vector-borne diseases emergence carla a. sousa · projeto financiado por ec (contract number:...
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TRAVEL HEALTH 2018
Clinical Pathology
Museum
Community services✓ Shared Global Health mission✓ Research Institute and Center of excellence✓ Unique infra-structures
✓ Unique Community Services
✓ Shared Global Health mission✓ Research Institute and Center of excellence
✓Unique infra-structures
Infrastructure
Accredited animal house
(license id approval: 023351 and 023355)
Colonies in regular production
A. gambiae, A. stefhensi and A. atroparvus
Membrane Feeding Assays
Plasmodium berghei, Plasmodium vivax (Manaus Brasil)
ACCREDITED animal house
Projects office
GAP
Mosquito colonies and VB pathogens life cycle
Experimental infections
Cohort – migrants
600 Children 4
and 5 years of age
Amadora (Lisbon)
Biobank Bioinformatics Hub
Biosafety level 3 labM
OU
SE
MO
US
E
Security insectary
✓ Global Health Teaching
✓Recognition
“Knowledge for Development Initiative - IkfD” Based in IHMT NOVA, aims to train 80 new doctors per year
from Portuguese-speaking African countries.
UNESCO Center for research and advanced training.
The Research Center structure.
Diagnostics: nanotehncology, point of care
Drug/insecticide discovery & resistance
Public health information
Global pathogen dispersion & mobility of populations
Fair partnerships
Vulnerable populationsUniversal Health CareHealth Systems,Human Resources for Health
Travelers healthFebrile illnesses in the tropics
Molecular epidemiology PhylogeographyRespiratory diseasesAll genome analysis
Malaria, Leishmania, ArbovirusEntomology.Molecular epidemiology and evolution,Population geneticsHost-parasite interactions
PPSPopulation Health,
Policies and Services
IHCIndividual Health Care
THOPTuberculosis, HIV andOpportunistic Diseases
VBDVector Borne Diseases
Global pathogen dispersion & mobility of populations
Risk Assessment For the Emergence of Vector-Borne Diseases
• Vector habitat suitability in current and future climatic scenarios
• Predictive models for vector abundance
• Connectivity models
• Compartmental/statistical models for disease emergence
FCT/UNLDepartamento
AmbienteJúlia Seixas
IGOTJorge Rocha
César Capinha
Risk Assessment For the Emergence of Vector-Borne Diseases
2004/2006 - "Rarimosq - survey and risk analysis of mosquito borne diseases,
particularly arbovirosis, using remote detection".
2004/2010 - “EDEN - Emerging diseases in a European changing environment”.
Projeto financiado por EC (contract number: 010284-2).
2008/2010 - "MALVEO - Vulnerability Mapping to Malaria Vector from Earth
Observation Data - Anopheles atroparvus density mapping under climate
scenarios for Southern Portugal”.
2011/2014 - “AegYpti - Dengue in Madeira archipelago. Risk assessment for the
emergence of Aedes aegypti mediated arboviroses and tools for vector control”.
2018/… - “WARDEN - An operational early WARning system for DENgue and other
arboviral diseases in Madeira Island”
2018/…. - “TRIAD - HealTh RIsk and Social Vulnerability to Arboviral Diseases in
Mainland Portugal”
Risk Assessment For the Emergence of Vector-Borne Diseases
Malaria in Portugal
The vector:
Anopheles atroparvus Van Thiel, 1927
One of the 3 An. maculipennis sibling
species recorded in Portugal.
An. atroparvus
An. maculipennis s.s.
An. melanoon
The most abundant Anopheline.
Country-wide distribution.
Risk Assessment For the Emergence of Vector-Borne Diseases
Aedes aegyptiAedes albopictus
Importânciamédica
Agente de incomodidade
Vector:DengueFebreamarelaChikungunya
Antropofílico
Alimentam-se em humanos
Urbano e doméstico
Águasparadas e limpas
Criadourosfeitos peloHomem
Hábitos de picadadiurnos
Sinantrópico
Endofílico
Endo/exofágico
Controlovetorial
Eliminaçãofisica de criadouros
Aplicação de larvicidas
Aplicação de adulticidas(em surto)
Risk Assessment For the Emergence of Vector-Borne Diseases
Risk Assessment For the Emergence of Vector-Borne Diseases
76 records of presence and 16 of absence
-Indoors resting collections
-770 Collections sites
- 417 Localities
Risk Assessment For the Emergence of Vector-Borne Diseases
Risk Assessment For the Emergence of Vector-Borne Diseases
Risk Assessment For the Emergence of Vector-Borne Diseases
Risk Assessment For the Emergence of Vector-Borne Diseases
Risk Assessment For the Emergence of Vector-Borne Diseases
An operational early WARningsystem for DENgue and other
arboviral diseases in Madeira Island
PI: Carla A. SousaFunding: PTDC/SAU-PUB/30089/2017
Travellers flow data
Ongoing epidemics
Human population density
Mosquito vector densities
Disease importation risk
Virus extrinsic incubation period
Real-time computational integration of the2 components
Daily forecasts of risk of an arboviral outbreakup to 16 days
Spatial-temporal predictive modelsData assimilation module WARDEN
Spatialized real-timeclimate data
healTh RIsk and social vulnerability to Arboviral Diseases in mainland portugal
TRIAD
PI: Carla A. Sousa
Funding: PTDC/EGE-ECO/32511/2017
Aedes albopictusenvironmental envelope
Water availability
Vegetation indexes
Development traits under extremes of temperature
Development traits under extremes of humidity
Flows of people and goods
Urban systemdefinition
Transport & accessibility networks
Vector´s distribution and density models
Population social vulnerability
Disease transmission risk
Outbreak scenarios
using agent-based
simulation
Land Use Land Cover modelling
AbioticPredisposing
Factors
BioticPredisposing
Factors
Vulnerabilityand Risk
modelling
VectorBiology
Range of disease transmission
Obrigada
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