triple vessels & lm disease when to pci, when to...
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Triple vessels & LM disease When to PCI, When to CABG
Ts.Bs.Nguyễn Thượng Nghĩa
PGĐ TT Tim mạch – TK TMCT
BV Chợ Rẫy
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PROGRESS OF ATHEROSLEROSIS PLAQUE
Stary HC et al. Circulation 1995;92:1355-1374.
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Revascularisation vs medical treatment in patients with stable coronary artery disease: network meta-analysis 100 RCTs, N= 93553 pts, 1980-2013
BMJ 2014;348:g3859
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Revascularisation vs medical treatment in patients with stable coronary artery disease: network meta-analysis 100 RCTs, N= 93553 pts, 1980-2013
BMJ 2014;348:g3859
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FAME2: PCI Guided by Fractional Flow Reserve vs OMT
Xaplanteris P. et al. N Engl J Med 2018; 379:250-259
MACE: Death, MI , Urgent Revascularization Urgent Revascularization
N= 1222 (888) , T: 5 years
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Meta-analysis: PCI Guided by Fractional Flow Reserve vs OMT
Zimmermann FM. et al.European Heart Journal (2019) 40, 180–186
MACE: Death, MI
Meta-Analysis of 3 RCTs
DANAMI 3-PRIMULTI
Compare-Acute
FAME 2
N= 2400 , T: 35 months
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Objectives of treatment of triple vessel /LM coronary artery disease
1. Cải thiện triệu chứng & Chất lượng cuộc sống Tiêu chí “mềm”
2. Cải thiện tiên lượng Tiêu chí “cứng”: Tử vong, NMCT, Đau ngực tái phát, nhập viện
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Indication of myocardial revascularization (CABG/PCI)
• Nhom phân tâng nguy cơ cao khi lam nghiêm phap găng sưc, test chân đoan hinh anh.
• Tôn thương ĐMV năng, nguy cơ cao ( Thân chung, 3 nhanh, LAD, LCx, RCA đoan gân, SYNTAX cao)
• Điêu tri nôi khoa tôi ưu không cai thiên triêu chưng
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CÂN BẰNG GIỮA NGUY CƠ & LỢI ÍCH TÁI THÔNG ĐỘNG MẠCH VÀNH BẰNG CABG VS PCI
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Khuyến cáo Rx tái thông ĐMV trên Bệnh ĐMV 3 nhánh/Thân chung
Patel MR et al. J Am Coll Cardiol. 2017; 69:2012-41
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SYNTAX SCORES
Serruys P. et al, N Engl J Med 2009;360:961-71
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SYNTAX SCORE Calculator Mild: 0-22, Moderate:23-32; Severe:≥33
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Revascularization with CABG or PCI ? SYNTAX trial , N = 1800 pts
All cause Death Rate : CABG 11,9% vs PCI 13,9% (p=0,10) Cardiac Death Rate: CABG 9,0% vs PCI 9,0%
Chang-Wook Nam et al, JACC, Volume 58, Issue 12, September 2011
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Meta-analysis: CABG vs PCI 11 RCTs, 11 518 pts SIHD with LMCA/ Multivessel diseases
Head SJ. Et al. Lancet 2018;391:939–948
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In Diabetes Patients
1-year Mortality
5-year Mortality
Fan Zhang et al., Diabetes research and clinical practice 97(2):178-84 · April 2012
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In Diabetes Patients 1-year Mortaility repeat revascularization
Fan Zhang et al., Diabetes research and clinical practice 97(2):178-84 · April 2012
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Meta-analysis : CABG vs PCI in Diabetes Patients 11 RCTs, 11 518 pts SIHD with LMCA/ Multivessel
diseases
Head SJ. Et al. Lancet 2018;391:939–948
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CABG PCI
Class LOE Class LOE
Recommendations according to extent of CAD & T2DM
European Heart Journal (2019) 40, 87–165
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Tái thông Thân chung ĐM vành trái CABG hoặc PCI ?
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PCI vs. CABG for Left Main Disease Meta-analysis of 4 RCTs - N=1,611 Pts Demographics
Capodanno et al, JACC 2011;58:1426-32
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PCI vs. CABG for Left Main Disease Meta-analysis of 4 RCTs - N=1,611 Pts Mortality to 1 year
Capodanno et al, JACC 2011;58:1426-32
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PCI vs. CABG for Left Main Disease Meta-analysis of 4 RCTs - N=1,611 Pts 1-year MI
Capodanno et al, JACC 2011;58:1426-32
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PCI vs. CABG for Left Main Disease Meta-analysis of 4 RCTs - N=1,611 Pts 1-year Stroke
Capodanno et al, JACC 2011;58:1426-32 Palmerini T et al. JACC 2012;60:798-805
6
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PCI vs. CABG for Left Main Disease Meta-analysis of 4 RCTs - N=1,611 Pts MACCE 1 year
Capodanno et al, JACC 2011;58:1426-32
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PCI vs. CABG for Left Main Disease Meta-analysis of 4 RCTs - N=1,611 Pts Revascularization 1 year
Capodanno et al, JACC 2011;58:1426-32
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PCI vs. CABG for Left Main Disease SYNTAX Trial MACCE to 5 years
Mohr FW et al. Lancet 2013;381:629–38
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PCI vs. CABG for Left Main Disease SYNTAX Trial, SYNTAX Scores ≤ 32 MACCE to 5 years
Serruys PW et al. Lancet 2013;381:629–38 Mohr FW et al. Lancet 2013;381:629–38
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PCI vs. CABG for Left Main Disease SYNTAX Trial, SYNTAX Scores ≥ 33 MACCE to 5 years
Serruys PW et al. Lancet 2013;381:629–38 Mohr FW et al. Lancet 2013;381:629–38
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French Left Main Taxus (FLM Taxus) and the LEft MAin Xience (LEMAX) Registries
N=344 pts
Moynagh A et al. EuroIntervention 2013;9:452-62
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LM PCI vs CABG
Death
Trial
OR (95%CI) DES
Events, %
Favors DES
1 5
Favors CABG
Boudriot et al.
PRECOMBAT
0.39 (0.07, 2.07) 0.72 (0.38, 1.38)
2/ 100 17/ 300
5/101
23/300
2.60
14.59
0.90 (0.58, 1.39)
1.10
(0.67, 1.78)
1.38
(0.96, 1.99)
45/ 357
36/
592
71/
948
48/348 33/592 53/957
26.67 22.85 33.29
Overall (I-squared = 58.1%, p=0.61)
SYNTAX NOBLE EXCEL
1.03 (0.78, 1.35)
171/ 2297
162/ 2298
MI
CABG Weight Trial
OR (95%CI) DES
Events,
CABG
%
Weight
Favors DES
1 5
Favors CABG
Boudriot et al.
PRECOMBAT
1.01 (0.20, 5.13) 1.20 (0.36, 3.99)
3/ 100 6/ 300
3/101
5/300
7.97
12.50
28/ 357
29/
592 72/ 948
16/348 24.43 10/592 21.82 77/957 33.28
Overall (I-squared 100.00 = 23.7%, p=0.08)
SYNTAX NOBLE EXCEL
1.46 (0.88, 2.45)
138/ 2297
111/ 2298
100.00
1.77 (0.94, 3.33)
3.00
(1.45, 1.39) 0.94 (0.67, 1.31)
Nerlekar et al, Circ Cardiovasc Interv. 2016;9:e004729
Revascularization of LMCA CABG or PCI ? Contemporary Meta-Analysis (5 RCTs, N= 3887 pts)
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LM PCI vs CABG Contemporary Meta-Analysis
Nerlekar et al, Circ Cardiovasc Interv. 2016;9:e004729
Stroke
Trial
OR (95%CI) DES
Events, %
Favors DES
1 5
Favors CABG
PRECOMBAT 1.00 (0.14, 7.15)
2/ 300
2/300 12.06
p=0.53)
SYNTAX NOBLE EXCEL
Overall (I-squared
= 62.5%,
0.34 (0.12, 0.95)
2.32
(0.95, 5.68)
0.77
(0.43, 1.39) 0.88 (0.39, 1.97)
5/ 357
16/
592
20/
948 43/ 2197
14/348 7/592 26/957
49/
2197
25.14 27.99 34.81 100.00
Boudriot et al.
CABG Weight Trial
OR (95%CI) DES
Events,
2.58 (0.95, 7.01)
14/ 100
6/101
CABG
%
Weight
3.62
1
38/ 300
90/
357
71/
592 114/ 948
21/300 11.59
49/348 24.43 47/592 24.11 67/957 36.24
Overall (I-squared = 0.0%, p=<0.001)
Favors DES
PRECOMBAT
SYNTAX NOBLE EXCEL
1.85 (1.53, 2.23)
5
Favors CABG
327/ 2297
190/ 2298
100.00
1.93 (1.10, 3.37)
2.06
(1.40, 3.02)
1.58
(1.07, 2.33) 1.82 (1.32, 2.49)
Repeat revascularization
Revascularization of LMCA CABG or PCI ? Contemporary Meta-Analysis (5 RCTs, N=3887 pts)
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Revascularization of LMCA CABG or PCI ? Contemporary Meta-Analysis (11 RCTs, N= 4478 pts )
Head SJ, et al. Lancet 2018;391:939-48
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CABG PCI
Class LOE Class LOE
Recommendations according to extent of CAD & T2DM
European Heart Journal (2019) 40, 87–165
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N= 280 IABP KHÔNG IABP CHUNG
EUROSCORE II 8,55 ± 4,02% 2,02 ± 1,2% 7,67 ± 3,9%
QUAN SÁT 42,6%
(20/47) 5,6%
(13/233) 11,8%
(33/280)
NGHIÊN CỨU ĐÁNH GIÁ HIỆU QUẢ IABP/ CABG
Khoa Hồi sức- phẫu thuật tim, bệnh viện Chợ rẫy từ 1/2015 đến 12/2016
Tỉ lệ tử vong dự tính theo Euroscore II và Thực tế quan sát
(Luận văn Cao học Ng Cong Cưu – Pham Tho Tuan Anh – ĐH Y Duoc TPHCM 2017)
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Kết luận • Đa sô BN SIHD nên được điêu tri nội khoa tối ưu (GDMT) trươc khi điêu tri tai
tươi mau vơi CABG/PCI
• Mục tiêu tái tươi máu bệnh thân chung & bệnh mạch vành nhiêu nhánh Cải thiện triệu chứng và Cải thiện tiên lượng là chủ yếu
• Chọn lựa CABG & PCI trên tái thông ĐMV sẽ “cá thể hóa” dựa trên:
1. Giải phẫu, chức năng ĐMV cũng như tiên lượng bằng SYNTAX Scores, 2. Nguy cơ phẫu thuật bằng STS Scores (Ia), EUROSCORE II (IIb) 3. Tái thông hoàn toàn hoặc không hoàn toàn 4. Bệnh kèm theo đặc biệt bệnh đai tháo đường 5. Lựa chọn của bệnh nhân
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How to choose PCI or CABG on Patients with LMCA/Multivessel coronary heart disease
European Heart Journal (2019) 40, 87–165