PROFESSIONAL USE ONLY

APPLICATIONS• Immune System Support• Inflammatory Response Support• Blood Sugar Support• Athletic Support

VITALMEDIX ®

INTRODUCTIONVitalMedix is a proprietary blend of hydro-ethanol extracts from moringa leaf (Moringa oleifera) and Cat’s Claw bark (Uncaria tomentosa) which is also known as Samento. M. oleifera contains micronutrients such as calcium, iron, vitamin A and carotenoids, in addition to polyphenols such as phenolic acids and flavonoids, glucosinolates, isothiocyanates, tannins and saponins.1,2 The main polyphenols are quercetin, myrecytin, and kaempferol.2 M. oleifera may help with immune system support,3 inflammatory response support,4 blood glucose support,5,6 and athletic support.*7,8 Samento is extracted from the rare pentacyclic chemotype of U. tomentosa, which is TOA-free, with levels in trace amounts or undetectable. This pentacyclic oxindole alkaloid (POA)-predominant, tetracyclic oxindole alkaloid (TOA)-free form of U. tomentosa may help with inflammatory response support and immune system support.*9,10

VitalMedix is made at our U.S. manufacturing facility using a specialized proprietary extraction process that optimizes the constituents of the herbs in their original, unprocessed state to obtain broad-spectrum concentration. Because our extracts are made in our own facility, we control all aspects of quality, including stringent ID testing, microbial testing, and heavy metal testing. VitalMedix rigorously follows current good manufacturing practices (cGMP), as do our suppliers.

IMMUNE SYSTEM SUPPORTBoth M. oleifera and U. tomentosa may help to support a healthy immune response and maintain immune system homeostasis.*3,14 M. oleifera may help to support a healthy antibody response and to maintain neutrophils already within the normal range.*3 U. tomentosa may help to maintain neutrophil, Th1, and Th2 levels already within the normal range.*11,12,13,14 It should be noted that only TOA-free U. tomentosa (such as Samento) helps with immune support.*9

INFLAMMATORY RESPONSE SUPPORTM. oleifera may help to support a healthy inflammatory response.*4,15 In animal studies, it has been shown to help maintain IL-6, TNF-alpha, IL-1-beta, IFN-gamma and NF-kappa B already within the normal range.*16,17,18 U. tomentosa (pentacyclic chemotype) may also help to maintain and support a healthy inflammatory response.*10,19 U. tomentosa may help to support NF-kappa B levels already within the normal range in a dose-dependent manner,20,21 thus supporting both TNF-alpha and IL-1-beta within the normal range.*21

BLOOD SUGAR SUPPORTBoth M. oleifera and U. tomentosa may help with blood sugar support.*5,6,22,23 M. oleifera may help to inhibit the enzyme alpha-amylase, delaying the breakdown of polysaccharides.5 It may also support healthy insulin secretion and maintain healthy glucose levels already within the normal range.*5,6 U. tomentosa may help to inhibit the enzyme alpha-glucosidase, delaying the absorption of saccharides, and may help to support healthy insulin sensitivity.*25,26

ATHLETIC SUPPORTM. oleifera may help with athletic support, which is attributed to its polyphenol content.*7 It may help to delay the buildup of lactic acid and maintain the efficient metabolism of both glucose and lipids.*7,8

SAFETY & CAUTIONSM. oleifera is generally well-tolerated.27,28 M. oleifera may have additive effects when taken with antidiabetic drugs29,30 or antihypertensive drugs.31 M. oleifera may decrease the effectiveness of T4-containing drugs as it may inhibit the conversion of T4 to T3.32 There has been one case report of Stephen-Johnson syndrome following the ingestion of food containing M. oleifera leaves.33 M. oleifera may inhibit P450 CYP3A4 enzymes and therefore may slow the metabolism of drugs metabolized by CYP3A4.34

U. tomentosa is generally well tolerated. Gastrointestinal effects such as nausea, constipation, and diarrhea have been reported, though generally not at greater rates than with placebo.35 U. tomentosa may inhibit P450 CYP3A4 enzymes and therefore may slow the metabolism of drugs metabolized by CYP3A4.36 U. tomentosa should be avoided in those taking immunosuppressants, as it may interfere with immunosuppressant therapy.37 U. tomentosa may have additive effects with anticoagulants, generally attributed to the TOAs rhynchophylline and isorhynchophylline,38 as well as additive effects with antihypertensive drugs, generally attributed to the TOAs rhynchophylline and isorhynchophylline.39,40 As a reminder, Samento is TOA-free, with levels in trace amounts or undetectable.* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, or prevent any diseases.

PROFESSIONAL USE ONLY

REFERENCES1 Fahey, J. W. (2005). Moringa oleifera: a review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Tress for Life Journal, 1:5.2 Vergara-Jimenez, M., Almatrafi, M. M., & Fernandez, M. L. (2017). Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease. Antioxidants (Basel, Switzerland), 6(4), 91.3 Sudha, P., Asdaq, S. M., Dhamingi, S. S., & Chandrakala, G. K. (2010). Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in animals. Indian journal of physiology and pharmacology, 54(2), 133–140. 4 Xiao, X., Wang, J., Meng, C., Liang, W., Wang, T., Zhou, B., Wang, Y., Luo, X., Gao, L., & Zhang, L. (2020). Moringa oleifera Lam and its Therapeutic Effects in Immune Disorders. Frontiers in pharmacology, 11, 566783.5 Leone, A., Bertoli, S., Di Lello, S., Bassoli, A., Ravasenghi, S., Borgonovo, G., Forlani, F., & Battezzati, A. (2018). Effect of Moringa oleifera Leaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps. Nutrients, 10(10), 1494.6 Anthanont, P., Lumlerdkij, N., Akarasereenont, P., Vannasaeng, S., & Sriwijitkamol, A. (2016). Moringa Oleifera Leaf Increases Insulin Secretion after Single Dose Administration: A Preliminary Study in Healthy Subjects. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 99(3), 308–313. 7 Stohs, S. J., & Badmaev, V. (2016). A Review of Natural Stimulant and Non-stimulant Thermogenic Agents. Phytotherapy research : PTR, 30(5), 732–740.8 Lamou, B., Taiwe, G. S., Hamadou, A., Abene, Houlray, J., Atour, M. M., & Tan, P. V. (2016). Antioxidant and Antifatigue Properties of the Aqueous Extract of Moringa oleifera in Rats Subjected to Forced Swimming Endurance Test. Oxidative medicine and cellular longevity, 2016, 3517824.9 Batiha, G. E.-S., Magdy Beshbishy, A., Wasef, L., Elewa, Y. H. A., Abd El-Hack, M. E., Taha, A. E., Al-Sagheer, A. A., Devkota, H. P., & Tufarelli, V. (2020). Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities. Applied Sciences, 10(8), 2668.10 Aquino, R., De Feo, V., De Simone, F., Pizza, C., & Cirino, G. (1991). Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa. Journal of natural products, 54(2), 453–459.11 Montserrat-de la Paz, S., Fernandez-Arche, A., de la Puerta, R., Quilez, A. M., Muriana, F. J., Garcia-Gimenez, M. D., & Bermudez, B. (2016). Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23(2), 141–148.12 Núñez, C., Lozada-Requena, I., Ysmodes, T., Zegarra, D., Saldaña, F., & Aguilar, J. (2015). Nmunomodulación de Uncaria tomentosa sobre células dendríticas, il-12 y perfil TH1/TH2/TH17 en cáncer de mama [Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer]. Revista peruana de medicina experimental y salud publica, 32(4), 643–651.13 Winkler, C., Wirleitner, B., Schroecksnadel, K., Schennach, H., Mur, E., & Fuchs, D. (2004). In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cells. Planta medica, 70(3), 205–210.14 Domingues, A., Sartori, A., Valente, L. M., Golim, M. A., Siani, A. C., & Viero, R. M. (2011). Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile. Phytotherapy research : PTR, 25(8), 1229–1235.15 Kou, X., Li, B., Olayanju, J. B., Drake, J. M., & Chen, N. (2018). Nutraceutical or Pharmacological Potential of Moringa oleifera Lam. Nutrients, 10(3), 343.16 Bamagous, G. A., Al Ghamdi, S. S., Ibrahim, I. A. A., Mahfoz, A. M., Afify, M. A., Alsugoor, M H., Shammah, A. A., Arulselvan, P., & Rengarajan, T. (2018). Antidiabetic and antioxidant activity of ethyl acetate extract fraction of moringa oleifera leaves in streptozotocin-induced diabetes rats via inhibition of inflammatory mediators. Asian Pacific Journal of Tropical Biomedicine, 8(6): 320-327.17 Almatrafi, M. M., Vergara-Jimenez, M., Murillo, A. G., Norris, G. H., Blesso, C. N., & Fernandez, M. L. (2017). Moringa Leaves Prevent Hepatic Lipid Accumulation and Inflammation in Guinea Pigs by Reducing the Expression of Genes Involved in Lipid Metabolism. International journal of molecular sciences, 18(7), 1330.18 Abdel-Daim, M. M., Khalil, S. R., Awad, A., Abu Zeid, E. H., El-Aziz, R. A., & El-Serehy, H. A. (2020). Ethanolic Extract of Moringa oleifera Leaves Influences NF-kB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats. Nutrients, 12(4), 1031.19 Mur, E., Hartig, F., Eibl, G., & Schirmer, M. (2002). Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. The Journal of rheumatology, 29(4), 678–681.20 Sandoval-Chacón, M., Thompson, J. H., Zhang, X. J., Liu, X., Mannick, E. E., Sadowska-Krowicka, H., Charbonnet, R. M., Clark, D. A., & Miller, M. J. (1998). Antiinflammatory actions of cat's claw: the role of NF-kappaB. Alimentary pharmacology & therapeutics, 12(12), 1279–1289.21 Allen-Hall, L., Arnason, J. T., Cano, P., & Lafrenie, R. M. (2010). Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB. Journal of ethnopharmacology, 127(3), 685–693.22 Mbikay M. (2012). Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review. Frontiers in pharmacology, 3, 24.23 Villarruel-López, A., López-de la Mora, D. A., Vázquez-Paulino, O. D., Puebla-Mora, A. G., Torres-Vitela, M. R., Guerrero-Quiroz, L. A., & Nuño, K. (2018). Effect of Moringa oleifera consumption on diabetic rats. BMC complementary and alternative medicine, 18(1), 127.24 Wang, Z. W., Wang, J. S., Luo, J., & Kong, L. Y. (2013). a-Glucosidase inhibitory triterpenoids from the stem barks of Uncaria laevigata. Fitoterapia, 90, 30–37.25 Araujo, L., Feitosa, K. B., Murata, G. M., Furigo, I. C., Teixeira, S. A., Lucena, C. F., Ribeiro, L. M., Muscará, M. N., Costa, S., Donato, J., Jr, Bordin, S., Curi, R., & Carvalho, C. (2018). Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLD. Scientific reports, 8(1), 11013.26 Arauj, L. C. C., Furig, I. C., Murata, G. M., Donato, J., Bordin, S., Curi, R., & Carvalho, C. R. O. (2017). The insulin resistance induced by obesity is reversed by Uncaria tomentosa through modulation of inflammatory pathway in the liver of mice. Journal of Diabetes & Metabolism, 8:10(Suppl).27 Agrawal, B., & Mehta, A. (2008). Antiasthmatic activity of Moringa oleifera Lam: A clinical study. Indian journal of pharmacology, 40(1), 28–31.28 Stohs, S. J., Kaats, G. R., & Preuss, H. G. (2016). Safety and Efficacy of Banaba-Moringa oleifera-Green Coffee Bean Extracts and Vitamin D3 in a Sustained Release Weight Management Supplement. Phytotherapy research : PTR, 30(4), 681–688.29 Kar, A., Choudhary, B. K., & Bandyopadhyay, N. G. (2003). Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. Journal of Ethnopharmacology, 84(1), 105–108.30 Jaiswal, D., Rai, P. K., Kumar, A., Mehta, S., & Watal, G. (2009). Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. Journal of Ethnopharmacology, 123(3), 392. 31 Sun, M. C., Ruhomally, Z. B., Boojhawon, R., & Neergheen-Bhujun, V. S. (2020). Consumption of Moringa oleifera Lam Leaves Lowers Postprandial Blood Pressure. Journal of the American College of Nutrition, 39(1), 54–62.32 Tahiliani, P., & Kar, A. (2000). Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats. Pharmacological research, 41(3), 319–323.33 Witharana, E., Wijetunga, W., & Wijesinghe, S. (2018). Stevens - Johnson syndrome (SJS) following Murunga leaf (Moringa oleifera) consumption. The Ceylon medical journal, 63(4), 188–189.34 Monera, T. G., Wolfe, A. R., Maponga, C. C., Benet, L. Z., & Guglielmo, J. (2008). Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. Journal of infection in developing countries, 2(5), 379–383.35 de Paula, L. C., Fonseca, F., Perazzo, F., Cruz, F. M., Cubero, D., Trufelli, D. C., Martins, S. P., Santi, P. X., da Silva, E. A., & Del Giglio, A. (2015). Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. Journal of alternative and complementary medicine (New York, N.Y.), 21(1), 22–30.36 Budzinski, J. W., Foster, B. C., Vandenhoek, S., & Arnason, J. T. (2000). An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7(4), 273–282.37 Lamm, S., Sheng, Y., & Pero, R. W. (2001). Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine : international journal of phytotherapy and phytopharmacology, 8(4), 267–274.38 Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., & Zhou, J. Y. (1992). Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 13(2), 126–130.39 Zhou, J., & Zhou, S. (2010). Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. Journal of ethnopharmacology, 132(1), 15–27.40 Zhou, J. Y., & Zhou, S. W. (2012). Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia, 83(4), 617–626.

Lot #

Exp.

Jupiter, Florida 33458 USAwww.nutramedix.com561-745-2917

Dietary Supplement2 fl oz. (60 mL)

V000

000Supplement Facts

Serving Size 30 drops (1.5 mL)Servings Per Container 40Amount Per Serving

Proprietary BlendMoringa oleifera leaf extract andUncaria tomentosa bark extract (Pentacyclic chemotype)*Daily Value not established

Other ingredients: mineral water, ethanol (20-24%)

SHAKE WELL BEFORE EACH USE.Take 30 minutes before meals:

• Moderate support: 20 drops twice daily. • Maximum support: 30 drops twice daily.

Dosing may also be directed by your physician. Put drops in 4oz (120mL) of water and wait one minute before drinking. Do not use if pregnant or nursing. Stop use if adverse reactions develop.Keep out of reach of children.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

VITALMEDIXTM

IMMUNE / HEALTHY INFLAMMATORYRESPONSE SUPPORT †

100% of profits donated to IWasHungry.net

1.5 mL*