 10.1007/s10637-012-9849-z. Epub 2012 Jul 14.
Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid etc.
He added hydroxycitrate to our protocol.
![Page 61: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/61.jpg)
Schwartz L., Buhler L, Icard P, Lincet H, Steyaert J. Metabolic Treatment of Cancer, Anticancer Research
2014
The metabolic effects of ALA/HCA allows the reprogramming of cancer cells into oxidative
aerobic metabolism rather than anaerobic metabolism.
This ultimately should limit the availability of compounds
necessary for the growth of cancer.
![Page 62: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/62.jpg)
Alpha Lipoic Acid and Hydroxycitrate target at least two major
Enzymes in the metabolism of glucose.
Pyruvate Dehydrogenase Kinase and
ATP Citrate Lyase
![Page 63: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/63.jpg)
Hydroxycitric acid (hydroxycitrate)
HCA also inhibits pancreatic alpha-amylase (breaks down starch and glycogen) and intestinal alpha-glucosidase (breaks down starch into glucose), leading to a reduction in carbohydrate metabolism.
Studies of HCA have produced results that indicate
a potential for modulation of lipid and carbohydrate metabolism.
![Page 64: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/64.jpg)
Hydroxycitrate (HCA) also inhibits ATP Citrate Lyase (ACL)
which limits the conversion of cytoplasmic Citrate into Acetyl CoA available
for the synthesis of Lipids and aerobic carbohydrate metabolism.
![Page 65: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/65.jpg)
ATP citrate lyase
![Page 66: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/66.jpg)
Alpha Lipoic Acid (ALA) inhibits Pyruvate Dehyrogenase Kinase (PDK)
(the enzyme that stops Pyruvate Dehydrogenase)
More available Pyruvate Dehyrogenase (PDH), results in the increased Pyruvate
Being directed into the Krebs Cycle over the conversion of Pyruvate to Lactate
![Page 67: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/67.jpg)
Mrs. MC
68 yo woman with breast cancer. Initially refused Surgery, Chemotherapy, and Radiation. Pathology-Invasive ductal adenocarcinoma Nottingham
grade 2/3, Estrogen + Progesterone receptor -, pagetoid spread to skin Metastatic to L axilla lymph nodes
![Page 68: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/68.jpg)
March 15, 2013
![Page 69: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/69.jpg)
March 15, 2013
![Page 70: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/70.jpg)
Pet scan March 20, 2013
![Page 71: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/71.jpg)
Early June, 2013
Ca 27.29--60…39 Ca 15.3—27.5…19.6
![Page 72: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/72.jpg)
Visit to oncologist Late June 2013
• I suggested that Mrs. MC see a oncologist. She took my advice and tried taxol and herceptin for less than 3 weeks, became very ill, lost hair etc, and stopped conventional tx.
![Page 73: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/73.jpg)
July, 2013
![Page 74: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/74.jpg)
Added Black Salve
August 5, 2013
![Page 75: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/75.jpg)
Added Black Salve
August 5, 2013
![Page 76: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/76.jpg)
August 14, 2013
![Page 77: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/77.jpg)
August 14, 2013
![Page 78: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/78.jpg)
May 14, 2013----September 23, 2013
• Ca 27.29---60---39.5---16---11.5
• Ca 15.3---27.5---19.6---7.3
![Page 79: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/79.jpg)
�The long-term survival of a patient with pancreatic cancer and metastases to the
liver�
Berkson BM, Rubin DM, and Berkson AJ Integrative Cancer Therapies
Volume 5, Number 1, March 2006
Berkson and associates published the first human study that demonstrated the
therapeutic effects of ALA combined with LDN for cancer
B
![Page 80: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/80.jpg)
FIGURE ONE OCTOBER 8, 2002
Mr. TA
![Page 81: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/81.jpg)
FIGURE 2 OCTOBER 8, 2002
Mr. TA
Given no hope by MD Anderson
![Page 82: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/82.jpg)
FIGURE 11 FEBRUARY, 2006
Mr. TA
![Page 83: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/83.jpg)
FIGURE 12 FEBRUARY, 2006
Mr. TA
![Page 84: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/84.jpg)
FIGURE 13 AUGUST 2008
Mr. TA
![Page 85: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/85.jpg)
FIGURE 14 AUGUST 2008
Mr. TA
![Page 86: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/86.jpg)
Burton M. Berkson, Daniel M. Rubin, and Arthur J. Berkson Integr Cancer Ther. 2009 Mar;5(1):83-9.
Revisiting the ALA/N (α-Lipoic Acid/Low-Dose Naltrexone) Protocol for People With Metastatic
Pancreatic Cancer: A Report of 3 New Cases
B
![Page 87: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/87.jpg)
Pet Scan JANUARY O6
Mrs JK
Adeno- Carcinoma Pancreas
![Page 88: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/88.jpg)
Pet Scan JUNE 2006
Mrs. JK
![Page 89: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/89.jpg)
Hepatocellular Carcinoma following Hepatitis C
Mrs. JAL
60 year old RN
![Page 90: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/90.jpg)
Mrs JAL October 2006
![Page 91: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/91.jpg)
MRS JAL January 2009 28 months later
![Page 92: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/92.jpg)
Berkson BM, Rubin DM, Berkson AJ. Integr Cancer Ther. 2007 Sep;6(3):293-6.
Reversal of signs and symptoms of a B-cell lymphoma
in a patient using low-dose naltrexone.
![Page 93: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/93.jpg)
MR TM DECEMBER 2005
![Page 94: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/94.jpg)
MR. TM MAY 2006
6 months later
![Page 95: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/95.jpg)
Mr. JT Renal Cell Carcinoma 68 YO male
• Diagnosis June, 2008 Urinating blood. • CT mass L kidney with possible mets to lung. • Nephrectomy L. kidney. • MD Anderson administered biological response modifiers and
chemotherapeutics. TS continued To deteriorate. No effect on TS�s RCC.
• TS told to get his affairs in order, no hope for survival June, 2010. • TS presents to IMCNM August 16, 2010. • Put on IMCNM protocols. • March 2015, healthy, working, with no signs of disease.
![Page 96: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/96.jpg)
Mr. JT August 2010
![Page 97: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/97.jpg)
Mr. JT January 2011
![Page 98: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/98.jpg)
Mr.JT JAN. 2014
![Page 99: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/99.jpg)
Lipoic Acid Plus Low-Dose Naltrexone Reviewed for Cancer Treatment
• NCI staff and invited guests listen to Drs. Berkson and Donahue discuss their research and treatments on March 19, 2012
• A panel of researchers and clinicians was convened by the National Cancer Institute (NCI) for presentations and a roundtable discussion about �The State of the Science of Alpha-Lipoic Acid plus Low-Dose Naltrexone for the Treatment of Cancer.� The meeting was hosted by the Cancer Therapy Evaluation Program (CTEP), both part of the NCI Division of Cancer Treatment and Diagnosis (DCTD). The meeting provided an opportunity for NCI staff and outside experts to review and discuss case reports from Dr. Burton M. Berkson, an integrative medicine physician and Ph.D. in Biological Sciences, and Adjunct Professor. Dr. Berkson presented on his experience treating patients with alpha-lipoic acid plus low-dose naltrexone for various cancers and autoimmune diseases. The group also heard from Dr. Renee N. Donahue, (Zagon Group) Research Fellow at NCI about her pre-clinical research on the efficacy and proposed mechanism of action of LDN for the treatment of cancer.
![Page 100: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/100.jpg)
The cases being presented today by Dr. Berkson were submitted and given rigorous scientific evaluation under the NCI Best Case Series (BCS) protocol. The ultimate goal is to identify those integrative medicine interventions that have enough evidence to support NCI-initiated research. Dr. Berkson reported that a combination of ALA (intravenously and orally) and LDN (orally), along with diet, vitamins, and lifestyle changes caused several cancers to go dormant. Earlier in his medical career, Dr. Berkson published papers using ALA to repair liver damage in patients from mushroom poisoning and chronic infections with hepatitis C virus. He also cited a number of research articles in European medical journals showing ALA�s beneficial effects on cancer.
![Page 101: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/101.jpg)
Routes of Administration of Alpha Lipoic Acid
• Oral power in capsule. • Tablet • Liposomal Alpha Lipoic Acid (phospholipids from soy
lecithin) • Intra Muscular Alpha Lipoic Acid dissolved in
Trametamol • Intravenous Alpha Lipoic Acid dissolved with sodium
hydroxide and buffered and delivered in D5W or Normal Saline
![Page 102: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/102.jpg)
Europe and Asia very interested in Alpha lipoic acid.
Very little interest in the United States.
![Page 103: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/103.jpg)
What about ALA/N for systemic lupus erythematosus
and rheumatoid arthritis?
![Page 104: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/104.jpg)
ALA plus LDN for SLE and RA
0
100
200
300
400
500
600
700
0 2 4 6 8 10 12
2830323337384243444546474849505153596263
Months
ANA Levels
Raw 3 Point Data(Chart 2)
0
500
1000
1500
2000
2500
3000
0 2 4 6 8 10 12
best 3 point data
2182324647071
Months
RA (RF) SLE (ANA)
![Page 105: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/105.jpg)
Summary ALA is necessary for aerobic cell life. because ALA is essential for the conversion of pyruvate to acetyl Co A in the mitochondrion. ALA is the rate-limiting factor for the production of energy from our
cells. ALA inhibits pyruvate dehydrogenase kinase. ALA forces cells from an anaerobic metabolism into aerobic
metabolism. ALA has many uses in human medicine. The efficacy, the apparent lack of toxicity, the long clinical track records
of this agent in human medicine, all points toward the need for a clinical trial.
Why aren�t there any large scale clinical trials? The agent has too many successful indications.
![Page 106: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/106.jpg)
Drug Company Vice President confidential statement following Mayo Clinic positive results treating 1200 plus DM
neuropathy patients with IV ALA. • Diabet Med. 2004 Feb;21(2):114-21. • Treatment of symptomatic diabetic
polyneuropathy with the antioxidant alpha-lipoic acid.
• Ziegler D, Nowak H, Kempler P, Vargha P. Low PA.
• Med Klin (Munich).1999 Oct 15;94 Suppl 3:84-9.
• A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories.
• Berkson BM
• We want a drug with one indication. ALA has too many indications.
![Page 107: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/107.jpg)
Companies are working hard to change the alpha lipoic molecule so it can be used as a patented drug and not as useful for so many indications, however, up until now, the corrupted molecules don�t work nearly as well as the natural molecule.
![Page 108: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/108.jpg)
Most of the patients that I see have hepatitis C, diabetes complications, SLE, RA, etc. Patients sign informed consent forms. Conventional therapies explained carefully with complete objectivity. Most cancer patients that I see are end stage. They are told by their oncologist that nothing medically can be done. This lecture is just my experience and is not an authorization for others to experiment with these protocols.
![Page 109: Toronto, 2015 Alpha-Lipoic Acid s Effects on the ... · Int J Clin Pract. 2005 Jun;59(6):645-50. This study demonstrated that alpha-lipoic acid is an effective treatment for peripheral](https://reader034.vdocuments.net/reader034/viewer/2022050219/5f653c9e40b6192b352910b4/html5/thumbnails/109.jpg)
Books describing my therapies Also type in Berkson BM on Google, Google Scholar,
or PubMed