treatment of superficial fungal infections · 2016. 7. 19. · rct for tinea capitis (880 children)...
TRANSCRIPT
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Treatment of Superficial Fungal
InfectionsAmy Theos, MD
Associate Professor of Dermatology
University of Alabama
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Disclosures
I have no relevant conflicts of interest
Off-label treatments will be discussed
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Key Points
Tinea capitis requires treatment with an oral antifungal
Kerion is a treatment emergency
Id reactions often mistaken for drug allergy
Tinea versicolor is uncommon in childhood
Topical steroid combinations have no role for the treatment of tinea corporis
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Overview
Tinea capitis
Tinea corporis
“Tinea” versicolor
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Tinea Capitis
Many different clinical presentations Discrete patches of alopecia
with scale
Most common in school age children
Prevalence: 11% Birmingham
Most common in African Americans / Hispanics
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Tinea Capitis - Etiology
Most common organism in U.S.
Trichophyton tonsurans (90%): spread from person or fomites, endothrix, negative fluorescence
Microsporum canis (10%): spread from animals; ectothrix; positive fluorescence
Most common organism worldwide
M. canis
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Tinea Capitis
Varied clinical presentations “Black dot” Seborrheic dermatitis-like Pustules Kerion Asymptomatic carrier state
High index of suspicion in any child with scalp symptoms
Perform fungal culture when in doubt
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Tinea Capitis
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Tinea Capitis
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Tinea Capitis
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Tinea Capitis
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Tinea Capitis
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Tinea Capitis
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Diagnosis of Tinea Capitis
Clinical diagnosis
KOH of broken hairs
Fungal culture
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Tinea Capitis
Non-threatening techniques for specimen collection
Q-tip method
Saline moistened gauze pad
Sterile toothbrush
Obtain broken hairs
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Treatment of Tinea Capitis
Oral agents required
Topical antifungals as adjunct
Treat infected family members
Disinfect or discard fomites
Treat pets if M. canis
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Treatment of Tinea Capitis
Therapy must penetrate the hair follicle to be effective
Griseofulvin has been the “gold standard”
Alternatives:
Terbinafine
Fluconazole
Itraconazole
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Griseofulvin
Dose and duration has increased over the past 40 years 1974: 10 mg/kg/day for 4 weeks
1994: 10 – 20 mg/kg/day for 4 weeks
1997: 10 – 20 mg/kg/day for 4 – 6 weeks
Current: 20 - 25 mg/kg/day for 6 – 8 weeks (up to 16 weeks may be necessary)
FDA approved > 2 years of age
Ultramicrosize formulation 10 – 15 mg/kg/day
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Griseofulvin in Tinea Capitis
Advantages
Relatively safe
Available in liquid formulation
Disadvantages
Drug resistance
Poor compliance
Fungistatic
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Patients Who Require An Alternative to Griseofulvin
Intolerant of griseofulvin
GI upset, taste, headaches
Adverse reaction
Rash, hives
Phototoxic
Pregnancy category X
Non-responsive to griseofulvin
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Terbinafine for Tinea Capitis
Terbinafine
FDA approved 2007 for treatment of tinea capitis ≥ 4 years
125 mg or 187.5 mg granule packets or 250 mg tablets
< 25 kg: 125 mg/day
25 – 35 kg: 187.5 mg/day
> 35 kg: 250 mg/day
6 weeks
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Terbinafine for Tinea Capitis
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Terbinafine for Tinea Capitis
Terbinafine was superior to griseofulvin for the treatment of tinea capitis due to T. tonsurans, but not M. canis
No significant AE or abnormal liver transaminasesoccurred during study period
Safe and effective alternative to griseofulvin
Can be more cost effective than griseofulvin if use generic
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Non-FDA Approved Alternatives
Fluconazole
RCT for tinea capitis (880 children)
As effective as griseofulvin for M. canis and T. tonsurans
No significant differences between 3 week and 6 week treatment courses
6 mg/kg/day for 3 - 6 weeks
Available as liquid formulation
Approved in neonates/infants for fungal infections
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Non-FDA Approved Alternatives
Itraconzole Usage based on small pilot studies / anecdotes
Effective for M. canis and T. tonsurans
5 mg/kg for 4 – 6 weeks
Higher risk of hepatotoxicity
More drug interactions
Ketoconazole – do NOT use FDA removed dermatophyte infection as an approved
indication
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Adjunctive Treatments
Antifungal shampoo decrease risk of transmission
Treat symptomatic family members
Antifungal shampoo for family members
Disinfect or discard fomites
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Special Circumstances
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Kerion
Host inflammatory response
Painful, boggy, nodules with yellow crusting / pustules, lymphadenopathy
Treatment emergency
High risk of scarring
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Kerion
Griseofulvin is treatment of choice
Usually no need for topical or oral antibiotics
Prednisone can decrease pain, but doesn’t speed resolution or lessen risk of scarring
1 mg/kg/d x 5 days, then 0.5 mg/kg/d x 5 days
Adjunctive ketoconazole shampoo
Fungal cultures often negative
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Dermatophyt”id” Reaction
Hypersensitivity reaction
Often appears soon after antifungal started
Monomorphic papules/vesicles start at hairline, spread down face, ears, and chest
Pruritic
Treatment: continue griseofulvin, topical or oral steroid to rash, oral antihistamines
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Id Reaction
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Infant With Tinea Capitis
No FDA approved treatments for tinea capitis < 2 years old
Fungal culture mandatory
Identify source of infection
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Infant With Tinea Capitis
Treatment
Topical therapy may be adequate (ketoconazole 2% shampoo, topical azole gel or foam for better penetration)
Griseofulvin 15 mg/kg/d for 6 weeks
Fluconazole 6mg/kg/d for 3-6 weeks (FDA approval for use in neonates with non-dermatophyte fungal infections)
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Tinea Versicolor
Misnomer – NOT a dermatophyte
Malasezzia spp. a lipid-dependent yeast
More common in tropical climates
Most common in adolescents and young adults
Not contagious
Component of normal skin flora
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Tinea Versicolor
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Tinea Versicolor
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Tinea Versicolor
Topical treatment Ketoconazole 2% cream QD x 2 weeks
Ketoconazole 2% shampoo QD x 3 days
Selenium sulfide 2.5% lotion or shampoo x 10 minutes x 7 days
Terbinafine cream
Oral treatment (severe or resistant to topical) Itraconazole 400 mg x 1 dose
Fluconazole 300 mg once a week x 2 – 4 weeks
Griseofulvin and oral terbinafine not effective
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Tinea Versicolor
Recurrent disease
Ketoconazole 2% shampoo or selenium sulfide 2.5% monthly
Counsel patients that pigmentary changes can persist for many months
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Tinea Versicolor
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Tinea Corporis
Dermatophyte infection of body
Annular red patch with peripheral scaly border
T. rubrum most common
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Tinea Corporis
Topical antifungals usually sufficient
Over the counter or Rx
Azoles (i.e. miconazole), terbinafine, naftifine, ciclopirox
Nystatin NOT effective
Oral antifungals if fail topical, widespread, immune-compromised for 1-4 weeks
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Tinea Corporis
Topical steroids can worsen and prolong tineainfections
Combination topical antifungal and corticosteroid creams should be avoided
Topical steroids can cause skin atrophy
Mask erythema and scale making diagnosis difficult (tinea incognito)
Can result in folliculitis (Majocchi granuloma)
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Tinea Incognito
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Tinea Incognito
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Conclusions
Tinea capitis requires oral antifungal treatment
Griseofulvin and terbinafine appropriate first-line treatment
Fluconazole and itraconazole second-line treatment
Kerion is a treatment emergency and griseofulvin is the treatment of choice
Id reactions can mimic drug rash
Tinea versicolor is uncommon before adolescence
Avoid topical steroid preparations for tinea corporis