Transforming the CTRI and UCSD:From Silo to Collaboration

Gary S. Firestein, M.D.

Clinical and Translational Research Institute

• Organized Research Unit, est. 2010• Funded by institutional funds, CTSA, CTSA supplements,

UCOP, industry funding and NHLBI U54• ~$59 M extramural funding

• Informatics, clinical research and laboaratory infrastructure• Pilot project and Catalyst grants• KL2/TL1/CREST programs• co-funding of investigator initiated projects (30-60%)

• ~$50 M in grants requiring CTRI letter of support• 782 members

• 655 UCSD• SDSU, Sanford Burnham, Salk, LIAI, Venter, others

2010 2011 2012 2013

Nurses/Coord Nurses/Coord Nurses/Coord Nurses/Coord

Clinical Cores--DEXA--Exercise

Clinical Cores--DEXA--Exercise

Clinical Cores--DEXA--Exercise--Skin biopsy

Clinical Cores--DEXA--Exercise--Skin biopsy--Cardiac phenotype

Biostatistics Biostatistics Biostatistics Biostatistics

IRB service IRB service IRB service

Clinic Space (ECOB)

Clinic Space (ECOB)

Phase I unit

Center for Clinical Research 2010-2013

Clinical and Translational Research Institute

• Clinical services since 2011• 261 protocols in CCR (108 currently active)

• ~3000 visits/year• 93 infusions (56 in first half of 2013)• 220 skin biopsies • 45 IRB submission consultations

New CTRI to break down silos• Phase I unit

• Collaboration with the Cancer Center• Standard of Care billing• Experimental Pharmacy• Overnight stays• Begin in ECOB, then move to ACTRI

2010 2011 2012 2013

Biomarker Biomarker Biomarker Biomarker

Biorepository--Storage

Biorepository--Storage--Collection--Velos

Biorepository--Storage--Collection--Velos--Management

Affiliated Cores--Mass Spec

Affiliated Cores--Mass Spec--HT screening

Affiliated Cores--Mass Spec--HT Screening--Genomics

Launching Pad

Translational Research Technology 2010-2013

2010 2011 2012 2013

CDWR CDWR CDWR CDWR

CRIQueT CRIQueT CRIQueT

REDCap REDCap REDCap

ReX ReX

Biocomp Center--Genomics

Biocomp Center--Genomics--Epigenomics--Systems Biology

Velos Enterprise Velos

Data Concierge

Biomedical Informatics 2010-2013

Clinical and Translational Research Institute

• Informatics and Biomarker services since 2011• 485 protocols in Velos (252 active)• 62 Bioinformatics projects• 99 Biomarker projects• 19,027 biosamples processed or collected• 18,392 biomarker assays performed

New CTRI to break down silos

• Genomics and bioinformatics• Consolidate individual efforts at various centers in

the Institute for Genomic Medicine• Re-engineer BIOGEM• Center for Bioinformatics Analysis• Integrated assistance with study design, data

analysis, systems biology, ‘omics data• Collaboration and service models

CTRI Funding Education

• CTRI TL1 Program• 3 m or 1 yr training for medical and pharmacy students

• CTRI KL2 Program• Institutional K award $100 K/yr• 10 Scholars funded since 2010• ~80 participants

• CTRI CREST Program• Modular program that can lead to MAS• Co-funding by the CTRI to lower tuition• >100 participants

Simplifying access: ctri.ucsd.edu

2010 2011 2012 2013

Translational Translational Translational Translational

Clinical Clinical Clinical Clinical

Innovation Innovation Innovation Innovation

Catalyst--CTRI services

Catalyst --CTRI services

Catalyst --CTRI services--Biomarkers--Drug discovery

Personalized Medicine

Engineering in Medicine

Co-funding with other centers

Pilot project grant program 2010-2013

Resources available at the CTRI: Catalyst grants

New CTRI to break down silos

• Drug Discovery at Sanford-Burnham• High throughput screening• Catalyst grants

Resources available at the CTRI: Pilot project grants

CTRI Funding Innovation

Bringing engineers and clinicians together to apply technology to unmet medical needs

GEM Program:Galvanizing Engineering in Medicine

Altman CTRI Building: Designed to break down silos