How to use:1. Apply a pea-sized amount for the entire face 20 minutes after washing and patting dry, before bedtimea. Pea-sized: More is not betterb. Apply 20 minutes after: Topical retinoic acid should be applied to dry skin onlyc. Take the pea-sized amount from the tube and put on the tip of your fingerd. Gently dab it on different areas of your face avoiding contact with the corners of the nose, eyes, and mouth.e. Slowly rub it into the skin2. You may use a moisturizer 20 minutes after applying topical tretinoin or you may not use at all3. If your skin is getting too (erythematous) red or irritated (e.g. peeling), stop for a few days and continue.4. Start 2 times a week gradually working your way to every night

Daytime:1. Your skin is going to be more sensitive to the sun (causing more photoaging) so avoid or minimize sun exposure2. Use protective sunscreen generously and re-apply throughout the day (every 3-4 hours)

Contradindications:1. Doing any waxing or peels2. Pregnancy

Mechanism of action:1. Retinoic acid works at the level of gene transcription so it will take weeks before results are visible.2. Decreases cohesion between epidermal cells to increase epidermal cell turnover expulsion of open comedones and transforming closed to open comedones3. Promotes dermal collagen synthesis, new blood vessel formation, and thickens epidermis reduces fine lines and wrinkles