uruguayan women’s breast canceruruguayan women’s breast cancer knowledge: using novel modeling...

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Uruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A. 1 , Lydia P. Buki Ph.D. 2 , Micaela Reich, Ph.D. 3 , Selva Sanabria 4 , & Dolores Larrosa 4 1 University of Illinois at Urbana-Champaign, 2 University of Miami, 3 Universidad Católica del Uruguay, 4 Comisión Honoraria de Lucha Contra el Cáncer

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Page 1: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

Uruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling

Techniques

Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2,

Micaela Reich, Ph.D.3, Selva Sanabria4, & Dolores Larrosa4

1University of Illinois at Urbana-Champaign, 2University of Miami, 3Universidad Católica del Uruguay, 4Comisión Honoraria de Lucha Contra el Cáncer

Page 2: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

• Highest breast cancer mortality rate in Latin America and continues to increase over time (Ferlay et al., 2010; WHO, 2012)

Breast Cancer in Uruguay

2

24.3

20.1

14.7

12.3

0

5

10

15

20

25

30 2008 Breast Cancer Standardized Age-Adjusted Mortality Rates by Country

per 100,000 Women

Uruguay Argentina United States Brazil

20.7

24.3

18

19

20

21

22

23

24

25

Uruguay Breast Cancer Standardized Age-Adjusted Mortality Rates by Year per 100,000

Women

2004 2008

http://www.veomapas.com/mapa-politico-de-los-departamentos-del-uruguay-m280.html

(Ferlay et al., 2010; WHO, 2012)

Page 3: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

• Overall, research in this area is sparse

• In the U.S., women who have more breast cancer knowledge are more likely to:

• Be younger (Jimenez et al., 2011)

• Have children (Bird et al., 2010)

• Have higher levels of formal education (Ramirez et al., 2000)

• Obtain mammography screenings (Harris et al., 2003)

• Communities shape women’s breast cancer knowledge levels by hosting educational programs, providing access to information, and influencing the quality of resources available (Bigby, 2007)

Breast Cancer Knowledge in Uruguay

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Page 4: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

Health Literacy

4

Health Literacy

Cultural & Conceptual Knowledge

Oral Literacy Print Literacy Numeracy

(IOM, 2002)

Cultural & Conceptual Knowledge

Page 5: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

Cultural and Conceptual Knowledge

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Cultural & Conceptual Knowledge

Attitudes

Beliefs

Emotions

Knowledge

Cultural and conceptual knowledge represents the filter through which individuals obtain, process and understand

health information and options for diagnosis and treatment (IOM, 2002)

(Buki & Quintero Johnson, 2009)

Page 6: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

Examine the psychometric properties of the breast cancer knowledge subscale and explain the influence of individual level variables (mammography screening status, age, education level, area of residence) on participant characteristics and item responses.

Aim of the Study

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Page 7: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

• Recruitment and data collection were done in collaboration with the Comisión Honoraria de Lucha Contra el Cáncer

• National sample of 410 women ages 40-65 years was obtained from 5 departments: Artigas, Flores, Maldonado, Montevideo, and Treinta y Tres

• Approximately half of participants were up to date for mammography screening (

2 years)

Sample

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Mean %

Age 51 years -

Education level

10.43 years

-

Have Children

- 92%

Page 8: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

• Within the Item Response Theory (IRT) family

• Innovative measurement approach using generalized linear and non-linear mixed models (De Boeck & Wilson, 2004)

• Models how properties of items and participant characteristics influence item responses

• Provides information about participants to help determine differences in knowledge levels

• Appropriate method for handling measurement error and dependency within data

• Protects against inflating standard error

Explanatory Item Response Modeling (EIRM)

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Page 9: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

• Within the Uruguayan version of the Cancer Health Literacy Measure – Breast and Cervical Cancer (Buki & Reich,

2012)

• 12 items

• Sample item: “Younger women have a higher risk of getting breast cancer than older women.”

• Response format of “yes,” “no,” and “I don’t know”

• “I don’t know” responses collapsed into “no” responses for the analyses

• Alpha and Kuder-Richardson coefficients of reliability:

• α =.61, KR-20 = .62

Breast Cancer Knowledge Subscale

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Y1 Y2 Y3 Y4 Y5 Y6 Y7 Y8 Y9 Y10 Y11 Y12

Age x1

Mammography

status x2

Residency x3

Education x4

Having Children x5

BC Knowledge

Page 10: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

• A 2PL EIRM was fit to the data using SAS 9.3 PROC NLMIXED (SAS Institute, 2011)

• -2 Log Likelihood = 27551, AIC = 27593, BIC = 27725

• Likelihood ratio test indicated the model is significantly different, p <.0001

• Items 2, 7, 10, and 12 were dropped which improved item fit

• Women who were up to date for a mammogram, had children, and were from Flores and Artigas were more likely to have higher BC knowledge levels, p <.0001

• Women from Maldonado were more likely to have lower levels of BC knowledge, p <.0001

Results

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a1 b1 a3 b3 a4 b4 a5 b5 a6 b6 a8 b8

Mammography

status x4

(OR = 2.364)

Having Children x2

(OR = 1.978)

a9 b9 a11 b11

Maldonado x1

(OR =.794)

Artigas x5

(OR = 1.612)

Flores x3

(OR = 1.612)

= decrease in BC knowledge

Page 11: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

• Having children, mammography status, and women’s residency, explained breast cancer knowledge item responses

• Demonstrate utility of EIRM for health literacy measurement development

• Provide information on screening barriers and facilitators within a universal healthcare system

Implications and Future Directions

• Develop educational interventions to increase BC knowledge targeting women (40-65 years) who have not obtained a mammogram screening within 2 years, do not have children, and reside in Maldonado

Conclusion

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Page 12: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

Bigby, J. A. (2007). The role of communities in eliminating healthcare disparities: Getting down to the grassroots. In R. A. Williams (Ed.), Eliminating healthcare disparities in America: Beyond the IOM report. Totowa, NJ: Humana Press Inc.

Bird, Y., Moraros, J., Banegas, M.P., King, S., Prapasiri, S., & Thompson, B. (2010). Breast cancer knowledge and early detection among Hispanic women with a family history of breast cancer along the U.S.-Mexico border. Journal of Health Care for the Poor and Underserved, 21(2), 475-488.

Buki, L. P., & Reich, M. (2012). Adaptation and validation of the CLM-BCC for Uruguayan women. Unpublished manuscript. Buki, L. P., & Quintero Johnson, J. M. (2009, October). Cultural and conceptual knowledge: Conceptual and measurement

advances in health literacy. Poster presented at the meeting of the Health Literacy Annual Research Conference, Washington, D.C.

De Boeck, P., & Wilson, M. (2004). Explanatory item response models: A generalized linear and nonlinear approach. In P. De Boeck & M. Wilson (Ed.). New York City: Springer.

Ferlay, J., Shin, H. R., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2010). Cancer incidence and mortality worldwide: IARC CancerBase no 10. [GLOBOCAN 2008]. International Agency for Research on Cancer. Retrieved from http://globocan.iarc.fr

Harris, D., Miller, J., Davis, D. (2003). Racial differences in breast cancer screening, knowledge and compliance. Journal of the National Medical Association, 94(8), 693-701..

Institute of Medicine. (2002). Health literacy: A prescription to end confusion. Washington, D.C.: The National Academies Press. Jimenez, E. A., Xie, Y., Goldsteen, K., & Chalas, E. (2011). Promoting knowledge of cancer prevention and screening in an

underserved Hispanic women population: A culturally sensitive education program. Health Promotion Practice, 12(5), 698-695.

Ramirez, A., Suarez, L., Laufman, L., Barroso, C., & Chalela, P. (2000). Hispanic women’s breast and cervical cancer knowledge, attitudes, and screening behaviors. American Journal of Health Promotion, 14(5), 292-300.

Ratzan, S. C., & Parker, R. M. (2000). Introduction. In C. R. Selden, M. Zorn, S. C. Ratzan, & R. M. Parker (Eds.), National library of medicine current bibliographies in medicine: Health literacy. Bethesda, MD: National Institutes of Health, US Department of Health and Human Services: NLM Pub. No. CBM 2000-1.

SAS Institute. (2011). In Baxter A. (Ed.), Base SAS® 9.3 procedures guide. Cary, NC: SAS Institute Inc. World Health Organization (2012). Mortality database. Retrieved from

http://www.who.int/whosis/mort/download/en/index.html

References

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Page 13: Uruguayan Women’s Breast CancerUruguayan Women’s Breast Cancer Knowledge: Using Novel Modeling Techniques Deborah E. Linares M.A.1, Lydia P. Buki Ph.D.2, Micaela 4Reich, Ph.D.3,

Parameters Est. Std

Error df t value p value

b1/a1 -1.62 0.09 4007 -18.05 <.0001

b3/a3 4.07 0.68 4007 5.95 <.0001

b4/a4 -2.80 0.19 4007 -14.61 <.0001

b5/a5 -2.75 0.19 4007 -14.77 <.0001

b6/a6 -1.58 0.05 4007 -29.50 <.0001

b8/a8 -2.30 0.12 4007 -18.81 <.0001

b9/a9 -1.92 0.12 4007 -15.92 <.0001

b11/a11 -2.48 0.32 4007 -7.81 <.0001

Final Model Parameter Estimates

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