Uniform Picoscalar Oligodynamic Silver Hydrosol

(UPOSH) State-of-the-Art

Immune Offensive

© 2007 by Immunogenic Research Foundation, Inc.

UPOSH

This unique silver hydrosol could be described more accurately as one of the most effective immune agents ever discovered. UPOSH combats even the most severe or resistant immune challenges. Never in the history of silver-based therapeutics has such an active form of silver been developed. Were such a nanotechnology product available 50 or 60 years ago at the time when antibiotics emerged, many would argue that UPOSH would have rendered them obsolete. But due to the inadequate silver products that proliferated at that time, antibiotics flourished and silver was largely abandoned as the immune agent of choice. As a result of this nanotechnology breakthrough, many silver authorities today are stating that due to the compromised immune state of the global village arising of deadly resistant germs, it is time to return to the wide-spread use of silver in medicine.Apsley, JW. Microbial Multi-Drug Resistance (MDR) And Oligodynamic Silver.” IMREF Newsletter – September 2006. © 2006 by Immunogenic Research Foundation, Inc.

Objectives of the Presentation

At The End Of This Presentation You Will

Understand how the nutritional supplement UPOSHpromotes comprehensive restoration of immune functions

Understand how to properly use UPOSH Be introduced to the parameters of clinical research

and the follow-on peer-review submission process on studies incorporating UPOSH

75% of patients & consumers believe vitamin supplements improve immunity

61% believe supplements prevent colds

35% think herbs improve immunity

28% believe herbs are valuable in preventing immune problems

Recent Surveys Pertaining to UPOSH

1. Applied Biometrics 1997/Gallup 1996.

UPOSH’s Substantiated Nutrient Claims

UPOSH’s exceptional active ingredient:

The defining elements of silver products suspended in water that make them “active” as a dietary supplement are three-fold:

Particle size – defines silver’s scale of biological reach,

Particle charge – defines silver’s active state,

Particle concentration – defines silver’s safety and effectiveness.1,2

 UPOSH perfects these three attributes, confirmed by the electron microscope, atomic absorption analysis and a major university study.3

1. Yudkin, J, “Efficacy of Silver Ions in Enzymes of Bacterium coli.,” Enzymologia, 1937; 2:161-170. In: Russell, AD, Hugo, WB, “Antimicrobial Activity and Action of Silver,” Prog Med Chem, 1994; 31:357.2. Russell, AD, Hugo, WB, “Antimicrobial Activity and Action of Silver,” Prog Med Chem, 1994; 31:353.

3. Zhu, X, “Final Report For Ag+ Concentration of Argentyn 23,”Department of Marine Biology, Marine Physical Chemistry Laboratory, University of Miami, Apr 29th, 2003.

UPOSH (Left) versus typical commercial brand (Right)

Transmission Electron Microscope Slide @ 100,000x Magnification

Particle Sizes Documented with Transmission Electron Microscope Slide @ 100,000x Magnification

Particle Sizes average 8 Ångstroms

Particle Sizes average hundreds, even thousands of Ångstroms

Particle Charge visualized by uniformity of particle dispersion

UPOSH continued…

Dispersed particles carry charges making them bio-active, and thus repel one another while neutral or non-charged particles aggregate. UPOSH’s bioactivity has been rated @ +97% active by the University of Miami (2003).

Particle Concentration – 10 ppm & 23 ppm are safe andeffective concentrations yet contain over 300,000,000 to600,000,000 (respectively) particles in each drop!Once the right particle size and particle charge have been achieved, there’s absolutely no need to have more than a certain concentrationof silver. This permits multiple daily doses over a lifetime, asustaining health value feature.Note: The EPA has established a RfD (Daily Reference Dose) for the ingestion of silver

over a 70 year period.

Safe – 350 mcg (micrograms)

Critical – 980 mcg

1 tsp. 23 ppm = 115 mcg / 1 Tblsp. 23 ppm = 345 ppm

Therefore, UPOSH can safely be taken up to 2 Tablespoons (six teaspoons) daily for life!

UPOSH continued…

Typical Dosages

First sign of a cold or flu – Typically doctors prescribe 1 teaspoon every 30 minutes on an empty stomach until symptoms lessen, then 1 every hour on an empty stomach for the next 2 days.

Chronic Infections – Typically doctors prescribe 1 tablespoon every two hours on an empty stomach for several weeks to months.

Rentz EJ. The Broad-Spectrum Antimicrobial Properties of Oligodynamic Ag+ As Silver Hydrosol. Featured lecture presentation of the American Academy of Environmental Medicine (AAEM). 2003 Summer Conference.

Other Uses

Other uses often prescribed by doctors includetopical UPOSH intervention with burns, cuts, eyeinfections, ear aches, MRSA Staph infections,vaginal douches (with follow-up acidophilusimplants), nebulized UPOSH for lung infections,and rectal implants with UPOSH for colon andliver infections, and even cancer.

Gordon E, Holtorf K. Promising cure to URTI pandemics including the avian flu (H5N1): Has the final solution to the coming plagues been discovered? Part I. Townsend Letter. 2006 Feb-March;#271-2.Gordon E, Holtorf K. Promising cure to URTI pandemics including the avian flu (H5N1): Has the final solution to the coming plagues been discovered? Part II. Townsend Letter. 2006 April;#273. Apsley JW, Holtorf K, Gordon E, Anderson W, Buttar R. Nanotechnology’s latest oncolytic agent: Silver,cancer, & infection associations. Part III. Townsend Letter. 2006 May;(274):95-8.Hamilton-Miller JM, Shah S, Smith C. Silver Sulphadiazine: A comprehensive in vitro reassessment. Chemotherapy. 1993;39:406.

The scientific literature clearly suggests that UPOSH’s benefits as a dietary supplement include:

Stimulates overall fitness of the immune system

Is a precision tool for immunity offensives

Stimulates immature blood cells to become fully functional adult cells

Enhances white blood cells to find and overcome immune risks

Promotes a key white blood cell function essential for immunity

UPOSH’s Scientifically Documented Structure/Function Claims

Third Party Medical Documentation

The active ingredient of UPOSH has a medically documented track record proven over the last 100 years.

Authoritative Third Party documentation clearly confirms that UPOSH’s active ingredient is an historically unequaled superior immune tool.

Doctors and patients incorporating UPOSH into their practices and lives will be charged experientially with an understanding of silver and why it is truly the “first line of an immune offensive” in the holistic practice. These qualities will instill an excitement and confidence not only in the doctor, but in the ever growing number of critical patients brought back to health.

Result – Unprecedented & Consistent Clinical Results

Predictable Die-off Symptoms

Commonly, doctors will advise patients as towhether or not they are candidates for extensiveUPOSH therapy. Die-off symptoms from heavyinfections may include headache, nausea,dizziness, fever, malaise, muscle and joint pain,mental fog & fatigue, and occasionally rigors.Detoxification procedures prevent and mitigatethese predictable symptoms.

Dana Flavin, MD, MS (past Pharmacologist and Science Advisor to the Associate Bureau Director for Toxicology, Food & Drug Administration); and Dr. John W. Apsley, II, Executive Director ofIMREF. “Contraindications, Precautions And Best Practices Essential for UPOSH Therapy.” ©2006 by Immunogenic Research Foundation, Inc.