Update Arg-ADNIGustavo E. Sevlever , Ricardo F. Allegri (*),

Silvia Vázquez, Deborah R. Gustafson, Salvador M. Guinjoan, and Arg-ADNI group.

Memory and Aging Center

Institute for Neurological Research Buenos Aires, Argentina

Washington D.C., July 17, 2015*speaker

www.fleni.org.ar/alzheimer

Institute for Neurological Research

Institute for Neurological RehabilitationCenter for Molecular Imaging

Memory and Aging CenterInstitute for Neurological Research

FLENIBuenos Aires

Argentina

• Update arg-ADNI

• Preliminary Results

• Future Tasks

Update of Argentine ADNI

(*) Stream Chair

Management CommitteeAllegri RF, Sevlever G, Guinjoan S, Gustafson D, Vazquez S.

Clinical Stream

Cognitive Neurologists Ricardo F. Allegri (*)

Patricio Chrem MendezMaria Julieta Russo

Jorge Campos

Psychiatrists Salvador Guinjoan

Neuropsychologists María Eugenia Martín

Florencia Clarens Paula Harris

Neuroimaging Stream

Silvia Vazquez S (*) Esteban ObenausGerman Falasco

Leandro Urrutia

Fernando Ventrice

Laboratory Stream

Gustavo Sevlever (*) Horacio Martinetto

Ezequiel Surace

Miguel Riudavetz

Epidemiological Stream

Deb Gustafson (*)

Study CoordinatorPatricio Chrem Mendez

SecretaryNoelia Egido

Data EntryFederico Nahas

Arg-ADNIStaff

First patient / first visitQ1 2012

Last patient / last visitQ1 2013

First Year2013 / 2014

Arg-ADNIStudy Timeline

Month 302014 / 2015

Month 482015 / 2016

B

1

B

2,5

4 year

Arg-ADNIPatients’ Flowchart

Patients Screened at FLENINº= 60

Early MCINº=12

Healthy ControlsNº= 15

Late MCINº= 16

Dementia AD

Nº=13

Screening FailureNº= 7

Patients Screened to ADNINº= 108

2 Claustrophobia1 Psychiatric Disease 1 Cancer1 Adult ADHD2 without informant

Patients Followed (Baseline)

Nº= 56

DropoutNº= 3

2 removed inform.cons1 by distance/caregiver

Early MCINº=10

Healthy ControlsNº= 13

Late MCINº= 16

Dementia AD

Nº=12

Early MCINº=?

Healthy Controls

Nº= ?

Late MCINº= ?

Dementia AD

Nº=?

Patients Followed Month 12

Nº= 51

Patients Followed Month 48

Nº= ?

New Patients Invited to ADNI

Nº= 6

Early MCINº=1/10

Healthy ControlsNº= 7/13

Late MCINº= 7/16

Dementia AD

Nº=4/12

Patients Followed Month 30Nº= 19/51

DropoutNº= 5

2 removed inform.cons2 Cancer1 Institutionalized

12 30 months months

• Normal Control (nº=13) did not progress

• Early MCI (nº=10) 1 progressed (10%)

• Late MCI (nº=16) 4 progressed (25%)

Arg-ADNIFollow up

Rate of Progression

Screening / Baseline

%compl.

Month12

Month30

Month 48

Demographic data (+) 100% (+) (+) (+)

Clinical, NPS, NPSq (+) 100% (+) (+) (+)

Cognitive Reserve (MCI) (+) MCI

Blood (+) (+)

APOE (+) 100%

CSF AB42/Tau (+) 71% (+)

MRI (3T) (+) 100% (+) (+) (+)

FDG PET Scan (+) 100% (+)

PiB PET scan (+) 91% (+)

Tau PET scan (AVID) (+)

Arg-ADNISchedule of evaluations.

• Update arg-ADNI

• Preliminary Results

• Future Tasks

Update of Argentine ADNI

Brain 18FDG PET scan

Uptake Map

Hypometabolism Map

Brain 11C-PiB PET scan

Healthy

AD

AD

Arg-ADNI11C – PIB - PET imaging

Arg-ADNICognitive Reserve and Aβ-42 (CSF) in MCI patients

Paula Harris, Marcos Fernandez Suarez, Ezequiel Surace. et al., 2015(in press in Neurospcyhiatric Disease and Treatment)

Group 1 (Cut off <

532,5)

Group 2

(Cut off

532,5)

p

Nº 14 18 --

Age 70,5 (8,4) 65,6 (7,9) ns

Education 12,9 (4,3) 14,5 (3,8) ns

MMSE 28,5 (1,5) 28,5 (0,8) ns

CRQ 13,3 (5,5) 17,2 (2,9) p<0,0

5

TAP-BA 37 (9,9) 42,69

(6,2)

ns

CSF

Aβ1-42426,0

(87,0)

959,0

(251,0)

<0,00

1

TAU-T 501,3

(260,8)

200,6

(85,5)

<0,00

1

P-TAU 75,2

(45,8)

38,9

(16,2)

<0,05

Alz-profile 2,6 (7,8) 2,0 (0,6) ns

Correlation between Cognitive Reserve Questionnaire and A 1-42 level

CRQ: Cognitive Reserve Questionnaire (Rami et al., 2011)

Arg-ADNIFree Recall and Recognition in MCI patients

with amyloid (+) vs amyloid (-)MFlorencia Clarens, María E Martin; Fernanda. Tapajoz et al., 2015

Amyloid (-)

Amyloid(+)

p

Nº 11 12

Age 71.7 (6.7) 72.6 (6.3) ns

Education 13.9 (3.8) 12.5 (3.9) ns

MMSE 28.6 (1.1) 27.5 (2.5) ns

NPI 33.3 (12.2) 30.8 (12.5) ns

Test Result Variable(s) AreaStd.

Error(a)Asymptotic

Sig.(b)RAVLT total ,667 ,121 ,187

30 Minute Delay Total ,767 ,111 ,035

Recognition Score ,838 ,086 ,008

hipocampo izq ,525 ,128 ,843

hipocampo der ,550 ,127 ,692

Demographic data

Arg-ADNIFLENI Brain Bank

• Update arg-ADNI

• Preliminary Results

• Future Tasks

Update of Argentine ADNI

Tau tracer (PETscan) in ADNI Cohort

• AVID (AV 1451)

• Start-up: April 2016

Future TasksMonth

48

(+)

(+)

(+)

(+)

(+)

(+)

(+)

(+)

ADNI cohort (51ptes)

Demographic data

Clinical, NPS, NPSq

Cognitive Reserve (MCI)

Blood

APOE

CSF AB42/Tau

MRI (3T)

FDG PET Scan

PiB PET scan

Tau PET scan (AVID)

Arg-DIAN (Dominantly Inherited Alzheimer Network)

• National grant application (CONICET) • to study an Argentine DIAN cohort of 40 participant.

• Start-up: August, 2015 (Prof. J.Morris / Buenos Aires)

Future Tasks

AD Biomarkers in Down Syndrome

• PI: Dr. Ezequiel Surace

• National grant application (CONICET) April 2015• to study an Argentine cohort of 10 participant.

• Start-up May 2016

Future Tasks

Memory and Aging Center

Update Arg-ADNI

Memory and Aging Center

Institute for Neurological Research Buenos Aires, Argentina

Washington D.C., July 17, 2015