toxins 2017 program schedule at a glance - … · toxins 2017 program schedule at a glance selected...
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TOXINS 2017 Program Schedule at a Glance
Selected Oral PresentationsChair: Tony Ward (UK)
Wednesday, January 18, 2017All Day Exhibit Setup
10:00 - 19:00 Registration Open
10:00 - 18:00 Poster Setup
Opening SessionAuditorium and Castilla
18:00 – 18:30 Welcome and Opening Remarks and Lifetime Achievement Award Ceremony Joseph Jankovic (USA) Alberto Albanese (Italy)18:30 – 19:00 Unexpected Consequences Mark Hallett (USA)19:00 – 19:30 DasGupta Memorial Lecture Cesare Montecucco (Italy)
19:30 - 22:00 Welcome Reception Tapices Room
Thursday, January 19, 201707:00 - 18:30 Registration/Information
07:00 - 08:30 Exhibits (Patio Areas)
Plenary SessionAuditorium and Castilla
08:30 - 08:40 Welcome and Opening Remarks and Introduction of Keynote Speaker Andreas Rummel (Germany)
08:40 - 09:30 Keynote Presentation – Presynaptic Functions Erik M. Jorgensen (USA)
09:30 - 10:00 Assembly and Disassembly of the SNARE Complex Axel Brunger (USA)
10:00 - 10:30 What’s the Best Dosage and Interval for BoNT Injections in Dystonia and Spasticity Treatment? Jörg Wissel (Germany)
10:30 - 11:00 Break
11:00 - 11:30 Recent Developments in Clinical Trials of BoNT Alberto Albanese (Italy)
11:30 - 12:00 Advances in the Architecture of the BoNT Complex Rongsheng Jin (USA)12:00 - 13:45 Lunch (Patio Areas)
12:00 – 14:30 Exhibits (Patio Areas)
12:00 - 14:30 Poster Session (Patio Areas)
Clinical Tracks 1A & 1BCastilla Room
Clinical Track 2 A & 2 B
Clinical Workshops 1A & 1B Tapices Room
Oromandibular DystoniaSession Chair: Cynthia Comella (USA)
Cadaver LaboratorySession Chair: Ellen Gendler (USA)Discussant: Steven G. Yoelin (USA)
16:00 - 16:30 Break
14:30 - 16:00 Laboratory: Prosection of the Face and Neck Jonathan Sykes (USA)
Cosmetic Uses ISession Chair:
Hand Dystonia Session Chair: Mark Hallett (USA)
14:30 - 15:00 Pathophysiology and Therapy Other Than BoNT Kirsten Zeuner (Germany)
15:00 - 15:30 Review of Clinical Trials Codrin Lungu (USA)
15:30 - 16:00 Muscle Selection for BoNT Jennifer Goldman (USA)
16:00 - 16:30 Break
16:30 - 18:00 Hand Dystonia Injection Workshop Demonstrations on Live Patients Master Injector: Pedro Garcia-Ruiz (Spain)
14:30 - 15:00 Applying Tailored Assessment Scales in BoNT Injections Carlo Colosimo (Italy)
15:00 - 15:30 A Review of Evidence of BoNT Treatment Raymond Rosales (Philippines)
15:30 - 16:00 Practical Tips for BoNT Treatment Katja Kollewe (Germany)
16:00 - 16:30 Break
16:00 - 16:30 Break
Molecular Interactions lSession Chair: Giampietro Schiavo (United Kingdom)
16:30 - 17:00 Binding of BoNT to Glycosylated SV2 Stefan Mahrhold (Germany)
17:00 – 17:30 Botulinum Neurotoxin Type A Enters a Non-Recycling Pool of Synaptic Vesicles Frederic Meunier (Australia)
17:30 - 18:00 Botulinum Neurotoxins Inhibit
and A1 in Cultured Sensory Neurons Oliver Dolly (Ireland)
18:00 - 18:30 Translocation and Dissemination to Target Neurons of Botulinum Neurotoxin Type B in the Mouse Intestinal Wall
16:30 - 17:00 Overactive Bladder Management Strategy and Role of BoNT Michael Chancellor (USA)
17:00 – 17:30 Emerging Applications of BoNT to Treat Pelvic Pain Syndromes Christopher Smith (USA)
17:30 - 18:00 Update on BoNT Injections in MS and Interstitial Cystitis/Bladder Pain
Francisco Cruz (Portugal)
16:30-16:45 Muscle Selection For OnabotulinumtoxinA In Poststroke Lower-Limb Spasticity
Double-Blind, Placebo-Controlled Phase 3 Clinical Trial Alberto Esquenazi (USA)
16:45-17:00 Time to Retreatment After AbobotulinumtoxinA (Dysport) Injections in Children With Dynamic Equinus Foot Deformity Nigar Dursun (Turkey)
17:00-17:15 Safety of OnabotulinumtoxinA Treatment With Concomitant Antithrombotic Therapy In Patients With Post-Stroke Spasticity: A Pooled Analysis of Randomized, Double-Blind Studies Rozalina Dimitrova (USA)
17:15-17:30 Prospective, Single-Arm, Dose-Titration Study Of IncobotulinumtoxinA (Xeomin; Up To 800 U) For Treatment of Upper- and Lower-Limb Spasticity Jörg Wissel (Germany)
17:30-17:45 An International, Multicenter, Prospective, Randomized, Evaluator-Blinded Study
Injection Strategies For Treatment of Upper Limb Spasticity Tiina Rekand (Norway)
17:45-18:00 Discussion
16:30 - 17:00 Introduction to the Anatomy of Facial Aesthetics Jonathan Sykes (USA)
17:00 – 17:30 Evidence-Based Review of BoNT Injections for Aesthetic Use Doris Hexsel (Brazil)
17:30 - 18:00 A New Botulinum Toxin Type A for the Treatment of Glabellar Lines Steven G. Yoelin (USA)
Parallel Track I (Basic Science)Auditorium
Genetics and EvolutionSession Chair: Cesare Montecucco (Italy)
Time14:30 - 15:00 Regulation of C. botulinum Growth and Toxin Production Miia Lindström (Finland)
15:00 - 15:30 Botulinum Neurotoxin Homologs in Non-Clostridial Species Andrew Doxey (Canada)
15:30 - 15:45 Novel Botulinum Neurotoxin Pål Stenmark (Sweden)
15:45 - 16:00 A Functional Assay Devoid of Antibodies For Serotyping and Detection of Botulinum Neurotoxins Jasmin Weisemann (Germany)
Time
14:30 - 15:00 Pathophysiology and Clinical Features Ryuji Kaji (Japan)
15:00 - 15:30 Systematic Review of BoNT Treatment Cynthia Comella (USA)
15:30 - 16:00 Practical Tips for BoNT Treatment Helio Teive (Brazil)
16:00 - 16:30 Break
Time Time Time
Lifespan Management of Muscle Activity in Cerebral Palsy (CP)Session Chair: Katharine Alter (USA)
14:30 - 15:00 Management of Pediatric Cerebral Palsy Florian Heinen (Germany)
15:00 - 15:30 Management of Adolescents/Teens Sebastian Schröeder (Germany)
15:30 - 16:00 Transition and Management of Adults Cindy Ivanhoe (USA)
16:00 - 16:30 Break
Urological Use of BoNTSession Chair: Michael Chancellor (USA)
Clinical Workshops 2A & 2BHospital - Ramon y Cajal
Hemifacial Spasm and Blepharospasm Session Chair: Raymond Rosales (Philippines)
16:30 - 18:00 Hemifacial Spasm and Blepharospasm Injection Workshop Demonstrations on Live Patients Master Injector: Francisco Grandas (Spain)
Time
Clinical Workshops 3A & 3BHospital - Ramon y Cajal
14:30 - 15:00 Review of Long-Term Studies and Registries Buz Jinnah (USA)
15:00 - 15:30 What Are the Obstacles to Optimal Patient Outcomes? Dirk Dressler (Germany)
15:30 - 16:00 Joseph Tsui (Canada)
16:00 - 16:30 Break
Cervical Dystonia Session Chair: Buz Jinnah (USA)
16:30 - 18:00 Cervical Dystonia Injection Workshop Demonstrations on Live Patients Master Injector: Juan Carlos Martínez-Castrillo (Spain)
Time
Clinical Workshops 4A & 4B Hospital - Ramon y Cajal
Transportation to the Clinical Workshops at Hospital Ramon y Cajal will departthe Meliã Castilla (main entrance) from 13:45 - 14:00 and will return at 18:00
Friday, January 20, 201707:00 - 18:30 Registration/Information
07:00 - 08:30 Exhibits (Patio Areas)
Plenary SessionAuditorium and Castilla
08:30 - 09:00 Evidence on BoNT in Selected Disorders David Simpson (USA) 09:00 - 09:30 The Booming Number of Novel Botulinum Neurotoxins: A Pandora's Box of Novel Properties Eric Johnson (USA)
09:30 - 10:00 Potential New Uses of BoNT Injections in Movement Disorders Joseph Jankovic (USA)
10:00 - 10:30 Break
Peripheral Neurons Ornella Rossetto (Italy)
Matteo Caleo (Italy)
11:30-12:00 BoNT for Pain Syndromes Bahman Jabbari (USA)
12:00 - 13:45 Lunch (Patio Areas)
12:00 - 14:30 Exhibits (Patio Areas)
12:00 - 14:30 Poster Session (Patio Areas)
Auditorium
Detection and ProtectionSession Chair: Markus Kalkum (USA)
Time
Clinical Tracks 2A & 2BLe Jardin
Clinical Workshops 1A &1B
Spasmodic DysphoniaSession Chair: Andrew Blizter (USA)
Cosmetic and Dermatologic Uses IISession Chair: Ellen Gendler (USA)
14:30 - 15:00 Aesthetic BoNT Injections of the Face: Options and Outcomes Ellen Gendler (USA)
15:00 - 15:30 Beyond Rhytids: Facial Contouring With Botulinum Toxin Steven G. Yoelin (USA)
15:30 - 16:00 BoNT Injections for Hyperhidrosis: Technical Pearls Dee Anna Glaser (USA)
16:00 - 16:30 Break
16:30 - 18:00 Cosmetic and Dermatologic Uses II Injection Workshop Demonstrations on Live Patients Master Injector: Juan Sopena (Spain)
14:30 - 15:00 Pathophysiology, Assessment and Treatment of Spastic Paresis Jean-Michel Gracies (France)
15:00 - 15:30 Botulinum Toxin in the Treatment of Upper Extremity Spasticity Allison Brashear (USA)
15:30 - 16:00 Botulinum Toxin in the Treatment of Lower Extremity Spasticity Alberto Esquenazi (USA)
16:00 - 16:30 Break
Parallel Track I (Basic Science)Auditorium
Molecular Interactions llSession Chair: Mauricio Montal (USA)
14:30 - 15:00 Mechanisms of Intestinal Absorption of Botulinum Neurotoxin Complex Yukako Fujinaga (Japan)
15:00 - 15:15 In Vitro And In Vivo Evaluation Of
Giulia Zanetti (Italy)
15:15 - 15:30 In Vitro and Ex Vivo Screening of Candidate Therapeutics to Restore Neurotransmission in Nerve Terminals Intoxicated by Botulinum Neurotoxin Serotype A1 Phillip H. Beske (USA)
15:30- 15:45 HSP90, Thioredoxin And Thioredoxin Reductase Form A Chaperone-Redox Machinery Enabling The Catalytic Activity of Clostridial Neurotoxins Inside Nerve Terminals Marco Pirazzini (Italy)
15:45- 16:00 Role of SNARE Proteins in Tumorigenesis and Protein-Engineering SNARE-Inactivating Anti-Cancer Therapeutics Jianghui Meng (Ireland)
16:00 - 16:30 Break
Time
TimeTime Time
Headache and Pain
14:30 - 15:00 Botulinum Toxins for Chronic Migraine: Clinical Trials and Technical Aspects Cristina Tassorelli (Italy)
15:00 - 15:30 Predictors of Botulinum Toxin Treatment Response in Chronic Migraine Rami Burstein (USA)15:30 - 16:00 Botulinum Toxin for Neuropathic Pain David Simpson (USA)16:00 - 16:30 Break
Clinical Workshops 2A & 2BHospital - La Paz
Spasticity Session Chair: Allison Brashear (USA)Discussant: Tony Ward (United Kingdom)
16:30 - 18:00 Spasticity Injection Workshop Demonstrations on Live Patients Master Injectors: Susana Moraleda & Mercedes Martínez-Moreno (Spain)
Time
Clinical Workshops 3A & 3BHospital - La Paz
14:30 - 15:00 EMG/Guidance and Polymyography Marina de Koning-Tijssen (The Netherlands)
15:00 - 15:30 Ultrasound Katharine Alter (USA)
15:30 - 16:00 Other Techniques Erle Lim (Singapore)
16:00 - 16:30 Break
16:30 - 18:00 Lifespan Management of Muscle Activity in Cerebral Palsy Injection Workshop Demonstrations on Live Patients Master Injector: Samuel Ignacio Pascual-Pascual (Spain)
Time
Clinical Workshops 4A & 4BHospital - La Paz
Novel BoNTs and Toxin Engineering Session Co-Chairs: Sabine Pellett (USA) Dorothea Sesardic (UK)
16:30 - 17:00 Structural and Functional Insights Into the Interaction of BoNT/A Light Chain With SNAP-25 and SNAP-23 Thomas Binz (Germany)
17:00 – 17:15
Daniel Scheps (Germany)
17:15 – 17:30 Engineering Destruction Sites Into Botulinum Neurotoxins Dina Anderson (UK)
17:30 – 17:45 Improved Stability Manuela López de la Paz (Germany) 17:45 – 18:00 Potency and Duration of Action of BoNT/FA in Cell Models and in Mice Sabine Pellett (USA)
18:00 – 18:30 Non-Paralytic BoNTs for Pain Control Bazbek Davletov (UK)
14:30 - 15:00 Spasmodic Dysphonia Enrico Alfonsi (Italy)
15:00 - 15:30 Long-Term Experience With BoNT for Spasmodic Dysphonia Andrew Blitzer (USA)
15:30 - 16:00 Other Speech and Voice Disorders Treatable with BoNT Pedro Garcia-Ruiz (Spain)
16:00 - 16:30 Break Other Neurological UsesSession Chair: Francisco Cardoso (Brazil)
16:30 - 17:00 BoNT in Parkinsonism: The When, How, and Which for BoNT Injections Francisco Cardoso (Brazil)
17:00 – 17:30 Tremors: The When, How, and Which for BoNT Injections Roongroj Bhidayasiri (Thailand)
17:30 – 18:00 Tics: The When, How, and Which for BoNT Injections Peter Moore (United Kingdom)
16:30 - 18:00 Headache Injection Workshop Video and Live Patient Demonstration Master Injector: Margarita Sánchez del Río (Spain)
Techniques for Localizing Muscles for BoNT InjectionsSession Chair: Marina de Koning-Tijssen (The Netherlands)
Saturday, January 21, 201707:00 - 18:30 Registration/Information
07:00 - 08:30 Exhibits
Plenary SessionAuditorium and Castilla
07:45 - 08:30 INA Members’ Business Meeting
08:30 - 08:45 Poster Awards Joseph Jankovic (USA) Alberto Albanese (Italy)
08:45 - 09:00 A Weissella oryzae Botulinum-Like Toxin Cleaves VAMP Within The Juxtamembrane Domain Cesare Montecucco (Italy)
09:00 - 09:20 Controversy - PRO: BoNT for Headache: PREEMPT vs. Individualized Treatment John Rothrock (USA)
09:20 - 09:40 Controversy - CON: BoNT for Headache: PREEMPT vs. Individualized Treatment Mark Green (USA)
09:40 - 10:20 TeNT Uptake and Transport Giampietro Schiavo (United Kingdom)
10:20 - 10:30 Closing Remarks Giampietro Schiavo (United Kingdom)
10:30 -11:00 Break
11:00 - 11:30 CMAP for Quantitative Detection of BoNTs Yasushi Torii (Japan)
11:30 – 11:45 Engineered Luciferase Pro-Enzymes for the Bioluminescent Detection of Botulinum Neurotoxins Markus Kalkum (USA)
11:45 – 12:00 Development of the BINACLE (Binding and Cleavage) Assay for the In Vitro Potency Testing of Botulinum Neurotoxins Heike Behrensdorf-Nicol (Germany)
12:00 - 12:30 Endopep-MS and Hc-Based Neutralizing Oligoclonal Antibody Mixture Ran Zichel (Israel)
12.30 - 13:00 Outcome of the ANTIBOTABE mAB Development Project Michael Hust (Germany)
Clinical Tracks 1A & 1 BCastilla Room
Selected Oral Presentations
14:30 - 14:45 High Prevalence of Neutralizing Antibodies In BoNT/A Long-Term–Treated Patients With Focal Dystonia and Spasticity Harald Hefter (Germany)
14:45-15:00 Real-Life Use of OnabotulinumtoxinA For The Treatment Of Chronic Migraine: 12-Month REPOSE Study Interim Analysis Julio Pascual (Spain)
15:00-15:15 A Phase 2, Open-Label, Dose-Escalating Study to Evaluate The Safety And For Injection (RT002) In Isolated Cervical Dystonia Cynthia L. Comella (USA)
15:15-15:30 Clinical Relevance Of Treatment With OnabotulinumtoxinA In Patients With Cervical Dystonia: Results From The CD PROBE Study Khashayar Dashtipour (USA)
15:30-15:45 MYSTICOL: A Controlled Study Of Myobloc In The Treatment Of Sialorrhea In Parkinson’s Disease (PD) and Other Neurological Conditions Thomas Clinch (USA)
15:45-16:00 Discussion
T
Transportation to the Clinical Workshops at Hospital La Paz will departthe Meliã Castilla (main entrance) from 13:45 - 14:00 and will return at 18:00
BoNT/C
Session Chair: Mark Green (USA)Session Chair: Daniel Truong (USA)
Time Time Time
Basic Science Track
Ellen Gendler (USA)
El Escorial Room
El Escorial Room