transforming pharma to academia

Transforming Big Pharma into Big Academia

Yale University West Campus

Christopher Incarvito, PhDDirector of Research Technology, Yale University West

Campus

• Research Labs 434,000 GSF• Administration 346,000• Specialty Storage 426,000• General Storage 257,000• Campus Support 105,000• Other functions 32,000• Total Building 1,600,000 GSF

West Campus by the Numbers136 Acres, 17 buildings

April 12, 2023 243rd ACS National Meeting, San Diego, CA 2

Aerial View of Yale West Campus




Office, FacilitiesOffice,

FacilitiesResear

chResear

ch

Specialty,

Storage

Specialty,

Storage

Yale University Strategic Goals

• Maintain the position of Yale’s fine arts schools as the strongest university-based programs in the nation.

• Improve the international standing of science and engineering at Yale

• Broaden and deepen the clinical excellence of the School of Medicine

• Establish global leadership in environmental education, research, and practice

• Make Yale a leader in the digital dissemination of scholarly resources


Yale West Campus Challenges

• Access– Distance from the main campuses

• Identity– How to integrate the West Campus with the rest

of Yale

• Space– Medicinal chemistry facility with corporate focus

• Vision– Short time frame from purchase to

implementation


West Campus Operating Principles

• Scientific focus on challenges of human sustainability– Health, Environment and Energy

• Institute based research programs that cross traditional departmental boundaries

• Strengthen and integrate science and engineering faculty across the University– Medical School, School of Engineering, Yale

College• Expand core facilities to support research


Nanobiology

CellBiology

CancerBiology

ChemicalBiology

MicrobialDiversity

SystemsBiology

Energy

Sciences

BiodesignCSCS

GG RiRi

YCGA

CoresHPC

WCAC

SMDC

HTCB

CMD


Facilities Planning

• Work directly with Architects and Builders– Conduit for end users• Get what they want

– Scientific representation• Get what they need

– Administrative representation• Get what is best


Facilities Planning





Active Projects


Case Studies1. Open design concept– Integrated Science and Technology Center (B24-

2/3)2. Old design vs. new design– Advanced Biosciences Center (B31-2/3)

3. Ideal Space– Molecular Innovations Center (B27)

4. Unique offerings– High-energy Experimental Station (C23)

5. Arts integration– Center for Cultural Preservation (A21)

6. Student life


Integrated Science and Technology Center


Integrated Science and Technology Center

Open Design, Interactive Areas


Nanobiology

23,524 GSF


Open conceptShared facilities/equipmentFaculty close to laboratories

Advanced Biosciences Center


Cancer

Biology

29,675 GSF

Advanced Biosciences Center


Cancer

Biology

SystemsBiology

29,675 GSF

Microbial Diversity

A Tale of Two Floors


2008 design 2011 design



• 1 small conference room

• 1 warm room, 1 cold• No shared space• No flex space

2008 design


2008 design



2011 design2008 design

Conference




ConferenceCold




ConferenceColdFlex




ConferenceColdFlexShared Specialty




ConferenceColdFlexShared SpecialtyShared Radiation




ConferenceColdFlexShared SpecialtyShared RadiationShared Safety

Bayer Hydrogenation Plant


Anchor or Unexpected Asset?

• No need for the intended use• Isolated• Dated• Less than ideal use of building space

• But… it can house extreme experiments

• Worry less about what it can do, and more about what we can’t do elsewhere


Anchor or Unexpected Asset


Zhengrong WangGeology and Geophysics

Anchor or Unexpected Asset


Zhengrong WangGeology and Geophysics

200 bar, 500 °C200 bar, 500 °C


Anchor or Unexpected Asset Zhengrong Wang

Geology and Geophysics

Repurpose


Repurpose

• 50,000 reinforced concrete roof

• Update life-safety apparatus

• Hand over keys



6.5 km lithostatic pressue!!!

EnergySciences

Molecular Innovations Center


Chemical

Biology

55,984 GSF

Small Project Kickstart



Shared Microbial Culture


Shared Radiation


Solvent Storage


Instrumentation


Save for the future

Center for Cultural Preservation


Acknowledgements

• Lisa D’Angelo• Scott Strobel• Yale University• www.yale.edu/westcampus


CHAS 24 – Transforming Big Pharma into Big Academia – Yale University West Campus

Challenges of Design, Construction and Transitioning to Operations for New Laboratory FacilitiesWednesday, March 28

9:05 AMSan Diego Mariott Marquis & Marina

Balboa / SMMM

transforming pharma to academia

Education

san diego

rd acs national meeting

yale college

scientific representation

administrative representation

campus support105

end users

builders conduit