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Curriculum Vitae (January 2018) Scott W. Ballinger, PhD.

UNIVERSITY OF ALABAMA AT BIRMINGHAM SCHOOL OF MEDICINE

FACULTY CURRICULUM VITAE

PERSONAL INFORMATION: Scott W. Ballinger US citizen Language: English 470 Aradon Trace Odenville, AL 205-629-3863 RANK/TITLE: Professor, tenured Department of Pathology Division of Molecular and Cellular Pathology 530 Biomedical Research Building II 901 19th Street South Birmingham, AL 35294-2180 205-934-4621 EDUCATION: Texas A&M University, College Station, TX Zoology, B.S. 1983 Texas A&M University, College Station, TX Wildlife Fisheries, M.S 1987 Emory University School of Medicine, Atlanta, GA Biochemistry, Ph.D. 1993 POSTDOCTORAL TRAINING: 1993-1994 Environmental Pathology Postdoctoral Fellow, Vermont Cancer Center,

University of Vermont, Burlington, VT 1994-1996 Alexander Hollaender Distinguished Postdoctoral Fellow, Vermont

Cancer Center, Burlington, VT ACADEMIC APPOINTMENTS: 2015- present Professor, Nathan Shock Center for Aging, University of Alabama at Birmingham, Birmingham, AL. 2014- present Senior Scientist, Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 2014- present Senior Scientist, Nutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL 2011- present Professor, Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, AL 2011-present Professor, Comprehensive Cardiovascular Center, University of

Scott W. Ballinger, PhD

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Alabama at Birmingham, Birmingham, AL 2011-present Professor, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 2011-present Professor, tenured, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 2011-present Professor, Department of Environmental Health Sciences, University

of Alabama at Birmingham, Birmingham, AL 2011-present Professor, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 2010-2011 Associate Professor, Center for Cardiovascular Biology, University of Alabama at Birmingham, Birmingham, AL 2009-2011 Associate Professor, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 2005-2011 Associate Professor, tenured, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 2002-2005 Associate Professor, tenure earning, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 2002-2011 Associate Professor, Department of Environmental Health Sciences,

University of Alabama at Birmingham, Birmingham, AL 2002-2011 Associate Professor, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 2000-2002 Assistant Professor, Department of Pharmacology, University of Texas Medical Branch, Galveston, TX 2000-2002 Assistant Professor, Department of Preventative Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 1998-2002 Assistant Professor, Sealy Center for Molecular Cardiology, University of Texas Medical Branch, Galveston, TX 1996-1998 Assistant Scientist, Sealy Center for Molecular Cardiology, University of Texas Medical Branch, Galveston, TX AWARDS/HONORS: Alexander Hollaender Distinguished Fellowship: U.S. Department of Energy Environmental Pathology Fellowship: University of Vermont-NIH Young Investigator Award: American Lung Association: New Hampshire-Vermont Burroughs-Wellcome Nominee: University of Vermont Outstanding Faculty Award, Molecular and Cellular Pathology Graduate Students College of Science Academy of Distinguished Former Students Award, Texas A&M University PROFESSIONAL SOCIETIES: Environmental Mutagen Society American Heart Association American Association for the Advancement of Science The Society for Free Radical Biology & Medicine The Nitric Oxide Society Society of Toxicology


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COUNCILS AND COMMITTEES: National: 2017 NIH study section, ad hoc, SEP for NIDDK Program Projects (PO1) 2017- CARDIA, Genetics Subcommittee 2017- CARDIA, Systems Biology Committee 2016 NIH study section, alternate chair, “Systemic Injury and Environmental

Exposure” 2016 NIH study section, ad hoc, NITM (OA)1 NHLBI Institutional Training

Mechanism (T32) 2015 NIH study section, ad hoc, ViCTER Program 2015- present NIH study section, regular member, “Systemic Injury and

Environmental Exposure” 2014 NIH study section, ad hoc, “Cellular Mechanisms of Aging and

Development” 2014 VA study section, “Cellular Mechanisms of Aging and Development” 2013 Mitochondrial Research Foundation, Study Section 2012 VA study section, “Special Emphasis Merit Review Panel of Gulf War

Research” 2012 NIH study section, ad hoc, “Basic Research in Calcific Aortic Valve

Disease” (RO1) RFA HL-12-015 2011 NIH Director’s Early Independence Award (EIA) Program Phase I

Study Section 2011 NIH study section, ad hoc Mouse Metabolic Phenotyping Center

Grants 2010 NIH study section, ad hoc, MIM 2009-2016 Member, Unified Peer Review Steering Committee, American Heart

Association (this committee provides oversight of the regional and national study sections)

2007-2012 Chair, Vascular Wall Biology Study Section, American Heart Association

2006-2007 Co-Chair, American Heart Association Southeastern Affiliate study section 2A 2006 NIH study section, ad hoc, AICS 2005-2012 Study Section Member, American Heart Association Southeastern Affiliate 2005-2010 Study Section Member, James and Esther King Biomedical Research

Program 1999-2003 Study Section Member, Grant Review Committee, Tobacco-Related

Grant Programs 1999-2003 Study Section Member, American Heart Association Western Affiliate University: 2017 - present Member, Selection Committee, College of Science Academy of

Distinguished Former Students, Texas A&M University 2017 - present Member, Pathology Research Advisory Committee


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2017 MCP Divisional Representative for the Department of Pathology Incentive Plan Development.

2017 Member, 2017 Organizing Committee, Regional Redox Symposium, Society for Redox Biology and Medicine.

2016 -present Vice-Chair, School of Medicine Faculty Council 2015 -present Member, Department of Pathology Promotion and Tenure Committee 2015 -present Member, School of Medicine Faculty Council 2011-present Member, Council of Core Facilities Directors 2011- 2012 Member, Faculty Advisory Council, Department of Pathology 2011 Member, Diabetes Workgroup (UAB Strategic Plan) 2010-2016 Member, Graduate Biological Sciences Steering and Oversight

Committee 2010-2013 Faculty Senate 2010 Member, Oxidative Stress and Mitochondria Workgroup, Diabetes,

Obesity & Metabolism Research Strategic Planning Steering Committee

2009-present Member, PBMM Theme Steering Committee 2009-2010 Member, Faculty Search Committee, Department of Pathology and

The Comprehensive Diabetes Center 2007-present Chair, Center for Free Radical Biology Travel Award Committee 2007-2009 Member, Pathology in Focus Editorial Committee 2006-2007 Member, Policy for Non-Tenure Faculty Committee 2005-present Member, Center for Free Radical Biology Steering Committee 2005-2008 Member, Graduate Council 2005 Member, Environmental Health Sciences Faculty Search Committee 2004 Chair, Molecular and Cellular Pathology Faculty Search Committee 2004 Member, Environmental and Health Sciences Faculty Search

Committee 2004-2009 Member, IBS Graduate Admissions 2004-2009 Member, IBS Steering Committee 2003-2008 Chair, Molecular and Cellular Pathology Graduate Recruitment Subcommittee 2003-2008 Member, Standing Committee, Graduate Admissions (Molecular and Cellular Pathology) UNIVERSITY ACTIVITIES: 2015-present Director, NIH Predoctoral Training Program in Cardiovascular

Pathophysiology at the University of Alabama at Birmingham 2015-present Mentor, SCRTP 2010-2013 Senator, Faculty Senate 2010-2012 Co-Director, Core C, UAB-UCSD O’Brien Core Center for Acute Kidney

Injury Research 2010-present Faculty, NIH MERIT Program 2009-present Mentor, UAB PREP Scholars Program 2009-present Coursemaster, GBS 707, GBS Core Curriculum 2009-2015 Co-director, NIH Predoctoral Training Program in Cardiovascular Pathophysiology at the University of Alabama at Birmingham 2007-present Director, Bio-Analytical Redox Biology Core, Diabetes Research


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Training Center 2007-present Mentor, SIBS program 2005-2008 Director, Molecular and Cellular Pathology Graduate Program 2005-present Mentor, Pathology Summer PREP program Mentorship – Primary Mentor: Graduate Students: Zhen Yang, graduated 2006 (PhD, Molecular and Cellular Pathology) Gin Chuang, graduated 2010 (PhD, Molecular and Cellular Pathology) Courtney Shin, graduated 2010 (MS, Biology) Corey Harrison, graduated 2011 (PhD, Molecular and Cellular Pathology) Jessica Fetterman, graduated 2011 (PhD, Molecular and Cellular Pathology) Mashieka James, graduated 2012 (PhD, Molecular and Cellular Pathology) Kimberly Dunham, graduated 2014 (PhD, Molecular and Cellular Pathology) Kyle Feeley, graduated 2014 (PhD, Cancer Biology) Alexander Bray, Medical Scientist Training Program (MSTP) 2017 (PhD, Cancer

Biology) Melissa Sammy, Molecular and Cellular Pathology Jamelle Brown, Pathobiology and Molecular Medicine Allison Walsh, 2015 Summer Cancer Research Training Program Postdoctoral fellows: David Krzywanski, PhD 2008 – 2010 (postdoctoral fellow, currently an Assistant

Professor, tenure-track at LSU). Danielle Cruthirds, PhD 2007 – 2008 (postdoctoral fellow, currently a tenured

Associate Professor at Samford University) Yavuz Cakir, PhD 2008 – 2010 (postdoctoral fellow, currently an Assistant Professor

at Benedict College, SC). Co-Mentor: Gordon Fisher, PhD (K99 mentor) Nutrition Sciences (currently on tenure track as

Assistant Professor, UAB Nutrition Sciences 2012) Faculty Mentorship: Min Xie, MD, KO8 mentorship committee (Assistant Professor of Medicine) Jegen Kandasamy, MD, co-mentor for career development (Assistant Professor of

Medicine, Neonatalogy) Liou Sun, PhD, mentor for career development (Assistant Professor of Biology) Jessica Fetterman, PhD (K99 co-mentor - Assistant Professor of Medicine, Boston

University) Thesis Committee Membership: Zhen Yang, graduated 2006 (PhD, Molecular and Cellular Pathology) Torey Combs, graduated 2008 (MS, Molecular and Cellular Pathology) Brian Dranka, graduated 2009 (PhD, Molecular and Cellular Pathology) Li Dong Zhai, graduated 2009 (PhD, Molecular and Cellular Pathology) Gin Chuang, graduated 2010 (PhD, Molecular and Cellular Pathology) Courtney Shin, graduated 2010 (MS, Biology) Patricia P. Jumbo Lucioni, graduated 2010 (PhD, Nutrition Sciences) Adrienne King, graduated 2010 (PhD, Environmental Health Sciences) Joel Jules, graduated 2010 (PhD, Molecular and Cellular Pathology) Corey Harrison, graduated 2011 (PhD, Molecular and Cellular Pathology)


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Jessica Fetterman, graduated 2011 (PhD, Molecular and Cellular Pathology) Ashlee Preston, graduated 2011 (PhD, Molecular and Cellular Pathology) Katherine Tuggle, graduated 2012 (PhD, Environmental Health Sciences) Christopher Calderon, graduated 2013 (MS, Physiology & Biophysics) Kimberly Dunham, graduated 2014 (PhD, Molecular and Cellular Pathology) Kyle Feeley, graduated 2014 (PhD,Cancer Biology) Samantha Giordano, graduated 2014 (PhD, Molecular and Cellular Pathology) Stephanie Wall, graduated 2015 (PhD, Molecular and Cellular Pathology) Matthew Dodson graduated 2015 (PhD, Pathobiology and Molecular Medicine) Danielle Yancey graduated 2015 (PhD, Pathobiology and Molecular Medicine Ryan Stapley graduated 2015 (PhD, Molecular and Cellular Pathology) Saranya Ravi graduated 2015 (PhD, Pathobiology and Molecular Medicine) Philip Kramer graduated 2015 (PhD, Pathobiology and Molecular Medicine) Katie Litts graduated 2016 (PhD, Visual Sciences) Matthew Smith graduated 2016 (PhD, Pathobiology and Molecular Medicine) Alexander Bray, 2017 Medical Scientist Training Program (MSTP) (PhD, Cancer

Biology) Melissa Sammy, Molecular and Cellular Pathology Jamelle Brown, Pathobiology and Molecular Medicine Jennifer Valcin, Genetics and Genomics Brent Jones, Cell and Developmental Biology Kellie Regal, Pathobiology and Molecular Medicine Stephanie Boas, Neuroscience Ashley N Connelly, Immunology EDITORIAL BOARD MEMBERSHIPS: 2014-present Editorial Board Member, Journal of Molecular Medicine 1998-2005 Editorial Board Member, Reviews in Mutation Research Regular manuscript reviewer: American Journal of Physiology, Arteriosclerosis Thrombosis and Vascular Biology, Biochemical Journal, Biochimica et Biophysica Acta, Biochemical Genetics, Cancer Research, Cardiology, Cardiovascular Toxicology, Circulation, Circulation Research, Endocrinology, Environmental Health Perspectives, European Heart Journal, Free Radical Biology & Medicine, Gene, Genetics, Journal of Biological Chemistry, Journal of Molecular and Cellular Cardiology, Journal of Molecular Medicine, Mitochondrion, Mutation Research, PNAS, Nitric Oxide, PLoS, Redox Biology, Toxicology MAJOR RESEARCH INTERESTS: Dr. Ballinger’s group hypothesizes that mitochondrial – nuclear genetic interaction processes significantly influence common disease development. Because the genetic selection processes for mitochondrial – nuclear interaction are influenced by survival and reproductive success, the changing environmental challenges from original prehistoric conditions to contemporary (along with increased lifespan) have significantly affected cell function. In this regard, his work explores the influence of “mito-Mendelian” genetics upon bioenergetics, inflammation, metabolism, and nuclear gene expression. For these studies, he invented and has developed the Mitochondrial – Nuclear eXchange (MNX) model that enables unambiguous testing of mitochondrial and nuclear genetic backgrounds upon cell function and disease development. From this research, it is becoming clear that “mito-Mendelian” genetics influences cell function and response to acute and chronic stimuli. Consequently, the genetic basis for disease is not based solely upon Mendelian nor Mitochondrial genetics, but is the consequence of “mito-Mendelian” genetics. This concept is paradigm challenging.


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Current laboratory projects investigate the role for mito-Mendelian genetics upon various metabolic diseases (cancer, cardiovascular, and obesity). TEACHING EXPERIENCE: Curriculum Development – Coursemaster: 6/2012-present Coursemaster and curriculum development, GBS 758/PAT 778

(New Perspectives in Cardiovascular Biology) 8/2011-present Coursemaster and curriculum development, GBS 707

(Graduate Biochemistry – Core curriculum) 8/2010-2011 Co-Coursemaster and curriculum development,GBS707

(Graduate Biochemistry – Core Curriculum) 3/2008-present Co-Coursemaster and curriculum development, PAT 777

(Autopsy Experience) 6/2008-6/2011 Coursemaster and curriculum development, IBS 709/PAT 778

(New Perspectives in Cardiovascular Biology) 1/2005-2009 Co-Coursemaster and curriculum development, IBS 701

(Module 2: Physiology and pathophysiology of organ systems) 9/2003-2009 Head and curriculum development, Metabolism Block, IBS 700 (Biochemistry) Lecturer: 2018- Colloquium Genetics/Genomics 2017- GRD 717 faculty facilitator 9/2014-present MSTP 793 10/2013-present GBS 708 1/2012-present GBS 749/ENH 706 1/2012-present GBS 720 3/2011-present GBS 772 8/2010-present GBS 707 6/2007-2009 IBS 706 1/2004-2009 IBS 702 9/2003-2013 ENH 650 9/2003-2012 PAT 700 9/2003-2009 Evaluator, PAT704 1/2002-5/2002 Small Group Facilitator, Med School Curriculum, Dermatology/Hematology/Musculoskeletal 10 medical students, The University of Texas Medical Branch, Galveston, TX 1/2000-5/2002 Clinical Teaching - Basic Research Rotation, Internal Medicine Residency Program- 4 MD residents [overall evaluation 8.75 on a scale of 1 (unsatisfactory) – 9 (superior)], The University of Texas Medical Branch, Galveston, TX 1/2002-5/2002 Lecturer, “Fundamentals of Toxicology”-Cardiovascular Toxicology Long Distance Learning Curriculum, University of Texas, Corpus Christi, TX 9/2001-12/2001 Lecturer, Advanced Genetics (Mitochondrial Biogenesis), Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, TX 9/2001-12/2001 Lecturer, BBSC 6119 Environmental and Nutritional Pathology,


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The University of Texas Medical Branch, Galveston, TX 1/2001-5/2002 Lecturer,BBSC 6403 Molecular Biology and Genetics, The University of Texas Medical Branch, Galveston, TX 1/2001-5/2002 Lecturer,BBSC 6111 Cardiovascular and Respiratory Systems The University of Texas Medical Branch, Galveston, TX 1/2001 Lecturer, “Environmental Causes of Cardiovascular Diseases” Toxicology Training Program, The University of Texas Medical Branch, Galveston, TX Spring 1995,1999 Guest Instructor, Honors Genetics (301), Texas A&M University, College Station, TX GRANT SUPPORT: Active: National Institutes of Health Research Award (P30 AG050886) Comparative Energetics and Aging (07/01/15 – 06/30/20) Co-director, Comparative Mitochondrial Health Assessment Core (Core D) National Institutes of Health Research Award (T32 HL007918) Training Program in Cardiovascular Pathophysiology (07/01/2009-06/30/2019) Primary Investigator $1,399,910 (total direct costs of project) National Institutes of Health Research Award (F30 HL127992) Mitochondrial Genetic Background Influences Susceptibility to Atherosclerosis (08/01/15-07/31/17) Sponsor (Alexander Bray, MSTP Fellow) $33,258/yr direct costs National Institutes of Health Research Award (R01DK096388) Race/Adiposity Interactions Regulate Mechanisms Determining Insulin Sensitivity (04/01/13-03/31/18) Co-Investigator $350,400/yr direct costs National Institutes of Health Research Award (P30 DK079626) (03/01/13 – 02/28/18) Project Leader and Director, (Core A) $129,992/yr direct costs National Institutes of Health Research Award (R21ES024203) Apical trans-membrane electron transport drives ELF reducing capacity (09/30/2015-09/30/2017) Co-Investigator $275,000 (total direct costs of project) Inactive: National Institutes of Health Research Award (RO1 HL109785) (04/10/12-03/31/16) Mitochondrial Haplotype Influences LV Dysfunction in Heart Failure Co-Investigator $250,000/yr direct costs National Institutes of Health Research Award/Boston University (PO1 HL081587) (04/01/11-02/29/16) Metabolic Control of Endothelial Cell Phenotype Primary Investigator $19,533/yr direct costs


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National Institutes of Health Research Award (RO1 HL103859) (07/19/11-04/30/16) Mitochondrial-Nuclear Interactions and CVD Susceptibility Primary Investigator $474,789/yr direct costs National Institutes of Health Research Award (R01 AA13395) National Institutes of Health Research Award (R01 DK75865) National Institutes of Health Research Award (R01 DK096388) Comprehensive Cancer Center Collaborative Programmatic Development Grant Diabetes Research Training Center Pilot Program Grant National Institutes of Health Research Award (RO1 HL094518) National Institutes of Health Research Award (P01 HL081587) Philip Morris External Research Program The Clayton Foundation for Research American Cancer Society Special Grants: Vermont Division John Sealy Memorial Endowment Award: New Investigator Award National Institutes of Health Research Award (RO3ES09318-1) American Heart Association Research Award (160023Y) National Institutes of Health Research Award (RO1ES11172) Department of Defense Concept Award (W81XWH-07-1-0540) National Institutes of Health Research Award (RO1 HL77419) Pending: National Institutes of Health Research Award (P30 DK079626) UAB Diabetes Research Center (03/01/13 – 02/28/18) Project Leader and Director, (Core A) This is the competitive renewal for the UAB DRC. In Revision: National Institutes of Health Research Award RO1 HD092019-01 (revision to be submitted for October deadline) Impact of maternal-fetal mitochondrial genetic differences on fertility, development, and metabolism Primary Investigator This is a revised proposal that examines the effects of maternal – fetal mtDNA “mismatch” upon fertility, fecundity, and adult metabolism in the offspring, which has direct implications on proposed approaches to mitochondrial gene therapy. OTHER: PATENTS: “Mitochondrial DNA Damage as a Predictor of Coronary Atherosclerotic Heart Disease” Patent # 6,322,974 (Nov 27, 2001) “Mitochondrial-Nuclear exchanged cells, tissues, organs, and animals” Patent # 9,040,771 (Jan 27, 2012)


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“Mitochondrial-Nuclear exchanged cells, tissues, organs and animals” Patent # 9,592,306 (Feb 14, 2017) OMIM (Online Mendelian Inheritance in Man) #520000 Diabetes and Deafness, Maternally Inherited; MIDD Aka: Ballinger – Wallace Syndrome OMIM is a comprehensive, authoritative compendium of human genes and genetic phenotypes that is freely available and updated daily. This database was initiated in the early 1960s by Dr. Victor A. McKusick as a catalog of Mendelian traits and disorders, entitled Mendelian Inheritance in Man (MIM). Twelve book editions of MIM were published between 1966 and 1998. The online version, OMIM, was created in 1985 by a collaboration between the National Library of Medicine and the William H. Welch Medical Library at Johns Hopkins. It was made generally available on the internet starting in 1987. In 1995, OMIM was developed for the World Wide Web by NCBI, the National Center for Biotechnology Information. Session Chair: Mitochondrial Genetics and OMICs, Physiological Bioenergetics—Mitochondria from Bench to Bedside, American Physiologic Society 2017, San Diego, CA (August 27-30, 2017). BIBLIOGRAPHY: 8117 citations h-index 35 i10-index 56 MANUSCRIPTS: Published (* indicates co-communicating authorship): 1. Carr, S.M., Ballinger, S.W., Derr, J.N., Blankenship, L.H., and Bickham, J.W.

Mitochondrial DNA analysis of hybridization between sympatric white-tailed deer and mule deer in west Texas. Proc. Nat. Acad. Sci. USA, 83: 9576-9580; 1986.

2. Schurr, T.G., Ballinger, S.W., Gan, Y.Y., Hodge, J.A., Merriwether, D.A.,

Lawrence, D.N., Knowler, W.C., Weiss, K.M., and Wallace, D.C. Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies indicating they are derived from four primary maternal lineages. Am. J. Hum. Genet. 46: 613-623; 1990.

3. Shoffner, J.M., Lott, M.T., Lezza, A.M.S., Seibel, P., Ballinger, S.W., and Wallace,

D.C. Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial tRNALys mutation. Cell 61: 931-937; 1990.

4. Morales, J.C., Ballinger, S.W., Bickham, J.W., Greenbaum, I.F., and Schlitter,

D.A. Genetic relationships among eight species of Eptesicus and Pipestrellus (Chiroptera: Vespertilionidae). J. Mammal. 72(2): 286-291; 1991.

5. Merriwether, D.A., Clark, A.G., Ballinger, S.W., Schurr, T.G., Soodyall, H.,

Jenkins, T., Sherry, S.T., and Wallace, D.C. The structure of the human mitochondrial DNA variation. J. Mol. Evol. 33: 543-555; 1991.


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6. Ballinger, S.W., Schurr, T.G., Torroni, A., Gan, Y.Y., Hodge, J.A., Hassan, K., Chen, K-H., and Wallace, D.C. Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient Mongoloid migrations. Genetics 130: 139-152; 1992.

7. Ballinger, S.W., Blankenship, L.H., Bickham, J.W., and Carr, S.M. Allozyme and

mitochondrial DNA analysis of a hybrid zone between white-tailed deer and mule deer (Odocoileus) in west Texas. Biochemical Genetics 30: 1-11; 1992.

8. Ballinger, S.W. Shoffner, J.M., Hedaya, E.V., Trounce, I., Polak, M.A., Koontz,

D.A., and Wallace, D.C. Maternally transmitted diabetes and deafness associated with a10.4 kb mitochondrial DNA deletion. Nature Genetics 1: 11-15; 1992.

9. Shoffner, J.M., Fernhoff, P.M., Krawiecki, N.S., Caplan, D.B., Holt, P.J., Kootnz,

D.A., Takei, Y., Newman, N.J., Ortiz, R.G., Polak, M.A., Ballinger, S.W., and Wallace, D.C. Subacute necrotizing encephalopathy: oxidative phosphorylation defects and the ATPase 6 point mutation. Neurology 42: 2168-2174; 1992.

10. Wallace, D.C., Lott, M.T., Shoffner, J.M., and Ballinger, S.W. Mitochondrial DNA

mutations in epilepsy and neurological disease. Epilepsia 35: S43-S50; 1994. 11. Ballinger, S.W. Shoffner, J.M., Gebhart, S., Koontz, D.A., and Wallace, D.C.

Mitochondrial diabetes revisited. Nature Genetics 7: 458-459; 1994. 12. Van Hove, J., Shanske, S., Ciacci, F., Ballinger, S.W., Shoffner, J.M., Wallace,

D.C., Harrika, T., Folkers, K., Bossen, E.H., and Kahler, S.G. Mitochondrial myopathy with anemia, cardiomyopathy, and lactic acidosis: A distinct late onset mitochondrial disorder. Am. J. Med. Genet. 51(2):114-120; 1994.

13. Ballinger,S.W.; Shoffner,J.M.; Wallace,D.C. Mitochondrial Myopathies - Genetic-

Aspects. Current Topics in Bioenergetics, 17: 59-98; 1994. 14. Wallace, D.C., Shoffner, J.M., Trounce, I., Brown, M.D., Ballinger, S.W., Corral-

Debrinski, M., Horton, T., Jun, A.S., and Lott, M.J. Mitochondrial DNA mutations in human degenerative diseases and aging. Biochimica et Biophysica Acta 1271: 141-151; 1995.

15. Ballinger, S.W.*, Bouder, T.G., Davis, G.S., Judice, S.A., Nicklas, J.A., and Albertini, R.J. Mitochondrial genome damage associated with cigarette smoking. Cancer Res. 56: 5692-5697; 1996.

16. Ballinger, S.W., Conklin, C.A., Ruef, J., Horaist, C., and Runge, M.S.

Mitochondrial DNA is preferentially damaged in aorta from apoE mice. Circ. 98: I-115; 1998.

17. Yan, C-N, Ballinger, S.W., Doan, R., Yakes, F.M., Van Houten, B., Freeman, B.A.,

and Runge, M.S. Peroxynitrite mediates mitochondrial DNA damage and dysfunction in vitro. Circ. 98 (17): I-734; 1998.

18. Ballinger, S.W., Van Houten, B., Jin, G-F, Conklin, C.A., and Godley, B.F.

Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells. Exp. Eye Res. 68: 765-772; 1999.


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19. Knight, C.A., Zhaoyong, H., Burow, D.L., Horaist, C., Pinkerton, K., and Ballinger, S.W. Cigarette smoke causes increased mitochondrial DNA damage and atherosclerotic lesion formation in apolipoprotein E null mice. Circ. 100 (18): I-259; 1999.

20. Ballinger, S.W., Patterson, C., Yan, C-N, Doan, R., Burow, D.L., Young, C.G.,

Yakes, F.M., Van Houten, B., Ballinger, C.A., Freeman, B.A., Runge, M.S. Hydrogen Peroxide and Peroxynitrite-Induced Mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circulation Research 86: 960-966; 2000.

21. Moon, S-K, Thompson, L.J., Madamanchi, N., Ballinger, S.W., Papaconstantinou,

J., Horaist, C., Runge, M.S., Patterson, C. Aging, oxidative responses and proliferative capacity in cultured mouse aortic smooth muscle cells. Am J. Physiol Heart Circ Physiol 280: H2779 – H2788 2001.

22. Knight-Lozano, C.A., Young, C.G., Burow, D.L., Hu, Z-Y, Uyeminami, D.,

Pinkerton, K.E., Ischiropoulos, H., Wallace, D.C., and Ballinger, S.W. Cigarette smoke mediates mitochondrial damage in cardiovascular tissues from normocholesterolemic and hypercholesterolemic mice. Circulation 105: 849 – 854 2002.

23. Ballinger, S.W., Patterson, C., Knight-Lozano, C.A., Burow, D.L., Conklin, C.A.,

Hu, Z-Y., Reuf, J., Horaist, C., Lebovitz, R., Hunter, G., McIntyre, K., Runge, M.S. Mitochondrial Integrity and Function in Atherogenesis. Circulation 106: 544-549 2002.

24. Ballinger, S.W., Judice, S.A., Nicklas, J.A., Albertini, R.J., O’Neill, J.P. DNA

sequence anlysis of interlocus recombination between the human T-cell receptor gamma variable (GV) and beta diversity joining (BD/BJ) sequences on chromosome 7 (inversion 7). Environmental and Molecular Mutatgenesis 40: 85-92 2002.

25. Birnbaum, Y., Ashitkov, T., Uretsky, B.F., Ballinger, S.W., Motamedi, M.

Reduction of infarct size by short-term pretreatment with atorvastatin. Cardiovascular Drugs and Therapy 17: 25-30 2003.

26. Venkatraman, A., Landar, A., Davis, A.J., Chamlee, L., Sanderson, T., Kim, H.,

Page, G., Pompilius, M., Ballinger, S.W., Darley-Usmar, V., Bailey, S.M. Effect of chronic ethanol consumption on the rat liver mitochondrial proteome and genome. Gastroenterology J. Biol. Chem 279: 22092 – 22101 2004.

27. Yang, Z., Knight, C.A., Mamerow, M.M., Vickers, K., Penn, A., Postlethwait, E.M.,

Ballinger, S.W. Prenatal Environmental Tobacco Smoke Exposure Promotes Adult Atherogenesis and Mitochondrial Damage in apolipoprotein E -/- Mice fed a Chow Diet. Circulation 110: 3715-3720 2004.

28. Young, C.G., Knight, C.A., Vickers, K., Madamanchi, N.R., Runge, M.S.,

Ischiropoulos, H., Ballinger, S.W. Differential Effects of Exercise on Aortic Mitochondria. Journal of American Physiology 288: H1683-H1689 2005.

29. Vartanian, V., Lowell, B., Wood, T.G., Ceci, J.D., George, S., Ballinger, S.W.,

Corless, C.L., McCullough, A.K., Lloyd, R.S. The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proceeding of the National


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Academy of Sciences, USA Proceeding of the National Academy of Sciences, USA 103 (6) 1864-1869. 2006.

30. Pan, G., Yang, Z., Ballinger, S.W., McDonald, J.M. Pathogenesis of

osteopenia/osteoporosis induced by highly active anti-retroviral therapy for AIDS. Ann. N.Y. Acad. Sci. 1068: 297–308 2006.

31. Gutierrez, J. Ballinger, S.W., Darley-Usmar, V.M., Landar, A. Free radicals,

mitochondria, and oxidized lipids: The emerging role in signal transduction in vascular cells. Circulation Research 99: 924-932 2006.

32. Bailey, S.M., Robinson, G., Pinner, A., Chamlee, L., Ulasova, E., Pompilius, M.,

Page, G.P., Chhieng, D., Jhala, N., Landar, A., Kharbanda, K.K., Ballinger, S.W., Darley-Usmar, V.M. S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in rat liver. Am J Physiol Gatrointest Liver Physiol 291(5): G857-G867 2006.

33. Yang, Z., Harrison, C., Chuang, G., Ballinger, S.W. The role of tobacco smoke-

induced mitochondrial DNA damage in vascular dysfunction and atherosclerosis. Mutation Research 621: 61-74 2007.

34. Cakir, Y. Yang, Z., Pompilius, M., Bailey, S. Pinkerton, K.E., Ballinger, S.W.

Concurrent alcohol and environmental tobacco smoke exposure significantly increase mitochondrial damage and atherogenesis in apoE -/- mice. Free Rad. Biol. Med. 43: 1279-1288 2007.

35. Bailey, S.M., Mantena, S.K., Cakir, Y., Chhieng, D., Pinkerton, K.E., Ballinger, S.W.

Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE-/-mouse: Implications for a "multi-hit" hypothesis of fatty liver disease. Free Rad. Biol. Med. 46: 928-938 2009.

36. Chuang G.C., Yang Z., Westbrook D.G., Pompilius M., Ballinger C.A., White C.R.,

Krzywanski D.M., Postlethwait E.M., Ballinger S.W. Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage and atherogenesis. Am J Physiol Lung Cell Mol Physiol. 297: L209-216 2009.

37. Westbrook, D.G., Anderson, P, Pinkerton, K.E., Ballinger, S.W. Perinatal tobacco

smoke exposure significantly increases vascular oxidative stress, mitochondrial damage and dysfunction in non-human primates. Cardiovascular Toxicology 10: 216 – 226 2010.

38. Ulasova, E., Gladden, J.D., Zheng, J., Chen, Y., Pat, B., Bradley, W., Powell, P.,

Zhmijewski, J., Zelickson, B., Ballinger, S.W., Darley-Usmar, V., Dell’Italia, L.J. Extracellular matrix loss in acute volume overload causes structural alterations and dysfunction in cardiomyocyte subsarcolemmal mitochondria. Journal of Molecular and Cellular Cardiology 50: 147-156, 2011.

39. Harrison, C.M., Pompilius, M., Pinkerton, K.E., Ballinger, S.W. Mitochondrial

oxidative stress influences atherogenic risk and cytokine induced oxidant production. Environmental Health Perspectives 119 (5): 676-681, 2011.

40. Zhai, L., Ballinger, S.W., Messina, J.L. Potential role of reactive oxygen species in

injury-induced hepatic insulin resistance. Molecular Endocrinology 25 (3): 492-502, 2011.


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41. Gladden JD, Zellickson B, Wei, C. Ulasova E, Zheng, J., Ahmed M, Chen Y, Baman M,

Ballinger S.W., Darley-Usmar V, Dell’Italia LJ. Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload. Free Radical Biology and Medicine, 51: 1975-1984, 2011.

42. Hill, B.G., Benavides, G.A., Lancaster, J.R., Ballinger, S.W., Dell’Italia, L.J., Zhang, J., Darley-Usmar, V.M. Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol. Chem. 393: 1485 -1512, 2012.

43. Fetterman, J., Pompilius, M., Westbrook, D.G., Uyeminami, D., Brown, J., Pinkerton, K.E., Ballinger, S.W. Developmental exposure to second-hand smoke increases atherogenesis and alters mitochondrial DNA copy number and deletions in apoE -/- mice. PLoS ONE, 8(6): e66835. June 25 2013.

44. Fetterman, J., Zelickson, B., Johnson, L., Moellering, D.R., Westbrook, D.G.,

Pompilius, M., Sammy, M.J., Salman, E.D., Johnson, M., Dunham-Snary, K.J., Cao, X., Bradley, W.E., Zhang, J., Wei, C.C., Chacko, B., Schurr, T.G., Kesterson, R.A., Dell’Italia, L.J., Darley-Usmar, V.M., Welch, D.R., Ballinger, S.W. Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload. Biochemical Journal – Metabolism 455: 157-167 2013.

45. Chacko, B.K., Kramer, P.A., Ravi, S., Johnson, M.S., Hardy, R.W., Ballinger, S.W.,

Darley-Usmar, V.M. Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes and neutrophils and the oxidative burst from human blood. Laboratory Investigation 93: 590-600, 2013.

46. Gladden, J., Zelickson, B., Guichard, J., Ahmed, M., Yancey, D., Ballinger, S.W., Shanmugam, M., Babu, G., Darley-Usmar, V.M., Dell’Italia, L.J., Johnson, M. Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload. Am J. Physiology Heart and Circ. Physiol. 305: H1440-H1450, 2013.

47. Liu, W., Beck, B.H., Vaidya, K.S., Nash, K.T., Feeley, K.P. , Ballinger, S.W., Pounds,

K.M., Denning, W.L., Diers, A.R., Landar, A., Dhar, A., Iwakuma, T., Welch, D.R. Metastasis suppressor KISS1 appears to reverse the Warburg effect by enhancing mitochondrial biogenesis. Cancer Research 74(3): 954-963, 2014.

48. Dunham-Snary, K.J., Sandel, M.W., Westbrook, D.G., Ballinger, S.W. A method

for assessing mitochondrial bioenergetics in whole white adipose tissues. Redox Biology 2: 656-660, 2014.

49. Chacko, B., Kramer, P., Ravi, S., Benavides, G., Mitchell, T., Dranka, B.P., Ferrick,

D., Singal, A.K., Ballinger, S.W., Bailey, S.M., Zhang, J., Darley-Usmar, V.M. The bioenergetic health index: a new concept in mitochondrial translational research. Clinical Science 127: 367-373, 2014.


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50. Betancourt, A.M., King, A.L., Fetterman, J.L., Millender-Swain, T., Finley, R.D., Oliva, C.R., Crowe, D.R., Ballinger, S.W.*, Bailey, S.M. Mitochondrial-nuclear genome interactions in nonalcoholic fatty liver disease in mice. Biochemical Journal 46 1 (2): 223-232, 2014.

51. Feeley, K.P., Westbrook, D.G., Bray, A.W., Ballinger, S.W. An ex-vivo model for

evaluating bioenergetics in aortic rings. Redox Biology 2: 1003-1007, 2014. 52. Datta, G., Kramer, P., Johnson, M.S., Sawada, H., Smythies, L.E., Crossman, D.,

Chacko, B., Ballinger, S.W., Westbrook, D., Mayakonda, P., Anantharamaiah, G.M., Darley-Usmar, V.M., White, C.R. Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4F. Biochemical J 467: 517-527, 2015.

53. Feeley, K.P., Bray, A.W., Westbrook, D.G., Johnson, L.W., Kesterson, R.A.,

Ballinger, S.W.*, Welch, D.R. Mitochondrial genetics regulate breast cancer tumorigenicity and metastatic potential. Cancer Research 75: 4429-4436, 2015.

54. Dunham-Snary, K.J., Ballinger, S.W. Mitochondrial DNA mismatch matters.

Science 349: 1449-1450, 2015.

55. Krzywanski, D.A., Moellering, D., Westbrook, D.G., Dunham, K., Brown, J., Bray, A., Feeley, K.P., Sammy, M.J., Smith, M.R., Schurr, T.G., Vita, J., Ambalavanan, N., Calhoun, D., Dell Italia, L., Ballinger, S.W. Endothelial cell bioenergetics and mitochondrial DNA damage differ in humans having African and West Eurasian maternal ancestry. Circulation: Cardiovascular Genetics 9:26-36, 2016.

56. Fetterman, J.L., Holbrook, M., Westbrook, D.G., Brown, J.A., Feeley, K.P., Breton-

Romero, R., Linder, E.A., Berk, B.D., Weisbrod, R.M., Widlanskky, M.E., Gokce, N., Ballinger, S.W., Hamburg, N.M. Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease. Cardiovascular Diabetology 15:53-60, 2016.

57. Kesterson, R.A., Johnson, L.W., Lambert, L.J., Vivian, J.L., Welch, D.R.,

Ballinger, S.W. Generation of Mitochondrial – Nuclear eXchange Mice via Pronuclear Transfer. Bioprotocol 6 (20): e1976, 2016.

58. Andres, A.M., Tucker, K.C., Thomas, A., Taylor, D.J.R., Sengstock, D., Jahania,

S.M., Dabir, R., Pourpirali, S., Brown, J.A., Westbrook, D.G., Ballinger, S.W., Mentzer, R.M., Gottlieb, R.A. Evidence for mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass. Journal of Clinical Investigation Insights 2(4): e89303, 2017.

59. Kandasamy, J., Olave, N., Ballinger, S.W., Ambalavanan, N. Vascular endothelial

mitochondrial bioenergetics at birth predicts death or pulmonary outcome in preterm infants. American Journal of Respiratory and Critical Care Medicine 196(8):1040-1049, 2017.

Editorials:


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60. Patterson, C., Ballinger, S.W., Stouffer, G.A., and Runge, M.S. Antioxidant Vitamins: Sorting out the good and the not so good. J. Amer. Coll. Cardio. 34 (4): 1216-1218 1999.

61. Gower, B.A., Goree, L.L., Fisher, G., Ballinger, S.W. Could lowering fat intake reuce diabetes risk even if it doesn’t lead to weight loss? Diabetes Manage. 1 (6): 547-550, 2011.

Invited Reviews: 62. Ballinger, S.W. and Wallace, D.C. Maternally inherited diabetes and deafness.

The Endocrinologist 5(2): 104-112; 1995.

63. Burow, D.L., Madamanchi, N.R., and Ballinger, S.W. Environmentally mediated DNA damage. Recent Research Developments in Cancer, 2: 231-255 2000.

64. Cakir, Y., Ballinger, S.W. Redox Signaling, Oxidative, and Nitrosative Stress in the Vasculature, Antioxidants and Redox Signaling 7: 726-740 2005.

65. Yang, Z., Ballinger, S.W. Environmental Cardiology and Mitochondrial Disease, Drug Discovery Today: Disease Mechanisms 2: 71-75 2005.

66. Ballinger, S.W. Mitochondrial Damage and Dysfunction: A potential etiological

paradigm for cardiovascular disease, Free Radical Biology and Medicine, 38: 1278-1295 2005.

67. Kryzwanski, D.M., Moellering, D., Fetterman, J.L, Dunham-Snary, K.J., Sammy, M.J., Ballinger, S.W. The Mitochondrial Genetic Paradigm for Cardiovascular Disease Susceptibility and Cellular Function: A Complementary Concept to Mendelian Genetics. Laboratory Investigation 91 (8): 1122-1135 2011.

68. Mitchell, T., Chacko, B., Ballinger, S.W., Bailey, S., Zhang, J., Darley-Usmar, V. Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics. Biochem. Soc. Trans. 41(1): 127-133 2013.

69. Ballinger, S.W. Beyond retrograde and anterograde signaling: mitochondrial – nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibility. Biochem. Soc. Trans. 41 (1); 111-117 2013.

70. Dunham-Snary, K.J., Ballinger, S.W. Mitochondrial genetics & obesity: Evolutionary adaptation & contemporary disease susceptibility. Free Radical Biology and Medicine 65: 1229-1237 2013.

71. Allison, D.B., Antoine, L.H., Ballinger, S.W. et al. Aging and energetics’ ‘Top 40’ future

research opportunities 2010-2013 [v1; ref status: indexed, http://f1000r.es/4ae] F1000Research 3:219 2014 (doi: 10.12688/f1000research.5212.1)

72. Bray, A., Ballinger, S.W. Mitochondrial DNA mutations and cardiovascular disease.

Current Opinion in Cardiology 32(3):267–274, 2017.

http://f1000r.es/4ae

http://dx.doi.org/10.12688/f1000research.5212.1


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73. Fetterman, J.L., Sammy, M.J., Ballinger, S.W. Mitochondrial Toxicity to Tobacco Smoke and Air Pollution. Toxicology 391:18-33, 2017.

74. Malik, A., Ballinger, S.W., Darley-Usmar, V.M. Realizing the translational potential of metabolism, redox biology and bioenergetics health. Free Radical Biology and Medicine (in press).

Books: 75. Albertini, R.J., O’Neill, P., Ballinger, S.W., and Nicklas, J.A. Biomarkers of

Genetic Risk In Accomplishments in Cancer Research, (J.G.Fortner, editor), J.B. Lippincott Company, Philadelphia pp 99-114 (1996).

76. Ballinger, S.W. Atherosclerosis: Deregulation of Mitochondrial Function, A

Potential Common Theme for Cardiovascular Disease Development. In Oxidative Stress in Ageing (Miwa, S., Muller, F., Beckman, K., editors), Humana Press, Totowa, NJ pp 165-189 (2008).

77. Zelickson, B.R., Ballinger, S.W., Dell Italia, L., Zhang, J., Darley-Usmar, V.M. Reactive

oxygen and nitrogen species, interactions with mitochondria and pathophysiology. In Encyclopedia of Biological Chemistry, Elsevier, 4: 17-22 (2013).

Submitted: Original manuscripts- 78. Dunham-Snary, K.J., Sandel, M.W., Sammy, M.J., Westbrook, D.G., Xiao, R.,

McMonigle, R.J., Ratcliffe, W.F., Penn, A., Young, M.E., Ballinger, S.W. Mito-Mendelian Genetics: Effects in modulating adiposity and nuclear gene expression in vivo.

79. Sweatt, S.K., Cherrington, A., Ovalle, F., Fisher, G., Ballinger, S.W. Gower, B.A.

Psychosocial stress may affect risk for type 2 diabetes by increasing chronic inflammation.

In Preparation: 80. Sammy, M.J. Connelly, A., Brown, J., Westbrook, D.G., Holleman, C., Habegger,

K., Ballinger, S.W. Mito – Mendelian effects upon in vivo glucose metabolism and insulin sensitivity in healthy mice (in preparation).

81. Bray, A.W., Westbrook, D.G., White, C.R., Sun, Y., Chen, Y., Bradley, W.E., Dell’Italia, L.J., Ballinger, S.W. Mitochondrial DNA polymorphisms minimally impact progression of atherosclerosis (in preparation).

82. Guichard, J.L., Benavides, G.A., Bradley, W.E., Powell, P.C., Collawn, J., Darley-Usmar, V., Sandel, M.W., Cui, G., Ballinger, S.W.*, Dell’Italia, L.J. Mitochondrial genetic background modulates the nuclear genome expression in isolated adult cardiomyocytes of volume overload. (in preparation).

83. Yang, J., He, J., Ismail, M., Tweeten, S., Gao, L., Ballinger, S.W., Young, M., Prabhu, S., Zhang, J., Xie, M. HDAC inhibition-enhanced autophagy rescues mitochondrial homeostasis during cardiac ischemia/reperfusion injury. (in preparation).


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PUBLISHED ABSTRACTS (since 2005):

1. Yang, Z., Young, C., Knight, C.A. Pompilius, M. Postlethwait, E.M., Ballinger, S.W. Ozone exposure increases cardiovascular mitochondrial damage and atherogenesis in mice. Free Radical Biology & Medicine 39: S161 2005.

2. George, S. Yang, Z., Westbrook, D., Ballinger, C.A., Postlethwait, E.M., Ballinger, S.W. Ozone exposure mediates mitochondrial damage in cardiovascular tissues from non-human primates. Free Radical Biology & Medicine 39: S158 2005.

3. Westbrook, D., Yang, Z., Pinkerton, K.E., Ballinger, S.W. Prenatal and childhood second-hand smoke exposure causes significant mitochondrial damage in aortic tissues from non-human primates. Free Radical Biology & Medicine 39: S160 2005.

4. Cakir, Y., Yang, Z., Pompilius, M., Bailey, S., Pinkerton, K.E., Ballinger, S.W. Combined effects of environmental tobacco smoke and alcohol on cardiovascular disease development and mitochondrial damage. Free Radical Biology & Medicine, 39: S158 2005

5. Ballinger, S.W. The impact of prenatal ETS exposure in adult cardiovascular disease development. Update on Mechanisms for Environmental Tobacco Smoke-Induced Health Effects (Symposium), Society of Toxicology, New Orleans, Louisiana, March 8, (2005)

6. Ballinger, S.W. Cigarette smoke exposure and cardiovascular mitochondrial damage: A potential mechanism for cardiovascular disease development. 1st International Symposium on Tobacco and Health, Shanghai, China. (June 8-9, 2006).

7. Westbrook, D., Yang, Z., Ballinger, S.W. Oxidant stress increases TNF-a mediated mitochondrial ROS production. Society for Free Radical Biology & Medicine, 41: S169 2006.

8. Ballinger, S.W. Environmental oxidant exposure causes mitochondrial damage associated with increased atherogenesis. 46th Annual Meeting of the Society of Toxicology, Charlotte, NC. Invited Symposium Lecture; Air pollution and atherosclerosis: impact of inhaled agents on vascular remodeling, dyslypidemia, and oxidative stress. (March 27, 2007).

9. Ulasova, E., Perez, J. Dubuison, J., Bradley, W.E., Zmijewski, J.W., Yang, Z., Pompilius, M., Ballinger, S., Landar, A. Parks, D.A., Dell’Italia, L.J., Darley-Usmar, V.M. Oral Quercetin Protects the Heart from Concentric Hypercholesterolemia. Society for Free Radical Biology & Medicine, 43: S102 2007

10. Chuang, G.C., Yang, Z., Pompilius, M., Postlethwait, E.M., Ballinger, S.W. Cyclic Ozone Exposure Alter Oxidative Markers in Apolipoprotein E-Deficient Murine Model of Atherosclerosis. Society for Free Radical Biology & Medicine, 43: S120, 2007

11. Harrison, C.M., Knight, C., Pompilius, M., Pinkerton, K., Ballinger, S.W. The Role of Mitochondrial Oxidant Stress in Influencing the Effects of Environmental Factors on CVD Susceptibility. Society for Free Radical Biology & Medicine, 43: S119, 2007

12. Chuang GC, Yang Z, Westbrook DG, Ballinger CA, White CR, Krzywanski DM, Postlethwait EM, and Ballinger SW. Ozone Exposure Induces Vascular Dysfunction, Cellular Oxidative Stress, and Mitochondrial Damage. Free Radical Biology and Medicine, 45: S142 2008.,

13. Harrison CM, Knight CA, Pompilius M, Pinkerton KP, and Ballinger SW. The Role of Mitochondrial Oxidative Stress in Cardiovascular Disease Development.


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Society for Free Radical Biology & Medicine 15th Annual Meeting, Indianapolis, IN, November 2008.

14. Fetterman, JL, Cruthirds D, Westbrook D, Pompilius M, Ulasova E, Moellering D, White CR, Darley-Usmar V, and Ballinger SW. Mouse strains with differential cardiovascular disease susceptibilities have significantly different measures of mitochondrial function and damage. Society for Free Radical Biology & Medicine 16th Annual Meeting, San Francisco, CA, November 2009.

15. Krzywanski DM, Moellering DR, Dell ’Italia L, and Ballinger SW. Racial differences in mitochondrial bioenergetics may contribute to endothelial dysfunction and cardiovascular disease susceptibility. Society for Free Radical Biology & Medicine 16th Annual Meeting, San Francisco, CA, November 2009.

16. Krzywanski DM, Westbrook, DG, Moellering DR, Lipsey, C, Dunham, KJ, Schurr, TG, Vita, J, Dell ’Italia L, and Ballinger SW. Variation in mitochondrial function may contribute to racial differences in cardiovascular disease susceptibility. Society for Free Radical Biology & Medicine 17th Annual Meeting, Orlando, FL, November 2010.

17. Fetterman, JL, Westbrook D, Pompilius M, Bailey, SM, and Ballinger SW. Developmental exposure to environmental tobacco smoke increases atherogenesis and alters mitochondrial DNA copy number and proteomics. Society for Free Radical Biology & Medicine 17th Annual Meeting, Orlando, FL, November 2010.

18. Chuang, GC, Postlethwait, EM, and Ballinger, SW. The Effects of Exposure Regimen and Age on Chronic Ozone Exposure Induction of Atherosclerosis, Free Radical Biology and Medicine, 49: S18, 2010.

19. Dunham-Snary, K.J., Westbrook, D.G., Sammy, M.J., Sandel, M.W., Ratcliffe, W., Pat, B., Young, M.E., Ballinger, S.W. The Role of Genetic Background on Mitochondrial Bioenergetics and Energy Balance. 19th Anuual Society for Free Radical Biology and Medicine Meeting, November 14-18, 2012. San Diego, CA. Free Rad. Biol. Med. 53: S94 2012.

20. Bray, A.W., Fetterman J.L., Westbrook D.G., Ballinger S.W. Mitochondrial Haplotype and Economy Influence Individual Susceptibility to Atherosclerosis and Cardiovascular Disease SFRBM 20th Annual Meeting, November 20, 2013. San Antonio, Texas.

21. Dunham-Snary, K.J., Westbrook, D.G., Sammy, M.J., Sandel, M.W., Ratcliffe, W.F., Young, M.E., Ballinger, S.W. The Mitochondrial Genome Influence Body Composition, Energy Balance and Mitochondrial Bioenergetics in Mice. 20th Annual Society for Free Radical Biology and Medicine Meeting, November 20-24, 2013. San Antonio, TX.

22. Dunham-Snary, K.J., Ratcliffe, W., Pat, B., Young, M.E., Ballinger, S.W. Influence of the mitochondrial genome on cardiac function and metabolism. 11th Annual Scientific Sessions of the Society for Heart and Vascular Metabolism, September 29 – October 2, 2013. Cambridge, MD.


24. Liu, W., B.H. Beck, K.S. Vaidya, K.T. Nash, A.R. Diers, K.P. Feeley, A. Landar, S.W. Ballinger, and D.R. Welch. 2013. The KISS1 metastasis suppressor appears to reverse the Warburg effect by enhancing mitochondrial biogenesis. AACR metastasis-inducing and metastasis-suppressive pathways poster session, Washington DC.

25. Feeley, K.P., A.W. Bray, J.L. Fetterman, D.G. Westbrook, L.W. Johnson, R.A. Kesterson, D.R. Welch, and S.W. Ballinger. 2013. Mitochondrial genetics in the


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regulation of tumorigenicity and metastatic potential. AACR Advances in Breast Cancer Research poster session A, San Diego, California.

26. Melissa J Sammy and Scott W Ballinger 2014. Mitochondrial DNA Contributes to the Development of Age Related Insulin Resistance in C57BL/6J and C3H/HeN mice. SFRBM 21st Annual Meeting. Seattle, WA.

27. Bray, A.W., Fetterman J.L., Westbrook D.G., Ballinger S.W. 2014. A Novel Ex Vivo Method for Measuring Vascular Bioenergetics. SFRBM 21st Annual Meeting, Seattle, WA.

28. Bray, A.W., Feeley, K.P., Westbrook, D.G., Hurst, D.R., Ballinger, S.W. 2014. The Role of Mitochondrial Genetic Background in Melanoma Growth. UAB Comprehensive Cancer Center 16th Annual Research Retreat and Research Competition, November 5. Birmingham, AL.

29. Brown JA, Krzywanski DM, Ballinger SW. “Bioenergetic Differences in Humans Having African and Eurasian Maternal Origins.” Bridge to the Doctorate Winter Conference 2015. University of Alabama at Birmingham, Birmingham AL (2015).

30. Bush NC, Kramer PA, Brown JA, Chacko BK, Darley-Usmar VM, Lockhart ME, Ballinger SW, Gower BA. Platelet mitochondrial function as a non-invasive marker for liver fat accumulation in health adults. The Obesity Society’s Annual Meeting. Los Angeles, California (2015).

POSTER EXHIBITS (since 2005): 1. Yang, Z., Young, C., Knight, C.A. Pompilius, M. Postlethwait, E.M., Ballinger,

S.W. Ozone exposure increases cardiovascular mitochondrial damage and atherogenesis in mice. Free Radical Biology & Medicine Austin, TX, 2005.

2. George, S. Yang, Z., Westbrook, D., Ballinger, C.A., Postlethwait, E.M., Ballinger, S.W. Ozone exposure mediates mitochondrial damage in cardiovascular tissues from non-human primates. Free Radical Biology & Medicine Austin, TX, 2005.

3. Westbrook, D., Yang, Z., Pinkerton, K.E., Ballinger, S.W. Prenatal and childhood second-hand smoke exposure causes significant mitochondrial damage in aortic tissues from non-human primates. Free Radical Biology & Medicine Austin, TX, 2005.

4. Cakir, Y., Yang, Z., Pompilius, M., Bailey, S., Pinkerton, K.E., Ballinger, S.W. Combined effects of environmental tobacco smoke and alcohol on cardiovascular disease development and mitochondrial damage. Free Radical Biology & Medicine Austin, TX, 2005.

5. Chuang GC, Yang Z, Pompilius M, Postlethwait EM, and Ballinger SW. Improving the Modeling of Ozone Exposure and Atherosclerosis using Apolipoprotein E-null Mice. UAB Graduate Student Research Day, March 3 2007

6. Chuang, G.C., Yang, Z., Pompilius, M., Postlethwait, E.M., Ballinger, S.W. Cyclic Ozone Exposure Alter Oxidative Markers in Apolipoprotein E-Deficient Murine Model of Atherosclerosis. Society for Free Radical Biology & Medicine 14th Annual Meeting, Denver, CO, November 2007.

7. Harrison, C.M., Knight, C., Pompilius, M., Pinkerton, K., Ballinger, S.W. The Role of Mitochondrial Oxidant Stress in Influencing the Effects of Environmental Factors on CVD Susceptibility. Society for Free Radical Biology & Medicine 14th Annual Meeting, Denver, CO, November 2007.


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8. Chuang GC, Yang Z, Westbrook DG, White CR, Krzywanski DM, Postlethwait EM, and Ballinger SW. Ozone Exposure Induces Endothelial Dysfunction: Oxidative Stress and Nitric Oxide as Potential Mechanisms. 19th Annual Vascular Biology and Hypertension Symposium, Birmingham, AL, September 2008

9. Chuang GC, Yang Z, Westbrook DG, Ballinger CA, White CR, Krzywanski DM, Postlethwait EM, and Ballinger SW. Ozone Exposure Induces Vascular Dysfunction, Cellular Oxidative Stress, and Mitochondrial Damage. Society for Free Radical Biology & Medicine 15th Annual Meeting, Indianapolis, IN, November 2008

10. Harrison CM, Knight CA, Pompilius M, Pinkerton KP, and Ballinger SW. The Role of Mitochondrial Oxidative Stress in Cardiovascular Disease Development. Society for Free Radical Biology & Medicine 15th Annual Meeting, Indianapolis, IN, November 2008.

11. Fetterman, JL, Cruthirds D, Westbrook D, Pompilius M, Ulasova E, Moellering D, White CR, Darley-Usmar V, and Ballinger SW. Mouse strains with differential cardiovascular disease susceptibilities have significantly different measures of mitochondrial function and damage. Society for Free Radical Biology & Medicine 16th Annual Meeting, San Francisco, CA, November 2009.

12. Krzywanski, D.M,, Moellering, D.G., Dell’Italia, L. Ballinger, S.W. Racial differences in mitochondrial bioenergetics may contribute to endothelial dysfunction and cardiovascular disease susceptibility. 20th Annual Vascular Biology and Hypertension Symposium, Birmingham, AL. September 14-15, 2009.

13. Krzywanski DM, Moellering DR, Dell ’Italia L, and Ballinger SW. Racial differences in mitochondrial bioenergetics may contribute to endothelial dysfunction and cardiovascular disease susceptibility. Society for Free Radical Biology & Medicine 16th Annual Meeting, San Francisco, CA, November 2009.

14. Dunham, K.J., Andringa, K.K., Bailey, S.M. Chronic alcohol consumption decreases mitochondrial complex I, IV, and V activities: assessment by clear native gel electrophoresis. UAB Rotation Student Project Presentation, December 11, 2009. Birmingham, AL.

15. Krzywanski, D.M., Westbrook, D.G., Moellering, D.R., Lipsey, C., Dunham, K.J., Schurr, T.G., Vita, J.A., Dell’ Italia, L.J., Ballinger, S.W. Variation in mitochondrial bioenergetics and reactive species production may contribute to racial differences in cardiovascular disease susceptibility. 17th Annual Society for Free Radical Biology and Medicine Annual Meeting, November 17-21, 2010. Orlando, FL. (Free Rad. Biol. Med. 49: S25 2010.)

16. Dunham, K.J., Westbrook, D.G., Krzywanski, D.M., Ballinger, S.W. Analysis of mitochondrial oxygen use and oxidant-induced mtDNA damage in primary cell lines of various haplogroups. UAB Rotation Student Project Presentation, April 16, 2010. Birmingham, AL.

17. Krzywanski DM, Westbrook, DG, Moellering DR, Lipsey, C, Dunham, KJ, Schurr, TG, Vita, J, Dell ’Italia L, and Ballinger SW. Variation in mitochondrial function may contribute to racial differences in cardiovascular disease susceptibility. 21th Annual Vascular Biology and Hypertension Symposium. Birmingham, AL, Sept 13, 2010.

18. Fetterman, JL, Westbrook D, Pompilius M, Bailey, SM, and Ballinger SW. Developmental exposure to environmental tobacco smoke increases atherogenesis and alters mitochondrial DNA copy number and proteomics. Society for Free Radical Biology & Medicine 17th Annual Meeting, Orlando, FL, November 2010.


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19. Chuang, GC, Postlethwait, EM, and Ballinger, SW. The Effects of Exposure Regimen and Age on Chronic Ozone Exposure Induction of Atherosclerosis, Society for Free Radical Biology & Medicine 17th Annual Meeting, Orlando, FL, November 2010.

20. Chuang GC, Postlethwait EM, and Ballinger SW. The effects of exposure regimen and age on chronic ozone exposure induction of atherosclerosis. Society for Free Radical Biology & Medicine 17th Annual Meeting, Orlando, Florida, USA, November 2010.

21. Sammy MJ, Westbrook D, Johnson L, Kesterson R, Ballinger S. Relationship between mitochondrial haplotype and function in murine aortic cells. University of Alabama at Birmingham, Departments of Pathology and Genetics (Presented at American Physiology Society Professional Skills Training Course 2010, Orlando FL; Integrative Biomedical Sciences poster session 2009, Birmingham AL)

22. Sammy MJ, Westbrook DJ, Gavrikova TA, Lewis KM, Johnson LW, Kesterson RA, Messina JL and Ballinger SW. The Role of Mitochondrial Genetic Background in Susceptibility to Type II Diabetes. University of Alabama at Birmingham, Departments of Pathology and Genetics. (Presented at UAB Comprehensive Center for Translational Science Scientific Symposium 2011; Pathology Graduate Student Research Day 2011; Diabetes Research Day 2011; Howard Hughes Med-Grad Retreat 2011, Birmingham AL)

23. Brown JA, Sthanam M, Sammy MJ, Westbrook DG, and Ballinger SW. Assessment of a complex V mutation and metabolic economy between C3H/HeH and C3H/HeN mice. 2011 Annual Biomedical Research Conference for Minority Students, St Louis, MO, November 2011.

24. Brown JA, Sthanam M, Sammy MJ, Westbrook DG, and Ballinger SW. Assessment of a Complex V Mutation between C3H/HeJ and C3H/HeN Mice. (Presented at the Annual Biomedical Research Conference for Minority Students (ABRCMS) 2011, St. Louis MO).

25. Feeley, K.P., J.L. Fetterman, D.G. Westbrook, L.W. Johnson, D.R. Welch, and S.W. Ballinger. 2011. Assessing the impact of mitochondrial background on metastatic susceptibility. Howard Hughes Med-Grad Student Retreat, Birmingham, Alabama.

26. Dunham-Snary, K.J., Fetterman, J.L., Sammy, M.J., Westbrook, D.G., Ballinger, S.W. The role of mitochondrial genetic background on food intake and weight gain in mice. UAB Pathology Graduate Student Research Day. October 21, 2011. Birmingham, AL.

27. Feeley, K.P., A.W. Bray, J.L. Fetterman, D.G. Westbrook, L.W. Johnson, D.R. Welch, and S.W. Ballinger. 2012. The role of mitochondrial genetics in the regulation of metastatic potential. Howard Hughes Med-Grad Student Retreat, Birmingham, Alabama.

28. Sammy MJ, Westbrook DJ, Gavrikova TA, Lewis KM, Messina JL and Ballinger SW. Liver Mitochondrial Function is Altered by Dietary Induced Insulin Resistance in C57BL/6J Mice. University of Alabama at Birmingham, Department of Pathology. (Presented at the Howard Hughes Medical Institute Cluster Meeting at Vanderbilt University 2012, Nashville TN)

29. Feeley, K.P., A.W. Bray, J.L. Fetterman, D.G. Westbrook, L.W. Johnson, D.R. Welch, and S.W. Ballinger. 2012. The role of mitochondrial genetics in the regulation of metastatic potential. UAB Comprehensive Cancer Center Retreat, Birmingham, Alabama.


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30. Feeley, K.P., A.W. Bray, J.L. Fetterman, D.G. Westbrook, L.W. Johnson, D.R. Welch, and S.W. Ballinger. 2012. The role of mitochondrial genetics in the regulation of metastatic potential. UAB Pathology Trainee Research Day, Birmingham, Alabama.

31. Dunham-Snary, K.J., Westbrook, D.G., Sammy, M.J., Ratcliffe, W., Pat, B., Young, M.E., Ballinger, S.W. The Role of Mitochondrial Genetic Background on Caloric Utilization and Mitochondrial Bioenergetics. UAB 2012 GBSO Biennial Research Retreat, September 22, 2012. Birmingham, AL.

32. Dunham-Snary, K.J., Westbrook, D.G., Sammy, M.J., Sandel, M.W., Ratcliffe, W., Pat, B., Young, M.E., Ballinger, S.W. The Role of Genetic Background on Mitochondrial Bioenergetics and Energy Balance. 19th Anuual Society for Free Radical Biology and Medicine Meeting, November 14-18, 2012. San Diego, CA.

33. Bray, A.W., Feeley, K.P., Westbrook, D.G., Hurst, D.R., Ballinger, S.W. The role of mitochondrial haplotype in B16F1 melanoma growth. UAB Medical Student Research Day, Birmingham, Alabama, October 30, 2012.

34. Feeley, K.P., Bray, A.W.. Fetterman, J.L. Westbrook, D.G Johnson, L.W. Welch, D.R. and Ballinger, S.W. 2012. The role of mitochondrial genetics in the regulation of metastatic potential. UAB Comprehensive Cancer Center Retreat, Birmingham, Alabama, October 29, 2012.

35. Brown, J., Sthanam, M., Sammy, M. J., Westbrook, D.G. and Ballinger, S.W. Assessment of a Complex V Mutation and Metabolic Economy between C3H/HeJ and C3H/HeN Mice. UAB Graduate Student Research Day, February 22, 2012.

36. Brown, J., Dunham-Snary, K.J., Westbrook, D.G., Ballinger, S.W. Assessment of Mitochondrial Fusion and Fission Protein Expression in C3H/HeN and C57BL/6J Mice. GBS Summer Poster Session, August 15, 2012.

37. Sammy, M.J, Westbrook, D.J., Gavrikova, T.A., Lewis, K.M., Messina, J.L. and Ballinger S.W. Liver Mitochondrial Function is Altered by Dietary Induced Insulin Resistance in C57BL/6J Mice. Howard Hughes Medical Institute Cluster Meeting. Vanderbilt University. June 2012.

38. Sammy, M.J., Westbrook, D.J., Gavrikova, T.A., Lewis, K.M., Messina, J.L. and Ballinger, S.W. Replacing the Mitochondrial of C57BL/6J Mice with C3H/HeN Mitochondria Improves Insulin Sensitivity on High Fat Diet. Pathology Trainee Research Day. University of Alabama at Birmingham. October 2012

39. Bray, A.W., Feeley, K.P., Westbrook, D.G., Hurst, D.R., Ballinger, S.W. The Role of Mitochondrial Genetic Background in Melanoma Growth. Dale J. Benos Medical Student Research Day, October 30, 2012. Birmingham, AL.

40. Bray, A.W., Feeley, K.P., Westbrook, D.G., Hurst, D.R., Ballinger, S.W. The Role of Mitochondrial Genetic Background in Melanoma Growth. UAB Comprehensive Cancer Center 15th Annual Research Retreat and Research Competition, October 29, 2012. Birmingham, AL.

41. Brown JA, Dunham-Snary K, Westbrook DG, and Ballinger SW. Assessment of Mitochondrial Fusion and Fission Protein Expression in C3H/HeN and C57BL/6J Mice. University of Alabama at Birmingham, Department of Pathology and GBS Graduate Training Program (Graduate Biomedical Sciences poster session 2012, Birmingham, AL)


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42. Dunham-Snary, K.J., Westbrook, D.G., Sammy, M.J., Ratcliffe, W., Pat, B., Young, M.E., Ballinger, S.W. The Role of Genetic Background on Mitochondrial Bioenergetics and Energy Balance. 19th Annual Society for Free Radical Biology and Medicine Meeting, November 14-18, 2012. San Diego, CA. (Free Rad. Biol. Med. 53: S94 2012.)

43. Dunham-Snary, K.J., Westbrook, D.G., Sammy, M.J., Ratcliffe, W., Pat, B., Young, M.E., Ballinger, S.W. The Role of Mitochondrial Genetic Background on Caloric Utilization and Mitochondrial Bioenergetics. UAB 2012 Pathology Trainee Research Day, October 26, 2012. Birmingham, AL.

44. Dunham-Snary, K.J., Westbrook, D.G., Sammy, M.J., Ratcliffe, W., Pat, B., Young, M.E., Ballinger, S.W. The Role of Mitochondrial Genetic Background on Caloric Utilization and Mitochondrial Bioenergetics. UAB 2012 GBSO Biennial Research Retreat, September 22, 2012. Birmingham, AL.


46. Bray, A.W., Feeley, K.P., Westbrook, D.G., Hurst, D.R., Ballinger, S.W. The Role of Mitochondrial Genetic Background in Melanoma Growth. UAB Comprehensive Cancer Center 16th Annual Research Retreat and Research Competition, November 5, 2013. Birmingham, AL.

47. Bray, A.W., Feeley, K.P., Westbrook, D.G., Hurst, D.R., Ballinger, S.W. The Role of Mitochondrial Genetic Background in Melanoma Growth. Dale J. Benos Medical Student Research Day, October 29, 2013. Birmingham, AL.

48. Bray, A.W., Feeley, K.P., Westbrook, D.G., Hurst, D.R., Ballinger, S.W. The Role of Mitochondrial Genetic Background in Melanoma Growth. Southeastern Medical Scientist Symposium 2013, October 26, 2013. Birmingham, AL.

49. Bray, A.W., Fetterman J.L., Westbrook D.G., Ballinger S.W. Mitochondrial Haplotype and Economy Influence Individual Susceptibility to Atherosclerosis and Cardiovascular Disease. Comprehensive Cardiovascular Center 2nd Annual Symposium, October 25, 2013. Birmingham, AL.

50. Bray, A.W., Fetterman J.L., Westbrook D.G., Ballinger S.W. Mitochondrial Haplotype and Economy Influence Individual Susceptibility to Atherosclerosis and Cardiovascular Disease. 4th Annual Vascular Biology & Hypertension Symposium, September 23, 2013. Birmingham, AL.

51. Liu, W., B.H. Beck, K.S. Vaidya, K.T. Nash, A.R. Diers, K.P. Feeley, A. Landar, S.W. Ballinger, and D.R. Welch. 2013. The KISS1 metastasis suppressor appears to reverse the Warburg effect by enhancing mitochondrial biogenesis. AACR metastasis-inducing and metastasis-suppressive pathways poster session, Washington DC.

52. Feeley, K.P., A.W. Bray, J.L. Fetterman, D.G. Westbrook, L.W. Johnson, R.A. Kesterson, D.R. Welch, and S.W. Ballinger. 2013. Mitochondrial genetics in the regulation of tumorigenicity and metastatic potential. AACR Advances in Breast Cancer Research poster session A, San Diego, California.

53. Dunham-Snary, K.J., Ratcliffe, W., Pat, B., Young, M.E., Ballinger, S.W. Influence of the mitochondrial genome on cardiac function, metabolism and ischemia/reperfusion tolerance. 2nd Annual UAB Comprehensive Cardiovascular Center Symposium, October 25 - 26, 2013. Hoover, AL.


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54. Dunham-Snary, K.J., Westbrook, D.G., Sammy, M.J., Sandel, M.W., Ratcliffe, W., Young, M.E. Ballinger, S.W. The Role of Mitochondrial Genetic Background on Body Composition and Energy Balance. UAB 2013 Pathology Trainee Research Day, October 18, 2013. Birmingham, AL.

55. Dunham-Snary, K.J., Ratcliffe, W., Pat, B., Young, M.E., Ballinger, S.W. Influence of the mitochondrial genome on cardiac function and metabolism. 11th Annual Scientific Sessions of the Society for Heart & Vascular Metabolism, September 29 – October 2, 2013. Cambridge, MD.

56. Dunham-Snary, K.J., Westbrook, D.G., Sammy, M.J., Sandel, M.W., Ratcliffe, W., Young, M.E. Ballinger, S.W. The Role of Mitochondrial Genetic Background on Body Composition and Energy Balance. 4th Annual UAB Diabetes Research Day, May 7, 2013. Birmingham, AL.

57. Sammy MJ, Dunham-Snary KJ, Brown JA, Gavrikova TA, Johnson LW, Kesterson RA, Messina JL and Ballinger SW. Mitochondrial Genetic Background Influences Susceptibility to Insulin Resistance in C57BL/6J Mice. Departments of Cell and Molecular Pathology and Genetics. University of Alabama at Birmingham. (Presented at UAB’s Diabetes Research Day 2013, Birmingham AL)

58. Melissa J Sammy and Scott W Ballinger 2014. Mitochondrial DNA Contributes to the Development of Age Related Insulin Resistance in C57BL/6J and C3H/HeN mice. SFRBM 21st Annual Meeting. Seattle, WA.

59. Bray, A.W., Fetterman J.L., Westbrook D.G., Ballinger S.W. 2014. A Novel Ex Vivo Method for Measuring Vascular Bioenergetics. SFRBM 21st Annual Meeting, Seattle, WA.

60. Bray, A.W., Feeley, K.P., Westbrook, D.G., Hurst, D.R., Ballinger, S.W. 2014. The Role of Mitochondrial Genetic Background in Melanoma Growth. UAB Comprehensive Cancer Center 16th Annual Research Retreat and Research Competition, November 5. Birmingham, AL.

61. Brown JA, Krzywanski DM, Ballinger SW. “Bioenergetic Differences in Humans Having African and Eurasian Maternal Origins.” Bridge to the Doctorate Winter Conference 2015. University of Alabama at Birmingham, Birmingham AL (2015).

62. Bush NC, Kramer PA, Brown JA, Chacko BK, Darley-Usmar VM, Lockhart ME, Ballinger SW, Gower BA. Platelet mitochondrial function as a non-invasive marker for liver fat accumulation in health adults. The Obesity Society’s Annual Meeting. Los Angeles, California (2015).

63. Mitochondrial DNA Sequence Contributes to Obesity in a Mouse Model. Sammy MJ and Ballinger SW. Department of Pathology, Division of Molecular and Cellular Pathology. University of Alabama at Birmingham. (Presented at the 26th Annual Vascular Biology and Hypertension Symposium and the Comprehensive Cardiovascular Center 4th Annual Symposium 2015, Birmingham AL)

64. . Evaluating Glucose Metabolism in C57BL6/J and C3H/HeN Mice: Implications for Interpretation of Glucose and Insulin Tolerance Data. Sammy MJ and Ballinger SW. Department of Pathology, Division of Molecular and Cellular Pathology. University of Alabama at Birmingham. (Presented at the 5th Annual Diabetes Research Day 2014, Birmingham AL)


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ORAL PRESENTATIONS (Invited): International Meetings: Ballinger, S.W. Assessment of Oxidative Stress. International Symposium on Coronary

Thrombosis and Atherosclerosis: Update in Theories, Trials, and Treatment, Galveston, TX, May 5 (1999).

Ballinger, S.W. Cigarette smoke exposure and cardiovascular mitochondrial damage: A potential mechanism for cardiovascular disease development. 1st International Symposium on Tobacco and Health, Shanghai, China. (June 8-9, 2006).

Ballinger, S.W. Developmental exposure to cigarette smoke influences individual susceptibility to CVD. PMERP Symposium, Chantilly, VA (December 10, 2007).

Ballinger, S.W. Mitochondrial damage associated with increased atherogenesis. 2008 AAAS Annual Meeting, Boston, MA Invited Symposium Lecture: Air Pollution and Atherosclerosis (February 18, 2008).

Ballinger, S.W. Methods for detecting mitochondrial DNA damage. Sunrise Symposium, Society for Free Radical Biology & Medicine, San Francisco, CA (November 20, 2009).

Ballinger, S.W. Mitochondria and vascular function. Invited Symposium Lecture: 9th Annual Meeting of the Society for Heart and Vascular Metabolism (SHVM), Brussels, Belgium (June 18-22, 2011).

Ballinger, S.W. The Mitochondrial Paradigm in Contemporary Disease Development. Invited Symposium Lecture: 16th Biochemical Society/Society for Free Radical Research International “Translating the Powerhouse: Redox Signaling”. Imperial College, London, UK (September 6-9, 2012).

Ballinger, S.W. Concepts of Mitochondrial Quality. Invited Symposium Lecture: 19th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM), Pre-Meeting Workshop I, San Diego, CA (November 14, 2012).

Ballinger, S.W. Mitochondrial – Nuclear Genetics, 2018 Gordon Research Conference on “Oxygen Radicals”, Ventura, CA, USA (February 4-9th 2018).

National Meetings: Ballinger, S.W. Peroxynitrite mediates mitochondrial DNA damage and dysfunction in vitro. American Heart Association, Dallas, TX November 15 (1998). Ballinger, S.W. Mitochondrial DNA is preferentially damaged in aorta from apoE mice. American Heart Association, New Orleans, LA November 13 (1999). Ballinger, S.W. Mitochondrial damage and dysfunction: A potential etiological

paradigm for cardiovascular disease. National Institutes of Environmental Health Sciences Symposium, "Pollutants and Heart Disease", Louisville, KY, Oct 16-17 (2004).

Ballinger, S.W. The impact of prenatal ETS exposure in adult cardiovascular disease development. Update on Mechanisms for Environmental Tobacco Smoke-Induced Health Effects (Symposium), Society of Toxicology, New Orleans, Louisiana, March 6-10 (2005).

Ballinger, S.W. Environmental oxidant exposure causes mitochondrial damage associated with increased atherogenesis. 46th Annual Meeting of the Society of Toxicology, Charlotte, NC Invited Symposium Lecture; Air pollution and atherosclerosis: impact of inhaled agents on vascular remodeling,


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dyslypidemia, and oxidative stress (March 27, 2007). Ballinger, S.W. Mitochondrial damage associated with increased atherogenesis. 2008

AAAS Annual Meeting, Boston, MA Invited Symposium Lecture: Air Pollution and Atherosclerosis (February 18, 2008).

Ballinger, S.W. Mitochondrial damage and dysfunction as a mechanism for environmentally mediated cardiovascular disease (Platform lecture). NIEHS-EPA Symposium: Air Pollution and Cardiovascular Disease. Seattle, WA (June 21, 2010).

Ballinger, S.W. Aging and Atherosclerosis – Mitochondria. ACCME accredited course, “Enhanced Risk of Cardiovascular Disease in Patients with Autoimmune Disorders”. Columbia University, New York, NY (December 7-8, 2012).

Ballinger, S.W. Concepts of Mitochondrial Quality. 19th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM), Pre-Meeting Workshop I, San Diego, CA (November 2012). Ballinger, S.W. Evolutionary Selection and Mitochondrial Genetics: Implications on Cardiovascular Disease Susceptibility. American Society for Pharmacology and Experimental Therapeutics, Experimental Biology 2014, San Diego, CA (April, 2014). Ballinger, S.W. Mitochondrial – Nuclear Crosstalk and Disease: Mito-Mendelian Genetics. American Physiologic Society 2015, Tampa, FL (September 2015). Ballinger, S.W. Mitochondrial Nuclear eXchange (MNX) Models and Mito-Mendelian Genetics:

Relevance to Disease. North Slope Bourough (NSB) of Alaska Bowhead Genomics Workshop, the Battelle Memorial Institute,

Columbus, OH (October 2015). Ballinger, S.W., Mito-Mendelian Genetics and Cardiometabolic Disease Susceptiblity.

Mitochondrial Symposium, Cedars-Sinai Heart Institute, Los Angeles, CA (May 2016) Ballinger, S.W. Energy School: The role of mtDNA in bioenergetics and cross talk with the nuclear genome. Physiological Bioenergetics—Mitochondria from Bench to Bedside, American Physiologic Society 2017, San Diego, CA (August 27-30, 2017). Local and regional meetings: Ballinger, S.W. Mitochondrial genes and neuromuscular disease. Invitational seminar for the

Pymatuning Meetings (Pennsylvania State, University of Pittsburgh, and Rutgers University), Pymatuning Laboratory of Ecology, PA, August 23-25 (1991).

Ballinger, S.W. Mitochondrial DNA mutations and OXPHOS disease. National Institute of Aging, Baltimore, MD, February 1 (1993).

Ballinger, S.W. Maternally transmitted DM and deafness. 13th annual Canadian-New York-New England Clinical Genetics Conference, Burlington, VT, May 25-26 (1995).

Ballinger, S.W. Mitochondrial Integrity and Function in Atherogenesis. Toxicology Training Program Mini-Symposium: Molecular Mechanisms of Cardiovascular Injury, University of Texas Medical Branch, Galveston, TX, September 6 (2000).

Ballinger, S.W. Methods for Assessing Oxidant Injury. Toxicology Training Program Mini- Symposium: Molecular Mechanisms of Cardiovascular Injury, University of Texas Medical Branch, Galveston, TX, September 6 (2000). Ballinger, S.W. Genetic Models of Atherosclerosis; Measuring Lesion Development

and Mitochondrial Damage. A Workshop on molecular approaches and techniques in cardiovascular research, Training program in cardiovascular pathophysiology,


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the center for free radical biology, University of Alabama at Birmingham, Birmingham, AL January 21 (2003).

Ballinger, S.W. Impact of Cardiovascular Disease Risk Factors on Mitochondrial Damage, Function, and Atherogenesis. 12th Southeastern Lipid Research Conference. Callaway Gardens, Pine Mountain, Georgia, September 20 (2003). Ballinger, S.W. Cardiovascular Disease: What’s your risk? American Heart

Association, Birmingham Heart Guild, Birmingham, AL (September 19, 2007). Ballinger, S.W. Mitochondria and Cardiovascular Disease Susceptibility. 20th Annual

Vascular Biology and Hypertension Symposium. Birmingham, AL (Sept 14, 2009) Ballinger, S.W. Mitochondrial – nuclear interaction as a determinant for cardiovascular

disease susceptibility. 21th Annual Vascular Biology and Hypertension Symposium. Birmingham, AL (September 13, 2010)

Ballinger, S.W. Mitochondrial Function and Prehistoric Selection. Sigma Xi Scientific Research Society. Birmingham, AL (September 21, 2010)

Ballinger, S.W. Selection for Mitochondrial Function and Prehistoric Adaptation: Impact on Contemporary Disease Susceptibility? Birmingham Archaeological Society, Natural History Department, McWane Science Center, Birmingham, AL (December 14, 2010).

Ballinger, S.W. The role of mitochondrial genetic background in susceptibility to type II diabetes. UAB Diabetes Research Day, UAB Comprehensive Diabetes Center, Birmingham, AL (May 10, 2011).

Ballinger, S.W. Mitochondrial Genetics and Disease Susceptibility, 7th Annual Genetics Scientific Retreat, University of Alabama Department of Genetics and Hudson Alpha Institute for Biotechnology, Huntsville, AL (October 26, 2012).

Ballinger, S.W. Mitochondrial DNA, BioTeach (CB-500), McWane Science Center, Birmingham, AL (June 8, 2016).

Ballinger, S.W. Mitochondrial DNA, BioTeach (CB-500), McWane Science Center, Birmingham, AL (June 15, 2017).

Universities: Ballinger, S.W. Mitochondrial DNA mutations and OXPHOS disease. Environmental

Toxicology seminar series, Massachusetts Institute of Technology, Boston, MA, February 11 (1993).

Ballinger, S.W. Mitochondrial genes and OXPHOS disease. Environmental Pathology seminar series, University of Vermont, Burlington, VT, October 24-25 (1994).

Ballinger, S.W. OXPHOS disease and mutation. Graduate faculty of genetics seminar series. Texas A&M University, College Station, TX, April 27 (1995).

Ballinger, S.W. Cigarette smoking mediates mitochondrial DNA damage. Sealy Center for Molecular Science Seminar Series, The University of Texas Medical Branch, Galveston, TX, August 3 (1996).

Ballinger, S.W. Mitochondrial DNA damage and chronic disease. Department of Toxicology Grand Rounds. The University of Texas Medical Branch,Galveston, TX, October (1997).

Ballinger, S.W. The Role of Reactive Oxygen Species in Mitochondrial DNA Damage and Atherosclerosis. Department of Internal Medicine. The University of Texas Medical

Branch,Galveston, TX, April 15 (1998).


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Ballinger, S.W. Atherosclerotic lesion development and mitochondrial damage in a mouse model for atherosclerosis. Department of Internal Medicine Grand Rounds, University of Texas Medical Branch, Galveston, TX, November 19 (1999).

Ballinger, S.W. Mitochondrial DNA damage associated with risk factors for cardiovascular disease. Department of Veterinary Sciences Seminar Series, Texas A&M University, College Station, TX, March 12 (1999).

Ballinger, S.W. Atherosclerotic lesion development and mitochondrial damage in a mouse model for atherosclerosis: The effects of ETS and hypercholesterolemia. NIEHS Seminar Series, University of Texas Medical Branch, Galveston, TX, December 8 (1999).

Ballinger, S.W. Risk Factors for Cardiovascular Disease, Mitochondrial Damage, and Atherosclerosis. Texas A&M University, College Station, TX, October 2 (2000). Ballinger, S.W. Mitochondrial damage in cardiovascular disease. Department of Molecular

Medicine and Genetics, Wayne State, Detroit, MI, October 26 (2000). Ballinger, S.W. Mitochondrial damage and function in atherogenesis. Department of Internal

Medicine, University of Texas Medical Branch, Galveston, TX April 20 (2001). Ballinger, S.W. The effects of pro- and anti-atherogenic factors upon mitochondria,

Department of Pharmacology, University of Texas Medical Branch, Galveston, TX April 27 (2001).

Ballinger, S.W. Cardiovascular disease risk factors and mitochondrial damage. Columbia University, Department of Biochemistry (Invited by graduate students), New York, New York, April 30 (2001).

Ballinger, S.W. Cardiovascular disease risk factors and mitochondrial damage. Louisiana State University, Department of Veterinary Sciences seminar series, Baton Rouge, LA, May (2001).

Ballinger, S.W. The effects of environmental tobacco smoke exposure on mitochondrial damage and function in cardiovascular disease. Vascular Biology/Hypertension Program Seminar Series, The University of Alabama at Birmingham, April 30, (2004).

Ballinger, S.W. The impact of adult and prenatal environmental exposures in adult cardiovascular disease development. Louisana State University, Baton Rouge, Louisiana, April 7, (2005).

Ballinger, S.W. Mitochondrial Mutation, Damage and Dysfunction: A Factor in Disease Development. Department of Preventative Medicine and Community Health, University of Texas Medical Branch, Galveston, TX, October 27, (2005) Invited by graduate students.

Ballinger, S.W. The Mitochondrion and Disease: The Canary in the Coal Mine? Advances in Molecular and Cellular Pathology, Birmingham, AL. January 5 (2006).

Ballinger, S.W. Mitochondrial Damage in Vascular Dysfunction an Atherosclerosis Advances in Molecular and Cellular Pathology, Birmingham, AL. October 26 (2006). Ballinger, S.W. The role of the mitochondrion in cardiovascular disease development.

LSU Health Science Center Seminar Series, New Orleans, LA (December 4, 2007) Invited by graduate students.

Ballinger, S.W. The potential role of the mitochondrion in cardiovascular disease and the evolution of disease susceptibility. UAB Hypertension Seminar Series, Birmingham, AL. (December 14, 2007).


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Ballinger, S.W. Mitochondrial Paradigms for Disease Susceptibility and Development. Nephrology Research Training Center Seminar Series, University of Alabama at Birmingham, AL (Dec 14, 2009).

Ballinger, S.W. The mitochondrial paradigm for disease development. Molecular and Cellular Pathology Seminar Series, University of Alabama at Birmingham, AL (Jan 28, 2010)

Ballinger, S.W. Mitochondrial function and damage as a major risk factor for individual susceptibility for disease development. Nutrition Obesity Research Center Seminar Series, University of Alabama at Birmingham, AL (February 16, 2010).

Ballinger, S.W. The role of mitochondrial function in the development of cardiovascular disease. Visiting Lecture Series: Boston University, Whitaker Cardiovascular Institute, Boston, MA (March 23, 2010).

Ballinger, S.W. The mitochondrial paradigm for disease susceptibility: Prehistoric events influencing contemporary disease risk. Dean’s Distinguished Scientist Seminar Series, University of South Alabama, Mobile, AL (April 22, 2010) Invited by graduate students..

Ballinger, S.W. Mitochondrial function and damage as a major risk factor for individual susceptibility for disease development. Center for Research on Occupational and Environmental Toxicology Seminar Series, Oregon Health & Science University, Portland, OR. (June 7, 2010).

Ballinger, S.W. and Messina, J.L. Role of Mitochondrial Genetic Background in the Development of Insulin Resistance. Diabetes Research Training Center Pilot Presentation Seminars, Birmingham, AL (November 18, 2010).

Ballinger, S.W. The role of the mitochondrion in cardiovascular disease susceptibility. Cardiology Grand Rounds, University of Alabama at Birmingham, Birmingham, AL (August 31, 2011).

Ballinger, S.W. The role of the mitochondrion in cardiovascular disease susceptibility. Pulmonary Medicine, University of Alabama at Birmingham, Birmingham, AL (December 2, 2011).

Ballinger, S.W. Mitochondrial haplotype influences cardiovascular disease development and cell function. Cell Biology Seminar Series, Lousiana State University, Baton Rouge (September 6, 2011).

Ballinger, S.W. Mitochondrial influence of common disease development. Center for Molecular Medicine and Genetics Seminar Series, Wayne State University, Detriot, MI (February 23, 2012) Invited by graduate students.

Ballinger, S.W. The role of mitochondrial genetic background in disease susceptibility. Cleveland Clinic Pathobiology Seminar Series, Lerner Research Institute, Cleveland, OH (October 16, 2012) Invited by graduate students.

Ballinger, S.W. The influence of mitochondrial damage and oxidative stress upon cardiovascular disease development mediated by environmental oxidants. Department of Toxicology Seminar Series, Duke University, Chapel Hill, NC (March 22, 2013).

Ballinger, S.W. The Mitochondrial Nuclear eXchange (MNX) Animal Model: Potential Implications in Medicine and Agriculture. Department of Animal Sciences and College of Veterinary Medicine, Auburn University, AL (August 17, 2015).

Ballinger, S.W. The role of Mito-Mendelian genetics in determining disease susceptibility


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University of Alabama at Birmingham Vascular Biology & Hypertension Seminar, Birmingham, AL (April 22, 2016).

Ballinger, S.W. Mito-Mendelian genetics as the basis for determining metabolic response to cardiovascular disease risk factors. National Institute of Environmental Health Sciences, Research Triangle, NC (May 11, 2016).

Ballinger, S.W. Nuclear – mitochondrial genetic interaction as the basis for common disease risk. Cardiovascular Research Institute Feature Lecturer, Moorehouse School of Medicine, Atlanta, GA (September 8, 2016).

Ballinger, S.W. Mito-Mendelian Genetics: Effects in modulating disease penetrance and risk. School of Veterinary Medicine Seminar Series, Louisiana State University, Baton Rouge, LA (February 16, 2017) Invited by graduate students.

Ballinger, S.W. Nuclear – mitochondrial genetic interaction as Mito-Mendelian Genetics: Its role in influencing disease risk and gene expression. Physiology Seminar Series, Department of Physiology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK (March 23, 2017).

Ballinger, S.W. Nuclear – mitochondrial interaction as the underlying mechanism for determining individual response to disease risk factors. University of Kentucky, Lexington, KY (November, 2017).

Ballinger, S.W. Nuclear – mitochondrial genetic interaction on disease risk and metabolism. East Carolina University (January 18, 2018)

university of alabama at birmingham school of …€¦ · 1994-1996 alexander hollaender...

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