toxicity analysis, ld50, lc50, chronic toxic
TRANSCRIPT
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ANALISA TOKSISITAS
Usalab-id.com
Alex Bernadi
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Analisa Toksisitas
• Lethal Dosage 50 (LD50)
• Lethal Concentrate 50 (LC50)
• Chronic Toxicity (CT)
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LD 50
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Definisi LD50 adalah dosis tertentuyang dinyatakan dalam miligram beratbahan uji per kilogram berat badan (BB)hewan uji yang menghasilkan 50 %respon kematian pada populasi hewanuji dalam jangka waktu tertentu.
Regulasi: PP No.85 Tahun 1999menyatakan bahwa nilai ambang batasLD50 secara oral adalah 15 mg/kg BB.
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RESULT
AKLIMATISASILD 50
FINDING RANGE TEST
OBSERVASI
DEFINITIVE TEST
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LC 50
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LC-50 ialah nilai konsentrasimematikan dari suatu bahandidalam suatu perairan ygdiperkirakan dapat menyebabkanefek kematian sebesar 50%terhadap populasi bota ujitertentu. ( 96 jam setelahperlakuan). 96 hrs LC 50
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• Metode Statis : exposure time 90 jam1
• Hewan Uji: benur udangwindu PL 20 - 252
• Toxicity Analysis Report LC50 – 96 jam3
Tata cara Analisa LC50
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Katagori Toksisitas
Kategori Toksisitas Nilai LC50 (mg/L)
1. Sangat Beracun (Very toxic) < 12. Beracun (Toxic) 1 – 1003. Moderat (Moderately toxic) 100 – 10004. Sedikit Beracun (Slightly toxic) 1000 – 10.0005. Hampir tak Beracun (Almost non-toxic) 10.000 – 100.0006. Tak Beracun (Non toxic) >100.000
Klasifikasi tingkat toksisitas bahan-bahan kimia untuk kegiatanpertambangan gas dan minyak bumi di Australia (Hinwood et al., 1994)
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RESULT
AKLIMATISASILC 50
FINDING RANGE TEST
OBSERVASI
DEFINITIVE TEST
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CT
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Toksisitas kronis adalah ujitoksisitas yang meliputipengamatan terhadap stimulus-stimulus yang dapat menghambatatau mengganggu kehidupan biotauji secara terus menerus dalamjangka waktu relatif lama
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• Metode Statis : exposure time 6 bulan1
• Hewan Uji: Tikus U 5-8 mggu BB 100 - 1202
• Toxicity Chronis Analysis Report 3 bln & 6 bln + LD50
3
Tata cara CT