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Using fMRI to detect conscious awareness Adrian M. Owen MRC Cognition and Brain Sciences Unit, Cambridge, UK http://web.me.com/adrian.owen

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Page 1: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Using fMRI to detect conscious awareness

Adrian M. Owen

MRC Cognition and Brain Sciences Unit, Cambridge, UK

http://web.me.com/adrian.owen

Page 2: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

“The limits of consciousness are hard to define satisfactorily

and we can only infer the self-awareness of others by their

appearance and their acts”

Plum and Posner, The Diagnosis of Stupor and Coma, 1966

Page 3: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Davis et al., PNAS, 2007

Coleman et al., BRAIN, 2007

Page 4: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Speech-specific responses are common in disorders of consciousness

Coleman et al., Brain, 2009

Page 5: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Speech-specific responses in VS and MCS

Coleman et al., Brain, 2009

Page 6: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

“….Imagine playing tennis”

Boly et al., Neuroimage, 2007; Owen et al., Science, 2006

Page 7: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Instructions:

“If you want to say „yes‟, imagine playing tennis”

“Is your husband

called Terry?”�

“Is your husband

called Charlie?”�

“Is your dog

called Charlie?”�“Is your dog

called Terry?”�

Owen & Coleman, Nature Reviews Neurosciences, 2008

Page 8: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”
Page 9: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Owen et al., Science, 313, 1402, 2006

Page 10: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Owen et al., Science, 313, 1402, 2006

Page 11: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Monti/Vanhaudenhuyse et al., NEJM, 2010

Page 12: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Monti/Vanhaudenhuyse et al., NEJM, 2010

Page 13: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Monti/Vanhaudenhuyse et al., NEJM, 2010

Page 14: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

“The limits of consciousness are hard to define satisfactorily

and we can only infer the self-awareness of others by their

appearance and their acts”

Plum and Posner, The Diagnosis of Stupor and Coma, 1966

Page 15: Using fMRI to detect conscious awareness Adrian M. OwenInstructions: “If you want to say „yes‟, imagine playing tennis” “Is your husband called Terry?” called Terry?”

Thanks…

Wolfson Brain Imaging Centre, Cambridge

Martin Coleman

David Menon

John Pickard

Anthony Absalom

Ram Adapa

MRC Cognition and Brain Sciences Unit

Tristan Bekinschtein

Damian Cruse

Rhodri Cusack

Matt Davis

Diets Jolles

Martin Monti

Beth Parkin

University of Liege

Audrey Vanhaudenhuyse

Melanie Boly

Steven Laureys


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