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Page 1: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Page 2: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 3: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

SCF

Ras

GDP

Inactive

nucleus

Page 4: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 5: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 6: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 7: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 8: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 9: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 10: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 11: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 12: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 13: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 14: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 15: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 16: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 17: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 18: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 19: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 20: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 21: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 22: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

v

SCF

Ras

GDP

Inactive

nucleus

Page 23: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 24: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 25: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 26: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 27: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 28: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 29: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 30: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 31: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 32: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 33: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 34: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 35: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 36: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 37: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 38: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 39: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 40: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 41: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 42: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 43: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 44: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 45: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 46: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 47: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 48: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

Page 49: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDP

Inactive

nucleus

P

P

P

P

Page 50: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

Active!

nucleus

Page 51: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

Active!

nucleus

Page 52: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

Active!

nucleus

Page 53: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 54: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 55: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 56: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 57: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 58: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 59: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 60: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 61: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 62: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 63: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 64: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 65: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 66: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 67: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 68: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 69: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 70: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 71: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 72: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 73: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 74: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 75: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 76: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 77: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 78: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 79: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 80: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 81: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 82: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 83: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 84: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 85: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 86: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 87: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 88: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 89: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 90: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 91: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 92: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 93: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 94: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 95: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 96: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 97: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

Src

Page 98: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Page 99: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Active!

Page 100: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Active!

Page 101: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Active!

Page 102: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 103: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 104: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 105: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 106: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 107: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 108: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 109: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 110: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcP

Shc

Page 111: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShc

Page 112: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShc

Page 113: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Page 114: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 115: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 116: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 117: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 118: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 119: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 120: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 121: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 122: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 123: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 124: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 125: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 126: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 127: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 128: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 129: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

GTP

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 130: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

GTP

P

PP

P

Ras

GDP

Inactive

nucleus

SrcPShcP

Grb2 Sos

Page 131: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDPGTPP

PP

P

RasInactive

nucleus

SrcPShcP

Grb2 Sos

Page 132: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GDPGTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Page 133: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Active!

Page 134: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Active!

InactiveRaf-1

Page 135: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos Active!

Raf-1

Page 136: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

MEK

Inactive

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Page 137: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Inactive

Page 138: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Inactive

P

Page 139: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Page 140: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Page 141: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Inactive

Page 142: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

Active!

P

Inactive

Page 143: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

Page 144: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

Page 145: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

Page 146: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Inactive

PP

Page 147: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Active!

PP

Page 148: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

Page 149: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

Page 150: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Erk PP

Page 151: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 152: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 153: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 154: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 155: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

Raf-1

P

Page 156: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

Ras

nucleus

SrcPShcP

Grb2 Sos

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Page 157: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription!

Page 158: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

Page 159: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

Page 160: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

Page 161: v SCF Ras GDP Inactive nucleus SCF Ras GDP Inactive nucleus

Erk PP

MEK

Ras

GTP

Ras

GTPP

PP

P

RasSrcPShcP

Grb2 Sos

Raf-1

P

Transcription! cell growth

SCF calculation

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