u0 7 - 1830
DESCRIPTION
U0 7 - 1830. #840761421 DM with neuropathy, retinopathy with proteinuria. 45 YO African Canadian came in with ESOB. Crea of 1500 mmol/L His baseline Cr was 150 mmol/L in March 2006. PMH: DM x 15 years. Last HgbA1C 14.5% Lab: Anemia, Proteinuria (10 grams/day) Reasons for Biopsy: - PowerPoint PPT PresentationTRANSCRIPT
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U07-1830
#840761421
• DM with neuropathy, retinopathy with proteinuria
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• 45 YO African Canadian came in with ESOB. Crea of 1500 mmol/L
• His baseline Cr was 150 mmol/L in March 2006.• PMH: DM x 15 years. Last HgbA1C 14.5%• Lab: Anemia, Proteinuria (10 grams/day)• Reasons for Biopsy: - Fast decline of GFR- Patient believes!…………………And Biopsy showed……………….
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IF• IgG- Negative.• IgA- Negative.• IgM- Moderate vascular staining. Moderate staining of glomerular
hyalinosis lesions.• C3- Mild to moderate vascular staining. Mild to moderate staining
of hyalinosis lesions.• C1q- Mild vascular staining. • Kappa- Negative.• Lambda- Negative.• Fibrinogen- Mild staining of fibrous crescent. Mild interstitial
staining. • Albumin- Mild linear TBM staining, a common finding in diabetes.
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IgM
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IgM
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C3
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C3
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Clq
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Fibrin
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Fibrin
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Albumin
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EM
• Is pending
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DiagnosisRenal Biopsy:• Nodular diabetic glomerulosclerosis with
extensive parenchymal scarring and atrophy and glomerular scarring nearing end-stage disease.