ubc's
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Scheme Of Presentation History Umbilical Cord Types Of Umbilical Cord Stem Cells Collection Of UBC’s Preservance Of UBC’s UBC’S Storage Banks Companies In Pakistan Advantages Disadvantages Conclusion References
History
First sibling-donor cord blood transplant was performed in 1988, the National Institute of Health (NIH) awarded a grant to Dr. Pablo Rubinstein to develop the world's first cord blood program at the New York Blood Center (NYBC).
Umbilical Cord The umbilical cord connects a baby in the womb to
its mother. It runs from an opening in your baby’s stomach to the placenta in the womb.
The average cord is about 50cm (20 inches) long.
Umbilical Cord
Cord blood stem cells Cord tissue stem cells
Umbilical Cord
Cord Blood Stem Cells
Cord blood comes from a newborn’s umbilical cord and can be collected immediately after birth.
It contains powerful stem (haematopoietic stem cells) that have been used to regenerate healthy blood and immune systems.
Cord blood stem cells are currently used to treat a range of blood disorders and immune system conditions such as leukaemia , anemia and autoimmune diseases.
So far, cord blood stem cells have been used in more than 35,000 transplants worldwide.
Cord Tissue Stem Cells
Contains unique and powerful stem cells that may help repair and heal the body in different ways than cord blood.
These cells create structural and connective tissue and are currently being evaluated in 30+ clinical trials to treat heart disease, stroke and spinal cord damage, among others.
Cord Tissue Stem Cells
Three key cell types from six cord tissue regions ;
All cell types from a variety of tissues are being researched to potentially treat 11+ therapeutic areas.
Collection Of UBC’s
Method most commonly used in clinical practice is the "closed technique”.
The technician cannulates the vein of the severed umbilical cord using a needle that is connected to a blood bag, and cord blood flows through the needle into the bag.
On average, the closed technique enables collection of about 75 ml of cord blood (Christopher D Et al 2004).
How to preserve CB After the collection, the cord
blood unit is shipped to the lab and processed, and then cryopreserved.
Cryoprotectants such as glycerol or dimethyl sulphoxide.
After cryogenic protectants added blood unit should be placed in freezer or extra cold vessel .
Eg :- Nitrogen liquid (-196 degree celsius)
Storage Cord blood is stored by both public and private Cord
blood banks.
Benefit of the general public.
Cost Free.
Public Use of the donor
or donor's relatives.
$2000 for collection and approximately $125 per year for storage.
Private
Companies in Pakistan1- Stem Cells PakistanStem Cells Pakistan – Stem Cells Ltd Pakistan DistributorTel : +92 3335608851Tel : +92 512801480Mezzanine Floor, Khalid Plaza, Jinnah Avenue, Blue Area Islamabad
2- Cryo Cell Pakistan
Cryo-Cell PakistanAddress:30-C Mezzanine Floor27th StreetTauheed Commercial AreaPhase-5 DHAKarachi, Pakistan 75500
Advantages Cord blood is a rich, natural, controversy-free source of life-
saving stem cells. The collection of cord blood does not harm the mother or child,
and does not interfere with the birthing process. Umbilical cord blood has the potential to cure over 80 diseases. Recent research has shown tremendous potential for cord blood
stem cells to be used in regenerative medicine, which may cure even more diseases.
Cord blood is readily available when needed, if collected and banked.
Cord blood stem cells are the “youngest” and most adaptable form of cells, and the body more readily accepts the cells into its system.
Cord blood has a broader match potential than bone marrow, which means that the patient and donor do not have to be a “perfect match.”
Cord blood stem cells are more resistant to infection, have fewer side effects after the transplant and require fewer transplant drugs than bone marrow stem cells.
There are nearly 10 times as many blood producing cells in cord blood. Studies suggest that cord blood may also have a better ability to generate blood cells than bone marrow. This provides more opportunity for future medical advancements.
Disadvantages The main disadvantage of cord blood is that the
volume collected is fixed and relatively small. Therefore, the number of stem cells available for
transplantation is low compared to the number of cells that can be collected in customizable bone marrow or peripheral blood stem cell harvests.
It’s a very costly in private bank. Risk of high contamination . High risk to be miss match genetic typing.
Conclusion Source of stem cells from biological
waste. Collection of cord stem cells is painless. Collection of cord stem cells is risk free
to mother and baby. Cord blood stem cells are much more
tolerant to HLA tissue mismatching than bone marrow therefore leading to lower rate.
Cord blood stem cells have a greater ability to differentiate into other cell types.
Save Cord blood save your future. Cord blood stem cells are being used in
the treatment of 40 medical conditions with over 72 potential disease targets.
References
I. http://stemcellspakistan.com/II. http://www.cryo-cell.com/III. https://en.wikipedia.org/wiki/Cord_blood#cite_no
te-6IV. http://www.cordblood.com/benefits-cord-blood/c
ord-tissue