utu research faculty of medicine · 2018-06-05 · pharmacoepidemiology of statins and oral...

UTU Research Faculty of Medicine

Zhi Jane Chen

Lymphocytes and Inflammation

• Th17 and iTreg in inflammatory/autoimmune axis

• Th17 and iTreg differentiation

• Immune and hormonal responses

• Pathogenesis of immune-mediated diseases

BioCity Turku Centre for Lifespan Research

Juha Grönroos

Minimally invasive surgery/Acute appendicitis

• GI surgery

• Pancreatobiliary diseases

• Colorectal cancer

• Endoscopic and laparoscopic biliary and pancreatic

surgery

• Treatment of acute appendicitis

Ulvi Gursoy

Bacterial Signaling Molecules in

Immune Response Regulation and

Biofilm Eradication; Exploring the Role

of Nrf2/ARE Pathway in Periodontitis

• Bacterial messenger molecule analogs

• Biofilms and Biomarkers

• Molecular mechanisms of the Nrf2/ARE

pathway

Merja Haaparanta-Solin

PET imaging of neuropathological changes

in animal models of Alzheimer's disease

• Alzheimer's disease

• endocannabinoid modulation

• brain energy metabolism

• neuroinflammation

• norepinephrine function

• beta-amyloid plaque and tau formation

BioCity Turku Translational Infectious Disease and Immunity Research Programme,

and Turku Brain and Mind Center

Terho Heikkinen

Respiratory tract infections in children:

epidemiology, management, prevention,

and total impact on the society

• Pediatrics

• Respiratory infections

• Vaccinations

• Health economics

BioCity Turku Translational Infectious Disease and Immunity Research Programme

Terhi Heino

The role of mesenchymal stem cells

in fracture healing

• Mesenchymal stem cells

• Bone formation and regeneration

• Signaling mechanisms in fracture healing

• Molecular and cellular interactions


Veijo Hukkanen

Herpesviruses as friends and enemies

• latency of HSV and its prevention

• delivery and targeting methods for HSV gene

therapy

• HSV diversity

• HSV diagnostics


Risto Huupponen

Pharmacoepidemiology of statins and

oral anticoagulants

• the association of adherence to statins on

therapeutic outcomes and on the cost-

effectiveness of statin treatment

• drug interactions with warfarin at the

population level

Jukka Hytönen

Lyme borreliosis: a comprehensive approach

• Prevalence of ticks and epidemiology of

borrelioses

• Susceptibility of humans to disseminated LB

• Pathogenesis of LB: adhesins, tissue tropism

• Molecular and cellular events in neuroborreliosis

• Diagnostics for borrelioses, biomarkers

• Development of PET/CT imaging of LB


Pekka Hänninen

Laboratory of Biophysics

• instrumentation and methods for light microscopy,

correlative multimodal microscopy and bio-analysis

• New super-resolution techniques: 3D super

resolved tomography, nano-probes, in-vitro models

and photoacoustic microscopy methods (PAM)

• Chemical fingerprinting technique

BioCity Turku Diagnostic Technologies and Applications

Erika Isolauri

Neonatal exposures, Adverse outcomes, Mucosal

immunology and Intestinal microbiota (NAMI)

• The impact of early microbial colonization patterns on

the growth of children/obesity risk - long-term follow-up.

• Characterizing foeto-maternal microbe contact.

• Defining a microbial marker as an indicator of the risk of

complicated pregnancy impacting on dysbiosis and

abnormal growth in the child.


Kaisa Ivaska

Bone and energy metabolism

• Diabetic bone disease

• Effects of energy metabolism on bone

cells and bone microenvironment

• Osteoblasts

• Osteocalcin


Panu Jaakkola

Oxygen sensing molecules in kidney cancer

• Renal clear cell carcinoma (ccRCC)

• hypoxia-inducible factor (HIF)

• prolyl hydroxylase enzymes (PHD) 1-3

• Hippel-Lindau tumor suppressor protein (pVHL)

BioCity Turku Receptor Programme

Ilkka Julkunen

Mechanisms of activation of innate immunity in

viral infections

• viral infections, viral proteins (vaccines) and viral

genetic material in the activation of host immune

responses (DCs, macrophages)

• novel mechanisms to prevent the replication of viruses

and excessive inflammatory responses

• Seroepidemiological studies: Influenza and RSV

• Disease mechanisms in pandemic influenza vaccine

induced narcolepsy


Hannu Järveläinen

Extracellular matrix macromolecules in health

and disease – with special reference to

cardiovascular diseases and cancer

• Extracellular matrix macromolecules - proteoglycans

and hyaluronan - in atherogenesis, excess

angiogenesis and tumorigenesis.

• Decorin and decorin-based gene therapy

• Angiogenesis

Associated to BioCity Turku Computational and Molecular Methodologies for Life Sciences

Tuomas Kiviniemi

CAREFIB Consortium

• atrial fibrillation

• a retrospective epidemiological CAREAVR study

• a prospective CAREBANK biobank

• a prospective CARECLOSURE trial.

BioCity Turku Diagnostic technologies and applications

Markku Koulu

Prenatal programming of energy

balance and metabolism

• Metformin-induced metabolic programming

and changes in gene expression

• Metabolic effects of prenatal metformin

exposure in different pre- and postnatal

conditions

Veli-Matti Kähäri

Skin cancer and proteinase research group

• Molecular mechanisms in progression, invasion

and metastasis of cutaneous squamous cell

carcinoma (cSCC)

• new biomarkers for evaluating the risk of

progression and metastasis of cSCC and identify

novel therapeutic targets

• the role and regulation of proteinases MMPs in

tissue repair and fibrosis


Eija Könönen

Periodontal inflammation and infection-

induced inflammation

• periodontal infection and infection-induced

inflammation

• oral biofilm-host interaction

• impact of periodontal disease on systemic conditions

• salivary diagnostics in periodontology


Riitta Lahesmaa

Molecular Systems Immunology

• Molecular markers in type 1 diabetes (T1D) –

integration of omics, autoantibody, genetics and

demographic data

• Holistic approach in characterization of the novel

genes and pathways in with primary human

CD4+ T helper (Th) cell differentiation


Tiina Laitala-Leinonen

RNA- or trauma -mediated gene regulation

• Short regulatory RNA physiology: siRNAs, shRNAs,

microRNAs

• Short regulatory RNA involvement in tissue healing

after trauma

• (BAAC) Biological Assessment of Acute Concussions

in athletes

• Entesophyte project: calcific spur formation at the

Achilles tendon

• EUROCLAST: extensive vesicular trafficking in bone-

resorbing osteoclasts


Liisa Lehtonen

Neonatal Research

• The PIPARI Study

• Close Collaboration with Parents - Evaluation of the

Intervention

• International Closeness Survey in the SCENE Group

• International Network for Evaluating Outcomes

(iNeo) of Neonates


Lund Riikka

Biomedical Epigenomics

• Regulation of stem cell state and transformation

• Epigenetic mechanisms of childhood leukemia

Epigenomics of childhood rhinovirus-induced

wheezing and asthma

• Epigenomic alterations in aging and Alzheimer’s

disease

BioCity Turku Computational and Molecular Methodologies for Life Sciences

Pieta Mattila

Lymphocyte Cytoskeleton Group

• B cell activation

• Actin cytoskeleton

• Antigen receptor signaling and

remodeling of the cytoskeleton

• Advanced microscopic methods


Sari Mäkelä

Diet and cancer

• Dietary factors in hormone-dependent cancers (breast

and prostate cancer)

• Altered sex steroid action and obesity-related metabolic

dysregulation

• Plant-derived polyphenols (e.g. lignans, stilbenoids,

flavonoids)

• Preclinical in vivo models

BioCity Turku Center for Lifespan Research

Jorma Määttä

Myeloid cells in regulation of chronic

inflammation, autoimmunity and tumor

microenvironment

• Myeloid cells in immune response

• Tumor associated macrophages and tumor

microenvironment

• Exosomal miRNA communication

• Treatments based on bisphosphonate metabolites


Matej Orešič

Systems Medicine

• Metabolomics

• Integrative bioinformatics

• Personalized medicine

• MZmine open source project = software for

metabolomics data processing


Ville Peltola

Detecting viral infections and targeting

antibiotic use in children with MxA protein

and other biomarkers

• Viral and bacterial respiratory tract infections in

children

• Detecting viral infections and targeting antibiotic

use in children with MxA protein and other

biomarkers


Juha Peltonen

Cancer syndrome / Rasopathy NF1:

pathoetiology and epidemiology

• Neurofibromatosis (NF1)

• NF1 mutation

• Hyperactivation of Ras pathway

• Altered drug metabolism


Sirkku Peltonen

Neurofibromatosis and Cell-cell Interaction Group

• Epidermal tight junctions in skin diseases

• Cell-cell interactions of and gene expression of Schwann

cells

• Gene expression profiling of cultured keratinocytes

• Basic science aspects, translational studies and clinical

research of neurofibromatosis 1.


Matti Poutanen

Mechanisms of Steroid Hormone Action

• Intracrinology

• The role of HSD17B enzymes in regulating the amount

and type of ligand for nuclear receptor action

• The role of local sex steroid synthesis in the

etiopathogenesis of breast and prostate cancer

• The role of intra tissue sex steroid synthesis and steroid

hormone action in endometrium and the role of the

enzymes in etiopathogenesis of endometriosis

BioCity Centre for Lifespan Research

Arto Pulliainen

Cellular microbiology – how bacteria

manipulate host cell signaling

• Bacterial pathogenesis and new human

bacterial pathogens

• Identification and function of bacterial

toxins/effector proteins

• Development of new antimicrobials


Pia Rantakari

Endothelium and embryonic leukocyte

migration

• Leukocyte migration during fetal ontogeny

• Embryonic origin of cells in adults

• Tissue development and adult pathophysiology

Jaana Rautava

Oral mucosal diseases and oral cancer

• Human papillomavirus (HPV) infection in the

mouth and the interaction between HPV and

bacterial microbiome

• Potentially malignant lesions/conditions of oral

mucosa

• Crohn’s disease and oral diseases

• Medication related osteonecrosis of the jaws

Päivi Rautava

• The Finnish Family Competence Study 1985-

• Reproductive and Sexual Life Span of Women 2010-

• The Development of Maternity and Child Health Care

Services 2010-

• The development of health care service structure by

using the information resources of the electronic

patient records and other registries 2011-


Samuli Rautava

Early microbial contact and child health

• Modulating early microbial contact infants at risk of

aberrant compositional development of gut

microbiota

• Early antibiotic exposure, gut microbiota and risk of

disease

• Gut microbiota and preterm birth - from prediction to

prevention


Teijo Saari

Precision Medicine in Anesthesiology:

Individualization of Pain Therapy and Perioperative

Care with Pharmacometric and Omics Studies

• Pharmacokinetics and –dynamics (PK-PD)

• PK-PD models for drugs

• Pharmacometric model development

• Individualized therapy


Sanna Salanterä

Digital Nursing Turku

• Knowledge-Based Management in the Acute Care Setting

and Perioperative Nursing

• IoT for Basic Nursing Care

• Basic Nursing Care (The Step)

• Tailored Information for Patient’s and Professionals (Tailor)

• Research Group on Health Games (TEPE)

Paulina Salminen

Acute appendicitis and bariatric surgery studies

• Clinical surgical studies and translational research

• Pathophysiological mechanisms of surgically treated

diseases

• Bariatric surgery and obesity

• Acute appendicitis

• Gut microbiota

• Inflammatory biomarkers

Eriika Savontaus

Neuroendocrine mechanisms in pathogenesis

and therapeutics of cardiometabolic diseases

• Neuropeptides NPY and POMC (melanocortins)

• Obesity, body weight and composition

• Tissue-specific mechanisms of NPY and

melanocortin action

• Drug development for metabolic and cardiovascular

diseases


Harry Scheinin

Anesthesia Mechanisms

• Exploration of neural correlates of human

consciousness.

• New tools for distinguishing consciousness,

connectedness and responsiveness.

• Development of EEG-based methods to

measure consciousness and the depth of

general anesthesia.

Turku Brain and Mind Center

Johanna Schleutker

Genetic predisposition to cancer

• Prostate and breast cancer genetics

• Identification of predisposing genes

• Diagnosis and treatment

• Prognostic biomarkers


Sari Stenholm

Life-long determinants of healthy aging

• Healthy aging at work and at retirement -

Finnish Retirement and Aging Study (FIREA)

• Integrated Datasets across Europe for Ageing

Research (IDEAR) network

• Psychosocial work environment and healthy

ageing

Riitta Suhonen

Older Individuals' Health, Nursing and

Services

• Health, health determinants and promotion of health

• Complex service systems

• Nursing care

Petri Susi

Molecular determinants of picornaviral

disease

• Diagnostics: development of detection assays

• Viral tropism in model systems

• Virus evolution: natural sequence variation and

its consequences in infectivity


Pekka Taimen

Nuclear Lamins and Human Disease

• Nuclear lamina proteins

• Laminopathies

• Cancer progression

• Lamin mutations

https://fi.linkedin.com/in/pekka-taimen-52636366

Olli Tenovuo

Traumatic brain injury research group

• Mechanisms of TBI

• Individual diagnostics of TBI

• Detection and characterization of injury

types and mechanisms

Turku Brain and Mind Center

Mika Teräs

Medical physics research

• Instrumentation in nuclear medicine

imaging

• Dual gating in cardiac PET

• Perfusion in cardiac imaging

• Optimization in radiation dosimetry

Arzu Tezvergil-Mutluay

Adhesive Dentistry Research Group

• Tooth-restorative materials

• Tissue engineering

• Nanoscale biomimetic materials and

biomimetic remineralization

• Metalloproteinase regulation

BioCity Turku Biomaterial and Medical Device Research Programme

Jorma Toppari

Developmental determinants of

reproductive health and type 1 diabetes

• Reproductive health

• Reproductive hormones

• Environment and endocrine disruptors

• Cohort studies


Johanna Tuomela

Innate immunity receptor (TLR9) in cancer

• Breast and prostate cancer

• Toll-like receptor-9 (TLR9)

• Molecular pathways in cancer cells

• Biomarkers and drug targets


Waris, Matti

Host response and molecular variation in

respiratory and enteric virus infections

• Respiratory and enteric viruses

• Molecular diagnostics tools: microarray

techniques with phosphor reporters

• treatment and prevention of respiratory virus

infections.

• Associated projects:• Innate immunity in rhinovirus infections

• Application of MxA assay in clinical diagnotics

• Epidemiology of respiratory virus infections

• AIRBORNE: Assessing hospital-aquired infection risks

to healthcare workers from patients infected with

aerosol-transmitted pathogens


Jukka Westermarck

Cancer Cell Signaling

• Human cancers

• Phosphorylation

• Protein phosphatase 2A (PP2A)

• CIP2A (PP2A inhibitor protein)


utu research faculty of medicine · 2018-06-05 · pharmacoepidemiology of statins and oral...

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