update on fleischner criteria for pulmonary nodules
TRANSCRIPT
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Update on Fleischner Criteria for Pulmonary Nodules
Hiren J Mehta MD
Associate Professor of Medicine
Division of Pulmonary and Critical Care Medicine
University of Florida
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Disclosures
• None pertaining to the talk
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Objectives
1. Review the history of the Fleischner guidelines
2. Discuss the changes found in the 2017 edition a. the changes in nodule size criterion for follow up and the follow up schedulesb. expanded list that the recommendations “do not apply to”c. is a patient “High Risk” if they have only one “Lung Cancer Risk Factor”
3. What are the current guidelines for lung cancer screening and Lung-RADS assessments and how they differ from the Fleischnerguidelines
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History of Fleischner Society
• The Fleischner Society is named after Felix Fleischner, M.D., a pioneer in the pathogenesis and diagnosis of lung disease using the chest radiograph.
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History of Fleischner Society
• Felix Fleischner was born in Vienna in 1893 and received his medical degree in 1919 from the University of Vienna.
• He came to US in 1938 and spent his first 2 years at the Massachusetts General Hospital followed by 2 years in private practice.
• He was appointed to the staff at Boston’s Beth Israel Hospital in 1942 as their first full time radiologist, serving as dept chair from 1945-1960
J Thorac Imaging Volume 25, Number 1, February 2010
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History of Fleischner Society
• In November 1969, a group of 8 radiologists including Doctors Robert Fraser, Leo Rigler, Benjamin Felson, George Simon, Norman Blank, Richard Greenspan, Eric Milne, and Morris Simon first met to form a new society to study chest disease.
• Dr Fleischner was invited to the meeting, but when he suddenly died of a heart attack while swimming on August, 3 months before the meeting.
• The group dedicated and named the new organization, the FleischnerSociety.
J Thorac Imaging Volume 25, Number 1, February 2010
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History of Fleischner Society
• Mission statement
- develop a better understanding of chest diseases
- to foster chest radiology as an art and a science, and
- to stimulate all aspects of teaching and research.
• The Fleischner Society is now 50 years young.
• It has 65 active members (and 35 less active senior members) of varying disciplines.
J Thorac Imaging Volume 25, Number 1, February 2010
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History of Fleischner Society
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Lung Nodules
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Lung nodules
• Since the introduction of helical CT in the early 1990s and multi–detector row CT in the late 1990s, the detection of nodules has become routine.
• A vast majority these nodules are <7 mm in diameter and most of them are benign.
• Guidelines for the management of the SPN were published in 2003 by the American College of Chest Physicians
Lung Cancer 2003;41(suppl 2):S40.
Radiology2004;231(1):164–168.
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Lung nodules
• ACCP recommended 3, 6, 12, and 24 month CT follow-up intervals, also without any specified lower size limit.
• Likelihood of malignancy in a lung nodule increases with size.
• Nodules smaller than 4mm that will eventually turn into lethal cancers is very low (1%)
Chest 2003;123(suppl 1):89S–96S.
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Original 2005 guidelines
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Limitations
• These guidelines exclude
- GGO and subsolid nodules
- Patients <35 years of age
- Patients with known malignancy
- Non incidental and screen detected nodules
- Immunosuppressed patients
- Nodules > 8mm
- Solitary vs multiple nodules
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Subsolid nodules
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Subsolid nodules
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<5mm GGN
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> 5mm Pure GGN
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Significance of short interval follow up
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Part Solid nodule (Solid component <5mm)
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Part solid nodules (Solid component >5mm)
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Multiple subsolid nodules
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Updated 2017 guidelines
Radiology: Volume 284: Number 1—July 2017
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2017 Guidelines (Solitary Solid nodule)
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• The risk of cancer in never smokers and in younger patients is significantly lower, with a RR of 0.15 when compared to heavy smokers.
• Risk of cancer in solid nodules <6 mm in patients at high risk is <1%
• Suspicious morphology, upper lobe location, or both can increase cancer risk into the 1%–5% range
Clin Cancer Res 2009;15(18):5626–5645.
Eur Respir J 2013;42(6):1659–1667.
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• Average estimated risk of malignancy in 6-8 mm nodules in high risk patients is 0.5-2%.
• The average risk of cancer in an 8-mm solitary nodule is 3% depending on morphology and location
• As nodules become larger, their morphology becomes more distinct, and management should be strongly influenced by the appearance of the nodule rather than by size alone
N Engl J Med 2013;369(10):910–919.
Lancet Oncol 2014;15(12):1332–1341
Chest 2007;132(3 Suppl):108S–130S.
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2017 Guidelines (Multiple Solid nodules)
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• There is an increased in risk for primary cancer, as the total nodule count increased from 1 to 4, but a decrease in risk for those with five or more nodules, most of which likely resulted from prior granulomatous infection
Radiological Society of North America, 2015; 111.
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Updated guidelines (Solitary Subsolid nodule)
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• For GGN <6mm in size, 10% of such nodules may grow and that nearly 1% may progress to adenocarcinoma over many years.
• A solid component larger than 5 mm correlates with a substantial likelihood of local invasion
• For multiple subsolid lesions 6 mm or larger, the most suspicious nodule (which may not be the largest) should guide management
Radiology 2015;276(3):873–882.
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Updated guidelines (multiple subsolidnodules)
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Other risk factors
• Pulmonary fibrosis, particularly IPF, is an independent risk factor, with a hazard ratio of approximately 4.2
• Emphysema increases likelihood of malignancy
• Family history increases likelihood of malignancy by a factor of 1.5-1.8
• Smoking confers 10- to 35-fold increased risk
N Engl J Med 2006;354(4):333–342
Lancet 2011;377(9760):139–146
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Size does matter
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Nodule Malignancy predictors
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Nodule Malignancy Predictors
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Risk stratification
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What about screen detected nodules?
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It is not uncommon to find lung nodules
N Engl J Med 2011;365:395-409.
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Most nodules are non malignant
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Most cancers will be early stage
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Lung cancer survival based on stage
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Lung RADS
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Lung RADS
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