twelfth buffalo pharmaceutics symposium buffalo pharmaceutics symposium july 29-31, 2010 theme:...
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Twelfth Buffalo Pharmaceutics Symposium
July 29-31, 2010
Theme: Eminence in Pharmaceutical Sciences: Buffalo and Beyond
Department of Pharmaceutical Sciences University at Buffalo, SUNY
TWELFTH BUFFALO PHARMACEUTICS SYMPOSIUM
JULY 29-31, 2010
Theme: Eminence in Pharmaceutical Sciences: Buffalo and Beyond
Thursday July 29: Tribute to Dr. Ho-Leung Fung 6:00 PM Opening Reception: Buffalo Niagara Marriott, Amherst, NY
Friday July 30: Center for the Arts: Screening Room
8:30 – 8:35 AM: Opening remarks
Donald E. Mager, University at Buffalo, SUNY
8:35 – 8:40 AM Dean’s Welcome Wayne K. Anderson, University at Buffalo, SUNY
8:40 – 9:00 AM Department Highlights
William J. Jusko, University at Buffalo, SUNY
Session I: Protein Therapeutics Chair: Joseph P. Balthasar, University at Buffalo Co‐Chair: Mohammad Tabrizi, AnaptysBio 9:00 – 9:05 AM Introduction 9:05 – 9:30 AM Quantitative Prediction of Human Pharmacokinetics for Monoclonal
Antibodies: Retrospective Analysis of Monkey as a Single Species for First‐in‐Human Prediction
Chris Endres, Amgen 9:30 – 10:00 AM Application of a Mechanistic Preclinical PK/PD Model to Select First in
Human Starting Doses of an IgG2 Antibody Alison Betts, Pfizer 10:00 – 10:30 AM Pharmacokinetic Analysis of Monoclonal Antibodies Engineered for
High‐Affinity Binding to FcRn
Rong Deng, Genentech 10:30 – 11:00 AM Coffee Break 11:00 – 11:30 AM Use of LC/MS/MS to Quantify Monoclonal Antibodies in Complex Tissue
Matrices: Application to Investigate the Blood‐Brain‐Barrier for mAb Jun Qu, University at Buffalo, SUNY 11:30 – 12:00 PM Applications of Mathematical Modeling to Guide the Discovery and
Development of New Immunotherapies Joseph P. Balthasar, University at Buffalo
12:00 – 1:00PM Box Lunch at Center for the Arts
Session II: Drug Transporters Chair: Marilyn E. Morris, University at Buffalo, SUNY Co‐Chair: Kelly Mahar Doan, GlaxoSmithKline 1:00 – 1:40 PM Clinical Significance of Pharmacogenomics and Drug‐Drug Interaction in
Transporter‐Mediated Pharmacokinetics/Pharmacodynamics Yuichi Sugiyama, University of Tokyo 1:40 – 2:10 PM Drug Transporters and Enzymes in the Rodent and Human Blood‐Brain
Barrier Jean-Michel Scherrmann, University Paris Descartes
2:10 – 2:40 PM Hepatoselective Drug Targeting Steven Hansel, Pfizer Global Research 2:40 – 3:10 PM Coffee Break
3:10 – 3:40 AM Exploiting Intestinal Transporters: The Route into the Body Gordon L. Amidon, University of Michigan 3:40 – 4:00 PM Role of the vitamin D receptor on the regulation of transporters and
enzymes K. Sandy Pang, University of Toronto 4:00 – 5:30 PM Poster Session: CFA Black Box Theater
6:00 PM Dinner and Exclusive Visit to The Buffalo Zoo
Saturday July 31: Center for the Arts: Screening Room
Session III: Pharmacokinetics and Pharmacodynamics Chair: William J. Jusko, University at Buffalo, SUNY Co‐Chair: Daniel E. Salazar, Daiichi Sankyo 8:45 – 9:00 AM Introduction and Historical Perspectives William J. Jusko, University at Buffalo, SUNY 9:00 – 9:30 AM Integration of PK/PD in R&D Continuum
Lisa Benincosa, Hoffmann‐La Roche
9:30 – 10:00 AM Pharmacometrics at FDA: From 2010 to 2020 Vision Lawrence J. Lesko, Food and Drug Administration
10:00 – 10:30 AM Whither Systems Pharmacology Modeling? Donald E. Mager, University at Buffalo, SUNY 10:30 – 11:00 AM Coffee Break 11:00 – 11:20 AM PK/PD Intrigues of the Erythropoietic System Wojciech Krzyzanski, University at Buffalo, SUNY 11:20 – 11:40 AM QT Evaluation of Oncology Drug Products YoungJin Moon, Food and Drug Administration 11:40 – 12:00 PM PK/PD Modeling in Cancer Therapeutics Gerald Fetterly, Roswell Park Cancer Institute 12:00 – 2:00PM Group Photo and BPS Picnic Luncheon: Lake La Salle
Session IV: Pharmacogenomics and Personalized Medicine
Chair: Javier Blanco, University at Buffalo, SUNY Co‐Chair: Daniel Brazeau, University at Buffalo, SUNY 2:00 – 2:30 PM Detecting and Interpreting Polymorphisms Affecting Transcription and
Splicing of ADME Genes and their Clinical Consequence Erin G. Schuetz, St. Jude Children’s Research Hospital 2:30 – 3:00 PM Genome‐Wide Pharmacogenomics Studies
Mark J. Ratain, University of Chicago Medical Center 3:00 – 3:30 PM Polymorphisms affecting gene regulation and mRNA processing:
Implications for Pharmacogenetics Wolfgang Sadee, The Ohio State University
3:30 – 4:00 PM Coffee Break 4:00 – 4:20 PM Anthracycline‐related Cardiomyopathy in Childhood Cancer Survivors
and Associations with Polymorphisms in the Carbonyl Reductase Genes: A Children's Oncology Group Study
Javier G. Blanco, University at Buffalo, SUNY 4:20 – 4:40 PM Kava Hepatotoxicity: Does Pharmacogenomics Play a Role? Iqbal Ramzan, The University of Sydney 4:40 – 5:00 PM Genetic Determinants of Thienopyridine Response Joseph R. Walker, Daiichi Sankyo Pharma Development 5:00 PM Closing remarks and departure
Poster Session: July 30, 2010, 4:00 – 5:30 PM, CFA Black Box Theater
1. Urvi Telang, Deepika Lal, Patricia Zagst, Eunice S. Wang, and Gerald J. Fetterly. Roswell
Park Cancer Institute. Investigation of the mechanism of aflibercept mediated modulation of doxorubicin anti‐tumor effects in a preclinical model of leukemia: Development of a pharmacokinetic‐pharmacodynamic model to guide combination dosing strategies.
2. An Guohua and Marilyn E. Morris. Department of Pharmaceutical Sciences, University at
Buffalo, SUNY. A PBPK model of mitoxantrone in mice: A mechanistic model incorporating DNA binding.
3. Alice Cristina Rodrigues1,2, Xin Li2, and Aiming Yu2. 1Department of Clinical and
Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo; and 2Department of Pharmaceutical Sciences, University at Buffalo, SUNY. Differential regulation of microRNAs expression by xenobiotic agents in MCF‐7 and Caco‐2 cells.
4. Robert D. Arnold, Ibrahim Aljuffali, Ha Nguyen, Jason N. Mock, and Brian S. Cummings.
Department of Pharmaceutical and Biomedical Sciences, University of Georgia. Effects of metronomic dosing of topotecan on prostate anticancer activity.
5. Yanguang Cao, Wei Gao, and William J. Jusko. Department of Pharmaceutical Sciences,
University at Buffalo, SUNY. Pharmacokinetic/Pharmacodynamic modeling of GLP‐1 in healthy rats.
6. Xi‐Ling Jiang, Hong‐Wu Shen, Ai‐Ming Yu. Department of Pharmaceutical Sciences,
University at Buffalo, SUNY. Modification of the thermoregulatory effect of 5‐methoxy‐N,N‐dimethyltryptamine by harmaline.
7. Xiaotao Duan,1,2 Lubna Abuqayyas,1 Joseph P. Balthasar,1 and Jun Qu 1,2 . 1 Department of
Pharmaceutical Sciences, University at Buffalo, SUNY; and 2 New York State Center of Excellence in Bioinformatics and Life Sciences. The nano‐LC/MS based strategy: A highly sensitive and accurate tool for the quantitative characterization of therapeutic monoclonal antibodies in biological fluids and tissues.
8. Sihem Ait‐Oudhia, Jun Yang, Robert M. Straubinger, and Donald E. Mager. Department of
Pharmaceutical Sciences, University at Buffalo, SUNY. Meta‐analysis of three paclitaxel delivery systems using a pharmacokinetic model and its associations with tolerability.
9. Chao Xu, Vaishali Chudasama, and Donald E. Mager. Department of Pharmaceutical
Sciences, University at Buffalo, SUNY. Molecular determinants of corticosteroid exposure in rats.
10. Yang Chen and Joseph Balthasar. Department of Pharmaceutical Sciences, University at
Buffalo, SUNY. A physiologically‐based pharmacokinetic (PBPK) model for disposition of IgG with altered FcRn binding kinetics.
11. Leonid Kagan, Michael R. Turner, Sathy V. Balu‐Iyer, and Donald E. Mager. Department of
Pharmaceutical Sciences, University at Buffalo, SUNY. Bioavailability of monoclonal antibodies following subcutaneous administration.
12. Xiaoyu Yan and Wojciech Krzyzanski. Department of Pharmaceutical Sciences, University at
Buffalo, SUNY. Using a population modeling approach to determine the minimum effective concentration of recombinant human erythropoietin in human.
13. Samuel A. Roiko, Melanie A Felmlee, Bridget L. Morse, and Marilyn E. Morris. Department
of Pharmaceutical Sciences, University at Buffalo, SUNY. Gamma‐hydroxybutyric acid toxicodynamics correlate with extracellular concentrations in brain.
14. Jin Cao1, Frank Engler1, Xiaotao Duan1,2, Jun Li1,2, Hao Wang1,2, and Jun Qu1,2. 1Department
of Pharmaceutical Sciences, University at Buffalo, SUNY; and 2New York State Center of Excellence in Bioinformatics and Life Sciences. A rapid, reproducible, on‐the‐fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application in clinical analysis.
15. Yash Gandhi1, Suraj Bhansali1, Munawwar Sajjad2, Joseph Spernyak3, and Marilyn E.
Morris1. Departments of 1Pharmaceutical Sciences and 2Nuclear Medicine, University at Buffalo, SUNY; and 3Roswell Park Cancer Institute. Lymphatic uptake of proteins: Use of micro‐PET.
16. Dipak S. Pisal and Sathy V. Balu‐Iyer. Department of Pharmaceutical Sciences, University at
Buffalo, SUNY. Role of macromolecular interaction on the catabolism of FVIII and FVIII‐lipidic complex.
17. Brent W. Footer1,2, Sebastian Rehberg4, Perenlei Enkhbaatar4, Helena M. Linge3,
Lillian D. Traber4, David M. Parish2, Edmund J. Miller3, Daniel L. Traber4, and Jerome J. Schentag1,2. 1Department of Pharmaceutical Sciences, University at Buffalo, SUNY; 2CPL Associates, LLC, Buffalo, NY; 3The Feinstein Institute for Medical Research, Manhasset, NY; and 4University of Texas Medical Branch. Progression modeling of serious infections caused by methicillin‐resistant Staphylococcus aureus (MRSA).
18. Dipti Pawaskar1, Robert M Straubinger1, Gerald J Fetterly2, Wen W Ma2, and William J
Jusko1. 1Deptartment of Pharmaceutical Sciences, University at Buffalo, SUNY; and 2Roswell Park Cancer Institute, Buffalo, NY. Pharmacodynamic interaction of everolimus and sorafenib using in vitro whole blood lymphocyte proliferation.
19. Masato Yasuhara and Yasuyoshi Ishiwata. Department of Hospital Pharmacy, Tokyo Medical and Dental University. Pharmacodynamics of gatifloxacin‐induced dysglycemia in rats.
20. Melanie Felmlee, Dapeng Cui, Brenda Cirincione, and Marilyn E. Morris. Department of
Pharmaceutical Sciences, University at Buffalo, SUNY. A mechanistic pharmacokinetic model for the drug of abuse gamma‐hydroxybutyric acid in rats.
21. Hoi‐Kei Lon, Qi Zhang, Dongyang Liu, Debra C. DuBois, Richard R. Almon, and William J.
Jusko. Department of Pharmaceutical Sciences and Department of Biological Sciences, University at Buffalo, SUNY. Pharmacokinetic ‐ pharmacodynamic ‐ disease progression model for effect of etanercept in Lewis rats with collagen‐induced arthritis.
22. Lubna Abuqayyas and Joseph Balthasar. Department of Pharmaceutical
Sciences, University at Buffalo, SUNY. Investigation of the influence of Fc‐receptors on IgG distribution to the brain.
23. Lubna Abuqayyas and Joseph Balthasar. Department of Pharmaceutical
Sciences, University at Buffalo, SUNY. Investigation of the influence of FcγR on the elimination and distribution of monoclonal antibodies (mAb).
24. Krithika Arun Shetty1, Frank V. Bright2, Jerome J. Schentag1,3. 1Department of
Pharmaceutical Sciences and 2Department of Chemistry, University at Buffalo, SUNY; 3CPL Associates, LLC, Buffalo, NY. A microdialysis system with a 'reagent‐free' detector for the continuous quantification of therapeutic proteins in vivo.
25. Jun Li1,3, Rebeccah Young1,3, Brian J. Page2,3, Marc S. Halfon3,4, John M. Canty Jr2,3, Jun
Qu1,3. 1Department of Pharmaceutical Sciences, University at Buffalo, SUNY; 2Departments of Medicine, Physiology and Biophysics, and the Center for Research in Cardiovascular Medicine, VA WNY Healthcare System at Buffalo, University at Buffalo, SUNY; 3New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY; and 4Department of Biochemistry, University at Buffalo, SUNY. An in‐depth analysis of swine plasma proteome using combinatorial peptide ligand libraries (CPLL), dual‐enzyme digestion and dual‐activation sequencing with nano‐LC/LTQ/Orbitrap/ETD.
26. Hongwu Shen, Chao Wu, Xiling Jiang and Aiming Yu. Department of Pharmaceutical
Sciences, University at Buffalo, SUNY. Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5‐methoxy‐N,N‐dimethyltryptamine metabolism and pharmacokinetics.
27. Pei‐Suen Tsou1, Nadin N. Talia1, Sonsoles Piera2, Sergio A. Jimenez2, James R. Seibold1,3,
Kristine Phillips1, and Alisa E. Koch1,4. 1University of Michigan Medical School, Ann Arbor, MI; 2Thomas Jefferson University, Philadelphia, PA; 3University of Connecticut Health
Center, Farmington, CT; and 4VA Medical Service, Ann Arbor, MI. The effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma fibroblasts.
28. Yuzhuo Pan, Amy Zhou, and Aiming Yu. Department of Pharmaceutical Sciences, University
at Buffalo, SUNY. MicroRNA‐1291 regulates multidrug resistance‐associated protein 1 (MRP1/ABCC1).
29. Qiuying Cheng, Jianping Zhang, and Javier G. Blanco. Department of Pharmaceutical
Sciences, University at Buffalo, SUNY. Human CBR3 is regulated by the master redox switch Nrf2 through conserved antioxidant response elements in the gene promoter.
30. James L Kalabus, Carrie C Sanborn, Raqeeb G Jamil, Qiuying Cheng, and Javier G Blanco.
Department of Pharmaceutical Sciences, University at Buffalo, SUNY. Expression of the anthracycline metabolizing enzyme carbonyl reductase 1 (CBR1) in hearts from donors with Down syndrome.
31. Chia‐Ching Wu, Srinidi Mohan, Soyoung Shin, Sun Mi Fung, and Ho‐Leung Fung.
Department of Pharmaceutical Sciences, University at Buffalo, SUNY. Effects of superoxide on nitric oxide synthase activity and L‐arginine transport in human endothelial cells.
32. John H. Paasch. Winsilico. Understanding and modeling Waldenstrom's macroglobulinemia
and the response to treatment – A systems engineer's approach. 33. John M. Harrold, Leonid Kagan, Li Zhang, and Donald E. Mager. Department of
Pharmaceutical Sciences, University at Buffalo, SUNY. Mechanistic exposure‐response model of combination rituximab chemotherapy in murine lymphoma xenografts.
34. Nathaniel A. Page, Pei‐Suen Tsou, Sun Mi Fung, and Ho‐Leung Fung. Department of
Pharmaceutical Sciences, University at Buffalo, SUNY. Aldehyde dehydrogenase 1 in the metabolism and bioactivation of organic nitrates.
35. Fang Wu1, Suraj G. Bhansali1, Earl J. Bergey2, Marilyn E. Morris1. 1Departments of
Pharmaceutical Sciences and 2Institute for Lasers, Photonics and Biophotonics, University at Buffalo, SUNY. Fluorescence imaging of the lymphatic uptake of proteins: Molecular weight dependence.
36. Sukyung Woo, Tristan Sissung, William Figg. Clinical Pharmacology Program, Center for
Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Genetic Polymorphisms in VEGF and VEGFR2 on Drug Exposure, Toxicity, and Clinical Outcome in Patients Receiving VEGF Pathway‐Targeting Agents.
SYMPOSIUM ATTENDEES* Richard Almon Lubna Abuqayyas University at Buffalo, NY University at Buffalo, NY Sihem Ait Oudhia Gordon L. Amidon University at Buffalo, NY University of Michigan, Michigan Wayne Anderson Robert Arnold University at Buffalo, NY University of Georgia, Georgia Jeanine Ballard Joseph Balthasar Merck, Pennsylvania University at Buffalo, NY Marianne Bauerlein James Baxter University at Buffalo, NY Boehringer-Ingelhein, Connecticut Lisa Benincosa Alison Betts Roche, Connecticut Pfizer, Connecticut Suraj Bhansali Kavitha Bhasi University at Buffalo, NY Allergan, California Sebastien Bihorel Javier Blanco Cognigen, New York University at Buffalo, NY Kathleen Boje Brian Booth University at Buffalo, NY FDA, Washington, DC Daniel Brazeau Gayle Brazeau University at Buffalo, NY University at Buffalo, NY Jack Brown Jurgen Bulitta University at Buffalo, NY Ordway Research, New York Yanguang Cao Alice Ceacareanu University at Buffalo, NY University at Buffalo, NY Gurkishan Chadha Robert Chau University at Buffalo, NY University at Buffalo, NY Nancy Chen Ting Chen Merck, Pennsylvania University at Buffalo, NY Yang Chen Qiuying Chen University at Buffalo, NY University at Buffalo, NY
Lucie Chevillard Vaishali Chudasama University at Buffalo, NY University at Buffalo, NY Brenda Cirincione Inger Darling University at Buffalo, NY Cognigen, New York Rutwij Dave Rong Deng University at Buffalo, NY Genentech, California Kelly Doan Xiaotao Duan Merck, Pennsylvania University at Buffalo, NY Debra Dubois Frank Engler University at Buffalo, NY University at Buffalo, NY Christopher Endres James Ermer Amgen, Washington Shire Group, Pennsylvania Anas Fathallah Jing Fang University at Buffalo, NY University at Buffalo, NY Melanie Felmlee Gerald Fetterly University at Buffalo, NY Roswell Park Cancer Institute, NY Jill Fielder-Kelly Brent Footer Cognigen, New York University at Buffalo, NY Alan Forrest Jennifer Fretland University at Buffalo, NY Roche, New Jersey Ho-Leung Fung Sun-Mi Fung University at Buffalo, NY University at Buffalo, NY Puneet Gaitonde Raymond Galinsky University at Buffalo, NY Purdue University, Indiana Yash Gandhi Wei Gao University at Buffalo, NY University at Buffalo, NY Wenqing Gao Ashifa Gebre University at Buffalo, NY University at Buffalo, NY Patrick Glassman Petra Goelzer University at Buffalo, NY Roche, New Jersey
William Greco Steven Hansel University at Buffalo, NY Pfizer, Connecticut David Haughey William Hayton ICON, New York Ohio State University, Ohio Yang He Raqeeb Jamil University at Buffalo, NY University at Buffalo, NY David Jaworowicz Xiling Jiang Cognigen, New York University at Buffalo, NY William Jusko Leonid Kagan University at Buffalo, NY University at Buffalo, NY James Kalabus Jonathan Knights University at Buffalo, NY University at Buffalo, NY Matt Kosloski Wojciech Krzyzanski University at Buffalo, NY University at Buffalo, NY Connie Landersdorfer Shankar Lanke Ordway Research, New York University at Buffalo, NY Wooin Lee Lawrence Lesko University of Kentucky, Kentucky FDA, Washington DC Diane Letina Gerhard Levy University at Buffalo, NY University at Buffalo, NY Hong Li Jun Li University at Buffalo, NY University at Buffalo, NY Dongyang Liu Hoi Kei Lon University at Buffalo, NY University at Buffalo, NY Ping Lu Qiang Lu Merck, Pennsylvania Cognigen, New York Beth Ludwig Neang Ly Cognigen, New York University at Buffalo, NY Mindy Magee Donald Mager GlaxoSmithKline, Pennsylvania University at Buffalo, NY
Sophie Magreault Anshu Marathe University at Buffalo, NY FDA, Maryland Nobuko Matsushima Kayla Maxwell Daiichi Sankyo, New Jersey University at Buffalo, NY Edward McNiff Murad Melhem Agennix USA, New Jersey Ordway Research, New York Samira Merali-Garonzik Raymond Miller University at Buffalo, NY Daiichi Sankyo, New Jersey Marlene Modi Sandeep Modi Bristol Myer Squibb, New Jersey Bristol Myer Squibb, New Jersey Vidhi Mody Srinidi Mohan University at Buffalo, NY University at Buffalo, NY Young-Jin Moon Marilyn Morris FDA, Maryland University at Buffalo, NY Bridget Morse Charvi Nanavati University at Buffalo, NY University at Buffalo, NY Jing Nie Kathleen O’Connell Roche, New Jersey University at Buffalo, NY John Paasch Nate Page Winsilico, Massachusetts University at Buffalo, NY Yuzhuo Pan Sandy Pang University at Buffalo, NY University of Toronto, Canada Ridhi Parasrampuria Dipti Pawaskar University at Buffalo, NY University at Buffalo, NY Aaron Peng Luann Phillips University at Buffalo, NY Cognigen, New York Dipak Pisal Thomayant Prueksaritanont University at Buffalo, NY Merck, Pennsylvania Jun Qu Laura Radecki University at Buffalo, NY University at Buffalo, NY
Radha Ramakrishnan Igbal Ramzan University at Buffalo, NY University of Sydney, Australia Mark Ratain Joe Raybon University of Chicago. Illinois BristolMeyerSquibb, Connecticut Anauya Raybon-Hazra Wolfgang Richter Pfizer, Connecticut Hoffmann-LaRoche, Switzerland Mario Rocci Alice Rodrigues ICON, New York University at Buffalo, NY Samuel Roiko Wolfgang Sadee University at Buffalo, NY Ohio State University, Ohio Daniel Salazar Jerry Schentag Daiichi Sankyo, New Jersey University at Buffalo, NY Jean-Michel Scherrmann Erin Schuetz University of Paris, France St. Jude Children’s Hospital, TN Dhavalkumar Shah Hongwu Shen University at Buffalo, NY University at Buffalo, NY Krithika Shetty Soyoung Shin University at Buffalo, NY University at Buffalo, NY Indrajeet Singh Dave Soda University at Buffalo, NY University at Buffalo, NY SaeHeum Song Robert Straubinger Daiichi Sankyo, New Jersey University at Buffalo, NY Yuichi Sugiyama Mohammad Tabrizi University of Tokyo, Japan AnaptysBio, California Mitalee Tamhane Jian-Ping Tang University at Buffalo, NY Roche, New Jersey Edit Tarcsa Urvi Telang-Aras Abbott, Massachusetts Roswell Park Cancer Institute, NY Karen Thudium Kenneth Tramposch University at Buffalo, NY University at Buffalo, NY
Eliza Tsou Chengjian Tu University of Michigan, Michigan University at Buffalo, NY Michael Turner Shweta Urva University at Buffalo, NY Novartis, New Jersey Scott VanWart Nisha Vijay Ordway Research, New York University at Buffalo, NY Joseph Walker Ellen Wang Daiichi Sankyo, New Jersey Pfizer, Connecticut Jun Wang Ruby Wiegand University at Buffalo, NY Wittnau, Germany Ulf Wiegand Susan Willavize Roche, Germany Cognigen, New York Theresa Wilson Zachary Wintrob Pfizer, Connecticut University at Buffalo, NY Sukyung Woo Chia-Ching Wu NIH, Bethesda, MD University at Buffalo, NY Fang Wu Chao Xu University at Buffalo, NY University at Buffalo, NY Xiaoyu Yang Xinning Yang University at Buffalo, NY FDA, Washington DC Masato Yasuhara Aiming Yu Tokyo M&D University, Japan University at Buffalo, NY Li Yu Li Zhang Roche, New Jersey University at Buffalo, NY Xiaochen Zhao Bo Zheng University at Buffalo, NY University at Buffalo, NY Jianguo Zhi Roche, New Jersey
*ATTENDEES as of July 22, 2010
Directions to The Buffalo Zoo
Acknowledgments
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