towards optimal use of gut health supporting feed additives · 3/4/2018 · phytogenic feed...
TRANSCRIPT
TOWARDS OPTIMAL USE OF GUT HEALTH SUPPORTING FEED ADDITIVES
Dr. Daniel Ramirez
Gut health
=
Performance
Effective digestion
& absorption
- Nutritional status
- Absorption of feedwater, minerals.
- Fecal consistency Gut mucosa
- Mucus layer
- Epithelium
- GALT
Microbiota
- Complex
composition
- Activity (exc)Effective Immune
system
- GI Barrier
- Mucus production
- HDP production
- IgA activity
Homeostasis
- Normal physiological function
Diet
- Macro micro nutrient
- Additives
- Antinutritional factor
- Indigestible fractions
Gut health is important formaximizing the health, welfare,and performance of poultry.
Defining gut health
“Gut health” could be defined asthe correct interactions amongthese physiological functions.
Functional feed additives can improve intestinal development and function
FFA positively affect microbiota, maximizing poultry health, and growth whilstenhancing the efficiency of feed conversion.
Among feed additives alternatives Precision Delivery Coated Butyrate (PDCB)and some Phytogenic Components (PC) probably represent the best potential toapproach the balance of the gut health ecosystem.
What is butyrate?
salt of naturally occurring short-chain fatty acid
many beneficial effects in the gut
How does butyrate mediate all these effects?
+
-
animal host cell
(e.g. gut epith. cell, immune
cell,...)
bacterium
(e.g. Salmonella)
+
-
Functional feed additives can improve intestinal development and function
12
3
increased secretion of digestive fluids
energy source for liver
villi development
gut empowerment; intestinal barrier
reduction of inflammation
triggers enteric endocrine system
energy source for colonic cells
prevention of colonisation by pathogens
better absorption of water → dryer faeces
Phytogenic feed additives: the secret is in selecting the best molecules aiming at several targets, as good as possible
feed intake
digestion
antibacterial
anti-oxidation
Quorum Sensing
Phytogenic feed additives: the secret is in selecting the best molecules aiming at several targets, as good as possible
Selection of efficacious anti-oxidativecompounds via literature study anddatabase analysis
Mode of action: antibacterial effect
Neg. ctrl AGP APEX
Ec O149 Ec O157 Lb pl Lb casei
1E+00
1E+01
1E+02
1E+03
1E+04
1E+05
1E+06
1E+07
Phytogenic feed additives: Mode of action: Quorum Sensing
A form of bacterial communication dependent on population-density
Phytogenic feed additives: Mode of action: Quorum Sensing
• 2 QS signal systems tested (with Univ. of Ghent)
• bioactive components from botanicals:
tested separately and in mixes,
at concentrations well-below MIC
...
strength of QS signal 1 (%)
0 20 40 60 80 100
no EO
+ EO 1
+ EO 2
+ EO 3
strength of QS signal 2 (%)
0 20 40 60 80 100
no EO
+ EO 1
+ EO 2
+ EO 3
no botanical added
+ botanical 1
+ botanical 2
+ botanical 3
PC + EO core
PC components
shuts down QS!
p < 0.0001
Performance effect of precision delivery coated butyrate ( PDCB) and Phytobiotics
784 day-old male Cobb 500® chicks, 4 treatment groups 7 replicates of 28 birds.
Effect of different concentrations of PDCB 0.25, 0.5, 1 kg/ton
Effect of PDCB + Phytobiotics in the grower and finisher rations, on top of adding PDCB in the starter feed.
Zootechnical parameters measured at: 21,35, 42 days
Material & Mthods
GroupPhases
Pre-starter Starter Growth withdrawal
1 AGP + AA AGP + AA AGP + AA AGP
2 AA AA AA
3 PDCB 1 kg/t + AA PDCB 1 kg/t + AA PDCB 0,5 kg/t + AA PDCB 0,25 kg/t
4 PDCB 1 kg/t + AA PDCB 1 kg/t + AA PC 0,15 kg/t + AA PC 0,15 kg/t
AA - anticoccidiostat
AGP - Growth promoter
Material & Mthods Fa
cilit
ies
Experiment 1 - Figure 1Technical parameters - PDCB levels in starter at 21 day
1291
1297
1318
1273
1250
1260
1270
1280
1290
1300
1310
1320
1330
1-21 (d)
feed intake (FI) FCR Weight (AW)
1.37
1.34
1.33
1.30
1.26
1.28
1.3
1.32
1.34
1.36
1.38
1-21 (d)
943
968
993978
910
920
930
940
950
960
970
980
990
1000
1-21 (d)
P = 0.04 P = 0.05 P = 0.08
NC PDCB 0,50-0-0 PDCB 0,75-0-0 PDCB 1,00-0-0
Experiment 2 - Figure 2Technical parameters - PDCB levels in starter at 42 day
3162
3173
32503218
3100
3120
3140
3160
3180
3200
3220
3240
3260
1-42 (d)
feed intake (FI) FCR Weight (AW)
5219
5245
53025292
5160
5180
5200
5220
5240
5260
5280
5300
5320
1-42 (d)
1.65
1.64
1.63
1.64
1.62
1.625
1.63
1.635
1.64
1.645
1.65
1-42 (d)
P = 0.05
NC PDCB 0,50-0-0 PDCB 0,75-0-0 PDCB 1,00-0-0
Experiment 2 - Figure 3Performance at day 21 - PDCB+BO in grower
943
993
979
999
910920930940950960970980990
10001010
1-21 (d)
feed intake (FI) 21 d FCR (corrected) 21d Weight (AW) 21 d
1291
1299
1304
1313
1280
1285
1290
1295
1300
1305
1310
1315
1-21 (d)
1.42
1.37
1.39
1.37
1.34
1.35
1.36
1.37
1.38
1.39
1.4
1.41
1.42
1.43
1-21 (d)
b a ab a
Control AGP PDCB PDCB+BO
P = 0.05
Experiment 2 - Figure 4Performance at day 21 - PDCB+BO in grower
feed intake (FI) 42 d FCR (Corrected) 42 d Weight (AW) 42 d
3191
3217
3249
3274
3140
3160
3180
3200
3220
3240
3260
3280
3300
1-42 (d)
5227
5163
5280
5396
5000
5050
5100
5150
5200
5250
5300
5350
5400
5450
1-42 (d)
1.64
1.621.62
1.62
1.61
1.615
1.62
1.625
1.63
1.635
1.64
1.645
1-42 (d)
ab b ab a b ab a a
Control AGP PDCB PDCB+BO
Conclusions
An improvement of feed intake at day 42 (p=0.01)
With increasing PDCB inclusion levels, we found an improvement in feed intake(FI) (p=0.04), body weight (BW) (p=0.08) and feed efficiency (FCR) (p=0.05) atday 21,
Better weight gain (p=0.05) at the end of the trial (42d).
The best result on final weight was observed for the treatment combiningPDCB in the starter feed with PC in the grower and finisher rations.
Integral program to prevent and control disease
Particle size
Digestibility macro & micro nutrients
Mycotoxin control
Nutrition
Diagnostics
Prevention (vaccination)
Programas AF
Veterinary medicine
Growth promoters
Prevention
Challenges
Intestinal health
Hygiene
Biosecurity
Vaccination
AF programs
AB reduction in phases
i. 20%
ii. 40%
iii. 60%
Management
Nutrition
Veterinary medicine
Inmune response
Intestinal integrity
Increase in HDP
Microbiome control
Nutrients maximization
(enzymes)