Department of PediatricsDivision of Pediatric NephrologyP.O. Box 016960 (M-714)Miami, Florida 33101

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PAIDMiami, FL

Permit No. 438

PEDIATRIC NEPHROLOGY 43rd YEAR SEMINARMarch 10 - March 13, 2016The Alexander All Suite Ocean Front ResortMiami Beach, Florida

Sponsored by the

Presented by the Division of Pediatric Nephrology, Department of Pediatrics and the Division of Renal Pathology, Department of Pathology

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For More Information call 305-243-6716Visit us at http://pediatrics.med.miami.edu/nephrology/seminar

MIAMI BEACH, FL The AlexanderALL SUITE OCEAN FRONT RESORT5225 Collins Avenue Miami Beach, FL 33140

43rd MiaMi Pediatric NePhrology SeMiNar aNd reNal Pathology courSe

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Celebrating World Kidney Day March 10, 2016

MARCH 10 - MARCH 13, 2016

WEDNESDAY, MARCH 9, 20166:00-8:00 P.M. REGISTRATION

THURSDAY MARCH 10, 2015PRE-SEMINAR PEDIATRIC RENAL PATHOLOGY COURSE CHAIR: Laura Barisoni ASSOCIATE CHAIRS: Helen Liapis and David B.Thomas

7:00-8:00 A.M. REGISTRATION. Continental Breakfast.8:00-8:10 A.M. INTRODUCTION. Opening Remarks. Gastón E. Zilleruelo, Laura Barisoni SESSION 1: INTRODUCTION TO RENAL PATHOLOGYModerator: Laura Barisoni 8:10-8:30 A.M. Processing and Reporting of Renal Biopsies David B. Thomas 8:30-9:00 A.M. Algorithmic Approach to Renal Diseases Laura Barisoni

SESSION 2: AN APPROACH TO CLASSIFICATION OF GLOMERULAR DISEASESModerator: Surya Seshan

9:00-9:30 A.M. CNS and Infantile Nephrotic Syndrome Helen Liapis9:30-10:00 A.M. Podocytopathies - Laura Barisoni10:00-10:30 A.M. Lupus nephritis - Surya Seshan10:30-11:00 A.M. BREAK11:00-11:30 A.M. IgA Nephropathy - Surya Seshan11:30-12:00 P.M. MPGN and C3 glomerulopathies - Laura Barisoni12:00-12:30 P.M. Endotheliopathies - Surya Seshan12:30-12:40 P.M. Discussion12:40-1:40 P.M. LUNCH

SESSION 3A: DEVELOPMENTAL/CYSTIC DISORDERSModerator: Helen Liapis

1:40-02:10 P.M. Pathology of Cystic Diseases - Helen Liapis2:10-2:40 P.M. Clinical Aspects of Cystic Disorders Jayanthi Chandar2:40-3:10 P.M. Pathology of CAKUT - Helen Liapis3:10-3:40 P.M. Clinical Aspects of CAKUT - Chryso Katsoufis3:40-4:00 P.M. BREAK

SESSION 3B: CLINICO-PATHOLOGIC CORRELATIONSModerators: David B. Thomas, Wacharee Seeherunvong

4:00-5:00 P.M. CASE DISCUSSIONS5:00-6:00 P.M. Renal Pathology Medical Knowledge Competence Assessment6:00-7:00 P.M. WORLD KIDNEY DAY CELEBRATION

FRIDAY, MARCH 11, 2016PEDIATRIC NEPHROLOGY SEMINARCHAIR: Gaston Zilleruelo ASSOCIATE CHAIRS: Carolyn L. Abitbol and Michael Freundlich

7:00-8:00 A.M. REGISTRATION. Continental Breakfast.

SESSION 4: GENETICS/DEVELOPMENTALNEPHROLOGYModerators: Friedhelm Hildebrandt, Robert L. Chevalier 8:00-8:20 A.M. Genetics of Renal Cystic Disorders Friedhelm Hildebrandt

8:20-8:40 A.M. Congenital Nephron Endowment Carolyn L. Abitbol 8:40-9:00 A.M. Life Cycle of the Kidney: From Conception to Adult Life - Robert L. Chevalier 9:00-9:20 A.M. Neonatal AKI: What we Know, What we Need to Learn - David Askenazi 9:20-9:40 A.M. Impact of the use of Microarrays in Ped Nephrology - Mathew Sampson 9:40-10:00 A.M. Panel Discussion10:00-10:30 A.M. BREAK/Visit ExhibitsSESSION 5: NEW FRONTIERS IN PEDIATRIC NEPHROLOGYModerators: Guido Filler, Frederick J. Kaskel 10:30-10:50 A.M. Traditional and Not So Traditional Risk Factors for CVD in CKD - Guido Filler 10:50-11:10 A.M. Role of Tubular Dysfunction in the Progression of CKD - Robert L. Chevalier 11:10-11:30 A.M. Pharmacotherapy of Cardiovascular Drugs in CKD - Mauricio Cohen 11:30-11:50 A.M. Management of Refractory Edema Frederick J. Kaskel 11:50-12:10 P.M. Tubular Proteinuria: Is It Harmful, How to Treat? Guido Filler 12:10-12:30 P.M. Atypical HUS: Updates and Controversies Craig B. Langman 12:30-1:00 P.M. Panel Discussion1:00-2:00 P.M. LUNCH (Meet The Professors)SESSION 6: PEDIATRIC NEPHROLOGY FOR THE PRACTITIONERModerators: Rosanna Coppo, Kazumoto Iijima2:00-2:20 P.M. Hypercalcemia: The Nephrology Consult Uri S. Alon 2:20-2:50 P.M. Acid-Base Disorders: Tips and Pitfalls Larry Greenbaum 2:50-3:10 P.M. HyperOxaluria Type I: Early Screening and Management - Pierre Cochat 3:10-3:30 P.M. IgA Nephropathy in Children: Risk Factors for Progression - Rosanna Coppo 3:30-3:45 P.M. Panel Discussion3:45-4:00 P.M. BREAKSESSION 7: WORKSHOP ON PEDIATRIC RENAL GU DISORDERSModerators: Chryso Katsoufis, Vera Koch 4:00-4:20 P.M. Role of Genetics in CAKUT Friedhelm Hildebrandt 4:20-4:40 P.M. Urology Challenges in Infants Born with CAKUT Rafael Gosalbez 4:40-5:00 P.M. Medical Management Challenges in Infants Born with CAKUT Chryso Katsoufis 5:00-5:20 P.M. Hypercalciuria: Role of Urine Calcium/Citrate Ratio - Uri S. Alon 5:20-6:00 P.M. Panel Discussion 6:00-6:30 P.M. SPECIAL PRESENTATION: Overview of Pediatric Nephrology in the World Pierre Cochat 6:30-7:30 P.M. WELCOME RECEPTION

Program PEDIATRIC NEPHROLOGY SEMINAR 2016

Program PEDIATRIC NEPHROLOGY SEMINAR 2016

SATURDAY MARCH 12, 20167:00-8:00 A.M. REGISTRATION. Continental Breakfast.

SESSION 8: RECENT ADVANCES IN GLOMERULAR DISORDERSModerators: William E. Smoyer, Larry Greenbaum

8:00-8:20 A.M. New Targets Identification Strategies for Glomerular Disorders - Alessia Fornoni8:20-8:40 A.M. Genetics in Nephrotic Syndrome: An Update Friedhelm Hildebrandt 8:40-9:00 A.M. Role of Reactive Oxygen Species in the Progression of CKD - H. William Schnaper9:00-9:20 A.M. Hypercoagulable Status in Nephrotic Syndrome William E. Smoyer9:20-9:40 A.M. The RAS and Vit D in Cardiovascular Diseases: Lessons Applicable to CKD - Leon Ferder9:40-10:00 A.M. Newer Treatments for Proteinuric Disorders Larry Greenbaum10:00-10:30 A.M. Panel Discussion10:30-11:00 A.M. BREAK/Visit Exhibits11:00-11:30 A.M. The José Strauss Visiting Professor Award Gastón Zilleruelo, José Strauss

SESSION 9: WHAT’S NEW IN HYPERTENSIONModerators: Joseph T. Flynn, Deborah Lewis

11:30-11:50 A.M. HTN in the NICU - Joseph T. Flynn 11:50-12:10 A.M. Using Simplified BP Tables to Avoid Underdiagnosing Childhood HTN - Guido Filler 12:10-12:30 P.M. Vascular Abnormalities in Children with CKD Mark Mitsnefes 12:30-1:00 P.M. Panel Discussion1:00-2:00 P.M. LUNCH (Meet the Professors)SESSION 10: BONE DISEASE AND THE KIDNEYModerators: Michael Freundlich, Uri S. Alon 2:00-2:20 P.M. When are Routine FGF23 Measurements Needed in Clinical Practice? - Isidro Salusky 2:20-2:40 P.M. CKD-MBD and Cardiac Hypertrophy: Established and Evolving Concepts - Michael Freundlich 2:40-3:00 P.M. Cinacalcet in Children: When and How to Use It? Uri S. Alon3:00-3:30 P.M. Panel Discussion3:30-4:00 P.M. BREAKSESSION 11: WORKSHOP ON GROWTH AND NUTRITION IN CKDModerators: Carolyn L. Abitbol, John D. Mahan

4:00-4:20 P.M. New Insights on the Pathogenesis of Growth Impairment in CKD - Francisco Cano 4:20-4:40 P.M. Nutritional Assessment and Management of Children with CKD - John D. Mahan 4:40-5:00 P.M. Nutritional Management in Dialysis Bradley A. Warady 5:00-5:20 P.M. Use of Growth Hormone in Children with CKD Franz Schaefer 5:20-5:40 P.M. Special Management Strategies in Acute and Chronic Pediatric Dialysis Patients Carolyn L. Abitbol 5:40-6:15 P.M. Case Studies and Discussion

6:15-6:30 P.M. Growth and Nutrition Medical Knowledge Competency Assessment

SUNDAY, MARCH 13, 20167:00-8:00 A.M. REGISTRATION. Continental Breakfast.

SESSION 12: CKD/DIALYSIS/TRANSPLANT CHALLENGESModerators: Bradley A. Warady, H. Kim Yap 8:00-8:20 A.M. Re-transplantation in Children following Rejection or Recurrence of Disease: What are the Challenges and How can we Overcome them? - Richard N. Fine 8:20-8:40 A.M. What has CKiD Contributed to our Knowledge? Bradley A. Warady 8:40-9:00 A.M. Pediatric Dialysis Programs in Developing Countries - Mignon McCulloch 9:00-9:20 A.M. A Multi-Year Patient Transition Program to Adult Care - Bradley A. Warady 9:20-9:40 A.M. Should we Monitor MMF levels in Children Post- transplant? - Guido Filler9:40-10:00 A.M. Tolerance in Kidney Transplantation: Are We There Yet? - George Burke III10:00-10:20 A.M. Promoting Literacy and Functional Health Literacy in Children Pre and Post-transplant Jayanthi Chandar 10:20-10:40 A.M. Panel Discussion10:40-11:00 A.M. BREAK11:00-11:20 A.M. Management of Neonatal AKI : No One is Too Small - David Askenazi 11:20-11:40 A.M. Should All Blood Purification Methods be Provided by Pediatric Nephrology? - Guido Filler 11:40-12:00 P.M. CRRT: Update 2016 - Timothy E. Bunchman

Alexander Hotel Sessions Conclude

SESSION 13: WORKSHOP ON PEDIATRIC CRITICAL CARE NEPHROLOGY(To be conducted at Holtz Children’s Hospital/Jackson Memorial Hospital) Coordinator: Carolyn L. Abitbol 1:00-1:10 P.M. INTRODUCTION - Carolyn L. Abitbol 1:10-1:30 P.M. Developing a Program: Challenges and Rewards Evel Michel 1:30-2:00 P.M. AKI Modalities with Versatility - David Askenazi2:00-2:20 P.M. Management of Critical Hyperammonemia Patrick Brophy 2:20-2:40 P.M. Vascular Access for Acute Dialytic Modalities Michael A. Nares2:40-3:00 P.M. Special Indications and Challenges of CRRT Timothy E. Bunchman 3:00-4:30 P.M. Workshop Stations: CVVHDF, TPE, CVVHUF, CCPD - Wacharee Seeherunvong, Chryso Katsoufis, Marissa Defreitas, Francisco Cano, Sheila Coakley, Marie Saintvil, Marcia Young, Beverly Jackson, Kelli Walker4:30-5:00 P.M. Final Assessment and Certificates Carolyn L. Abitbol

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ACKNOWLEDGEMENTSENDORSEMENTS

Carolyn L. Abitbol, M.D. Professor of Pediatrics Division of Pediatric Nephrology, Medical Director, Pediatric Dialysis Unit Holtz Children’s Hospital, Associate Chair Pediatric Nephrology Seminar

Laura Barisoni, M.D. Professor of Pathology, Division Chief, Renal Pathology Service, Department of Pathology, Chair Renal Pathology Course

George Burke III, M.D. Professor of Surgery. Division of Transplant. Miami Transplant Institute

Jayanthi Chandar, M.D. Associate Professor of Clinical Pediatrics, Division of Pediatric Nephrology. Medical Director Pediatric Kidney Transplant

Mauricio G. Cohen, M.D., FACC Associate Professor of Medicine, Director Cardiac Catheterization Laboratory, University of Miami Hospital

Sheila Coakley, RN Pediatric Dialysis Unit, Nicklaus Children’s Hospital

Marissa Defreitas, M.D. Assistant Professor of Clinical Pediatrics Division of Pediatric Nephrology

Michael Freundlich, M.D. Professor of Clinical Pediatrics, Division of Pediatric Nephrology, Associate Chair Pediatric Nephrology Seminar

Leon Ferder, M.D. Professor of Medicine and Physiology University of Puerto Rico, Voluntary Faculty at the University of Miami (In Process)

Alessia Fornoni, M.D., Ph.D. Associate Professor of Medicine Director, Peggy and Harold Katz Family Drug Discovery Center, University of Miami Miller School of Medicine

Rafael Gosalbez, M.D. Chief of Pediatric Urology, Holtz Children’s Hospital

Beverly Jackson, RN Pediatric Dialysis Unit, Holtz Children’s Hospital

Chryso Katsoufis, M.D. Assistant Professor of Clinical Pediatrics Division of Pediatric Nephrology

Evel Michel, DNP, ARNP Nurse Manager, Pediatric Dialysis Unit, Holtz Children’s Hospital

Michael A. Nares, M.D. Director, Pediatric Intensive Care Unit, Holtz Children’s Hospital Assistant Professor of Clinical Pediatrics, Division of Pediatric Critical Care Medicine

Marie Saintvil, RN Pediatric Dialysis Unit, Nicklaus Children’s Hospital

José Strauss, M.D. Emeritus Professor, Division of Pediatric Nephrology, Former Chairman Pediatric Nephrology Seminars

David B. Thomas, M.D. Professor of Pathology, Department of Pathology, Associate Chair Renal Pathology Course

Wacharee Seeherunvong, M.D. Assistant Professor of Clinical Pediatrics, Division of Pediatric Nephrology

Kelli Walker, ARNP, MSN Therapy Development Specialist Gambro

Marcia Young, RN Pediatric Dialysis Unit, Holtz Children’s Hospital

Gastón E. Zilleruelo, M.D. Professor of Pediatrics, Director, Division of Pediatric Nephrology, Chair, Pediatric Nephrology Seminar

Uri S. Alon, M.D. Professor of Pediatrics and Director of Research and Education, Division of Pediatric Nephrology, Children’s Mercy Hospital, University of Missouri, Kansas City, MO

David Askenazi, M.D. Associate Professor of Pediatrics, Pediatric Nephrology, University of Birmingham, Medical Director, Pediatric and Infant Center for Acute Nephrology, Children’s Hospital, Alabama, AL

Patrick Brophy, M.D. Director of Pediatric Nephrology, Children’s Hospital, Iowa City, IA

Timothy E. Bunchman M.D. Professor of Pediatrics and Director Pediatric Nephrology, Transplantation and Rheumatology, University of Virginia, Richmond, VA

Francisco Cano, M.D. Profesor de Pediatria, Unidad de Nefrologia Infantil, Hospital Luis Calvo-Mackenna, Santiago, Chile

Robert L. Chevalier, M.D. David Harrison Professor of Pediatrics University of Virginia, Charlottesville, VA

Pierre Cochat, M.D., Ph.D. Responsable du Pôle des Spécialités Pédiatriques, Service de Néphrologie Rhumatologie Dermatologie, Centre de Référence des Maladies Rares ‘Néphrogones’ Hôpital Femme Mère Enfant & Université Claude-Bernard, Secretary General, International Pediatric Nephrology Association, IPNA, Lyon, Bron Cedex, France

Rosanna Coppo, M.D. Director, Nephrology, Dialysis and Transplantation Unit, Regina Margherita Children’s University Hospital, Turin, Italy

Guido Filler, M.D., Ph.D. Professor of Pediatrics, Chair Department of Pediatrics, Children’s Hospital, London Health Science Centre University of Western Ontario, Canada

Richard N. Fine, M.D. Professor of Pediatrics, State University of NY at Stony Brook, NY

Joseph T. Flynn, M.D., MS Dr. Robert O. Hickman Endowed Chair in Pediatric Nephrology, Professor of Pediatrics, University of Washington, Chief, Division of Nephrology Seattle Children’s Hospital, Seattle, WA

Larry Greenbaum, M.D. Professor of Pediatrics and Chief Pediatric Nephrology Emory University, Atlanta

Friedhelm Hildebrandt, M.D. Chief Division of Nephrology, Boston Children’s Hospital, Professor of Pediatrics, Harvard Medical School Boston, MA

Kazumoto Iijima, M.D., Ph.D. Professor and Chairman, Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan. IPNA Councilor

Frederick J. Kaskel, M.D., Ph.D. Division of Pediatric Nephrology, Children’s Hospital at Montefiore, Professor and Vice Chair of Pediatrics, Director for Child Health, Einstein/Montefiore Institute for Clinical and Translational Research

Vera Koch, M.D. Professor of Pediatric Nephrology, Instituto da Crianza do Hospital das Clinicas, Universidad of Sao Paulo, School of Medicine, Brazil. Secretary General ALANEPE. IPNA Councilor.

Craig B. Langman, M.D. The Issac A. Abt M.D. Professor of Kidney Diseases, Feinberg School of Medicine, Northwestern University, Head Kidney Diseases, Lurie Children’s Hospital of Chicago, Chicago, IL

Deborah Lewis, M.D. Professor of Pediatric Nephrology Sydney, Australia. IPNA Councilor.

Helen Liapis, M.D. Pathologist at Nephropath, Retired Professor of Pathology & Immunology, Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University School of Medicine St. Louis, MO; Co-Chair Renal Pathology Course

John D. Mahan, M.D. Professor, Department of Pediatrics Program Director, Pediatric Residency Program Program Director, Pediatric Nephrology Fellowship Program Vice Chair for Education, The Ohio State University COM, Columbus, OH

Mignon McCulloch, M.D. Associate Professor, Pediatric ICU Consultant/Pediatric Nephrologist, Red Cross Hospital and University of Cape Town, Toronto, Ontario, CA. IPNA Councilor

Mark Mitsnefes, M.D., MS Professor of Pediatrics, Division of Nephrology and Hypertension, Program Director Clinical Translational Research Center, Cincinnati Children’s Hospital, OH

Mathew Sampson, M.D. Assistant Professor of Pediatrics, University of Michigan, Ann Arbor, MI

William E. Smoyer, M.D. C. Robert Kidder Chair Vicepresident, Clinical and Translational Research, Director Center for Clinical and Translational Research. The Research Institute at Nationwide Children’s Hospital, Columbus, OH

Isidro Salusky, M.D. Distinguished Professor of Pediatrics, Chief, Division of Pediatric Nephrology, Director Clinical Translational Center, Associate Dean of Clinical Research, David Geffen School of Medicine at UCLA, Los Angeles, CA

Franz Schaeffer, M.D. Pediatric Nephrology, University of Heildelberg, Germany. IPNA Councilor

H. William Schnaper, M.D. Professor of Pediatrics; Vice Chairman, Children’s Memorial Medical Center, Feinberg School of Medicine, Northwestern University, Chicago, IL

Surya Seshan, M.D. Professor of Pathology, Department of Pathology, The New York Hospital-Cornell Medical Center, New York, NY

Bradley A. Warady, M.D. Professor of Pediatrics, University of Missouri-Kansas City School of Medicine, Director, Division of Pediatric Nephrology; Director, Dialysis and Transplantation, Children’s Mercy Hospital, Kansas City, MO, Treasurer IPNA

H. Kim Yap, M.D., FRCP Head and Senior Consultant, Division of Pediatric Nephrology, National University of Singapore, Singapore. IPNA Councilor

Flanked by the roaring Atlantic Ocean and rippling Intracoastal Waterway, the Alexander All Suite Ocean Front Resort is located in the heart of

Miami Beach. Attendees will enjoy late-winter in South Florida which is unlike that in any other part of the U.S. thanks to a subtropical climate and strong

Caribbean/Latin American influences. It’s just the right place for recharging your personal and professional perspectives in the company of friends and

colleagues. You won’t need your coat, boots, or umbrella, but a light jacket may feel good in Miami’s moonlit evening breezes and super-air

conditioned restaurants.

Room Rates: US $299.00 + US $15.00 Resort Fee and 13% tax-Single/Double Occupancy- European plan

(meals not included).

Room rates apply three day prior to, during and three days after the Seminar. Reservations must be received by February 9, 2016 to take advantage of the above rate. Please use attendee code 38Q335 when making your

reservations for a discounted rate. After this date, reservation requests will be considered on a space available basis.

Advanced Registration Fee:Renal Pathology Course ONLY US $125.00

Pediatric Nephrology Seminar ONLY US $350.00

Pediatric Renal Pathology Course and Pediatric Nephrology Seminar US $450.00

CRRT Workshop on Sunday afternoon ONLY US $ 50.00

Physicians in Training (except Grantees), Nurses and Allied Health Professionals* US $295.00

* Physicians in Training will need letter of verification from Chief of service. Tuition includes admission to scientific sessions, a course flash drive and continental breakfasts. After February 27, 2016 and (On-Site) US $550.00 for physician in practice and US $330.00 for others.

PLEASE NOTE THAT ONLY US CHECKS AND MONEY ORDERS CAN BE ACCEPTED FOR ONSITE REGISTRATION. NO CREDIT CARDS CAN BE ACCEPTED ON SITE.

Services for the Disabled:If special arrangements are required for an individual with a disability to attend this conference, please contact: Ivette Arauz, (305) 585-6726 and the Alexander All Suite Ocean Front Resort 1-800-327-6121 or (305) 865-6500 no later than February 20, 2016.

For Additional Information, contact:Department of PediatricsDivision of Pediatric NephrologyP.O. Box 016960 (M-714)Miami, FL 33101Tel. (305) 585-6726Email: pediatricnephrology@med.miami.edu

To register online, visit http://pediatrics.med.miami.edu/nephrology/seminar select conference you are attending and click register and pay.

Registration Cancellation PolicyRefunds will be made only if written notice of cancellation is received prior to February 27, 2016. A US $75.00 fee is charged to all refunds. After this date, no refunds will be made. In cases where a course is cancelled due to insufficient registrations, a full tuition refund will be made.

Hotel InformatIon

The Alexander ALL SUITE OCEANFRONT RESORT

5225 Collins Avenue, Miami Beach, FL 33140Tel: 1-800-327-6121 or (305) 865-6500

Email: reservations@alexanderhotel.com

PEDIATRIC NEPHROLOGY SEMINAR XLIIIRegistration Information

PROGRAM DIRECTOR: Gastón Zilleruelo, M.D. ASSOCIATE PROGRAM DIRECTORS:

Carolyn L. Abitbol, M.D. and Michael Freundlich, M.D.FOUNDED BY: José Strauss, M.D.

.COURSE DESCRIPTIONThe Miami Pediatric Nephrology Seminar now in its 43nd year is an unique international gathering of pediatric and adult nephrologists, pediatricians, internists, general practitioners, renal pathologists, neonatologists, pediatric urologists, transplant surgeons, nurses, nutritionists and allied health professionals from all over the United States and the world sponsored by the University of Miami, Leonard Miller School of Medicine and Holtz Children’s Hospital at Jackson Memorial Hospital. The content is basic, the approach is clinical. Conceptual and practical problems are featured in a balance of formal presentations followed by informal discussions. Topics covered relate research advances to the understanding of mechanisms of renal disease, pathological expressions and clinical diagnosis and management. All registrants have opportunities to be involved in a dynamic exchange of information, experience, and insight. Selection of topics, faculty and format are based on suggestions from past Seminar participants and current questions. The 43rd Pediatric Nephrology Seminar and the preceding Renal Pathology Course will include a total of 13 Sessions from March 10-13, 2016. This coming year we will have the opportunity to celebrate the 2016 World Kidney Day on March 10 and host the IPNA Executive Council Meeting which will take place concurrently during the first two days. The Pre-Seminar Renal Pathology Course is an intensive, one day comprehensive course covering all aspects of nephro-pathology starting with sample processing and transition to glomerular, tubular, cystic as well as systemic and metabolic disorders affecting pediatric and young adult patients finalizing with a clinico-pathologic correlations interactive Session. The Pediatric Nephrology Seminar will cover a wide range of topics including Developmental and Genetic Disorders of the Kidney, Glomerular Disorders and Nephrotic Syndrome, Pediatric Nephrology for the Clinician, Congenital Obstructive Uropathies and Nutrition and Growth in CKD (Workshops), Bone and Cardiovascular Diseases and Dialysis and Transplant Challenges. In addition, there will be an optional “hands-on” Workshop dealing with CRRT and Critical Care Pediatric Nephrology at the end of the Seminar specifically developed for physicians in-training. All the topics selected have high clinical research relevance and have not been covered in this format by other conferences in recent years. The Seminar will feature 30 distinguished Guest Faculty and 22 Local Faculty who will provide expertise and cordial exchanges including several panel discussions and Meet the Professor Luncheons. We hope you will enjoy attending this newly structured scientific meeting. Details regarding the full program, speakers, registration, grant applications and hotel reservations are available in our web page at http://pediatrics.med.miami.edu/nephrology/seminar.

CONFERENCES OBJECTIVES• Diagnose and treat the most frequent conditions by identifying recent

discoveries in basic, translational and clinical research in selected areas of pediatric nephrology, and assessing its impact in research development.

• Recognize and assess routine handling, processing and reporting of kidney biopsies with a systematic approach in the diagnosis of medical renal diseases in particular developmental and cystic disorders.

• Establish appropriate diagnosis and management of children with various medical renal diseases by assessing the histopathologic findings obtained from kidney biopsies.

• Assess and utilize diagnostic testing in the practitioner approach to infants and children with inherited pediatric nephrology disorders.

• Evaluate pathogenesis, complications and management of infants and children with congenital obstructive uropathies

• Recognize the pathogenesis, diagnose complications and select appropriate management of children with glomerular disorders

• Evaluate growth and the use recombinant growth hormone therapy in the management of children with growth impairment associated with chronic kidney disease (CKD) and assessment of nutrition abnormalities in children with this condition.

• Review recent knowledge in the evaluation and management of children with arterial hypertension

• Recognize the impact of kidney disease on the bone metabolism and cardiovascular system

• More effectively manage children with CKD, dialysis and transplant and its complications using newer drugs and modalities of renal replacement therapy

Upon completion of the Seminar, participants should be able to define the various etiologies and physiologic conditions relating to these subjects, select appropriate diagnostic procedures, understand that which may occur as a result of the disease process or treatment, and indicate appropriate therapy.

In addition, those able to do basic or clinical research focused on pediatric nephrology challenges, will be stimulated by those knowledgeable about research issues and be informed about support sources. It is anticipated that the exchanges of knowledge occurring during this meeting, will help identify future research directions and new approaches and technologies that will eventually lead to a better understanding of these conditions and improved treatment and prevention strategies. It is expected that the Faculty will serve as role models for future generations of Pediatric Nephrologists and serve to stimulate interest in this field as a career choice. The Pediatric Nephrology Seminars have successfully addressed for over 42 years the issues of selecting the best faculty speakers, formal lectures of short duration followed by panel discussions and case-based presentations. Informal exchanges throughout the meeting allows for clear improvement in the professional gaps of the intended audience. The faculty, format and educational design will allow learners to give better patient care with regards to early detection of kidney disease in children or its complications (i.e growth hormone deficiency) and a more evidence based management of these conditions.

ACTIVITY LEARNING OBJECTIVESGoals for the Scientific Conference/Seminar.The purpose of the Pediatric Nephrology Seminar XLIII and Renal Pathology Course will be to review the current state/knowledge of selected relevant areas of research in Pediatric Nephrology with clinical practice implications. The specific aims of the proposed scientific Seminar are:

1. To review the current understanding of the diagnosis and management of various kidney disorders with a focus on clinical research, clinico-pathologic correlations, current issues for the primary care practitioner, effects of nutrition, and recombinant growth hormone in chronic kidney disease, in-depth review on the nephrotic syndrome and selected glomerulopathies, on-going challenges in critical care nephrology, chronic kidney disease, dialysis and transplantation, and new developments in congenital obstructive uropathies and urolithiasis.

2. To identify the most critical and promising areas for future basic and clinical research efforts regarding Pediatric Nephrology.

3. To stimulate interest in Pediatric Nephrology as a career choice .

4. To provide role models for the next generation of Pediatric Nephrologists and a communication network for future collaboration and career support for retention of current trainees.

FACULTY DISCLOSURE AND CONFLICT OF INTEREST RESOLUTIONAll conflicts of interest of any individual(s) in a position to control the content of this CME activity will be identified and resolved prior to this educational activity being provided. Disclosure about provider and faculty relationships, or the lack thereof, will be provided to learners.

Pediatric Nephrology Seminar XLIII and the Renal Pathology Course are an international forum for pediatric and adult nephrologists, pediatricians, internists, general practitioners, renal pathologists, neonatologists, pediatric urologists, transplant surgeons, nurses, nutritionists and allied health professionals to review selected relevant subjects and share new scientific materials.

ACCREDITATIONThe University of Miami Leonard M. Miller School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATIONThe University of Miami Leonard M. Miller School of Medicine designates this live activity for a maximum of 37.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This seminar has been planned and implemented in accordance with the essential areas and policies of the Florida Board of Nursing for Continuing Education Provider #50-2105. The University of Miami School of Nursing and Health Studies designates this live activity for a maximum of 3 CEU credits.