twenty-six compelling conversations...

CONVERSATIONS WITH GIANTS IN MEDICINE 4137 jci.org Volume 124 Number 10 October 2014 Twenty-six compelling conversations I continue to believe I have the best job in science. Since May 2012, I’ve been the Edi- tor at Large for the JCI, and in this capac- ity, I’ve been the chief interviewer of those chosen for the series Conversations with Giants in Medicine. We’ve aired twenty- six interviews with twenty-eight notable scientists in the 2.5 years that this series has been part of the JCI (Figure 1). In that time, I’ve heard some amazing stories, the kind that are often better — and stranger — than fiction. In the high- light reel to accompany the October 2014 issue (posted online at http://www.jci.org/ videos/cgms), I’ve chosen some of the most memorable vignettes from the twenty-six Conversations. These stories give life to the life sciences. Want to hear Francis Collins talk about competition with Craig Venter to get the human genome sequenced? It’s in there. Also included are Mike Brown and Bob Leowitz teasing Joe Goldstein. There are uplifting and hilarious stories about Roy Vagelos almost getting court-martialed and the experiment that led Gene Braunwald to define hypertrophic cardiomyopathy. Don Seldin tells a story about arriving at UT Southwestern to a collection of shacks and garbage and transforming it into the pow- erhouse it is today. Their collective stories about the thrill of discovery and sometimes the delight in seeing work at the bench hold true in patients — it all has captivated me. The Conversations series will continue next month and through the coming years, and I hope that we can add to the current collection of interviews with two Knight Bachelors, eight Howard Hughes Medi- cal Investigators, ten winners of Lasker Awards, eight Nobel Laureates, twenty- five members of the Institute of Medicine, and twenty-four members of the National Academy of Sciences. Their stories are personal, courageous, insightful, and oftentimes rather entertaining. This video is also timed to appear on the birthday of the JCI. Ninety years ago, in October 1924, one of the greatest biomedi- cal journals was born. There are numerous excellent stories told in the pages of the JCI, and here’s to hoping for another ninety years. Ushma S. Neill Figure 1. Scientists interviewed for the series Conversations with Giants in Medicine. From top: Harold Varmus, Robert Lefkowitz, Joseph Goldstein, and Michael Brown. Second row: Bonnie Bassler, Bruce Beutler, Eugene Braunwald, Aaron Ciechanover, Francis Collins. Third row: Tony Fauci, Marc Feldmann, Napoleone Ferrara, Jeffrey Friedman, Donald Ganem. Fourth row: Paul Greengard, Paul Marks, John Oates, Stephen O’Rahilly, John Potts, Fifth row: Christine Seidman, Donald Seldin, Lloyd Hollingsworth Smith Jr., Bruce Spiegelman, Thomas Starzl. Bottom row: Thomas Südhof, Roy Vagelos, Jean Wilson, Tadataka Yamada. Reference information: J Clin Invest. 2014;124(10):4137. doi:10.1172/JCI78747.

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Page 1: Twenty-six compelling conversations Idm5migu4zj3pb.cloudfront.net/manuscripts/78000/78747/JCI78747.v1.pdf · CNSATINS IT INTS IN ICIN ci.org Volme 14 Nmer 1 ctoer 144137 Twenty-six

C o n v e r s a t i o n s w i t h g i a n t s i n m e d i C i n e

4 1 3 7jci.org Volume 124 Number 10 October 2014

Twenty-six compelling conversations

I continue to believe I have the best job in science. Since May 2012, I’ve been the Edi-tor at Large for the JCI, and in this capac-ity, I’ve been the chief interviewer of those chosen for the series Conversations with Giants in Medicine. We’ve aired twenty-six interviews with twenty-eight notable scientists in the 2.5 years that this series has been part of the JCI (Figure 1).

In that time, I’ve heard some amazing stories, the kind that are often better — and stranger — than fiction. In the high-light reel to accompany the October 2014 issue (posted online at http://www.jci.org/ videos/cgms), I’ve chosen some of the most memorable vignettes from the twenty-six Conversations. These stories give life to the life sciences. Want to hear Francis Collins talk about competition with Craig Venter to get the human genome sequenced? It’s in there. Also included are Mike Brown and Bob Lefkowitz teasing Joe Goldstein. There are uplifting and hilarious stories about Roy Vagelos almost getting court-martialed and the experiment that led Gene Braunwald to define hypertrophic cardiomyopathy. Don Seldin tells a story about arriving at UT Southwestern to a collection of shacks and garbage and transforming it into the pow-erhouse it is today. Their collective stories about the thrill of discovery and sometimes the delight in seeing work at the bench hold true in patients — it all has captivated me.

The Conversations series will continue next month and through the coming years, and I hope that we can add to the current collection of interviews with two Knight Bachelors, eight Howard Hughes Medi-cal Investigators, ten winners of Lasker Awards, eight Nobel Laureates, twenty-five members of the Institute of Medicine, and twenty-four members of the National Academy of Sciences. Their stories are personal, courageous, insightful, and oftentimes rather entertaining.

This video is also timed to appear on the birthday of the JCI. Ninety years ago, in October 1924, one of the greatest biomedi-cal journals was born. There are numerous excellent stories told in the pages of the JCI, and here’s to hoping for another ninety years.

Ushma S. Neill

Figure 1. Scientists interviewed for the series Conversations with Giants in Medicine. From top: Harold Varmus, Robert Lefkowitz, Joseph Goldstein, and Michael Brown. Second row: Bonnie Bassler, Bruce Beutler, Eugene Braunwald, Aaron Ciechanover, Francis Collins. Third row: Tony Fauci, Marc Feldmann, Napoleone Ferrara, Jeffrey Friedman, Donald Ganem. Fourth row: Paul Greengard, Paul Marks, John Oates, Stephen O’Rahilly, John Potts, Fifth row: Christine Seidman, Donald Seldin, Lloyd Hollingsworth Smith Jr., Bruce Spiegelman, Thomas Starzl. Bottom row: Thomas Südhof, Roy Vagelos, Jean Wilson, Tadataka Yamada.

Reference information: J Clin Invest. 2014;124(10):4137. doi:10.1172/JCI78747.

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