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NIMS UNIVERSITY, JAIPUR SYLLABUS B. TECH. (BIOTECHNOLOGY)

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Page 1: memberfiles.freewebs.commemberfiles.freewebs.com/70/97/62979770/documents/BTech... · Web viewSYLLABUS B. TECH. (BIOTECHNOLOGY) Semester-I Scheme of Examination Subject Hrs. per Week

NIMS UNIVERSITY, JAIPUR

SYLLABUS

B. TECH. (BIOTECHNOLOGY)

Page 2: memberfiles.freewebs.commemberfiles.freewebs.com/70/97/62979770/documents/BTech... · Web viewSYLLABUS B. TECH. (BIOTECHNOLOGY) Semester-I Scheme of Examination Subject Hrs. per Week

NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Semester-I

Scheme of Examination

Subject Hrs. per Week Exam. hrs Max. MarksTheory Papers L T P IA EXAM TOTALEnglish & Communication Skills

2 0 0 3 25 50 75

Engineering Mathematics-I 3 1 0 3 25 75 100Engineering Chemistry 3 1 0 3 25 75 100Engineering Mechanics 3 1 0 3 25 75 100Fundamentals of Computers 2 1 0 3 25 50 75Electronics Engineering 3 1 0 3 25 75 100Basic Environmental Engineering

2 1 0 3 25 75 100

PracticalsEngineering Chemistry Lab. 0 0 2 - 60 40 100Practical Geometry 0 0 2 - 50 25 75Computer Programming Lab.

0 0 2 - 50 25 75

Electronics Engineering Lab.

0 0 2 - 60 40 100

Grand Total 18 6 8 - 395 605 1000

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

English & Communication Skills

UNIT I: FAMILIARIZING1.1 Familiarizing English through reading-editorials from leading newspapers, leading

journals. Listening to pre-recorded tapes & reproduce vocally what have been heard, reproduce in writing form and answering questions.

1.2 Tongue twisters1.3 Quizzes like jumble words & sentencesUNIT II:

Formal letter writing, report writing, comprehension passage and summary, Abbreviations used in daily life.UNIT III: VOCUBLARY3.1 Synonyms, Antonyms, Homonyms, giving one word for many words.UNIT IV: THEME PRESENTATION4.1 Describing oneself4.2 Describing person or object4.3 Describing picture and photo

Engineering Mathematics-I

UNIT I: MATRICES1.1 Elementary row and column transformation1.2 Rank of matrix1.3 Inverse of a matrix by elementary transformation1.4 Solution of Simultaneous linear equations1.5 Eigen values and Eigen vectors1.6 Cayley-Hamilton Theorem (without proof)1.7 Diagonalization of a matrix.UNIT II: DIFFERENTIAL CALCULUS-I2.1 Asymptotes (Cartesian co-ordinate only)2.2 Concavity2.3 Convexity2.4 Point of Inflexion (Cartesian coordinate only)2.5 Curve tracing (Cartesian Curves only)UNIT III: DIFFERENTIAL CALCULUS-II3.1 Partial Differentiation3.2 Euler Theorem on Homogenous Functions3.3 Approximate calculations3.4 Maximum and Minima of Two and more Independent Variables3.5 Lagrange’s Method of MultipliersUNIT IV: INTEGRAL CALCULUS4.1 Applications in finding the length of simple curves4.2 Surface and Volume of Solids of Revolutions4.3 Double Integral4.4 Area and Volume by Double Integration4.5 Change of Order of Integration4.6 Beta Function and Gamma function (Simple properties)UNIT V: COORDINATE GEOMETRY OF THREE DIMENSIONS5.1 Equation of a Sphere5.2 Intersection of a Sphere and a plane5.3 Normal lines5.4 Right Circular Cone5.5 Right Circular Cylinder

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Engineering Chemistry

UNIT I: WATERCommon Impurities, Hardness, Degree of Hardness, Determination of Hardness

by Clark’s Test and Complexometric (EDTA) method, Municipal Water Supply, Requisites of drinking water, Purification of water, Sedimentation, Filtration, Sterilization, Break Point Chlorination, Water for stream making, Boiler troubles carry over corrosion, Sludge and Scale formation, Caustic embitterment, Methods of Water Treatment, Preliminary treatments, Preheating, Lime-Soda Process, Permutit (Zeolite) Process, De-ionizer or Demineralization, Feed water conditioning, Internal treatment, Blow down, Numerical problems based on water treatment (Lime-Soda process), Water quality standards, Water quality parameters DO, BOD, Solid Metals, Contents of Chloride, sulphate, phosphate, nitrate and micro-organisms, Analytical methods for measuring BOD, COD, DO, F, Oils, Metals (Cd, Cr, Hg, Pb) residual chloride and chlorine demand.UNIT II: FUELS

Introduction and characteristics of fuels, Origin and Classification of fuels, Chemical Fuels, Solid Fuels-(a) Coal (b) Proximate and Ultimate analysis of coal (c) Significance of the constituents (d) Gross and Net calorific value (e) Determination of Calorific value by Bomb Calorimeter (f) Metallurgical Coke (g) Coke- beehive, Coke oven and by-product coke ovens, Liquid Fuels-(a) Advantages (b) Petroleum and refining of petroleum (c) Synthetic petrol (d) Refining and reformation of gasoline (e) Knocking and Anti Knocking Agents (f) Octane number (g) Cetane number, Cracking Gaseous Fuels-(a) Advantages (b) Manufacturing Processes (c) Composition and Calorific Value of Coal gas and Oil gas (d) Determination of Calorific Value by Junker’s calorimeter (e) Flue gas analysis by Orsat Apparatus.UNIT III: PHASE RULE

Explanation and illustration of phase, Component and Degree of freedom, Phase rule and its thermodynamics derivation, One component system and its application to water system, Application of phase rule to sulphur system, Two component system, graphical representation, reduced phase rule equation, condensed state, Application of phase rule to lead silver system, Application of phase rule to potassium iodide and water system.UNIT IV: POLYMERS

Introduction, Classification, Mechanism of polymerization, Plastics, Types of plastic and their uses, Preparation, properties and uses of Polyethylene, Bakelite, Terylene and Nylon, Rubber, Natural Rubber, Synthetic Rubber viz. Buna-S, Buna-N, Butyl and Neoprene Rubbers, Vulcanization Process.UNIT V: LUBRICANTS

Classification of Lubricants, Types of lubrication, Properties and Uses, Viscosity & Viscosity Index, Flash Fire Point, Cloud and Pour Point, Emulsification.UNIT VI: CORROSION

Definition of Corrosion, Its significance in daily life, Theories of Corrosion, Galvanic Cell and Concentration Cell, Pitting and Stress Corrosion, Protection against Corrosion, Protective Metallic Coating.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

UNIT VII: NEW ENGINEERING MATERIALSSuper conductor, Organic Electronic Materials, Fullerenes and Optical fibers.

UNIT VIII: CEMENTManufacturing of Portland Cement, Vertical Shaft Kiln Technology, Chemistry of

Setting and Hardening.UNIT IX: REFRACTORIES

Definition, Properties and Classification, Properties of Silica and Fireclay refractories.UNIT X: GLASS

Preparation, varieties and uses of Glass.

ENGINEERING CHEMISTRY LABLIST OF EXPERIMENTS1. VOLUMETRIC ANALYSIS

- Determination of Hardness of water by EDTA method.- Determination of available chlorine in water- Determination of Ferrous Ammonium Sulphate- Determination of Sodium Hydroxide and Sodium Carbonate in an alkali

mixture2. GRAVIMETRIC ANALYSIS

- Determination of Barium as Barium Sulphate3. PHYSIOCHEMICAL ANALYSIS

- To determine the percentage composition of a given mixture by Viscosity Method

- To determine the percentage composition of a given mixture by Surface Tension Method

4. ANALYSIS OF INORGANIC MIXTURE- Test for Acidic Radicals- Test for combination of Acidic Radicals- Test for Basic Radicals

5. ANALYSIS OF ORGANIC COMPOUND- Detection of Elements-Nitrogen, Halogen and Sulphur- Detection of Functional Group- Determination of Boiling Point of the given Organic Compound- Determination of Melting Point of the given Organic Compound- To purify the given Compound by Sublimation.

Engineering Mechanics

UNIT I: INTRODUCTION1.1 Basic Concepts1.2 Thermodynamics system, properties, work and heat1.3 First Law of Thermodynamics1.4 Non-flow and flow energy equations1.5 Steady flow and unsteady flow1.6 Second Law of Thermodynamics1.7 Carnot Cycle, Clausis InequalityUNIT II: INTERNAL COMBUSTION ENGINE2.1 Otto and Diesel cycle2.2 Thermal Efficiency calculations2.3 Classification of Internal Combustion Engine2.4 Two and Four Stroke Engines

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

2.5 Construction and working of Petrol and Diesel Engines.UNIT III: GAS TURBINE PLANTS3.1 Ideal Brayton cycle3.2 Thermal EfficiencyUNIT IV: REFRIGIRATION & AIR-CONDITIONING4.1 Refrigeration and Air-Conditioning4.2 Vapor Compression Cycle4.3 Working principle and schematic diagram of refrigerators, air coolers, air

conditioners and ice plant 4.4 Psychometric ChartUNIT V: FORCE SYSTEM & ANALYSIS5.1 Basic concept

5.1.1 Law of motion5.1.2 Transfer of force to parallel position5.1.3 Resultant of planer force system5.1.4 Free Body diagram5.1.5 Equilibrium and its equation.

5.2 Friction: 5.2.1 Introduction5.2.2 Laws of Columb Friction5.2.3 Equilibrium of bodies involving dry friction-Belt Friction.

UNIT VI: STRESS & STRAIN ANALYSIS6.1 Introduction to Simple stress and Strain6.2 Normal shear stresses6.3 Stress-Strain diagram for ductile and elastic materials6.4 Elastic Constants6.5 One dimensional loading of members of varying cross section6.6 Strain Energy

MECHANICAL WORKSHOPA. FOUNDARY SHOP

1. Moulding Sands, Constituents and Characteristics2. Pattern, Definition, Materials types, Core prints3. Role of gate, runner, riser, core and chaplets4. Causes and remedies of some common casting defects like blow holes,

cavities, inclusions etc.B. WELDING, BRAZING AND SOLDERING SHOP

1. Definition of welding, brazing and soldering processes and their applications

2. Oxyacetylene gas welding process, equipment and techniques, types of flames and their applications

3. Manual metal arc welding technique and equipments, AC and DC welding 4. Electrodes: Constituents and functions of electrode coating, welding

positions5. Types of welded joints, common welding defect such as cracks,

undercutting, slag inclusion and boring

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

PRACTICAL GEOMETRY1. Lines, Lettering and Dimensioning2. Scales: Representative factor, plain scales, diagonal scales, scales of chords3. Conic Sections: Construction of ellipse, parabola and hyperbola by different

methods4. Normal and Tangents5. Special Curves: Cycloid, Epicycloids, Hypo-cycloid, Involutes, Archimedean and

logarithmic spiral6. Projection of points and lines, True inclinations and true length of straight lines,

Traces of straight lines, Auxiliary Plains7. Projection of planes and solids: Projection of planes, Projection of polyhedral,

Pyramids, Cylinder and Cone8. Sections of solids: Section of right solids by normal and inclined planes.9. Development Surfaces: Parallel line and radial line method for right solids

Fundamentals of Computer

UNIT I: INTRODUCTION1.1 Types of Computer and generation1.2 Basic architecture of Computer and its building blocks1.3 Input-output devices1.4 Memories UNIT II: NUMBER SYSTEM2.1 Binary, Octal, Decimal and Hexadecimal representation of numbers2.2 Representation of Character2.3 ASCII and EDCDIC codes2.4 Binary arithmetic: addition, subtraction, complimentsUNIT III: CLASSIFICATION of COMPUTER LANGUAGE3.1 Types of Computer languages-Machine, Assembly and High level Language3.2 Brief idea of operating systems, Assembler, Compiler, and Interpreter3.3 Need of Programming languages3.4 Programming in “C” language3.5 Flowchart and Algorithm development3.6 Defining problemsUNIT IV: DATA TYPE4.1 Data types, constant variables, operators and expressions4.2 Input-output statements4.3 Conditional and Control statements4.4 Arrays 4.5 FunctionUNIT V: ADVANCED CONCEPT5.1 Structure and Unions5.2 Pointers5.3 File handling

COMPUTER PROGRAMMING LABLIST OF EXPERIMENTS1. Simple input output program integer, real character and string2. Conditional statement program (if, if-else-if, switch case)3. Looping Program (for, while, do-while)4. Program based on array (one, two and three dimensions)5. Program using Structure and Union6. Program using functions (with and without recursion)7. Simple program using pointers8. File handling

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Electronics Engineering

UNIT I: SEMICONDUCTOR MATERIALS AND PROPERTIES Group-IV materials, Covalent Bond, Electron-hole concepts, Basic concept of

Energy Bands in materials, Concept of Forbidden Gap, Intrinsic and Extrinsic Semiconductor, Donors and Acceptors impuritiesUNIT II: JUNCTION DIODE

P-N Junction, Depletion layer, V-I characteristics, Diode Resistance and Capacitance, Diode Rating (average current, peak inverse voltage)UNIT III: DIODE APPLICATION

Rectifiers (Half Wave and Full Wave), Calculation of Transformer utilization factor and diode ratings, Calculation of Ripple Factor and Load Regulation, Filter (C-filter), Clipping Circuit, Clamping Circuit, Voltage MultipliersUNIT IV: BREAK DOWN DIODE

Break down mechanisms (Zener and Avalanche), Breakdown characteristics, Zener Diode, Zener Resistance, Applications of Zener Diode and its use as Shunt RegulatorUNIT V: BIPOLAR JUNCTION TRANSISTOR

Basic construction, Transistor action, CB, CC and CE configuration, Input/ Output characteristics, Biasing of Transistor- fixed bias, emitter bias, potential divider bias, Comparison of Biasing CircuitsUNIT VI: THYRISTORS

The Four Layer Diode, Bi-directional Thyristors, Uni-junction Transistor and its application in Thyristor CircuitUNIT VII: COMMUNICATION SYSTEM

Introduction to Modulation (AM, FM, & PM), Demodulation, Multiplexing, Super Hetrodyne Radio Receiver, Television, Elementary concepts of optical, satellite & mobile communicationUNIT VIII: ELECTRONICS ENGINEERING LAB1. Verifications of network theorems2. Study of diode characteristics3. Study the characteristics of junction Transistor

ELECTRONICS ENGINEERING LABLIST OF EXPERIMENTS1. Verifications of network theorems2. Study of diode characteristics3. Study the characteristics of junction Transistor

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Basic Environmental Engineering

UNIT I: ENVIRONMENT AND ECOLOGY 1. Introduction

Environment and Ecology Objectives of Ecological study Aspects of Ecology Ecosystem Community Ecology

UNIT II: SCIENCE OF ENVIRONMENT2.1 Hydrosphere

2.1.1 Physical, chemical and Biological properties of water and stress upon it owing to the impacts of-sources of Water Pollution.

2.1.2 Effect of water Pollution2.1.3 Quality of Potable Water

2.2 Atmosphere2.2.1 Origin of atmosphere 2.2.2 Structure of Atmosphere2.2.3 Element properties of the Atmosphere2.2.4 Physical, Chemical and Biological properties of Air.

UNIT III: ENVIRONMENT IMPACT ASSESSMENTS3.1 Introduction3.2 Environment Impact Assessment (EIA)3.3 Methodology of EIA3.4 Identification of Impact3.5 Role of EIA in Sustainable Development3.6 Limitation of EIA.UNIT IV: ENVIRONMENT MANAGEMENT4.1 Environmental Management Plan (EMP)4.2 Mitigation4.3 Environmental Monitoring4.4 Environmental Management4.5 Air Quality Management4.6 Water Management4.7 Soil Quality Management4.8 Noise Management 4.9 Ecosystem Management4.10 Forest4.11 Wild Life and Endangered Species4.12 Integrated Pest4.13 Integrated Energy ManagementUNIT V: ENVIORNMENT LEGISLATION5.1 Environment protection Laws in India:- The Water Act 1974; The Air Act 1981;

Wild Life Protection Act 1972; The Indian Forest Act 1927; The Environment Act 1986 and The Motor Vehicle Act 1988.

UNIT VI: CURRENT ENVIRONMENTAL ISSUES6.1 Introduction6.2 Global Warming and Green House Effect6.3 Acid Rain6.4 Depletion of Ozone layer6.5 Eutrophication6.6 Genetic erosion or Loss of Bio Diversity6.7 Increasing Sea level6.8 Artificial rain6.9 Environmental consideration of Rural Development, Sustainable Development.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Semester-II

Scheme of Examination

Subject Hrs. per Week Exam. hrs Max. MarksTheory Papers L T P IA EXAM TOTALEnglish & Communication Skills

2 1 - 3 10 40 50

Engineering Mathematics-II 3 1 - 3 25 75 100Physics 3 1 - 3 25 75 100Production Engineering 2 1 - 3 25 50 75Information Technology 2 1 - 3 10 40 50Electrical Engineering 3 1 - 3 25 75 100Environmental Pollution Control

3 1 - 3 25 75 100

PracticalsPhysics Lab. - - 2 - 40 60 100Mechanical Workshop - - 2 - 25 50 75Electrical Engineering Lab. - - 2 - 40 60 100I.T / Hardware Lab. - - 2 - 25 50 75Machine Drawing Lab. - - 2 - 25 50 75Grand Total 18 7 10 300 700 1000

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

English & Communication Skills

UNIT I: GRAMMARTenses, Determiners, Conversions, Preposition, Nouns and Articles.

UNIT IINote of Invitation (Formal, Informal).

UNIT III: SHORT PLAYSThe Dear Departed by Stanley HoughtonRefund by Fritz Karinthy

UNIT IV: POEMSMending wall by Robert FrostThis is going to hurt just a little bit by Odgen Nash

UNIT IV: SHORT STORIESThe Gift of Magi by O’HenryThe Nightingale and the Rose by Oscar WildeThe Fortune Teller by Karl Capek

Engineering Mathematics-II

UNIT I: DIFFERENTIAL EQUATIONS1.1 Differential Equations of first Order and First Degree1.2 Variable Separable form1.3 Homogenous forms1.4 Reducible to Homogenous form1.5 Linear form1.6 Exact form1.7 Reducible to Exact form1.8 Linear Differential Equations of Higher Order with constant Coefficients UNIT II: LAPLACE TRANSFORM2.1 Laplace Transform2.2 Existence Theorem2.3 Laplace transform of Derivatives and Integrals`2.4 Inverse Laplace Transform2.5 UNIT Step Function2.6 Dirac Delta Function2.7 Laplace Transform of Periodic Functions`2.8 Convolution Theorem2.9 Application to solve simple linear and simultaneous differential equationsUNIT III: DYNAMICS3.1 Radial and Transverse Velocities and Accelerations, 3.2 Tangential and Normal Accelerations, 3.3 Rectilinear motions in Resisting MediumUNIT IV: SERIES SOLUTIONS AND SPECIAL FUNCTION4.1 Series Solution of ODE 2nd order with variable coefficient (Complementary

Functions only) 4.2 Lagrange’s form and Standard forms

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

UNIT V: VECTOR CALCULUS5.1 Point Function, 5.2 Scalar and Vector field, 5.3 Gradient, 5.4 Divergence, 5.5 Curl of a vector and their physical interpretations, 5.6 Line Surface and Volume Integrals, Greens, Stocks and Gauss divergence

theorem

Physics

UNIT I: RELATIVISTIC MECHANICS1.1 Inertial and Non Inertial frames1.2 Michelson Morley Experiment1.3 Postulates of Special Theory of Relativity1.4 Galilean and Lorentz Transformation1.5 Length Contraction and Time Dilation1.6 Addition of Velocities1.7 Mass Energy Equivalence1.8 Variation of Mass with VelocityUNIT II: INTERFERENCE2.1 Spatial and Temporal Coherence2.2 Condition of Interference2.3 Fresnel’s Biprism2.4 Newton’s Rings

2.4.1 Theory and Experiment for determining Wavelength of Light2.4.2 Condition for observing Bright and Dark Fringes

UNIT III: DIFFRACTION3.1 Single Slit Diffraction

3.1.1 Position of Maxima and Minima3.1.2 Width of Central Maximum3.1.3 Intensity variation

3.2 Diffraction Grating3.2.1 Construction and theory and determination of Wavelength of Light using

Plane Transmission Grating3.2.2 Rayleigh’s Criterion of Resolution3.2.3 Resolving Power of Telescope and Microscope

UNIT IV: POLARIZATION4.1 Production and Analysis of Plane, Circularly and Elliptically Polarized Light4.2 Optical Activity4.3 Specific Rotation4.4 PolarimeterUNIT V: LASER5.1 Principle of Laser Action5.2 Einstein’s Coefficients5.3 Construction of He-Ne and Ruby LaserUNIT VI: HOLOGRAPHY6.1 Basic theory6.2 Applications of HolographyUNIT VII: FUNDAMENTALS OF SEMI-CONDUCTORS & ITS DEVICES7.1 Intrinsic and Extrinsic Semiconductors7.2 Charge Density in N and P type materials7.3 Concept of Fermi level and forbidden energy band gap 7.4 Hall Effect-Basic principle and theory and applications7.5 PN- junction diode-Theory and its working principle7.6 Light transmission through optical fiber

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

7.6.1 Construction and working7.6.2 Construction of optical fiber cables

7.6.3 Light Emitting Diodes (LEDs) 7.6.4 Solar Cells

7.7 Zener- Diode-Basic Principle, characteristics and application as Voltage Regulator.

UNIT VIII: MODERN PHYSICS8.1 Quantum Mechanics

8.1.1 Wave Particle Duality8.1.2 De-Broglie’s concept of Matter Waves8.1.3 Heisenberg’s Uncertainty Principle8.1.4 Schrodinger Wave Equation and its applications-(i) Particle in a box and

(ii) One Dimensional Harmonic Oscillator.8.2 Nuclear radiation detectors

8.2.1 Construction, working and properties of -(a) Ionization Chamber(b) Proportional Counter(c) G.M. Counter(d) Scintillation Counter.

8.3 X-Rays8.3.1 Diffraction of X-Rays8.3.2 Bragg’s Law8.3.3 Practical applications of X-Rays8.3.4 Crystal structure determination of any material

8.4 Magnetism8.4.1 Basic concept of Para-magnetism, Dia-magnetism and Ferro-magnetism8.4.2 Phenomenon of Hysteresis and its applications.

LIST OF EXPERIMENTS1. To determine the wave length of monochromatic light by Newton’s Rings.2. To determine the wave length of monochromatic light by Fresnel’s Briprism. 3. To determine the focal length of combination of two lenses separated by a

distance with the help of nodal slide and to verify the formula

4. To determine the specific rotation of cane sugar solution using half shade polarimeter.

5. To determine the wavelength of spectral lines using plane transmission grating.6. To determine the specific resistance of the material of a given wire using Carey

Foster’s Bridge.7. To determine the variation of magnetic field along the axis of current carrying

coil and then to estimate the radius of the coil.8. To verify Stefan’s Law by electrical method.9. To calibrate the given Voltmeter.10. To calibrate the given Ammeter.11. To study the Hall Effect and determine Hall coefficient, carrier density and

mobility of a given semiconductor material using Hall effect setup.12. To determine the energy band gap of a given semiconductor (Germanium) using

four probe method.13. To determine E.C.E. of copper using Helmholtz galvanometer.14. To determine the viscosity of water by Poiseuille’s method.

Production Engineering

UNIT I: INTRODUCTION & CLASSIFICATION OF MANUFACTURING PROCESSES

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Classification, Principle of working, specification and application of various machine tools, lathe machine, drilling machine, shaper and milling machine, Basic description and application of hot and cold working processes-forging, bending shearing, drawing and extrusionUNIT II: FOUNDARY & WELDING TECHNIQUES

Foundary Techniques-Types of Pattern and allowance, Mouldling Materials and Properties of Mouldling Sand, Foundry Tools and equipments, Processes of Green Sand Maudling, Gas welding-Principle and working of Oxyacetylene Welding, Gas welding flames, Arc welding-Principle and working of Arc Welding, Various types of Arc Welding techniques-TIG, MIG, Submerged Arc and Plasma Arc, Soldering and BrazingUNIT III: POWER TRANSMISSION

Transmission of power through Belt-Velocity ratio, length of belt, tension ratio, creep and slag of belt, power transmitted (numerical), Various Types of Drives-Rope Drive, Chain Drive and its classification, Gear drive-Type of Gears, Gear Train, Gear Drive Speed Ratio(numerical)UNIT IV: MECHANICS

Location of Centroid and Centre of Gravity, Area Moment of Inertia, Mass Moment of Inertia, Law of Machines, Variation of Mechanical Advantages, Efficiency and Reversibility of MachineUNIT V: WORK & ENERGY

Work, Energy-Potential, Kinetic and Spring, Work-Energy relation, Law of Conservation of EnergyUNIT VI: STEAM POWER PLANT

Classification of steam generators-Fire Tube and Water Tube, Construction and working of Simple Vertical, Babcock & Wilcox and Locomotive boiler, Layout and working of Steam Power Plant, Steam and Air Circuit Diagram, Rankine Cycle, Steam Table (without numerical)

PRODUCTION WORKSHOPA. STUDY OF CARPENTRY SHOP

1. Timber, Definition, Engineering Applications, Seasoning and Preservation.2. Plywood and Ply Boards

B. STUDY OF FITTING SHOPFiles, Materials and Classification

C. STUDY OF SMITHY SHOP1. Forging, forging principle, materials2. Operations like drawing, upsetting, bending and forge welding3. Use of forged part

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

MACHINE DRAWINGLIST OF EXPERIMENTS: 1. Introduction to Machine Drawing, Dimensioning, locations and placing. 2. Orthographic projections: First & third angle methods3. Sheet 1: Orthographic Projection (2 Problem)4. Sheet 2: Sectional View (2 Problem)5. Sheet 3: Riveted joints, lap joins, chain riveting, butt joins, zig-zag riverting (1

Problem)6. Sheet 4(1): Screw fasteners, different threads, Nuts & bolts locking devices; set

screws, foundation (1 Problem)7. Free hand sketches on a sketch book, as per listed below:-

(a) Different types of lines(b) Conventional representation of materials(c) Screw fasteners(d) Bearing: Ball, roller, needle, foot step bearing(e) Coupling: Protected type, flange, and pin type flexible coupling(f) Welding joints(g) Belts and Pulleys(h) Pipes and pie joints(i) Valves

Information Technology

UNIT I: INTRODUCTION TO INFORMATION TECHNOLOGYAn overview of Information Technology, Difference data and information, Quality

of Information, Value of Information, Information SystemUNIT II: INTERNET

Introduction to Internet: www, web browser, search engine and e-mail, Introduction to e-commerce, Electronic payment system, E-governance, EDI and its benefits, Introduction to Cryptography, Digital Signature and Smart Card TechnologyUNIT III: DATA COMMUNICATION

Introduction to WAN, MAN, LAN, Transmission Media, Data Communication Type, Introduction to OSI reference model, Analog to Digital System, Modulation, Demodulation, Network Topologies, Client Server Architecture, ISDN, Internet Infrastructure.UNIT IV: INTRODUCTION TO OPERATING SYSTEM

Overview definition and function of Operation system, Need for Operation System, Batch processing, Spooling, Multi-programming and Multi-processing, Time Sharing, Online processing, Real Time SystemUNIT V: APPLICATION SOFTWARE

Application Software their categories, System Software, User Interface GUI, Spread Sheet, Database Software, its feature and benefits

INFORMATION TECHNOLOGY LABLIST OF EXPERIMENTS1. Elementary concept of Operating System2. Given exposure to Window Environment 3. File and Program management in Windows4. Introduction to-MS WORD, MS EXCEL and MS Power Point5. Net Surfing and creation and usage of E-mail Account6. Tools for Data management

COMPUTER HARDWARE & INSTALLATION LAB1. Introduction to Computer System SUBJECT: 2. Building Block

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

3. Input Devices: Key Board, Mouse, and Joy stick, Wireless input devices, webcam, scanner

4. Output Devices: Monitor: LCD Screen, TFT Screen. Printer: Dot Matrix Printer, Inkjet Printer, Laser Printer.

5. CPU UNIT: Mother Board: Intel 945: Register, Capacitor, diode, PCI Slots, ISA Slots, AGP Video card, DIMM Socket, SIMM Socket, ATX Power supply connector, ROM, BIOS Battery, CPU socket, sound card, Graphics card, Driver

6. Memory: Ram: SDRAM, DDR RAM, DDR1, DDR2, Hard disk: SCSI HDD, SATA HDD, PATA HDD. CDROM, CD Writer, DVD Writer, Floppy drive

7. Power supply: SMPS UPS.8. Assembling9. Installation10. Troubleshooting

Electrical Engineering

UNIT I: STUDY STATUS OF ANALYSIS OF A.C. CIRCUITS1.1 Sinusoidal and Phasor representation of voltage and current1.2 Single Phase A.C Circuit1.3 Behavior of Resistance, Inductance and Capacitance and their combination in

Series & Parallel1.4 Power Factor1.5 Series-Parallel resonance band width & quality factor1.6 Magnetic circuitUNIT II: D.C. NETWORK THEORY2.1 Circuit theory concepts- Mesh & Node analysis2.2 Network theorems-Super-position Theorem, Thevenin’s Theorems, Norton’s

Theorem and Maximum power transfer Theorem2.3 Star Delta TransformationUNIT III: MEASURING INSTRUMENTS3.1 Constructions & Principle of operation of Voltage & Current measuring

instruments3.2 Introduction of Power Meters & Energy MetersUNIT IV: THREE PHASE A.C. CIRCUITS4.1 Star-Delta Connection4.2 Line & Phase voltage-current relation4.3 Three phase power & its measurementUNIT V: TRANSFORMER5.1 Principle of Operation of a Transformer5.2 Various types of designs of a Transformer5.3 Phasor Diagram5.4 Equivalent circuit5.5 Efficiency & voltage regulation of Single Phase Transformer5.6 O.C. & S.C. tests

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UNIT VI: D.C. MACHINES6.1 Principle of Electromechanical Energy conversion6.2 Types of D.C. machines6.3 Different parts of D.C. machines & applications 6.4 E.M.F. equationUNIT VII: A.C. MACHINES7.1 Single Phase Induction Motors- Principle of operation, methods of starting7.2 Three Phase Induction Motors- Principle of operation, types & methods of

starting7.3 Three Phase Synchronous Machines-Principle of operation & Application of

Synchronous Motor.LIST OF EXPERIMENTS1. External characteristics of D.C. shunt generator2. Speed control of DC shunt motor3. Testing of single phase energy meter4. Determination of parameters and losses in a single phase T/F by O.C. & S.C. test5. Measurement of efficiency of a single phase T/F by load test6. Measurement of power using 3 phase resistive load by two wattmeter method7. Study of running & reversing of 3-phase induction motor8. To determine load on D.C. Shunt Motor

Environmental Pollution Control

UNIT I: WATER POLLUTIONIntroduction, Water Quality Standards, Water Pollution, Self Purification of

Natural Water System, Waste Water Treatment, Control of Water Pollution.UNIT II: NOISE POLLUTION AND MARINE

Noise-Introduction, Effect of Noise Pollution, Measurement of Sound, Control of Noise Pollution, Cost of Noise Pollution

Marine-Introduction, Nature and Effect of Marine Pollution, Source of Marine Pollution, Control of Marine Pollution, Marine Pollution in India.UNIT III: RADIOACTIVE & CHEMICAL POLLUTION

Introduction, Radiation Fundamental, Types of Radiations, Source of Radioactive Pollution, Effect of Radioactive Pollution, Control of Radioactive Pollution, Chemical Pollution.UNIT IV: LANDSCAPE POLLUTION AND SOLID WASTE MANAGEMENT

Introduction, Sources and classification of Solid Wastes, Causes of Solid Waste Pollution, Health hazards of Landscape Pollution, Environmental impacts of Landscape pollution.UNIT V: ENVIRONMENTAL IMPACTS OF DEFORESTATION AND MINING

Deforestation-Introduction, Forests, Deforestation, Causes and effect of Deforestation, Forest Management, Dimensions of deforestation in India

Mining-Impact of surface and underground mining on environment, Impact of coal mining on human health.UNIT VI: AIR POLLUTION6.1 Introduction: Definitions of air pollution, Control of air pollution. 6.2 Air composition, cause of air pollution classification of air pollutants. Effects of

air pollution on Human health Environment (Photochemical smoge, ozone depletion, Acid rain, Global warming).

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Semester – III

Scheme of Examination

Subject Hrs. per Week Exam. Hrs Max. MarksTheory Papers L T P IA EXAM TOTALMaterial & Energy Balance 3 1 - - 25 75 100Cell Biology 3 1 - - 25 75 100Bioenergetics-I 3 1 - - 25 75 100Microbiology 3 1 - - 25 75 100Immunology 3 1 - - 25 75 100Object Oriented Programming Using C++

3 1 - - 25 75 100

PracticalsMicro-Biology Lab. - - 3 3 60 40 100Bioenergetics Lab. - - 3 3 60 40 100Cellbiology Lab. - - 3 3 60 40 100C++ Lab. - - 3 3 60 40 100Grand Total 18 6 12 - 390 610 1000

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Material and Energy Balance

UNIT I: INTRODUCTION TO CHEMICAL ENGINEERING CALCULATIONSUNITs and dimensions, the mole UNIT, conventions in methods of analysis and

measurement basis, temperature, pressures, the chemical equation and stoichiometry.UNIT II: GASES, VAPOURS, LIQUIDS AND SOLIDS

Ideal gas law calculations, real gas relationships, vapour pressure and liquids, saturation, partial saturation and humidity introduction to vapour-liquid equilibria for multicomponent systems, material balances involving condensation and vaporization.UNIT III: MATERIAL BALANCES

Material balance of physical processes with and without chemical reaction, including recycle, purge and bypass.UNIT IV: ENERGY BALANCES

Concept and UNITs, calculation of enthalpy changes, general balance with and without reactions, heats of solution and mixing, Unsteady-state material and energy balances.UNIT V: SOLIDS, LIQUIDS AND GASEOUS FUELS

Some industrial examples of the above, simple Estimation of physical properties (transport, thermodynamic) of fluids and mixtures.

Cell Biology

UNIT I: THE CELLStructural Organisation: Development of cell theory, Eukaryotic and

Prokaryotic cells., the nucleus and cell cycle (Mitosis and meiosis), The ultra structure of the cytoplasm- the cytoskeleton, microtubules, microtubular, organelles, microfilaments, Endomembrane organelles: mitochondria, chloroplast, lysosome, peroxisomes.UNIT II: TRANSPORT ACROSS CELL MEMBRANE

Molecular organization of cell membrane, passive and active transport, Na-K pump, Co-transport into prokaryotic cells, endocytosis and exocytosis, entry of viruses and toxins into cells. UNIT III: RECEPTORS AND MODELS OF EXTRA CELLULAR SIGNALING

Cytosolic, nuclear and membrane bound receptors, examples of receptors, autocrine, paracrine and endocrine model of action.UNIT IV: SIGNAL TRANSDUCTION

Signal amplification, different model of signal amplifications, Cyclic AMP, role of inositol phosphates messangers. Biosynthesis of inositol triphosphatases, cyclic GMP and G-proteins in signal transduction. Calcium models of signal amplification, phosphorylation of protein kinases.UNIT V: CELL CULTURE

Techniques of propagation of prokaryotic and eukaryotic cells. Cell line, generation of cell lines, maintenance of stock cells, characterization of cells, immunochemistry, morphological analysis techniques in cell culture, explant cultures, primary cultures, contamination, differentiation, three dimensional cultures, role of matrix in cell growth.Books: 1. Cell Biology by Lodish.2. Cell Biology by Albert.3. Cell & Molecular Biology by De Robertis, Lea and Febiger4. Cell & Molecular Biology by H. Baltimore, WH Freeman 5. Cell Biology by Kimball T. W. Wesley Pub.

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Bioenergetics–I

UNIT IImportant properties of water, the law of mass action, dissociation of water and

its ionic product, pH, Bronsted acids, ionization of weak acids and bases. Henderson Haeselbatch equation, Titration curves, buffering action and physiological buffers.UNIT II: CARBOHYDRATES

Definition classification, Basic structure, properties and functions of saccacharides and related compounds, di-saccharides and poly- saccharides. Structural polysaccharides-cellulose and chitin, storage polysaccharides-starch, glycogen, peptidoglycan and glycosaminoglycans, proteoglycans and glycoproteins.UNIT III: AMINO ACIDS AND PROTEINS

Structure, properties, classification and functions of amino acids, amino acid sequence determination, structure and function of proteins. Protein denaturation and renaturation, folding pathways, folding accessory proteins, proteins purification procedures.UNIT IV: LIPIDS

Structure, nomenclature and physical and chemical properties of fatty acids. Classification of lipids, general structure and functions of triacylglycerole, Phospholipids, Sphingolipids, glycolipids, cholesterol & lipoproteins structure, properties and function of steroids.UNIT V: ENZYMES

Nomenclature and classification, co-enzymes and co-factors, reaction and derivation of Mchaelis-Menten equation, Line weaver-Burke, plot, inhibition kinetics and allosteric regulation of enzymes, isozymes, mode of catalysis. UNIT VI: VITAMINS

Structure, Properties and Biology of Vitamins.References:Biochemistry LehningerBiochemistry Stump & CohenBiochemistry Voet & VoetBiochemistry Garrett & Grasim

Microbiology

Basics of microbial existence, classification and nomenclature; Isolation and identification: Bacteria, Fungi, Viruses; Structural organization and multiplication of microorganisms: Bacterial Cell wall, Gram positive, Gram negative, Archaebacteria; Nutritional requirements and growth curve, autotrophic and heterotrophic bacteria, batch and continuous culture of microbes; Aerobic and anaerobic bioenergetics; Host-microbe interactions; Antimicrobial secondary metabolites, Screening of new metabolite, strains used in screening, test systems, metabolite genes and functions; Preservation of food, Food and beverage fermentation. Food additives and supplements; Biogas, Bioremediation, Bioaugmentation; Leaching of ores by microorganisms: Organism for leaching, chemistry of microbial leaching, commercial processes; Biofertilizers, Biopesticides, Biosensors.

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ImmunologyUNIT I: INTRODUCTION

Innate and acquired immunity, active, passive and adoptive immunization, clonal selection theory, humoral and cellular Immunity, Regulation of Immune response; Cellular responses;

Activation and function of T and B cells, general properties and functional categories of cytokines, therapeutic and diagnostic exploitation of cytokines and cytokines receptors, role of Major Histocompatibility Complex (MHC) in the human response; Infection and immunity: Host defense against various classes of pathogen, mechanism by which pathogen invade immune responses, active and passive immunization, preparation of human immune serum globulins; Transplantation and tumor immunology; Relationship between donor and recipient, role of MHC molecules in Allograft rejection, Bone marrow and Hematopoietic stem cell transplantation, Tumor antigen, categories of tumor antigen, tumor immunopophylaxis; UNIT II: AUTOIMMUNITY

Criteria and causes of autoimmune diseases, Autoimmune hemolytic anemis, myasthenia diseases, Autoimmune hemolytic anemia, myasthenia gravis, systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis; Applied immunology: Antigen and antibody interactions, Affinity and Avidity, Agglutination and precipitation reactions, Immunoassays, Immunoflurescence, Fluorescence Activated Cell-Sorting Analysis, Microarrays to assess gene expression.

Object Oriented Programming Using C++UNIT I: AN OVERVIEW OF OBJECT ORIENTED PROGRAMMING

Rationale for object programming, procedural vs. objected oriented approach; advantages of OOP; characteristics of object oriented languages- objects, classes, inheritance, active data, message passing.UNIT II: OBJECT ORIENTED PROGRAMMING TOOLS AND C++

An overview of C++ programming, simple program construction, functions, statements, inputs / outputs. Variable and manipulators, data types. Library functions.UNIT II: FUNCTIONS

Function declaration, calling, passing arguments to functions and returning values from functions, reference arguments overloaded functions, variable and storage classes.UNIT IV: OBJECTS AND CLASSES

Classes and Objects, C++ objects and memory.UNIT V: ARRAYS

Definition, multidimensional arrays, arrays to functions, arrays of structure. Arrays as class members data, arrays of objects, arrays of strings.UNIT VI: OPERATOR OVERLOADING

Overloading unary, binary and arithmetic operators, adding polar coordinates. Concatening strings. Multiple overloading, pitfalls of operator overloading and conversation.UNIT VII: INHERITANCE

Derived class and base class, overriding memory functions, class hierarchy, public and private inheritance, multiple inheritance.UNIT VIII: POINTERS

Addresses and pointers, pointer and arrays, pointer and functions, use of pointers in strings, linked lists and memory management. UNIT IX: FILES AND STREAMS

Streams, strings and objects I/O, I/O with multiple objects, file operations using pointers.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

UNIT XObject Oriented Programming in simulation and artificial intelligence,

Programming environments.

MICROBOLOGY LAB.1. Study of following instruments:

Compound Microscope Autoclave Incubator Colony counter.

2. Sterilizations Techniques3. Staining Methods:

Negative stain Gram stain Acid Fast stain

4. Media Preparations5. Plating techniques6. Isolation of Microorganisms from soil7. Isolation of Microorganisms from water8. Serial Dilution9. Production of Alcohol10. Antibiotic resistance activity of Microorganisms

BIOENERGETICS LAB.1. Identification of different types of carbohydrates2. Difference between reducing & non-reducing sugar 3. Preparation of Buffer solution4. Ninhydrin & Biuret test of protein 5. Separation of protein & amino acids6. Enzymatic activity of salivery amylase on carbohydrates7. Identification of different types of vitamins8. Measurement of optical density of biomolecules.9. To determine the acid value of given oil.

CELLBIOLOGY LAB.1. Study of Microscope2. Study of cell under microscope3. Identification of Monocot root & shoot4. Identification of Dicot root &shoot5. Methods of chromatography6. Preparation of blood smears.

C++ LAB.C++ Programs: 1. Programs based on inheritance property.2. Programs of operator overloading (complex number arithmetic, polar coordinates).3. Programs using friend functions.4. Programs on various matrix operations.5. Stack operations using OOPs concepts.6. To implement Tower of Hanoi problem.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Semester – IV

Scheme of Examination

Subject Hrs. per Week Exam. Hrs Max. MarksTheory Papers L T P IA EXAM TOTALGenetics 3 1 - 3 25 75 100Plant Biotechnology 3 1 - 3 25 75 100Bioenergetics-II 3 1 - 3 25 75 100Molecular Biology 3 1 - 3 25 75 100Fluid Mechanics 3 1 - 3 25 75 100Development Biotech 3 1 - 3 25 75 100PracticalMolecular Genetics Lab. - - 3 - 60 40 100Plant Biotechnology Lab. - - 3 - 60 40 100Fluid Mechanicals Lab. - - 3 - 60 40 100Developmental Biotechnology

- - 3 - 60 40 100

Grand Total 18 6 12 - 390 610 1000

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

GeneticsThe relationship between genes and traits; Reproduction as the basis of

heredity; Overview of chromosomes, cell division, gametogenesis; Mendelian principles of genetics; Gene interactions; Quantitative inheritance; heritability; Extra nuclear genomes and inheritance; Chromosomal basis of inheritance and linkage; Construction of genetic and physical maps; Linkage and crossing over; Chromosomal changes and gene mutations; Population genetics; Genetic disorders and genetic counseling; Applications of genetics in agriculture and medicine.

Plant BiotechnologyUNIT I

Historical perspectives; Laboratory organization and tissue culture media; Cell tissue and organ culture, cryopreservation; Protoplast culture and applications; Plant regeneration and hardening; Micro propagation of disease free plants; Somaclonal variation, Production of haploid plants; Biotransformation, Production of secondary metabolites; Physical methods of transfer of genes to plant, vector less and vector mediated transformation; Transgenic plants and their commercialization, Development of insect resistance herbicide, salt and draught resistance plants; IPRs and biosafety guidelines; Molecular breeding and DNA fingerprinting.

Bioenergetics-IIUNIT I: BIOENERGETICS

First and second laws of thermodynamics and concept of free energy, high-energy phosphate compounds. UNIT II: CARBOHYDRATE METABOLISM

Glycolysis, kreb’s cycle. Pentose phosphate pathway, glyoxylate cycle, glyconeogenesis and glycogenesis, glucogenolysis. Anaerobic respiration and basics of fermentation.UNIT III: LIPID METABOLISM

Biosynthesis of odd and even carbon saturated and Unsaturated Fatty acids, formation of ketone bodies, biosynthesis of triacylglycerole, membrane phospholipids, cholesterol and steroids.UNIT IV: PROTEIN METABOLISM

Metabolic fate of amino group, transamination and deamination, decarboxylation and oxidative degradation of amino acid, Nitrogen exceretion and urea cycle.UNIT V: NUCLEIC ACID METABOLISM

Biosynthesis and break down of purine & pyrimidine nucleotide by De novo and salvage pathway.UNIT VI

Phosphorus and sulphur regulation.UNIT VII

Metabolic regulation of Vitamins.Books:Principles of biochemistry - Lehniger 3rd ed. McMilklanBiochemistry - G. ZubayBiochemistry - Stryer 5th ed. 2001 W. H. FreemanBiochemistry - Garret and Grasim Pub. Somders college.

Molecular Biology

UNIT I24

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Structure of Nucleic Acid and Chromosome organization, chromatin Structure, Complexity of eukaryotic chromosome, cot value; DNA Replication in prokaryote and eukaryotes, D-loop & rolling circle mode of replication, enzymes and accessory proteins, telomere replication, Transcription process in prokaryote & eukaryotes, types of RNA’S, transcriptional factors, regulation of transcription, RNA processing and RNP’s, splicesomes, mechanism of splicing of rRNA, tRNA & mRNA, Nuclear export and stability of mRNA; Translation: genetic code, degeneracy of genetic code, prokaryotic and eukaryotic translation, co and post translational modification of proteins, translational control Regulation of gene expression in prokaryote & eukaryote, promoter, enhancer, operon model, tumor suppression genes, gene silencing, DNA binding proteins, Zinc finger motif and feucine zipper; Application of antisense & molecules, types & structure of ribozymes, strategies for ribozymes designing, Application of antisense & ribozymes technologies; Genome sequencing: genome sizes, organelle genome, strategies for sequencing genome, methods of sequencing.

Fluid Mechanics

Nature of fluid, viscosity, Laminar-flow, Turbulent flow, steady flow, Prandtyl Boundary Layer, Velocity gradient, Hagen Poiseuille’s equation, Bernoulli Equation. Fluid friction. Types of fluid friction, friction from changes in velocity or direction, Resistance of immersed bodies: Friction in flow through packed beds. Flow measurements, Orifice and Venturi meters, Pitot tube, Rotameter and other types of meters, transportation of fluids, pipe fittings and valves, pumps, fundamentals of fluidization.

Mechanical operations: Principles of communication, types of comminuting equipment energy and power requirement, crushers, grinders, mixing, types of mixing, power consumption in mixing and agitation, mechanical separation, screening, types of screen filtration principle, constant pressure and constant rate filtration, settling classifiers, flotation and centrifugal separations.Books:1. McCabe, Smith & Harriot, UNIT Operations of Chemical Engineering TMH 5 th

edition.2. Geanklopolis, Transport Processes & UNIT Operations PHI 3rd edition.3. Coulson & Richardson. Chemical engineering Vol. I and II Butterworth Heinemann. 4. Badger, W.L. Bachero, J. T., Introduction to chemical Engineering MGH.5. Foust A.S. Wenzel, L.A. et. Al Principles of UNIT Operations 2nd edition, JWS.6. Perry, Chilton & Green, Chemical Engineers Handbook, MGH.

Developmental Biotech

Basic concepts, cell fate and commitment, its mechanism, mosaic and regulative development, maintenance of differentiation, pattern formation and compartments, morphogenesis, model organism, developmental nutrients. Transgenic organism in development. Cellular and microsurgical techniques. Genes and their role in development, signal transduction in development cell division cycle, cytoskeleton. Cell adhesion and the extra cellular matrix:

Unicellular models, sporulation in Bacillus subtillis, mating type switching in yeast, aggregation and culmination in dicyostelium discordeum. Sex gametes and fertilization-germ line specification, germ cell migration, gametogenes, gastrulation in invertebrate and vertebrate, cell lineage, Axis specification in vertebrates, fate of ectoderm, mesoderm and endoderm. Cell differentiation mechanism and factors affecting it. Developmental gradients in hydra, axial gradients in Drosophila development. Organoi genesis in invertebrates and vertebrates, plant development, plant versus animal development, development of plant embryo, development of seedling, root, shoot, leaf and flower. Programmed cell death, ageing and senesce.

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BOOKS:1. R. M. Twyman 2001 Developmental Biology. Viva books private Ltd. New Delhi.2. Gilbert S. 1997, Developmental Biology- 5th edition, sineaur Associate Inc. Slack

JMV 1991, From egg to embryo, Second edition Cambridge University Press U.K.

3. Wolpert L. 1997, Principles of development. Oxford University Press. Oxford University.

MOLECULAR GENETICS LAB.1. Bacterial slide preparations2. Extraction of DNA3. Electrophoresis4. Digestion of DNA by various Restriction Enzymes (Eco RI, HIND-II, etc.)5. Plasmid Extraction6. DNA Extraction.

PLANT BIOTECHNOLOGY LAB.1. Glassware cleaning and sterilization2. Media Preparation3. Establishment of suspension culture4. Micro propagation of any ornamental plant5. Isolation of Protoplast6. Protoplast fusion7. Selection of hybrid protoplast.

FLUID MECHANICALS LAB.Study of plumbing tools, pipe fittings, taps and valves. Calibration of flow meter

for gas and liquid flows. Measurement of flow using notches and weirs. Measurement of flow using orifices and mouth pieces under constant and varying heads. Reynolds’ experiment. Determination of velocity profile using Pitot tube. Flow through packed beds: estimation of pressure drop. Flow through fluidized beds. Fall of solid bodies and liquid drops through: determination of drag coefficient and verification of Stoke’s Law. Characteristics of pumps. Measurement of pressure. Measurement of viscosity, shear stress- shears rate relationships for non-Newtonian fluids. Losses in pipes and fittings: Determination of equivalent length.

DEVELOPMENTAL BIOTECHNOLOGY LAB.(1) To study the developmental stages of chicken(2) To study the developmental stages of monocot plant(3) To study the developmental stages of dicot plant(4) Study of Mitosis and Meiosis(5) Extracting Chromosome from drosophila(6) Plasmid Extraction

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Semester – V

Scheme of Examination

Subject Hrs. per Week Exam. Hrs Max. MarksTheory Papers L T P IA EXAM TOTALRecombinant DNA Technology

3 1 - 3 25 75 100

Dairy Technology 3 1 - 3 25 75 100Fermentation Technology 3 1 - 3 25 75 100Bioinformatics 3 1 - 3 25 75 100Heat Transfer 3 1 - 3 25 75 100Biostatistics 3 1 - 3 25 75 100PracticalBioinformatics Lab. - - 3 - 60 40 100Heat Transfer Lab. - - 3 - 60 40 100Fermentation Technology - - 3 - 60 40 100Seminar on Project Training - - 3 - 60 40 100Grand Total 18 6 12 - 390 610 1000

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Recombinant DNA Technology

UNIT I: INTRODUCTION TO GENE CLONING, TOOLS AND ENZYMES USED IN GENE MANIPULATION

Restriction enzymes DNA ligases DNA Polymerase Reverse Transcriptase Polynucleotide kinase, End labeling and other process used in Recombinant DNA technology. UNIT II: MAJOR CLONING VEHICLE AND THEIR APPLICATION

Plasmid vectors, cosmid, Phasemid, phage vector, YAC, BAC, Ti- plasmids, expression vector, shuttle vectors, binary vectors, Transposons.UNIT III

Making of genomic and cDNA libraries, their screening and major applicationUNIT IV

Production of transgenic microbes and their application in BiotechnologyUNIT V

Production of transgenic Animals and their application in BiotechnologyUNIT VI

Production of transgenic Plants and their application in Biotechnology BOOKS RECOMMENDED1. Gene Cloning - T. A. Brown 4th Ed Print 2001.2. Gene VII - Benzamin Lewin Oxford University Press. 1st Ed. Print 20033. From genes to Clones - Winacker 1st Ed. Print 2003. Panima Publishing Corp.4. From genes to Genomes - Dale and Schantz Jhon. Wiley and sons. Print 20025. Gene manipulation - Old and Primrose. Blackwell Science Print 2001.6. Molecular Biotechnology - Glick and Pasternak ASM Press.

Dairy Technology

UNIT I: MILKDefinition, Composition, Chemical and functional properties of milk components;

physicochemical properties of milk proteins, aggregation of Casein, micelles, factors affecting milk composition, milk secretion and lactation.UNIT II: MICRO-ORGANISMS

Important in dairy science and technology. Microbial spoilage of milk, hydrolytic rancidity in milk and milk products, auto-oxidation of milk fats and effects on milk quality.UNIT III: MILK PROCESSING OPERATIONS

Milk pasteurization, Homogenization & Sterilization. Effect of processing of milk components and their functional properties. UNIT IV

Skimming of milk, Cream & Cream characteristics, manufacture of yoghurt and other fermented milk products, Ice cream manufacture, Butter making technology, technology of cheese, processing of concentrated milk and dried milk powder.UNIT V

Milk quality control, sanitation in the dairy plant, adulteration of milk, dairy equipment maintenance and waste disposal.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Fermentation Technology

UNIT IAn introduction fermentation technology-basic microbial growth kinetics,

Isolation, preservation and improvement of industrially important microorganism Sterlization process, media for industrial fermentation, development of inocula for Industrial fermentations.UNIT II

Designing of a fermentor, operation and application. Instrumentation and Control, fermentation kinetics, optimization of fermentation process by Quantitative analysis. Aeration and agitation.UNIT III: PRODUCT RECOVERY OPERATIONS

Filteration, solvent extraction, adsorption-desorption process. Salt precipitation, Recovery of byproducts.UNIT IV: MEMBRANE BASED SEPARATION PROCESS

Reverse osmosis, ultra filtration. Micro filtration, ervaporation. Membrane modules, flux expression, concentration polarization. Membrane characterization methods.UNIT V

Downstream processing Recovery and purification of fermentation products, Effluent treatment.BOOKS RECOMMENDED1. Principles of fermentation technology - Stanbury, Whittaker and Hall, 2nd Ed.

1997. Aditya Books.2. Fermentation Microbiology and Biotechnology - E1-MAnsi and Bryce, 2002 3. Process Biotechnology Fundamental - Mukhopadhaya4. Biochemical Engineering and Biotechnology - Atkinson B and Mavituna F.

Bioinfomatrics

Introduction: Database model, raw database and processed database, data mining, data storage and retrieval; Querying in database and tools for querying BLASTA, FASTA: Gene finding, Hidden Markov Prediction of co-regulated genes for sequences; Sequences alignment: pairwise, substitution matrices, local, global; Multiple sequence alignment, clustering, prediction, Protein- protein interaction, binding site prediction, phylogenetic tree analysis; Structural database: Protein structure database (PDB), homology modeling, comparison and superposition of structures, Comparison of distance matrices, searching for patterns and motifs; Evolution of protein structure and sequences by comparing different organisms; Human genome: introduction, tools for analysis, gene finding, probing with Est’s Exon Microarray; Database, Functional genomics; Protein- protein interaction, protein chips, searching in databases.

Heat Transfer

UNIT I: INTRODUCTIONBasic concepts of heat and mass transfer, importance of heat and mass transfer

in food processing

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

UNIT II: CONDUCTIONPrinciples of conduction heat transfer Fourier’s law, derivation of general heat

conduction equation in cartsian and cylindrical coordinates, steady state heat transfer through slabs, plane walls, composite walls, cylinders, spheres etc. insulation and its purposes, critical thickness of insulation cylinder and spheres, general heat transfer equation for extended surfaces (Fins) UNIT III: CONVECTION

Natural and forced convection, nusselt number, dimensional analysis for free and forced convection dimensionless numbers used in convective heat transfer, important correlations for free and forced convection.UNIT IV: RADIATION

Introduction, reflection, absorption and transmission of radiation, characteristics of black, grey and real bodies in relation to thermal radiation, Stefan Boltzman law; Kirchoff’s law, Wein displacement laws, intensity of radiation, radiation between black bodies and diffused grey surfaces.UNIT V: HEAT EXCHANGERS

Classification, overall heat transfer coefficient, fouling factors, log-mean temperature difference for parallel and counter flow heat exchangers, heat transfer in shell and tube heat exchangers, effectiveness of parallel and counter flow heat exchanger by general and NTU (Number of Transfer UNITs) method, design of heat exchanger, application applications of plate heat exchanger in HTST pasteurizer with generation UNIT VI: EVAPORATOR

Types of evaporator – Natural circulation evaporators, Force circulation evaporator, falling film evaporators, climbing film evaporators, agitated thin-film evaporators and plate evaporators, principles of evaporation and evaporators.BOOKS RECOMMENDED1. Heat transfer, Principles and Applications PHI New Delhi 2001: Dutta B.K.2. Heat transfer - Rao. Y.V.C.

Biostatistics

UNIT IIntroduction, definition and functions of Biostatistics. Data collection and

presentation; Probability- Mathematical, Statistical and Axiomatic definitions, Addition and Multiplication Theorems; Probability Distribution Functions- Binomial, Poisson and Normal.UNIT II

Descriptive statistic; Measure of central tendency-Mean, Mode Standard Deviation, Coefficient of variation; Relationship between location and scale parameters.UNIT III

Inferential statistic; Confidence interval of the means: test of significance- hypothesis, one and two tail tests. Errors of the first and second order; student statistics-test of hypothesis that population means equals postulated mean, equality of two population means.UNIT IV

Analysis of variance; one way classification- Completely Randomized Design with equal and unequal sample sizes; two way classification Randomized block design (one observation per cell; Multiple Comparisons Chi- square Tests.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

UNIT VRelationship between variables; Correlation analysis-scatter diagrams,

correlation coefficient of determination; Regression analysis-least square method, best fit lines, regression equation.BOOKS RECOMMENDED1. Statistics Concept and application - H. frank and S.C. althoen. Cambridge

University Press2. Statistical Methods - G. W. Snedecor and W. G. Cochran3. Basic Statistics - B. L. Agarwal4. Principles and Procedure of Statistics - A Biometrical approach:- R.G.D. Steel and

J.H. Torrie.

BIOINFORMATICS LAB.1. C Programming2. C++ Programming3. Biological Data bases4. BLASTA, FASTA5. Sequence alignment and sequence search6. Predicting structure and function of gene7. Molecular evolution and phylogenetic trees.

HEAT TRANSFER LAB.Exp. 1: To calculate the heat loss from an insulated pipe.Exp. 2: To calculate the heat transfer coefficient for turbulent flow inside a pipe.Exp. 3: To calculate the log mean temperature and overall heat transfer

coefficient for a given heat exchanger.Exp. 4: Heat transfer for flow in packed beds.Exp. 5: To calculate heat transfer coefficient innatural convectionExp. 6: Study to heat transfer related to film type condensation / drop wise condensation Exp. 7: To calculate temperature correction factor for a given heat exchangerExp. 8: To calculate the fin efficiency for finned tube exchangerExp. 9: Study of heat transfer in agitated vessel (for Non-Neutonian fluid) Exp. 10: Study of heat transfer in boiling liquid Exp. 11: Study of heat transfer in cross-flow heat exchanger.

FERMENTATION TECHNOLOGY LAB.Exp. 1: Demonstration of oxidative and fermentative utilization of carbohydratesExp. 2: Use of alginate for cell immobilizationExp. 3: Microbial production of antibioticsExp. 4: Microbial production of enzymesExp.5: Microbial production of ethanolExp. 6: Determination of thermal death point Exp. 7: Determination of thermal death temperatureExp. 8: Qualitative test for end products of fermentationExp. 9: Estimation of Microbial biomass during fermentationExp. 10: Effect of environmental factors on the end product formation by fermentation

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

SEMINAR ON PROJECT TRAININGTraining Period – 16 June to 31 July

Students will be going and having training in a University or industry for maximum 30 days. There they will be working under the guidance of the higher authority. The student after completion of training will report back to college and will present a seminar on the same project undertaken.For this purpose student will be required a recommendation letter from University in order to apply for training in any University or Industry.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Semester – VI

Scheme of Examination

Subject Hrs. per Week Exam. Hrs Max. MarksTheory Papers L T P IA EXAM TOTALVaccine Biotechnology 3 1 - 3 25 75 100Animal Biotechnology 3 1 - 3 25 75 100Analysis Biotechnology 3 1 - 3 25 75 100Mass Transfer 3 1 - 3 25 75 100Food Technology 3 1 - 3 25 75 100Genome Analysis 3 1 - 3 25 75 100PracticalAnimal Biotechnology Lab.Analytical Techniques Lab. - - 3 - 60 40 100Mass Transfer Lab. - - 3 - 60 40 100Food Technology Lab. - - 3 - 60 40 100Grand Total 18 6 12 - 390 610 1000

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Vaccine Biotechnology

Introduction and history of Vaccine; Concept of Antigen and Antibody; Immunization, Immune response and it’s detection; Live and killed, Recombinant sub unit and Peptide Vaccines; Factors affecting design of vaccines; Vaccine for Vaccinia, Polio, Hepatitis B, Influenza and HIV; Pertusis, Cholera vaccine; Vaccine manufacturing and quality assurance, Cost benefit and cost effectiveness; Regulation, testing and safety of vaccines.

Animal Biotechnology

Animal cell culture: Basic principles, serum free and serum based media, scaling-up, characterization and preservation of cell lines, cytotoxicity and viability assays, Animal diseases and their therapy; Micromanipulation of embryos: Introduction, Basics and methodology; Valuable genes for animal biotechnology-insulin, interferon, somatostatin, Immunoglobulin etc; Transgenic animals: Retroviruses and DNA microinjection method, transgenic mice, catte, sheep, goat, pig and birds; Importance of transgenic animals in biotechnology.

Analysis Biotechnology

General principles, buffers; electro analytical methods: potentiometric and conductometric; photometry; chromatographic methods of separation: gel permeation, ion exchange, reverse phase and affinity chromatography, HPLC and FPLC: centrifugation; radiotracer technique: gel electrophoresis techniques: electro blotting and electroelution. Capillary electrophoresis. API-electrophoresis and MALDI-TOP mass spectrometry; analysis of carbohydrates, lipids, proteins and nucleic acids, biosensors and diagnostics. Nature and stability of biochemical metabolites; physical/chemical/biological techniques used in assays of biotechnology products. Principles and application of analytical instruments in biotechnology. On line bioprocess instrumentation and computer aided analysis.TEXTS/REFERENCES:1. D. Holem and H.Peck; Analytical Biochemistry. Longman, 1983.2. T.G. Cooper; The Tools of Biochemistry. Wiley Intersciences, 1997.3. R. Scopes, Protein Purification: Principles and Practices. Springer Verlag, 1982.4. Selected readings from Methods in Enzymology, Academics Press.

Mass Transfer

Introduction: Molecular diffusion in fluids, diffusivity and mass transfer Coefficient intaphase mass transfer. Mass transfer Equipments, gas Absorption, countercurrent multistage operation, plate column and packed Distillation. Vapour liquid Equilibira, flash vaporization, differential distillation, continous rectification, McCabe Thiele method, bubble cap distillation column. Liquid liquid equilibria, liquid extraction, liquid solid equilibria. Leaching humidification, wet and dry bulb temperatures. Psychrometric charts. Dehumidification and cooling towers. Drying and equilibrium drying operations, crystallization, adsorption and ion exchange.BOOKS RECOMMENDED: TITLE AUTHOR1. Mass transfer operation Treble. Robert E2. Units Operations of chemical engineering McCabe. Smith

Food Technology

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

UNIT IMicro-organism associated with food, factors affecting growth of micro-organism

in food, food spoilage.UNIT II: FERMENTED FOODS

Fermentation processes for manufacture of fermented food and food products-alcoholic beverages and other products, fermented milk products, pickles. UNIT III: PROTEIN FOODS AND NUTRACEUTICALS

SCP, mushrooms, food yeasts, algal proteins nutraceuticals from plant parts (flavonoids, caraotenoids, phytosterol) and their applications, curative foods and transgenic plant foods. Bioprotection and biopreservation.UNIT IV: ENZYMES IN FOOD

Mechanisms of enzyme functions and reactions in process techniques- starch and sugar convertion process, banking by amylases, deoxygenation and desugaring by glucose oxidase, cheese making by proteases. Beer mashing and chill proofing.UNIT V: PROCESS WASTE

Bioconvertion of whey, molasses, starch substrates and other food wastes to useful products.

Genome Analysis

UNIT IBasic structure of prokaryotic and eukaryotic genome.

UNIT IIChromatin model, concept of gene, linkage and crossing over, linkage analysis in

Drosophilla and neurospora.UNIT III

Pedigree analysis in human. Genetic mapping and its tools, genetic mapping of complex character.UNIT IV

Multigene families in human genome and repetitive DNA, C-Value paradox and complexity of genome.UNIT V

Physical mapping of genome; chromosome walking, chromosome painting, FISH, GISH, Zoo blot. Dot blot, VNTR, RFLP, RAPD, RACE, SNPs, Qtls, EST, CpG island identification. Exon trapping and sequence analysis.UNIT VI

Human genome project and its application to future of mankind.BOOKS RECOMMENDED:1. Genetics: Griffith and Suzuki2. Principles of Genetics: Gardner 8th Ed. Pring, 2002, Jho3. Genes VIII: Benzamin Lewin 1st Ed. 2003, Oxford University4. Genome: T.A. Brown, 1999, Jhon Wiley & Sons

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

ANIMAL BIOTECHNOLOGY LAB.Exp.: 1 Media preparationExp.: 2 Sterilization techniquesExp.: 3 Basic techniques of animals tissue culture in-vitroExp.: 4 Desegregation of tissue by different methods such as:

Mechanical Enzymatic (by collagenese, trypsin)

Exp.: 5 Isolation of plasmid DNAExp.: 6 Digestion of DNA by restriction enzymes

ANALYTICAL TECHNIQUES LAB.Exp.: 1 Chromatography techniques

Paper Glass Ion exchange

Exp.: 2 ELISA taste for AIDS Hepatitis B Hepatitis C

Exp.: 3 Blotting techniquesExp.: 4 Electrophoresis Exp.: 5 Spectro Photometer

MASS TRANSFER LAB.List of Experiments:1. To determine the diffusion coefficient of liquid vapour in air.2. To study the rate of dissolution of a rotating cylinder and then to calculate the

mass transfer coefficient.3. To investigate the mass transfer characteristic of a wetted wall column.4. To study the drying characteristic of a wet granular material using natural and

forced circulation in a tay dryer.5. To study the characteristics of spray dryer.6. Studies on solid-liquid extraction column.7. To find out the crystal yields with and without seeds.8. Liquid-liquid extraction in a packed column for co-current and counter current

flow of binary systems.9. To prepare the vapor-liquid equilibrium and Boiling point diagram for a binary

liquid mixture.10. To verify Rayleigh equation for differential distillation of binary system.11. Studies on the sieve plate distillation UNIT.12. Studies on bubble cap distillation column.13. To study the absorption on a gas in a packed column and calculation of NTU and

HTU.14. To perform batch adsorption and verify Freundich law and Langmuir isotherm.

FOOD TECHNOLOGYIntroduction: Molecular diffusion in fluids, diffusivity and mass transfer

Coefficient intaphase mass transfer.Mass transfer Equipments, gas Absorption, countercurrent multistage operation,

plate column and packed.Distillation. Vapour liquid Equilibria, flash vaporization, differential distillation,

continuous rectification, McCabe Thiele method, bubble cap distillation column.Liquid liquid equilibra, liquid extraction, liquid solid equilibra. Leaching

humidification, wet and dry bulb temperatures. Psychometric charts. Dehumidification and cooling towers.

Drying and equilibrium drying operations, crystallization, adsorption and ion exchange

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Books Recommended:TITLE AUTHOR1. Mass transfer operation Treble. Robert E2. Units Operations of chemical engineering McCabe. Smith

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Semester – VII

Scheme of Examination

Subject Hrs. per Week Exam. Hrs Max. MarksTheory Papers L T P IA EXAM TOTALIndustrial Microbiology & Enzyme Technology

3 1 - 3 25 75 100

Drug Designing 3 1 - 3 25 75 100DBMS (Data Base Management System)

3 1 - 3 25 75 100

Downstream Processing 3 1 - 3 25 75 100Environmental Biotech 3 1 - 3 25 75 100Industrial Management 3 1 - 3 25 75 100PracticalIndustrial Microbiology & Enzyme Technology Lab.

- - 3 - 60 40 100

DBMS (Data Base Management System) Lab.

- - 3 - 60 40 100

Environmental Biotechnology Lab.

- - 3 - 60 40 100

Training Seminar - - 3 - 60 40 100Grand Total 18 6 12 - 390 610 1000

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Industrial Microbiology & Enzyme Technology

UNIT IIntroduction, Classification of Microbial products. Microbial Processes for

Production of organic acids, solvents, antibiotics, enzymes, polysaccharides, lipids pigments and aroma.UNIT II

Equipments and Accessories for industrial processes. Stability of Enzymes. Enzymes stablization by selection and genetic Engineering, protein engineering.UNIT III

Reaction Environment rebuilding, Chemical modification, intramolecular crosses linking, immobilization.UNIT IV

Application of enzymes in industry, analytical purpose and medical therapyBOOKS RECOMMENDED1. Industrial microbiology - Casida Newage Publication 20012. Industrial microbiology - Prescott and Dunn CBS Publications 4th Ed. 19993. Enzymes - Trevor. Horwood 20014. Journals and Reviews.

Drug Designing

Drug target classification: DNA, RNA, post translational processing enzymes, metabolic enzymes involved in nucleic acid synthesis, G-protein coupled receptors, small molecule receptors, transporters; Target discovery and validation strategies: genomics, natural products, combitorial chemistry, general overview of modeling methodologies, structure based drug design, protein structure determination and alternative techniques; Structure based design: ‘de novo’ design methodologies, receptor mapping, 3-D database searching techniques; Design and development of combinatorial libraries for new lead generation: the molecular diversity problem, characterization, chemiometrics in drug design; QSAR: statistical techniques behind QSAR, drug metabolism, toxicity and pharmacokinetics.

DBMS (Data Base Management System)

UNIT IOverview and History of DBMS. File System vs DBMS. Advantage of DBMS

Describing and Storing Data in a DBMS. Queries in DBMS. Transaction management and Structure of a DBMS.UNIT II: ENTITY RELATIONSHIP MODEL

Overview of Data Design Entities, Attributes and Entity Sets, Relationship and Relationship Sets. Features of the ER Model-Key Constraints, Participation Constraints, Weak Entities, Class Hierarchies, Aggregation, Conceptual Data Base, Design with ER Model-Entity vs Attribute, Entity vs Relationship Binary vs Ternary Relationship and Aggregation vs ternary Relationship Conceptual Design for a Large Enterprise.UNIT III: RELATIONSHIP ALGEBRA AND CALCULUS

Relationship Algebra Selection and Projection, Set Operations, Renaming, Joints, Division, Relation Calculus, Expressive Power of Algebra and Calculus.UNIT IV: SQL QUERIES PROGRAMMING AND TRIGGERS

The Forms of a Basic SQL Query, Union, Intersection and Except, Nested Queries, Correlated Nested Queries, Set-Comparison Operations, Aggregate Operators,

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Null Values and Embedded SQL, Dynamic SQL, ODBC and JDBC, Triggers and Active Databases.UNIT V: SCHEMA REFINEMENT AND NORMAL FORMS

Introductions to Schema Refinement, Functional Dependencies, Boyce-Codd Normal Forms, Third Normal Form, Normalization-Decomposition into BCNF Decomposition into 3-NF.

Downstream Processing

UNIT IRole of down stream processing in biotechnological processes. Problems and

requirements of bioproduct purification. Economics of downstream processing in Biotechnology, cost-cutting strategies, characteristics of biological mixtures, process design criteria for various classes of bioproducts (high volume, low value product and low volume, high value product), physico-chemical basis of bioseparation processes, primary separation and recovery processes: Cell disruption methods for intracellular products, removal of insolubles, biomass (and particulate debris) separation techniques, flocculation and sedimentation, centrifugation and filtration methods.UNIT II

Enrichment Operations: Membrane-based separations (micro and ultrafiltration theory, design and configuration of membrane separation equipment, applications, precipitation methods (with salts, organic solvents, and polymers, extractive separation, aqueous two-phase extraction, supercritical extraction) in-situ product removal, integrated bioprocessing

UNIT IIIProduct resolution / fractionation: Adsorptive chromatographic separations

processes, electrophoresis separations (all electrophoresis techniques including capillary electrophoresis) hybrid separations technologies (membrane chromatography, electro chromatography etc)

Product Polishing: gel Permeation Chromatography, dialysis, Crytallisation. REFERENCES: 1. Wankat PC, Rate Controlled separations, Elsevier 19902. Belter PA and Cussler E, Bioesparations, Wiley 19853. Product Recovery in Bioprocess Technology, BIOTOL Series, VCH, 19904. Asenjo JM, Separation processes in Biotechnology, 1993, Marcel Dekker Inc

Environmental Biotech

Introduction, pollution monitoring, biotechnological treatment of waste; Introduction of water microbiology, waterborne infectious agents; Detection and control of pathogenic microbes in water, sewage & sludge; Wastewater characteristics-physical, chemical and biological; Wastewater treatment-activated sludge processes-biological nutrient removal, wastewater treatment efficiency assessment; Biotransformation and biodegradation of pollutants, methods for determining biodegradability; Biodegradation of Lignocelluloses, PAH, agriculture chemicals, halogenated biological techniques in the characterization of environmental populations of microorganisms; Emerging Technologies-bioreporters, biosensors and microprobes; Xenobiotics, bioremediation.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Industrial Management

UNIT IEvolution of Scientific Management and Industrial Engineering. Functions of

Management- Brief description of each function. System concept.Types of Organism structures as line, staff, functional, project and matrix

organizations.Types of companies and their formationPersonal Management- Objectives and functions- Recruitment, Selection,

Training and Induction concepts and Techniques.Accounting and financial Management – Principles of double entry – Preparation

of Financial statements Budget and budgetary control- Profit-Volume analysis.

UNIT IIFacilities Planning – Factors to be considered in site selection, layout planning,

plant layout, Systematic layout planning, computerized layout planning techniques.Introduction to Material Handling Principles.Work Study- Methods study and Time Measurement, Steps in methods

improvement – Use of chart and diagrams.Performance rating and Methods – Types of Allowances, computation of basic

time and Standard time – Examples. Wages & Incentives – System of Wage incentive Plans, Job evaluation and Merit rating.UNIT III

Industrial Relations:-Fatigue and methods of eliminating fatigue.Industrial disputes – Settlement Machinery- collective bargaining – Trade unions-

Workers participation in Industries in Indian context.Labour welfare and social security- Industrial safety- Methods and Techniques.Production planning and Control- Functions and Objectives-job, batch, mass and

continuous production- Economic lot size, Routing, Scheduling, Dispatching and Follow up. Materials management – Importance, Inventory, Types of systems, selective inventory control techniques.

Quality Engineering – Quality control- Quality Vs. Cost concept, Control chart for variables and attributes-

Introduction to ISO-9000 series (2000 version), ISO 14000 (2000 version) and Total Quality Management, Quality Information systems, Bench making and Documentation.

Introduction to Marketing and its Environment – Marketing concept, Marketing mix. REFERENCES:1. M. A. Sahaf: Management Accounting Principles & Practices, Vikas Publication Pvt.

Ltd.2. Grant and Levenworth: Statistical Quality Control, TMH3. Krafewski: Operations Management, Pearson Education 6th Edition.4. Introduction to work study – ILO5. Bester field: Total Quality Management, Pearson Education.6. Richard L Francis & John A white: Facility Layout & Location, Prentice Hall7. Kotler: Marketing Management, Pearson Education8. Roger G Schrodeu: Operations Management, Mc Graw Hill9. Stephen P Robbins, David A Decenyo: Fundamentals of Management, Pearson

Education10. Monappa: Industrial Relations, TMH.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

INDUSTRIAL MICROBIOLOGY & ENZYME TECHNOLOGY LAB . Extraction of commercially important enzymes from natural sources.

Development of enzymes from natural sources. Development of enzyme assays. Qualification of enzymes activity and specific activity.

Enzyme kinetics: Estimation of Michaelis Menten parameters. Effect of pH and temperature on enzyme activity, kinetics of inhibition.

Immobilisied enzyme reaction: Techniques of enzyme immobilization matrix entrapment, ionic and cross linking Column packing. Analysis of mass transfer effects on kinetics of immobilized enzyme reactions. Bioconversion studies with immobilized enzyme packed-bed reactors. Text Books: R. Eisenthal and M.J. Dansen, “Enzyme Assays- A Practical Approach”, IRL Press, Oxford University Press, Oxford 1993

DBMS (DATABASE MANAGEMENT SYSTEM) LAB . Student can use MySql (preferred open source856 DBMS) or any other

Commercial DBMS tool (MS-Access / ORACLE) at backend and C++ (preferred) VB/JAVA at front end.1. (a) Write a C++ program to store students records (roll no, name, father

name) of a class using file handling.(Using C++ and File handling).

(b) Re-write program 1, using any DBMS and any compatible language.(C++/MySQL) (VB and MS-Access)

2. Database creation/ deletion, table creation/ deletion.(a) Write a program to take a string as input from user. Create a database of

same name. Now ask user to input two more string, create two tables of these names in above database.

(b) Write a program, which ask user to enter database name and table name to delete. If database exist and table exist then delete that table.

3. Write a program, which ask user to enter a valid SQL query and display the result of that query.

4. Write a program in C++ to parse the user entered query and check the validity of query.(Only SELECT query with WHERE clause)

5. Create a database db1, having two tables t1 (id, name, age) and t2 (id, subject, marks).(a) Write a query to display name and age of given id (id should be asked as

input).(b) Write a query to display average age of all students.(c) Write a query to display mark-sheet of any student (whose id is given as

input).(d) Display list of all students sorted by the total marks in all subjects.

6. Design a Loan Approval and Repayment System to handle Customer's Application for Loan and handle loan repayments by depositing installments and reducing balances.

7. Design a Video Library Management System for managing issue and return of Video tapes/CD and manage customer's queries.

ENVIRONMENTAL BIOTECHNOLOGY LAB.1. To determine the pH value of given water samples.2. To determine the total dissolved solids in polluted water.3. To determine Dissolved Oxygen (DO) in polluted water.4. To determine the Biological Oxygen Demand (BOD) of the polluted water samples.5. To determine the Chemical Oxygen Demand (COD) of the given water samples.6. To determine the moisture content of the given soil samples.7. To determine the water holding capacity of given soil samples.8. To determine the pH value of the given soil samples.9. To determine the carbonate contents in the given soil samples.10. To determine the nitrate content in the given soil samples.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

11. Degradation of Xenobiotic compounds.

TRAINING SEMINARTraining Period – 16 June to 15 August

Students will be going and having training in a University or Industry for maximum 45 days. Recommendation letter has to be issued by the University.

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NIMS UNIVERSITY, JAIPUR B.TECH. (BIOTECHNOLOGY)

Semester – VIII

At least 4 months training in a University or Industry.Students will be undertaking a project work under the guidance of his/her incharge at the place of training.Submission of the Report/Dissertation made by the student and seminar to be presented on the same in University after completion of training/project.Degree will be awarded only after completion of this training, presentation of report/dissertation.

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