unc msk course day 5 lab xr unknowns (for self study)
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UNC MSK Course Day 5 Lab XR UNKNOWNS (for self study). UNC MSK Course Day 5 Lab XR. Location of lesion in bone Epiphyseal Metaphyseal Diaphyseal. UNC MSK Course Day 5 Lab XR. Location of lesion in bone Epiphyseal Giant cell tumor (adults) Chondroblastoma (children) Metaphyseal - PowerPoint PPT PresentationTRANSCRIPT
UNC MSK Course Day 5 Lab XR
Location of lesion in bone
Epiphyseal
•Giant cell tumor (adults)
•Chondroblastoma (children)
Metaphyseal
•All others not listed above or below
Diaphyseal
•Osteomyeliltis
•Ewing’s Sarcoma
•Fibrous Dysplasia
•Paget’s disease (actually throughout bone)
UNC MSK Course Day 5 Lab XR
Location in bone
Central
•Unicameral bone cyst
•Enchondroma
Peripheral
•Non-ossifying fibroma
•Osteoid osteoma
Expanding the bone
•Aneursymal bone cyst (not taught in MSK)•Pagets
Outside the bone
•Osteochondroma•Osteosarcoma
UNC MSK Course Day 5 Lab XR
Location in body (can occur elsewhere but have a predilection for)
Hand/foot
Proximal humerus
At rapidly growing physes of long bones
UNC MSK Course Day 5 Lab XR
Location in body (can occur elsewhere but have a predilection for)
Hand/foot
•Enchondroma
Proximal humerus
•Unicameral bone cyst
At rapidly growing physes of long bones (near knee, far from elbow)
•Osteosarcoma
UNC MSK Course Day 5 Lab XR
Location in body (can occur elsewhere but have a predilection for)
Where there is red marrow
Central skeleton
UNC MSK Course Day 5 Lab XR
Location in body (can occur elsewhere but have a predilection for)
Where there is red marrow (central bones including proximal femur and humerus)
•Metastases
•Multiple myeloma (later in disease, the destruction of the centrally located hematogenous marrow causes marrow metaplasia from fatty back to hematogenous in the long bones and subsequent spread of myeloma to limbs)
Central skeleton
•Chondrosarcoma (as opposed to enchondroma, so that a cartilage lesion in the pelvis is much more likely to be malignant than one in the finger)
UNC MSK Course Day 5 Lab XR
Patient age (most can occur at other ages but more common at age listed
Child
Adolescent
UNC MSK Course Day 5 Lab XR
Patient age (most can occur at other ages but more common at age listed
Child
•Rhabdosaroma
•Unicameral (solitary) cyst
•Osteomyelitis (hematogenous)
Adolescent
•Osteosarcoma
•Chondroblastoma
•Osteochondroma (discovered in adolescence or as young adult)
•Non-ossifying fibroma
UNC MSK Course Day 5 Lab XR
Patient age (most can occur at other ages but more common at age listed
Young adult
Middle age to elderly
UNC MSK Course Day 5 Lab XR
Patient age (most can occur at other ages but more common at age listed
Young adult
•Giant cell tumor
•Ewing’s sarcoma
•Osteoid osteoma
Middle age to elderly
•Metastases
•Multiple myeloma
•Chondrosarcoma
•Paget’s disease
•Malignant fibrous histiocytoma
UNC MSK Course Day 5 Lab XR
Lesion descriptors on XR
•“reactive rim of sclerotic bone” -
•“bone destruction with no reactive rim” –
•“mottled and moth eaten” –
•“punched out holes in bone” –
•“marrow cavity continues into lesion” –
•“onion skinning” –
•“Codman’s triangle” –
•“ground glass appearance” –
UNC MSK Course Day 5 Lab XR
Lesion descriptors on XR
•“reactive rim of sclerotic bone” - benign
•“bone destruction with no reactive rim” – malignant
•“mottled and moth eaten” – osteomyelitis
•“punched out holes in bone” – myeloma
•“marrow cavity continues into lesion” – osteochondroma
•“onion skinning” – layered new bone caused by peeling up of the periosteum due to rapid tumor growth (common in Ewing’s but can occur in other malignancies).
•“Codman’s triangle” – new bone triangle that occurs at the corner of where the periosteum is stripped as above (common in osteosarcoma but can occur in other malignancies).
•“ground glass appearance” –the lesions in fibrous dysplasia.
UNC MSK Course Day 5 Lab XR Lesion descriptors on XR
•“lucent nidus with reactive rim of sclerotic bone” -
•“central in bone” –
•“peripheral or cortical” –
•“respects the disc space” -
•“destroying the disc space” –
•“sunburst” –
•“Calcification” –
UNC MSK Course Day 5 Lab XR Lesion descriptors on XR
•“lucent nidus with reactive rim of sclerotic bone” - osteoid osteoma
•“central in bone” – unicameral bone cyst and enchondroma
•“peripheral or cortical” – osteoid osteoma and non-ossifying fibroma
•“respects the disc space” (destroys bone but not the IVD) – malignancy (avoids the disc as it is avascular).
•“destroying the disc space” – infection (prefers the disc because it is avascular).
•“sunburst” – exploding rays of new bone outside the original bone, common to osteosarcoma.
•“Calcification” – enchondroma, can be told from ossification because there are no trabeculae (a speckled, “snowflake” appearance is common)
UNC MSK Course Day 5 Lab XR Lesion descriptors on XR
•“hypertrabeculation” -
•“blastic” –
•“lytic” –
•“bone within a bone” –
•“sequestrum” –
•“involucrum” –
UNC MSK Course Day 5 Lab XR Lesion descriptors on XR
•“hypertrabeculation” - Paget’s disease
•“blastic” – the lesion is making new bone, common to osteosarcoma, prostatic metastases and occasionally breast metastatses.
•“lytic” – the lesion is destroying bone, common in malignancy and infection
•“bone within a bone” – appearance of one vertebra inside another common in Paget’s disease of the spine
•“sequestrum” – a fragment of dead bone walled off inside an infection
•“involucrum” – new bone formed around a sequestrum.
Age 25
Pathology?
Diaphyseal“bone destruction with no reactive rim” “onion skinning” “Codman’s triangle”
Ewing’s Sarcoma(Differential should include infection)
Age 25 Pathology?
Diaphyseal“reactive rim of sclerotic bone”“ground glass appearance”
Fibrous dysplasia
Age 60
Pathology?
“respects the disc space” (cancer)
Multiple myeloma (differential would include severe osteoporosis and metastatic disease)
Age 20
Pathology?
Eccentric
Reactive rim sclerotic bone
Shortly after physeal closure
Non-ossifying fibroma
Age 16
Pathology?
“marrow cavity continues into lesion”
Outside the bone
Discovered during growth spurt.
Stalk pointing away from growth plate.
Age 16
Pathology?
“marrow cavity continues into lesion”
Outside the bone
Discovered during growth spurt.
Stalk pointing away from growth plate.
Osteochondroma
Age 10
Pathology?
Central in bone
Proximal humerus
“reactive rim of sclerotic bone”
Unicameral bone cyst
Age 40, several months of pain in ankle
Pathology?
Destruction of ankle joint with joint space narrowing, erosions of bone.
Age 40, several months of pain in ankle
Pathology?
MRI shows synovitis and bone edema.
Differential diagnosis would include chronic infection such as tuberculosis or possibly monoarticular inflammatory disease.
Age 40, several months of pain in ankle
Pathology?
MRI shows synovitis and bone edema.
It is typical for infection to involve both sides of the joint as it is easy for infectious organisms to cross the avascular articular cartliage.
Age 60
Pathology?
“hypertrabeculation” (looks mottled and lumpy here)
Expanding the bone
Affecting entire bone (innominate)
Paget’s disease L innominate (patient also has nonunion of fractured ischium)
Age 20 Shoulder warm and swollen, moderate pain.
Pathology?
Neuropathic (Charcot if secondary to syphilis) shoulder secondary to syringomyelia. Bone is fragmented and destroyed and warmth leads to a differential of osteomyelits. Pain is present but not as severe as you would expect for degree of bone destruction.