Day 1 Monday September 25th

8:30 AM: Shuttle from hotel to the meeting venue Detroit Yacht Club - Belle Isle

9:00-9:30 AM: Welcome Address Introduction by Dr. Michael Ross (President of DOHaD) and Representative from NIEHS

9:30-11:30 AM: Session 1: Exposure Science I. Moderator: Vasantha Padmanabhan

9:30-10:00 AM: Keynote Speaker: Dr. Marisa Bartolomei – “In utero mouse model of BPA exposure: Metabolism, behavior and epigenetics”

10:00-10:15 AM: Coffee break*

10:15-11:45 AM: Oral Presentations

1. Amita Bansal: Sex- and Dose-Specific Transgenerational Effects of Bisphenol A on Metabolic Health. Trainee

2. Jill Reiter: Glyphosate Exposure Levels in Pregnant Women: An Indiana Birth Cohort Study. 3. Damaskini Valvi: Diabetogenic Risk in Young Adults Exposed to Perfluoroalkyl Substances over

the Lifecourse. Trainee4. Courtney Carignan: Preconception as a Sensitive Window of Exposure: Urinary Concentrations

of Organophosphate Flame Retardant and Fertility Outcomes among Couples Undergoing In Vitro Fertilization

5. Todd Everson: Placental expression of imprinted genes associated with cadmium exposure, primarily among male placental tissue. Trainee

6. Scott Belcher: Obesogenic Effects of Low-dose Cd Exposures in Children and a Mouse Model of Gestational Exposure: Preliminary Findings and Potential Mechanisms.

11:45 AM-1:15 PM: Buffet lunch* with Poster Session 1 and trainee breakout session on grant writing with Drs. Michael Ross and Mina Desai

1:15-3:15 PM: Session 2: Microbiome, Fetus and Placenta. Moderators: Sara Pinney and Roberto Romero

1:15-2:00 PM: Keynote Speakers: Dr. Linda Mansfield “Human microbiota mouse transplant models to study the effects of the early microbiome on development of inflammation, autoimmunity and allergy”, and Alexandra Sitarik “The Importance of the Early Life Gut Microbiome: Findings from the MAAP Study”

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2:00-3:15 PM: Oral Presentations: Fetus and Placenta1. Ron Magness: Aberrant estrogen metabolism in preeclampsia may cause dysregulation of

angiogenesis-mediated uterine blood flow via a novel uterine endothelial sympathomimetic system.

2. Cetewayo Rashid: Transcriptomic analysis reveals novel mechanisms mediating islet dysfunction in the intrauterine growth restricted (IUGR) rat. Trainee

3. Jennifer Straughen: The association between placental inflammation and BMI at age 7. 4. Keshari Thakali: Associations between Maternal Early Pregnancy Body Mass Index (BMI) and

Placental DNA Methylation at Term. 5. Julia Litzky: Maternal depression and anxiety on placental imprinted gene expression. Trainee

3:15-3:30 PM: Coffee break*

3:30-5:00 PM: Session 3: Obesity and Diabetes in Pregnancy. Moderators: Rob Lane and Wei Perng

3:30-4:00 PM: Keynote Speaker: Dr. Patrick Catalano – “Maternal Diabetes and GDM; short and long-term effects on the offspring”

4:00-5:30 PM: Oral Presentations

1. Wei Perng: Associations of cord blood metabolites with newborn anthropometry and cord blood hormones in Project Viva.

2. Kaela Varberg: Elevated Transgelin 1 induces dysfunction in endothelial colony forming cells from gestational diabetic pregnancies. Trainee

3. Agnlia Eisaghalian: Programmed Adipocytes Contribute to Obesity in Low Birth Weight Offspring: Interaction with Ambient Temperature and Fat Depots. Trainee

4. Seva Khambadkone: Maternal high fat diet exposure during pregnancy and lactation alters trabecular bone structure in rat offspring. Trainee

5. Miranda Johnson: Male and female HF offspring display marked sex differences in response to cocaine. Trainee

6. Lindsay Ellsworth: The Impact of Gestational Endocrine Disorders on Human Breast Milk Fat Characteristics and Infant Growth. Trainee

5:30 PM: Shuttle transfer (to Detroit Institute of Arts)

6:00-8:00 PM: Strolling dinner* at Detroit Institute of Arts: Great Hall and Diego Rivera Mural room

8:00 PM: Shuttle to Hotel from Detroit Institute of Arts

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Day 2: Tuesday September 26th

8:30 AM: Shuttle from hotel to the meeting venue Detroit Yacht Club - Belle Isle

9:00-11:30 AM: Session 4: Neuroscience. Moderators: Ron Magness and Marion van den Heuvel

9:00-9:30 AM: Keynote Speaker: Dr. Sebastien Bouret – “Leptin Action on the Fetal Brain: Impact on Glucose Homeostasis” 9:30-10:30 AM: Oral Presentations

1. Phillippe Grandjean: Burden of disease associated with developmental exposure to neurotoxicants.

2. Phu Tran: Coordinated roles of iron-dependent PHD and JARID in early-life iron deficiency-induced adult neural gene dysregulation.

3. Youssef Oulhote: Developmental exposure to potential neurotoxicants and children's cognitive function at 7 years: A multi-pollutant approach. Trainee

4. Marion van den Heuvel: Fetal Origins of Child Sleep Problems: The Role of Maternal Psychological Stress. Trainee

10:30-10:45 AM: Coffee break*

10:45-11:45 AM: Oral Presentations: Perinatal Environment

1. Muraly Puttabyatappa: Developmental Programming: Prenatal Testosterone Excess Induces Hepatic Fibrosis in the Female Sheep. Trainee

2. Cheyenne Dickerson: In Utero Exposure to Maternal Obesity Programs Offspring Hyperphagia and Obesity. Trainee

3. Hannah Hafner: The Effects of Lactational High Fat Diet Exposure on Insulin and Glucose Homeostasis in Mouse Offspring.

11:45 AM-1:30 PM: Buffet lunch* with Poster Session 2 and trainee breakout session on career development with Dr. Rebecca Simmons and Dr. Kent Thornburg

1:30-3:00 PM: Session 5: Interventions. Moderators: Amita Bansal and Brigid Gregg

1:30-2:00 PM: Keynote Speaker: Aryeh Stein “Exposure to improved nutrition from conception to age 2 y and adult cardiometabolic disease risk”

2:00-3:00 PM: Oral Presentations 5: Exposure Science II1. Jaclyn Goodrich: Newborn DNA Methylation Profiles Are Associated with Neonatal Iron

Deficiency and Toxicant Exposures in a Pilot Sample. 2. Micaela Stevenson: Gestational Exposure to Bisphenol A Induces Oxidative Stress in the

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Metabolic Tissues of the Female Sheep Offspring. Trainee3. Tracie Baker: Transgenerational male infertility due to endocrine disrupting chemical exposure

in zebrafish - transcriptomic and epigenetic changes. 4. Raquel Chamorro-Garcia: Ancestral perinatal obesogen exposure results in a transgenerational

thrifty phenotype in mice. Trainee

3:00-3:15 PM: Coffee break*

3:15-5:00 PM: Session 6: Perinatal Stress. Moderator: Tim Moran and Rebecca Simmons (or Ganesa Wegienka)

3:15-3:45 PM: Keynote Speaker: Dr. Regina Sullivan “Unique Neurobehavioral Impact of Infant Trauma within a Social Context: Lessons from an Animal Model”

3:45-5:00 PM: Oral Presentations

1. Zachary Laubach: Associations of early-life social experience with DNA methylation in free-living spotted hyenas. Trainee

2. Moriah Thomason: Maternal prenatal stress is associated with reduced efficiency in human fetal functional brain systems.

3. Susanne Brummelte: Behavioral and endocrine effects of prenatal antidepressant exposure and its discontinuation during pregnancy in an animal model of maternal depression.

4. Analia Loria: Early life stress and cardiometabolic risk: evidence of sex-specific mechanism in rodents.

5. Elizabeth Holdsworth: Maternal experiences of childhood adversity are associated with age at menarche and offspring asymmetric fetal growth. Trainee

5:00-6:00 PM: Business meeting general: Agenda

-Preparing for Elections -Bylaws-Formation of Council -Future meetings

6:00 PM: Shuttle transfer (Marriott)

6:30-8:00 PM: Strolling Dinner at the Marriott 42°N Room*

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Day 3: Wednesday September 27th

7:30 AM: Shuttle from hotel to the meeting venue Detroit Yacht Club - Belle Isle

8:00-9:00 AM: President’s Distinguished Lecture: Dr. Kent Thornburg – Placenta and Cardiovascular Health

9:00-10:30 AM: Session 7: Epigenetics. Moderators: Rob Waterland and Emily Blue

9:00-9:30 AM: Overview: Dr. Dana Dolinoy

9:30-10:30 AM: Oral Presentations

1. Jing Xue: Maternal vitamin D depletion perturbs CpG methylation at developmental genes in the germline. Trainee

2. Emily Blue: Integration of genome-wide methylation and gene expression data identifies epigenetically altered genes following intrauterine exposure to maternal diabetes

3. Bassem Shoucri: Retinoid X receptor activation alters the chromatin landscape to commit mesenchymal stem cells to the adipose lineage. Trainee

4. Sara Pinney: In utero exposure to bisphenol A alters genome wide DNA methylation and gene expression in human fetal stem cells.

10:30 AM-12:00 PM: President’s Address, Awards and Business Meeting

10:30-11:00 AM: Service Award: Jerry Heindel. Young Investigator Awards: To be announced for Best Poster and Best Oral Presentation.

12:00-1:30 PM: Buffet Lunch*

1:30 PM: Shuttle transfer to Detroit Metropolitan Airport (DTW)

*Please note registration includes all buffet lunches, coffee breaks and both strolling dinners. There is no cost for use of the shuttle.

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Congratulations to the 2017 Trainee Award RecipientsTrainee Travel Award (award of registration, up to 3 nights hotel reimbursement, $300 for travel costs)

Amita Bansal, University of PennsylvaniaBassem Shoucri, UC-Irvine

Trainee Registration Awards (the following individuals had their registration paid by the US DOHaD Society)

Jing Xue, University of North CarolinaMicaela Stevenson, University of MichiganJulia Litzky, Dartmouth/Emory University Marion van den Heuvel, Wayne State UniversityRaquel Chamorro-Garcia, UC-IrvinePaul Caldo, University of MissouriAmanda Barks, University of MinnesotaDanielle Meyer, Wayne State UniversitySeva Khambadkone, Johns Hopkins UniversityVictoria Andriessen, University of MichiganMiranda Johnson, Johns Hopkins UniversityUmesh Wankhade, Arkansas Children Nutrition CenterAgnlia Eisaghalian, Charles Drew University/LABioMedElizabeth Holdsworth, University at Albany, SUNYCheyenne Dickerson, Charles Drew University/LABioMed

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Thank you to our sponsors:

Platinum Sponsor Janssen Pharmaceutical Companies of Johnson and Johnson

Gold Sponsor The Department of Public Health Sciences at Henry Ford Health System

Silver Sponsor Wayne State University Center for Urban Responses to Environmental Stressors (CURES)

Grant support was received from the National Institute of Environmental Health Sciences (R13 ES029036).

Your Environment. Your Health

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Thank you to our Scientific Chair, Rebecca Simmons, M.D.

Special thanks to the following for all of their work on this meeting:

Our Henry Ford Health System team Beth StewartChad ColemanMary Ann AubuchonGabe BernatRobert Spain

Abstract ReviewersBrigid GreggRebecca SimmonsWei PerngEmily Blue

The US DOHaD Society Leadership team:Michael Ross, PresidentMina Desai, SecretaryGanesa Wegienka, Treasurer and Annual Meeting Host

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Poster Presentations

Session 1 Monday September 25, 20171. Paul Caldo Mice Lacking Membrane-Localized Estrogen Receptor 1 Exhibit Contrasting Uterine and

Vaginal Responses to Neonatal Estrogen Chemical Exposure

2. Wei Perng Associations of weight- and length-derived anthropometric indicators with body composition at birth and 5 months: The Healthy Start Study

3. Phoebe Stapleton Maternal Engineered Nanomaterial Inhalation Increases Cardiovascular Disease Susceptibility in Young Offspring

4. Erica Jansen Early childhood dietary patterns are related to timing of sexual maturation: a prospective study of children from Mexico City

5. Cetewayo Rashid Does paternal bisphenol A exposure affect offspring glucose tolerance? A peek through exposure windows reveals that timing is of the essence.

6. Hyesook Kim BPA Concentrations in Liquid Supernatants of Imported Canned Foods quantified by Sensitive BPA ELISA

7. Victoria Andriessen Gestational Bisphenol A (BPA) Exposure Induces Inflammatory and Lipotoxic Changes in the Adult Female Sheep Metabolic Tissues

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Session 2 Tuesday September 26, 2017

1. Jasmine Hect Impact of non-heme brain iron and age on cognitive ability during childhood and adolescence

2. John Dou Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation

3. Egle Bytautiene Prewit Thermogenesis and Uncoupling Protein 1 in the Mouse Model of the Developmental Programming of Metabolic Syndrome - Preliminary Investigations

4. Danielle Christifano The Relationship between Maternal Weight and the Fetal Autonomic Nervous System

5. Clark Sims Postpartum maternal fat distribution and its association with offspring body fat through the first year of life.

6. Umesh Wankhade Maternal high-fat diet modulates brown adipose tissue response to -adrenergic agonist

7. Analia Loria High Fat Diet Abolish the Development of Endothelial Dysfunction in Female Rats Exposed to Maternal Separation

8. Aline Andres Prenatal phthalate metabolite concentrations and infant fat mass across the first year of life: a pilot study

9. Lawrence Schell Biomonitoring using placenta: a potential biomarker of early life exposure to lead

10. Amanda Barks The effect of developmental neuronal iron deficiency on DNA hydroxymethylation

11. Danielle Meyer Developmental exposure to sublethal TCDD alters histology and gene expression in zebrafish testes across multiple generations

12. Julia Santos Can Honokiol be used to ameliorate preeclampsia?

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