TOXNETTOXNET

Toxicology and Environmental Toxicology and Environmental Health Information on the InternetHealth Information on the Internet

National Library of MedicineNational Library of Medicine

What is What is TOXNETTOXNET??

System of databasesSystem of databases

Information about toxicology, environmental health, Information about toxicology, environmental health, hazardous chemicals, and toxic releaseshazardous chemicals, and toxic releases

Developed by the National Library of Medicine Developed by the National Library of Medicine (NLM)(NLM)

http://toxnet.nlm.nih.gov/http://toxnet.nlm.nih.gov/

Types of FilesTypes of Files

DataData Literature (bibliographic)Literature (bibliographic) Chemical DictionaryChemical Dictionary Toxic Release InventoryToxic Release Inventory

Related: TOXMAP, TOXTown (consumer), Related: TOXMAP, TOXTown (consumer), PubMedPubMed

TOXNET TOXNET Data FilesData Files

There are 5 of themThere are 5 of them

Click the Click the ??

for additional for additional information about each information about each databasedatabase

Data FilesData Files

HSDBHSDB – Hazardous Substances Databank – Hazardous Substances Databank CCRISCCRIS - Chemical Carcinogenesis Research - Chemical Carcinogenesis Research

Information SystemInformation System GENTOXGENTOX – Mutagenicity studies (not – Mutagenicity studies (not

updated)updated) IRISIRIS – Integrated Risk Information System – Integrated Risk Information System ITERITER - International Toxicity Estimates for - International Toxicity Estimates for

Risk AssessmentRisk Assessment

Hazardous Substances Data BankHazardous Substances Data Bank((HSDBHSDB))

Online handbook compiled by NLMOnline handbook compiled by NLM 1 record per chemical1 record per chemical 5,000 + records5,000 + records Human and animal toxicityHuman and animal toxicity Safety and handlingSafety and handling Human health effectsHuman health effects Emergency medical treatment guidelinesEmergency medical treatment guidelines

Chemical Carcinogenesis Research Chemical Carcinogenesis Research Information System (Information System (CCRISCCRIS))

National Cancer Institute (NCI) dataNational Cancer Institute (NCI) data 9,000 + chemical records9,000 + chemical records Carcinogenicity studiesCarcinogenicity studies Tumor inhibition studiesTumor inhibition studies Tumor promotion studiesTumor promotion studies Mutagenicity studiesMutagenicity studies

Searching Data FilesSearching Data Files

Search all databases, orSearch all databases, or Select one database, orSelect one database, or Search “Multi-Database” to search just the Search “Multi-Database” to search just the

data filesdata files

Content areasContent areas of interest in of interest in HSDBHSDB

Human Health EffectsHuman Health Effects Emergency Medical TreatmentEmergency Medical Treatment AntidotesAntidotes Physical & chemical propertiesPhysical & chemical properties InteractionsInteractions Environmental fate & exposureEnvironmental fate & exposure ManufacturersManufacturers Uses: therapeutic, business, etc.Uses: therapeutic, business, etc.

TOXNET’s TOXNET’s 22 Literature Files Literature Files

TOXLINETOXLINE

TOXLINE Core – in PubMed, accessible TOXLINE Core – in PubMed, accessible through TOXNETthrough TOXNET

Search in PubMed via TOXLINE subset LimitSearch in PubMed via TOXLINE subset Limit PubMed Features:PubMed Features:

MESHMESH LimitsLimits MyNCBI, MyNCBI, See Related Articles, LinkOutSee Related Articles, LinkOut

TOXLINETOXLINE

TOXLINE Special – in TOXNET TOXLINE Special – in TOXNET onlyonly Both Core and Special can be searched in Both Core and Special can be searched in

TOXNETTOXNET

TOXNET Features:TOXNET Features: Search both Core and SpecialSearch both Core and Special Relevancy RankingRelevancy Ranking Link to other TOXNET databasesLink to other TOXNET databases

TRI:TRI: Toxics Release InventoryToxics Release Inventory

EPA information regarding the release of EPA information regarding the release of certain toxic chemicals certain toxic chemicals

Reporting is mandated by law and does Reporting is mandated by law and does notnot cover cover allall industries or industries or allall businesses businesses

Release years 1987 – data available in Release years 1987 – data available in TOXNET. Also available through EPA TOXNET. Also available through EPA websitewebsite

TRI TRI

Facility IdentificationFacility Identification Substance IdentificationSubstance Identification Environmental releaseEnvironmental release Waste treatment (on & off site)Waste treatment (on & off site) Source reduction and recyclingSource reduction and recycling

Searching TRISearching TRI

Search by chemical name or CAS

Specify release amount and type

Select a year or years

Search by facility name

Search by location

Search by SIC code

Mapping resultsMapping results

This button provides This button provides mapping capabilitiesmapping capabilities

Use it to see where the Use it to see where the releases in question releases in question were locatedwere located

ChemIDplusChemIDplus

Chemical dictionary/directory fileChemical dictionary/directory file Two versions: “Lite” & AdvancedTwo versions: “Lite” & Advanced 379,000 + chemical records379,000 + chemical records 257,000 + structural records257,000 + structural records

In the Advanced file onlyIn the Advanced file only Requires JAVA or CHIME software (free)Requires JAVA or CHIME software (free)

Direct link to other resourcesDirect link to other resources

ChemIDPlus VersionsChemIDPlus Versions

Lite:Lite: basic search of the chemical name, basic search of the chemical name,

registry numberregistry number Results screen allows you to search other Results screen allows you to search other

databases, and view information: basic, databases, and view information: basic, full, names, formulas, classification full, names, formulas, classification codes, registry numbers, notescodes, registry numbers, notes

ChemIDPlus VersionsChemIDPlus Versions

Advanced:Advanced: Advanced searching on chemical name, registry Advanced searching on chemical name, registry

number, molecular formula, classification code, number, molecular formula, classification code, toxicity, chemical property, chemical structure, toxicity, chemical property, chemical structure, molecular weightmolecular weight

Refine search with “similarity” percentagesRefine search with “similarity” percentages View and draw structures with special software View and draw structures with special software

such as Marvin, Chimesuch as Marvin, Chime Results screen provides all features of Lite plus Results screen provides all features of Lite plus

structure (can be 3D)structure (can be 3D)

Searching ChemIDplusSearching ChemIDplus

Search by chemical Search by chemical name or CAS Registry name or CAS Registry NumberNumber

Click on “search” to Click on “search” to retrieve results from the retrieve results from the “Lite” version“Lite” version

Use the Advanced Use the Advanced button to access the button to access the Advanced capabilitiesAdvanced capabilities

Advanced SearchingAdvanced Searching

Search by:Search by: SubstanceSubstance Toxicity rangesToxicity ranges Physical propertiesPhysical properties StructureStructure Molecular weightMolecular weight

NOTE: Results look the same. Differences are NOTE: Results look the same. Differences are searching and structuresearching and structure

Household Products DatabaseHousehold Products Database

Environmental Consumer Health informationEnvironmental Consumer Health information

Search for environmental effects of common Search for environmental effects of common household itemshousehold items

Categories: auto, pesticides, personal care, arts Categories: auto, pesticides, personal care, arts and crafts, home, landscape/yard, home and crafts, home, landscape/yard, home maintenance, pet care maintenance, pet care

TOXTOWNTOXTOWN

Environmental consumer health in everyday Environmental consumer health in everyday situationssituations

HaxMapHaxMap

Links jobs and hazardous tasks with Links jobs and hazardous tasks with occupational diseases and symptomsoccupational diseases and symptoms

Might NOT want to show this to students as Might NOT want to show this to students as they determine career direction!! they determine career direction!!