Update: Bio-economy Strategy

Presentation to the Portfolio Committee 27 May 2015

Outline

•The Bio-economy StrategyDefinition; Systems approach; Metrics;Opportunity; Challenges; & Governance

•Actions and activities:AgricultureHealth InnovationIndustry & EnvironmentIKS-based Technology Innovation

Defining the Bio-economy

Refers to activities that make use of bio-innovations, based on biological sources, materials and processes to generate sustainable economic social and environmental development.

In consultation with relevant stakeholders, the DST “has identified 3 key economic sectors – agriculture, health and industry – as being the most in need of, and likely to benefit from key levers to drive the implementation of the [strategy]”

Agriculture

Industry & Environment

Health

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So what is new in the Bio-economy strategy?

Opportunistic

(a) Coordinated, specific(b) Focused Value Chain (c) System enablers

PPPs eg Biovac

Small companies, eg Resyn, Kappa, Xsit, Inqaba, etc

Private sector not-for-profit

Aeras, Aurum, MMV, EDCTP MBI

Research Institutes

Bio-economy

Science Councils

Platforms & service providers

Universities

R,D & I

ICGEB

Gates Rockerfeller, Foundations

DST

DoH DTI

Government Departments

DEA

DAFF

DRDLR

Provincial

Funding Bodies

MRC

NRF

IDC -VCs

TIA

ARC

CSIR

SAPPI/Mondi; Winter Cereals Trust; SMRI; Novartis; Pfizer; DRI;PATH; L’Oreal; Afriplex;

Nestle

Pharmaceutical; Agricultural; Industrial

Communities; NGO’s; interface with science and business

Private sectorPUBLIC

PUB Prog

BiosafetySA Prograrmme

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• Coordination: awareness, national objectives, teamwork and cooperation/collaboration

• Strategic programmes to provide emphasis in priority areas

• System support initiatives (HCD, service platforms, IP management, entrepreneur training, pilot scale facilities; Clinical trialing resources, etc)

Coordinating committees

National use of MRC, ARC, CSIR expertise

SYSTEMS APPROACH

Techno-feasibility assessments6

Opportunity of Bio-innovation

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√

√

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•In 2014 South Africa’s GDP was R3,8 trillion. •Top 7 DST investee biotech co’s R1 billion turnover. •Need to benchmark current bio-economy (NACI) •US & European bio-economies target 5-6% GDP by 2030•If SA to reach that, it would form approx R190 billion (today’s terms)

.

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Challenges of Bio-innovation

•Most highly regulated scientific field(s) of endeavour.

•Most diversified applications (agric, health, manufacturing, energy, environment, etc). High level coordination is required.

•Applications for existing industry AND new industry•Rapidly developing fields (knowledge, equipment,

applications).•Some controversy (GE, stem cells & cloning).•The days of single blockbusters are gone. Need for

sophistication, contextualisation, personalisation and precision.

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Measuring the Bio-economy

High Level Impacts:1) Sophistication of products

2) Exports of technology products

3) Unit value of exports

Currently developing a ‘metrics’ approach:

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Outcomes per theme (economic, social, environmental)

• Eg. Technologies localized; household with food security; medicines developed; revenues generated

Outputs per theme (meeting objectives of themes)

• Publications; technologies; patents; companies; products

Cross cutting & ongoing activities of the Department

Cross-cutting initiatives•Public Understanding of Biotechnology (NRF)•Biosafety Communication Platform (TIA)•Bioinformatics and Functional Genomics human capital development (NRF)•Bioinformatics Platform (CHPC/CSIR)•Bio-entrepreneurship training (CSIR/TIA/eGoliBio)•Bioportal development (consortium)•Bio-economy Metrics (NACI)

Platforms•Centre for Proteomic and Genomic Research (TIA)•H3D Human Drug Discovery & Development (TIA)•Metabolomics (TIA)•Bioprocessing (TIA)•Southern African Human Genome Programme (SHIP)

Overview: Agriculture implementation plan

Agroprocessing and Agro-engineering

Natural Resource management

Indigenous African Knowledge based Agriculture

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Key Bio-economy activities of the Department

Agriculture - DST projects:•Eucalyptus Genome Programme (UP + industry)•Wheat pre-breeding platform (Grain SA + consortium)•Feasibility study Agro-innovation hubs (part of agri-parks)

TIA projects (some): •Cassava commercial trials- Limpopo, Mpumalanga + KZN•Microwave egg pasteurizer (CSIR, UP, industry)•Post-harvest biocontrol in table grapes (ARC, CSIR + industry)•Indigenous flower bulbs (ARC)•Sweet stem sorghum as biofuel feedstock (UKZN)•‘Beochic’ as a growth promoter in poultry (Industry)•AgraChem – fertilizers & biocontrol (Industry)

Build the Health Innovation System

Translational Architecture(ICTs, Knowledge Management, Modelling, Advanced Statistical

Analysis)

Translational Architecture(ICTs, Knowledge Management, Modelling, Advanced Statistical

Analysis)

New or improved

therapeutics & drug delivery

New or improved

therapeutics & drug delivery

New vaccines and other biologicals

New vaccines and other biologicals

New or improved

diagnostics

New or improved

diagnostics

Market access / Impact

monitoring

New medical devices

New medical devices

Discovery

Development

Dissemination

Product development cycle

Technology

develop-ment

Capacities &

capabilities

Decision support

Technology &

knowledge transfer

Overview: Health Implementation Plan

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Key Bio-economy activities of the Department

Health – SHIP projects:

Vaccine & Biologicals

Therapeutics/drug delivery

Diagnostics/devices

HIV 8 3 2

TB 8 3 5

Malaria - 2 1

NCD - 7 8

Overview: industry & Environment Implementation

Plan

BiomanufacturingBioprocessingBiopharmingBiocatalysis

BiocompositesBioGROWBioPACBioresins

BiorefineriesPhysicalChemicalThermalBiological

BiorefineriesPhysicalChemicalThermalBiological

Biomining, Waste & WastewaterBeneficiationBioMiningWater Biorefineries

Priority AreasPriority Areas

Commodity chemicals

Fine ChemicalsPharma-ceuticals

VaccinesBiologicsEnzymes

BiocompositeBioplasticsBiosynthetic materials

HeatElectricityBiodieselBioethanol

Remediation technologyMineral, oil,

and salt recovery

Sanitation solutions

Biochemicals & Biologics Biomaterials Bioenergy

Biomining, Waste &

Wastewater

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Key Bio-economy activities of the Department

Industry & Environment:

DST projects•Biocatalysis – developing human capital in useful enzymes (consortium)• Biorefinery modelling and new product development •Water Foot-printing Analysis for SA pulp Mills•From sucrose to high value commodity chemicals• Energy use reduction and monitoring opportunities in sugar factories.•Biomanufacturing Industry Development Centre (CSIR) – supporting industry start-ups.•Pyrolysis of plastic/fibre wastes

TIA•Sweet stem sorghum as biofuel feedstock (UKZN)•Continuous seed preparation for sugar processing (SMRI, Tongaat Hullet)

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Indigenous Knowledge-based Technology Innovation

TechnicalTechnical

Social/CulturalSocial/

Cultural

EconomicEconomic

Institutional

Institutional

Objective: Mainstreaming IK-based products

>80 community members trained

Various communities & knowledge holders involved/participating in validation and prototype development.

Key Bio-economy activities of the Department

Indigenous Knowledge-based Technology Innovation

Platform No. of Projects

Value-Added Products

African Medicines Platform 6 Projects

3 HIV/AIDS; 1 TB; 1 Diabetes; 1 Malaria

IK-Based Cosmeceuticals 8 Projects Skin, hair, ageingIK-Based Nutraceuticals 5 Projects

Nutrition, supplements, food products

IK-Based Health Beverages 6 Projects

Moringa, Honeybush, Haw-Haw, Amaranthus, etc

IK-Based Tech Transfer 5 ProjectsIK-Based Commercialisation 4 projects

Moringa, Honeybush, Nutri-veg drink

Key Bio-economy activities of the Department

Capacity building: IKS PhD, MSc and undergraduate students

Key Bio-economy activities of the Department

Partnership with University of Limpopo sitting on Limpopo Agro-food Technology Station (LATS)

Key Bio-economy activities of the Department

Construction of the Tooseng Processing Facility 15/04/2015

Key Bio-economy activities of the Department

Some of the Moringa related products that have been developed

Way forward:Bio-economy 2015/6

Implementation plans•Finalization & publication•Presentation to Treasury

Activities•Creation of Coordinating Committees (including govt, science councils, industry, academia) to advise DST on priorities & actions.•Development of R&D support models (similar to SHIP) at the ARC and CSIR.•Techno-feasibility study on Agro-innovation Hubs concluded.

New budget for the Bio-economy required

Some Bio-economy successes

Previously reported:•By 2014, the top 7 biotech companies had a combined annual turnover of nearly R1 billion (from a direct investment of R63million);•Eucalyptus Genome project – already providing cost savings to industry;•Xsit – already providing additional income to the citrus industry;•Umbiflow – providing for better maternal healthcare;•mTriage – better emergency care.New additions:•10 IK-Based Cosmeceuticals (anti-acne, anti-eczema, anti-wrinkle, anti-aging, skin toner, moisturisers and sun-screens) are ready for early commercialisation;•Access and benefit sharing agreement entered into with various communities in Gauteng, Northern Cape, Western Cape, and Eastern Cape; •Five new patents filed from IKS technologies.

Ndo livhuwaEnkosiThank youBaie dankieSiyabongaRe a lebogaHa Khensa Enkosi Ditebo