Vitamin B9

Puja Agarwal

OutlineOutline

Introduction Synthesis of Folic Acid in Bacterial

Cells. Spectroscopic Characteristics Folic Acid Benefits Types of Foods That contain folic acid Drug Interactions Mechanism of Action Studies on Folic Acid Conclusion & Future Direction

IntroductionIntroduction

What is Vitamin B9?

Vitamin B9 is folic acid.

What is the difference between folic acid & folate?

Folate is inactive form of folic acid

SynthesisSynthesis

+ CH3Cl AlCl3

CH3

KMnO4

H2O

COOH

HNO3

H2SO4

COOH

NO2

1. SnCl2

2. -OH

COOH

NH2

C

N

C

C C C

N

H

H

O

H H

HH

H

H

O

L-Glutamine

1313C NMRC NMR1*2*

3

4

5

6

7

8

10

11

12

13

14

15

16

17

11H NMRH NMR

A

B

C

D

E

F

G

J

K L

Benefits of Folic AcidBenefits of Folic Acid

Prevent Serious Birth Defects– Neural Tube Defects

Prevents Certain Types of Cancers – Colon & Breast Cancer

Prevents Alzheimer’s

Foods & Folic AcidFoods & Folic Acid

Leafy Green VegetablesCitrus FruitsPeanutsOatmealBreakfast CerealBreadsBeansLiverBrewer’s Yeast

Foods & Folic AcidFoods & Folic Acid

Drug InteractionsDrug Interactions

Nonsteriodal Anti-Inflammatory Drugs (NSAIDs)Cholesterol Lowering Agents.MethotraxateOral ContraceptivesAnti-DepressantsAntibiotics Proton Pump Inhibitor’s (PPI’s)Oral Diabetic Medications

Drug InteractionsDrug Interactions

Mechanism of ActionMechanism of ActionFolates are deconjugated in the cells of

intestinal walls into its monoglutamate form.

Mechanism of ActionMechanism of Action

Folates function as carbon donors in the synthesis of serine.

Mechanism of ActionMechanism of Action

Folates also play an important role in the synthesis of purines, pyrimidine bases & in the synthesis of tRNA.

Mechanism of ActionMechanism of Action

Folates also serve as methyl donors to create methylcobalamin, which is used for remethylation of homocysteine to methionine.

Methylcobalamin

Studies on Folic AcidStudies on Folic Acid

Blount et al (1997) recently showed that folate deficiency can cause a massive incorporation of uracil into human DNA, hence leading to chromosome breaks.

Another study by Kim et al (1997) suggested that folate deficiency induces DNA strand breaks and hypomethylation within the p53 gene.

Several other studies have also shown that Folic Acid deficiency can also cause Neural Tube Defects, Cancer, Alzheimer’s disease and Anemia.

ConclusionConclusion

Prevents Serious Birth Defects

Prevents Cancer

Prevents Alzheimer’s

Prevents Heart Disease & Stroke

Future DirectionFuture Direction

Folic acid can improve endothelial function

Folic acid plays an important role in production of normal red blood cells.

ReferencesReferences

http://web.chem.ucla.edu/~harding/cfqpp/ocp.pdf http://www.folicacidnow.net/ http://lpi.oregonstate.edu/infocenter/vitamins/fa/ http://vvv.com/healthnews/folate.html http://www.emedicine.com/MED/topic802.htm http://www.umm.edu/altmed/ConsSupplements/

VitaminB9FolicAcidcs.html Periz-Castrillon JL, Arranz-Pena ML, Luis DD.

Homocystine as a predictive factor for hip fracture in older persons. New England Journal of Medicine 2004;2:351-61

Dr. Adamcezski

QUESTIONS ?