Special IssueNorth America Special Issue Part II

Guest Editors: Justin Hanes, Laura M. Ensign, Rangaramanujam Kannan and Jung Soo Suk

OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETYAND THE JAPANESE SOCIETY OF DRUG DELIVERY SYSTEM

VOLUME 240, 28 OCTOBER 2016 ISSN: 0168-3659Vol. 240 JOURNAL OF CONTROLLED RELEASE 28 OCTOBER 2016

CONTENTS

Cited in: BIOSIS/Biological Abstracts; CAB Abstracts; Chemical Abstracts Services; Current Contents (Life Sciences); EMBASE/Excerpta Medica; International Pharmaceutical Abstracts; PUBMED/MEDLINE/Index Medicus; Polymer Contents; Science Citation Index. Also covered in the abstract and citation database Scopus®. Full text available in ScienceDirect ®

Available online at www.sciencedirect.com

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North America special issue Part II J. Hanes, L.M. Ensign, R. Kannan and J. Soo Suk 1

Drug delivery of the future: Chasing the invisible gorilla K. Park (West Lafayette, USA) 2

Design of smart HPMA copolymer-based nanomedicines J. Yang and J. Kope ̌ cek ( Salt Lake City, USA ) 9

Nanotechnology for protein delivery: Overview and perspectives M. Yu , J. Wu , J. Shi and O.C. Farokhzad (Boston, USA; Jeddah, Saudi Arabia ) 24

Delivery of drugs and macromolecules to the mitochondria for cancer therapy P. Lu , B.J. Bruno , M. Rabenau and C.S. Lim ( Salt Lake City, USA; Marburg, Germany ) 38

Extension of in vivo half-life of biologically active molecules by XTEN protein polymers V.N. Podust, S. Balan, B.-C. Sim, M.P. Coyle, U. Ernst, R.T. Peters and V. Schellenberger (Mountain View, Cambridge, USA) 52

Enzyme-triggered, cell penetrating peptide-mediated delivery of anti-tumor agents H. He , L. Sun , J. Ye , E. Liu , S. Chen , Q. Liang , M.C. Shin and V.C. Yang ( Tianjin, China; Jinju, South Korea; Ann Arbor, USA ) 67

Nanoparticles and nanofibers for topical drug delivery R. Goyal , L.K. Macri , H.M. Kaplan and J. Kohn ( Piscataway, USA ) 77

Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines J. Despanie , J.P. Dhandhukia , S.F. Hamm-Alvarez and J.A. MacKay ( Los Angeles, USA ) 93

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation K.S. Soni , S.S. Desale and T.K. Bronich ( Omaha, USA ) 109

Inhaled drug treatment for tuberculosis: Past progress and future prospects A.J. Hickey , P.G. Durham , A. Dharmadhikari and E.A. Nardell (Boston, USA ) 127

Microneedle patches for vaccination in developing countries J. Arya and M.R. Prausnitz ( Atlanta, USA ) 135

Hydrogel-based biosensors and sensing devices for drug delivery N.A. Peppas and D.S. Van Blarcom ( Austin, USA ) 142

Controlled release of biologics for the treatment of type 2 diabetes C.A. Gilroy, K.M. Luginbuhl and A. Chilkoti (Durham, USA) 151

Non-viral gene therapy: Gains and challenges of non-invasive administration methods M. Foldvari , D.W. Chen , N. Nafissi , D. Calderon , L. Narsineni and A. Rafiee (Waterloo, Canada ) 165

PEG- b -PLA micelles and PLGA- b -PEG- b -PLGA sol–gels for drug delivery H. Cho , J. Gao and G.S. Kwon (St. Louis, Madison, USA; Seoul, Republic of Korea ) 191

Drug delivery to macrophages: Challenges and opportunities Y. Pei and Y. Yeo ( West Lafayette, USA ) 202

Targeting specific cells in the brain with nanomedicines for CNS therapies F. Zhang , Y.-A. Lin , S. Kannan and R.M. Kannan (Baltimore, USA ) 212

Materials for non-viral intracellular delivery of messenger RNA therapeutics K.J. Kauffman , M.J. Webber and D.G. Anderson ( Cambridge, Boston, USA ) 227

Development of controlled release systems over the past 50 years in the area of contraception D.R. Friend ( San Diego, USA ) 235

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Special Issue: North America Special Issue Part II

Guest Editors: Justin Hanes, Laura M. Ensign, Rangaramanujam Kannan and Jung Soo Suk