transport of biological materials - ucl · transport of biological materials covering the...
TRANSCRIPT
![Page 1: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/1.jpg)
Transport of Biological Materials
Covering the classification, packaging and labelling of biological materials for transport in the UK and abroad
Dr Joanna MarshallUniversity Biological Safety Adviser
University of Edinburgh
![Page 2: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/2.jpg)
Reference documents and information source
Health and Safety Department website:http://www.safety.ed.ac.uk/resources/Bio/Guidance/Index.html
Various sections, Transport includes- Detailed guidance on transport of biological
materials *essential reading*- Specialist dangerous goods couriers- Suppliers of specialist packaging
![Page 3: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/3.jpg)
Individual workers responsibilitiesThat means YOU!
![Page 4: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/4.jpg)
International agreements for transport of dangerous goods
UN Recommendations/ Model Regulations form basis for international, national, regional and modal regulations
Road ADRRail RIDAir ICAO (IATA)Sea IMDG
![Page 5: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/5.jpg)
Road transport
• The Carriage of Dangerous Goods and Use of Transportable Pressure Equipment Regulations 2004– cross references to ADR (& RID)
Depending on the material other legislation may also apply, such as
• The Genetically Modified Organisms (Contained Use) Regulations 2000
![Page 6: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/6.jpg)
Air transport
• Technical Instructions for the Safe Transport of Dangerous Goods by Air– ICAO
• Dangerous Goods Regulations – IATA
![Page 7: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/7.jpg)
Applicability
• When transported by road by any means– except carriage between one part of the
University and another part situated in the immediate vicinity
– even if carry package yourself
• When transported by air – no exceptions– restrictions on how package carried
![Page 8: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/8.jpg)
A key point on air transport
• Dangerous goods must not be carried by passengers as/or in – checked baggage– carry-on baggage or – on their person
Dangerous goods must always be transported as separate packages in the hold and must always be declared
![Page 9: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/9.jpg)
"Dangerous Goods" for carriage
• Criteria defined under 9 UN hazard classes
• Classify and assign UN number and proper shipping name
• Each has entry in Dangerous Goods List which indicates– limitations– packaging – labelling– special provisions
![Page 10: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/10.jpg)
Class 6.2 - Infectious substances
• Substances known or reasonably expected to contain pathogens
• Can cause disease in humans or animals• Certain biological materials meet
definition– stringent requirements for classification,
packaging and labelling• Consider any other hazardous properties• Other biological materials
– specific requirements to package safely
![Page 11: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/11.jpg)
UN numbers and proper shipping names
• UN 2814INFECTIOUS SUBSTANCE, AFFECTING HUMANS
• UN 2900INFECTIOUS SUBSTANCE, AFFECTING ANIMALS ONLY
![Page 12: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/12.jpg)
UN numbers and proper shipping names
• UN 3373 DIAGNOSTIC SPECIMENS or CLINICAL SPECIMENS
• UN 3291 CLINICAL WASTE, UNSPECIFIED, N.O.S., (BIO) MEDICAL WASTE, N.O.S. or REGULATED MEDICAL WASTE
![Page 13: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/13.jpg)
2005 - revised categorisation scheme
• Based on risks during transport rather than risks associated with lab work
• Assign UN number depending on whether Category A or Category B
![Page 14: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/14.jpg)
Category A
– an infectious substance which is carried in a form that, when exposure to it occurs, is capable of causing permanent disability, life-threatening or fatal disease to humans or animals
• Refer to indicative list (not exhaustive)• Assign to
UN 2814 or UN 2900
![Page 15: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/15.jpg)
Category B
– an infectious substance which does not meet the criteria for inclusion in Category A
Assign to UN 3373 except cultures
![Page 16: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/16.jpg)
Cultures, stocks, etc
• Items containing high concentration or titre of micro-organisms– cultured/propagated/amplified/manipulated– either deliberately or unintentionally
• If infectious for humans or animals always Category A irrespective of whether micro-organism on indicative list
Assign to UN 2814 or UN 2900• Others not controlled
![Page 17: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/17.jpg)
Other materials that may contain infectious substances• Assign to either Category A or Category
B where appropriate
• Not controlled if – material not derived from humans or animals– possibility, but low probability, contain
pathogens, and – concentration at natural levels
Examples include foodstuffs, water and environmental samples
![Page 18: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/18.jpg)
Samples from humans or animals
• Minimum Category BAssign to UN 3373
• Specific samples Category A on basis of – medical history and symptoms– endemic local conditions– professional judgement on source material– individual circumstances
Assign to UN 2814 or UN 2900
![Page 19: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/19.jpg)
Important note for air transport
• Some operators apply additional restrictions
• See Operator Variations– eg AF-04 and LH-12
Blood and tissues carried only as UN 2814 or UN 2900
![Page 20: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/20.jpg)
Genetically modified micro-organisms (GMMs)
• If harmful to humans or animals (require CL2 or above for lab work)
Assign to UN 2814 or UN 2900
• Others not controlledexcept for certain vectors ….
![Page 21: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/21.jpg)
Non-infectious GMMs
• If requires CL 1 for handling but is capable of altering animals, plants or microbiological substances (when in contact with them) in a way not normally the result of natural reproductionthen classified in
Class 9 - Miscellaneous dangerous goods
Assign to UN 3245 with proper shipping name
GENETICALLY MODIFIED MICRO-ORGANSIMS
![Page 22: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/22.jpg)
Other materials subject to controls
• Genetically modified organisms • Infected live animals• Biological products• Wastes from bio-research
![Page 23: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/23.jpg)
Refrigerated/cooled materials
• Typically use either wet or dry ice• Both may affect packaging• Dry ice on Dangerous Goods List
UN 1845 CARBON DIOXIDE, SOLID– Minimal requirements for road transport– Various requirements for air transport
• Avoid using liquid nitrogen – contact UBSA for advice
![Page 24: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/24.jpg)
Biological materials NOT classified as "Dangerous Goods" for transport
• Micro-organisms that are not human or animal pathogens
• GMMs that can be handled at CL 1 and are not vectors (and plasmids, naked DNA etc)
• Samples from non- human and non-animal sources, that are either unlikely to contain pathogens or may do so at natural level
• Blood, tissues or organs collected for blood transfusion, preparation of blood products or for transplant (all in humans)
![Page 25: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/25.jpg)
Packaging
• All use triple layer system• For some must use UN type-approved
packaging• No limits on quantities per package for
road transport• Quantity limits on packages (and some
primarys) for air transport• Procedure and type specified in applicable
Packing Instruction
![Page 26: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/26.jpg)
Triple layer system
• Leakproof primary receptacle– wrapped in sufficient absorbent material to
absorb the entire contents• Leakproof secondary receptacle• Outer packaging (rigid)
Enclose paperwork between secondary and outerEither the primary or secondary must be able to withstand 95kPa pressure differential
![Page 27: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/27.jpg)
UN type-approved packaging
• Tested against specified criteria by an approved testing laboratory
• Allocated a unique mark by competent authority, this must be shown on package
• Mark includes code showing the type(s) of dangerous goods the particular packaging approved for
• For infectious substances includes code Class 6.2 in mark
• Valid only if use correctly and as tested
![Page 28: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/28.jpg)
![Page 29: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/29.jpg)
Quantity limits for air transport
• UN 2814 & UN 2900 (Category A)– Passenger aircraft 50ml/50g– Cargo aircraft 4L/4Kg
• UN 3373 (Category B)– All aircraft 4L/4Kg (1L per primary)
Excluding body parts, organs or whole bodies
![Page 30: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/30.jpg)
Quantity limits for air transport
• UN 3245 (non-infectious GMMs)– All aircraft 100ml/100g per primary
• UN 1845 (Dry ice)– 200Kg – or 2Kg in baggage if with non-dangerous
goods
![Page 31: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/31.jpg)
Packaging (PI #s for road/air)
• UN 2814 or UN 2900 (Category A) – Packing Instruction 620/602
UN type-approved
• UN 3373 (Category B)– Packing Instruction 650/650
![Page 32: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/32.jpg)
Packaging (PI #s for road/air)
• UN 3245 (non-infectious GMMs)– Packing Instruction 904/913
• UN 1845 (dry ice)– Packing Instruction ---/904
• Non dangerous goods - package safely
![Page 33: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/33.jpg)
Refrigerated/cooled
• Ensure packaging maintains integrity when ice melts or dissipates
• Must permit release of gas - ALWAYS place dry ice outside secondary
• Use cold packs or similar for wet ice• If Category A must ensure use UN
type-approved packaging properly• Various options
Eg combination packs, overpacks, thermal control units etc
![Page 34: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/34.jpg)
Labels
• Delivery address• Senders details• Emergency contact details
– name and telephone number
• And as appropriate– UN number and proper shipping name– Hazard warning label
![Page 35: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/35.jpg)
Category A
• Mark with UN number and proper shipping name
Either UN 2814 INFECTIOUS SUBSTANCE, AFFECTING HUMANS
OrUN 2900 INFECTIOUS SUBSTANCE, AFFECTING ANIMALS ONLY
![Page 36: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/36.jpg)
Category A
• And following hazard warning label
![Page 37: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/37.jpg)
Category B
• Mark with proper shipping name
Either DIAGNOSTIC SPECIMENS
OrCLINICAL SPECIMENS
![Page 38: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/38.jpg)
Category B
• And following mark
Note no biohazard sign or Class number
![Page 39: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/39.jpg)
Genetically modified micro-organisms (non-infectious)
• Mark with UN number and proper shipping name
UN 3245 GENETICALLY MODIFIED MICRO-ORGANSIMS
![Page 40: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/40.jpg)
Non-infectious GMMs
• And following hazard warning label
![Page 41: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/41.jpg)
Dry ice – transport by road
• Mark with wordsDRY ICE
UN number and hazard warning label is not required
![Page 42: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/42.jpg)
Dry ice – transport by air
• Mark with UN number, proper shipping name and net weight (Kg) of dry ice
UN 1845 DRY ICE ##Kg
![Page 43: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/43.jpg)
Dry ice – transport by air
• And following hazard warning label
![Page 44: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/44.jpg)
Packages containing liquids
• Must display the following Package Orientation label on two opposite sides
![Page 45: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/45.jpg)
Packages for cargo aircraft only
• Must display the following Cargo Aircraft Only label
For example if package over quantity limit for passenger aircraft
![Page 46: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/46.jpg)
Paperwork/documentation- within package
• Between secondary and outer• Must include
– Senders details– Delivery details– Emergency contact details– Description of the goods
• UN number and proper shipping name– And for UN 2814 or UN 2900
• add technical name after proper shipping name• itemised list of contents
![Page 47: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/47.jpg)
Paperwork/documentation- accompanying package
• For road transport– dangerous goods declaration form
(not required for UN 3373)
• For air transport– Air Waybill– Shipper’s Declaration for Dangerous Goods
(not required for UN 3373)
![Page 48: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/48.jpg)
Paperwork/documentation
• Detailed instructions on how to complete the Air Waybill and Shippers Declaration forms are included in Appendix 5 of guidance
![Page 49: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/49.jpg)
Sending dangerous goods by courier
• Must meet classification, packaging and labelling requirements
• Give full description of goods to courier in advance
• Some couriers will not carry dangerous goods or impose additional requirements
• It is illegal to conceal dangerous goods in any packaging not showing appropriate labels
![Page 50: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/50.jpg)
Sending dangerous goods by post
• Must meet both legislative and Post Office requirements
• Various prohibitions and restrictions– HG 4 and certain specified HG 3 pathogens
prohibited– dry ice prohibited– maximum amount of infectious substances
restricted to 50g or 50ml– only certain persons can send by post– cannot send dangerous goods in international
service
![Page 51: Transport of Biological Materials - UCL · Transport of Biological Materials Covering the classification, packaging and labelling of biological materials for transport in the UK and](https://reader034.vdocuments.net/reader034/viewer/2022052608/5af02b6f7f8b9aa9168d8034/html5/thumbnails/51.jpg)
Safebox?
• Purpose designed packaging produced by Royal Mail– for sending Category B materials
not suitable for Category A – can post in pillar box– complete ready to use kit– £2.20 each including pre-paid postage
• Further details on Royal Mail’s websitewww.royalmail.com and search for Safebox– see interactive demo