VOLUME 48 CONTENTS

No 1 JANUARY 1993 Page Editorials1 Chlamydia pneumoniae TJ3Marrie5 Cohabiting with domestic mites IH Feather, JA Warner, S THolgate, PJ_ Thompson, GA Stewart

Original articles10 Concentrations of the domestic house dust mite allergen Der p I after treatment with solidified benzyl benzoate

(Acarosan) or liquid nitrogen S Kaira, P Crank, J Hepworth, CA C Pickering, A A Woodcock14 Relation of passive smoking as assessed by salivary cotinine concentration and questionnaire to spirometric indices

in children D G Cook, PH Whincup, 0 Papacosta, D P Strachan, MJJ3'arvis, A Bryant21 Lung function, respiratory illness, and passive smoking in British primary school children R J Rona, S Chinn26 Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to

asthma symptoms, lung function, and bronchial responsiveness D S Robinson, A M Bentley, A Hartnell, A B Kay,S R Durham

33 Effect of arterial oxygen desaturation on six minute walk distance, perceived effort, and perceived breathlessness inpatients with airflow limitation VH FMak, J R Bugler, CM Roberts, S G Spiro

39 Airspace size in lungs of lifelong non-smokers: effect of age and sexM Gillooly, D Lamb44 Asthma related hospital treatment in Finland: 1972-86 TKeistinen, T Tuuponen, S-L Kivela48 Quantitative versus qualitative analysis of peak expiratory flow in occupational asthma J Cte, S Kennedy,

M Chan-Yeung52 Pulmonary endocrine cells ofAymara Indians from the Bolivian Andes D Williams, D Heath, J Gosney,

J Rios-Dalenz57 Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia

A Janin, G Torpier, P Courtin, M Capron, L Prin, A-B Tonnel, P-YHatron, B Gosselin63 Effect of bumetanide on toluene diisocyanate induced contractions in guinea pig airways C E Mapp, A Boniotti,

A Papi, CA Maggi, A Di Stefano, M Saetta, A Ciaccia, L M Fabbri68 Aerosolised ribavirin in patients with advanced cryptogenic fibrosing alveolitis: a pilot study C Agusti, A Xaubet,

E Ballester, A Alarc6n, C Picado70 Pulmonary gangrene and the air crescent signJM Reich75 Diagnosis of pulmonary cryptococcosis by ultrasound guided percutaneous aspiration L-N Lee, P-C Yang,

S-H Kuo, K-T Luh, D-B Chang, C-J Yu

Review series79 New perspectives on basic mechanisms in lung disease * 2-Neutrophil traffic in the lungs: role of

haemodynamics, cell adhesion, and deformability WMacNee, C Selby

Technical note89 A nomogram for obtaining the partial pressure of oxygen in alveolar air A Karnik, D R Karnad

Short reports91 Outbreak of Moraxella catarrhalis in a respiratory unit S J7 Richards, A P Greening, M C Enright, M G Morgan,

H McKenzie92 Severe bleomycin lung toxicity: reversal with high dose corticosteroids Jf Maher, PA Daly94 Pseudomyxoma of the pleural and peritoneal cavities G Radosavljevi6, B Nedelikovi6, VKaear

Letters to the editor96 Smoking among children and young people in Japan H Kawane * Controlled trial of respiratory muscle training in

chronic airflow limitation PNR Dekhuijzen, C L A van Herwaarden, H TM Folgering; G Guyatt

Miscellaneous95 Book notice - Notices

No 2 FEBRUARY 1993 Editorials97 New perspectives in Wegener's granulomatosis R B Dreisin100 Nocturnal asthma N J Douglas

Altounyan address103 Mediator and cytokine mechanisms in asthma S Holgate

Original articles110 Physiological effect of endobronchial radiotherapy in patients with major airway occlusion by carcinoma

J M Goldman, A S Bulman, A 7 RathmeUl, B M Carey, M F Muers, C A FJ'oslin115 Diagnostic rigid and flexible oesophagoscopy in carcinoma of the oesophagus: a comparison A J Ritchie,

J' McGuigan, K McManus, HM Stevenson, J R P Gibbons119 Influence of smoking habits on change in carbon monoxide transfer factor over 10 years in middle aged men

A Watson, HJ7oyce, L Hopper, N B Pride125 Arousal responses to added inspiratory resistance during REM and non-REM sleep in normal subjectsM Gugger,

S Bogershausen, L Schaffler130 Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic

patients: comparison with oral salbutamol J C Kidney, R WFuller, YM Worsdell, EA Lavender, KF Chung,PJ Barnes

134 Regular inhaled ,B agonist in asthma: effects on exacerbations and lung function D R Taylor, M R Sears,G P Herbison, EM Flannery, C G Print, D C Lake, D M Yates, M K Lucas, Q Li

139 Total population survey of the frequency and severity of asthma in 17 year old boys in an urban area in IsraelI Auerbach, C Springer, S Godfrey

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142 Relation of the hypertonic saline responsiveness of the airways to exercise induced asthma symptom severity and tohistamine or methacholine reactivityHK Makker, S T Holgate

148 Twelve month comparison of salmeterol and salbutamol as dry powder formulations in asthmatic patientsB Lundback, D WRawlinson, J B D Palmer on behalf ofa European study group

154 Pulmonary deposition of a nebulised aerosol during mechanical ventilation S H L Thomas, MJ O'Doherty,HM Fidler, CJ Page, D F Treacher, TO Nunan

160 Rapid detection ofpneumococcal antigen in pleural fluid of patients with community acquired pneumoniaWG Boersma, A Lfwenberg, Y Holloway, H Kuttschrutter, J A M Snijder, GH Koeter

163 Peak expiratory flow in rural residents of Tamil Nadu, India D Ray, A Rajaratnam, J Richard167 Ultrasound guided aspiration biopsy for pulmonary tuberculosis with unusual radiographic appearances A Yuan,

P-C Yang, D-B Chang, C-J Yu, L-N Lee, H-D Wu, S-H Kuo, K-TLuh171 Pulmonary alveolar microlithiasis: review of Turlish reports E S Ucan, A I Keyf, R Aydilek, Z Yalcin, S Sebit,

M Kudu, U Ok174 Attitudes to smoling and smoking habits among hospital staffS F Hussain, S Tjeder-Burton, IA Campbell,

PD 0 DaviesReview series

176 New perspectives on basic mechanisms in lung disease-3: Drug intervention in asthma: present and futureVA Alabaster, B A Moore

Short reports183 Bronchial rupture secondary to blunt chest trauma C Hartey, GN Momitt185 Primary malignant melanoma of the oesophagus with a left atrial metastasis M Chello, A R Marchese, A Panza,

P Mastroroberto, F Di Lello187 Diverticulosis of the main bronchi: a rare cause of recurrent bronchopneumonia in a child A Barbato, A Novello Jr,

D Zanolin, P Corner, E Talenti189 Broncho-oesophageal fistula treated effectively without surgical resection G WParry, A Juma, J E Dussek

Letters to the editor191 Pulmonary complications ofHIV disease S Crowley, GA Luzzi, VKitchen, E Claydon; R Miller, D Mitchell - Acute

pneumonitis associated with low dose methotrexate treatment for rheumatoid arthritis W Hassan, M Carpenter,C Kelly * Tuberculosis contact tracing: are the British Thoracic Society guidelines stil appropriate? A Bush

Miscellaneous192 Book notices - Notices * Correction

No 3 MARCH 1993 Editorials193 Tuberculosis and HIV: blind man's buffP D 0 Davies195 Diuretics and asthma PJ Barnes197 Asthma guidelines: who is guiding whom and where to?M G Pearson

Original articles199 Tuberculosis and HIV: estimates of the overlap in England and Wales JM Watson, S K Meredith,

E Whitmore-Overton, B Bannister, J H Darbyshire204 Changing patterns of respiratory disease in HIV positive patients in a referral centre in the United Kingdom

between 1986-7 and 1990-1 A D Pitkin, A D Grant, NM Foley, R F Miller208 The effect of inhaled frusemide on airway sensitivity to inhaled 4-5% sodium chloride aerosol in asthmatic subjects

L TRodwell, S D Anderson, JI du Toit, J P Seale214 Respiratory symptoms questionnaire for asthma epidemiology: validity and reproducibilityKM Venables, N Farrer,

L Sharp, B J Graneek, A J Newman Taylor220 Lung deposition of nebulised pentamidine in children MJ' O'Doherty, SHL Thomas, D Gibb, CJI Page,

C Harnngton, C Duggan, T0 Nunan, N TBateman227 Value of theophylline treatment in patients handicapped by chronic obstructive lung disease S E McKay,

CA Howie, A H Thomson, B Whiting, GJ Addis233 Large volume spacer devices and the influence of high dose beclomethasone dipropionate on hypothalamo-

pituitary-adrenal axis function PH Brown, A P Greening, G K Crompton239 Measurement of airway responsiveness to methacholine: relative importance of the precision of drug delivery and

the method of assessing response J R Beach, C L Young, A _J Avery, S C Stenton, JH Dennis, E H Walters,D J Hendrick

244 Association of severe asthma attacks with weather, pollen, and air pollutants 0 VJ Rossi, VL Kinnula, J Tienari,E Huhti

249 Relation between response to exercise and diumal variability of peak expiratory flow in primary school childrenTh Frischer, J Kuhr, R Meinert, WKarmaus, J Forster, R Urbanek

254 Forced oscillation technique and spirometry in cold air provocation tests G J Wesseling,IM L Vanderhoven-Augustin, E FM Wouters

260 Failure of frusemide to increase production of prostaglandin E2 in human nasal mucosa in vivo J Mullol, I Ramis,J' Prat, J Rosel-Catafau, A Xaubet, C PIera, E Gelpi, C Picado

264 Additive effects of exposure to silica dust and smoking on pulmonary epithelial permeability: a radioaerosol studywith technetium-99m labelled DTPA L E Nery, R T Florencio, PR M Sandoval, R T Rodrigues, G Alonso,G R Mason

269 Malignant mesothelioma in women A Dawson, A R Gibbs, FD Pooley, DM Griffiths, J Hoy275 Model for investigating snorers with suspected sleep apnoea H Rauscher, W Popp, H Zwick280 Evaluation of a computerised polysomnography system H Biernacka, NJ Douglas284 Deaths and necropsies in a thoracic unit D A R Boldy, C Jones, H Matthews, C Edwards287 Effect of oral bronchodilators on lung mucociliary clearance during sleep in patients with asthma A Hasani,J E Agnew, D Pavia, H Vora, S W Clarke

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Review series290 New perspectives on basic mechanisms in lung disease: 4-Why are the airways so vascular? J Widdicombe

Conference report296 Second Intemational Conference on Advances in Pulmonary Rehabilitation and Management of Chronic

Respiratory Failure, Venice, 4-7 November 1992MD L Morgan

Short reports298 Intrathoracic vagus nerve neurofibroma and sudden death in a patient with neurofibromatosis L T-C Chow,

B S-F Shum, W-H Chow300 Inhalation trauma due to overheating in a microwave oven A L Zanen, A P Rietveld

Letters to the editor303 Management of puhmonary embolismN WMorrell, WA Seed; J'M Shapiro, J7A Albino; HH Gray, S Firoozan a

National survey of notifications of tuberculosis in England and Wales in 1988 PD 0 Davies; S Meredith * Does apositive Heaf test reaction in Asian schoolchildren predict later breakdown of tuberculosis? PD 0 Davies;J7 B Cookson, A G I Cookson * Tuberculosis contact tracing: are the British Thoracic Society guidelines stillappropriate? PD 0 Davies

Miscellaneous302 Book notices

No 4 APRIL 1993 Editorials305 Inhaled corticosteroids in COPD: awaiting controlled trials JA Wedzicha308 Bronchodilators in infancy JfB Clough

Original articles309 Effects of high dose inhaled beclomethasone dipropionate, 750 ug and 1500 pg twice daily, and 40mg per day oral

prednisolone on lung function, symptoms, and bronchial hyperresponsiveness in patients with non-asthmatic chronicairflow obstruction D C Weir, PS Burge

317 Effect of salbutamol on histamine induced bronchoconstriction in healthy infants A J WHenderson, S Young,SM Stick, L I Landau, PN LeSouef

324 Comparative nasal effects of bradykinin and histamine; influence on nasal airways resistance and plasma proteinexudation K Rajakulasingam, R Polosa, L C K Lau, MK Church, S T Holgate, PH Howarth

330 Double blind trial of ionisers in children with asthma sensitive to the house dust mite J A Warner, JfL Marchant,JO Warner

334 Accuracy of the typical computed tomographic appearances of fibrosing alveolitis K T Tung, A U Wells,MB Rubens, JfM E Kirk, R M du Bois, DM Hansell

339 Palliation of symptoms in non-small cell lung cancer: a study by the Yorkshire Regional Cancer Organisationthoracic groupMF Muers, CE Round on behalfof the group

344 Synchronous primary lung cancers: prevalence in surgical material and clinical implications FA Carey,S C Donnelly, WS Walker, E WJ Cameron, D Lamb

347 Diagnosis of asbestosis by a time expanded wave form analysis, auscultation and high resolution computedtomography: a comparative study NAl jarad, B Strickland, G Bothamley, S Lock, R Logan-Sindair, R M Rudd

354 Measurement of inspiratory muscle performance with incremental threshold loading: a comparison of twotechniques PA Bardsley, S Bendey, H S Hall, SJI Singh, D H Evans, MDL Morgan

360 Surgical correction of nasal obstruction in the treatment of mild sleep apnoea: importance of cephalometry inpredicting outcome F Series, S St Pierre, G Carrier

364 Interference with the oxidative response of neutrophils by Streptococcus pneumoniae F E Perry, CJ Elson,L W Greenham, J R Catterall

370 A study of Spanish sepiolite workers KMcConnochie, C Bevan, R G Newcombe, J P Lyons, J W Skidmore,Y C Wagner

375 Body weight and weight gain related to pulmonary function decline in adults: a six year follow up study Y Chen,S L Home, Y A Dosman

381 Static lung volumes in healthy subjects assessed by helium dilution during occlusion of one mainstem bronchusBJohansen, 0 Biortuft, J Boe

385 Glycerol particle cigarettes: a less harmful option for chronic smokers G Sutherland, MA H Russell, YA Stapleton,C Feyerabend

388 Histological examination of peroperative frozen sections in suspected lung cancer S A M Nashef, Y G Kakadellis,PS Hasleton, Y S Whittaker, CM Gregory, M TYonesReview series

390 New perspectives on basic mechanisms in lung disease: 5-Respirable industrial fibres: mechanisms ofpathogenicity K Donaldson, R C Brown, GM Brown

Occasional review396 A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a

hypothesis J-A Karlsson

Short reports401 Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac N Blackwell, L Bangham,

M Hughes, D Melzack, I Trotman402 Miliary pulmonary cryptococcosis in a patient with the acquired immunodeficiency syndrome J D Douketis,

S Kesten404 Combined oesophageal adenocarcinoma and carcinoid in Barrett's oesophagitis: potential role of

enterochromaffin-like cells in oesophageal malignancy N R B Cary, D J Barron, J P McGoldrick, F C Wells405 Suture granuloma simulating lung neoplasm occurring after segmentectomy G Fink, P Herskovitz, M Nili,

H Hadar, A Rothem, SA Spitzer407 Malignant mesenchymoma of the chest wall in an adult S KJYain, M Afzal, M Mathew, S K Ramani

409 Liposarcomatous differentiation in diffuse pleural mesothelioma Y Krishna, M T Haqqani

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Letters to the editor411 Allergic alveolitis due to goose feathers in a duvetA Seaton * Effect of dietary sodium on the severity of bronchial

asthma T C Beard * Notification of tuberculosis: how many cases are never reported?JM Grange * Attenuation ofexercise induced asthma by local hyperthermiaMM Nieminen

Miscellaneous411 Book notices - Notices

Proceedings413 British Thoracic Society winter meeting 1992

No 5 MAY 1993 Editorials469 Photodynamic therapy of lung cancer S Lam470 Do bronchodilators adversely affect the prognosis of bronchial hyperresponsiveness? C P van Schayck,

C LA van Herwaarden

Original articles474 Experimental studies to assess the potential of photodynamic therapy for the treatment of bronchial carcinomas

S G T Smith, J Bedwell, A J MacRobert, MH Griffiths, S G Bown,MR Hetzel481 Reduced carbon monoxide transfer factor (TLco) in human immunodeficiency virus type I (HIV-1) infection as a

predictor for faster progression to AIDS R B Nieman, J Fleming, RJ Coker, J R William Harris, DM Mitchell486 Skeletal muscle metabolism during exercise and recovery in patients with respiratory failure CH Thompson,

RJ 0 Davies, G7 Kemp, DJI Taylor, GK Radda, B Rajagopalan491 Microscopic emphysema in relation to age and smoking habitM Gillooly, D Lamb496 Discriminant analysis of symptom pattern and serum antibody titres in humidifer related disease C McSharry,

KAnderson, A Speekenbrink, C Lewis, G Boyd501 Psychiatric and social aspects of brittle asthma GMF Garden, J G Ayres506 Lung deposition patterns of directly labelled salbutamol in normal subjects and in patients with reversible airflow

obstruction R Melchor, MF Biddiscombe, VHF Mak, MD Short, S G Spiro512 Variability of the plateau response to methacholine in subjects without respiratory symptomsMD Lougheed,

G Pearce-Pinto, NH Ilerk, G Ryan, A WMusk, A James518 Evaluation of albumin as a reference marker of dilution in bronchoalveolar lavage fluid from asthmatic and control

subjects C Ward, M Duddridge, J Fenwick, P V Gardiner, A Fleetwood, D Jf Hendrick, EH Walters523 Haemodynamic effects of pressure support and PEEP ventilation by nasal route in patients with stable chronic

obstructive pulmonary disease N Ambrosino, S Nava, A Torbicki, G Riccardi, C Fracchia, C Opasich, C Rampulla529 Nasal CPAP and weight loss in hypertensive patients with obstructive sleep apnoea H Rauscher, D Formanek,

W Popp, H Zwick534 Sleep related hypoxaemia in hypertensive and normotensive men I C Gleadhill, E E McCrum, C C Patterson,

G D Johnston, A Evans, J MacMahon537 Effects of posture on carbon dioxide responsiveness in patients with obstructive sleep apnoeaM Satoh, WHida,

T Chonan, S Okabe, H Miki, 0 Taguchi, Y Kikuchi, T Takishima542 Effect of azelastine on sulphur dioxide induced impairment of ciliary motility in airway epitheliumJ

_ Tamaoki,A Chiyotani, N Sakai, K Takeyama, K Konno

547 Salmeterol, formoterol and salbutamol in the isolated guinea pig trachea: differences in maximum relaxant effectand potency but not in functional antagonism A Linden, A Bergendal, A Ulman, B-E Skoogh, C-G Lofdahl

554 Sensory neuropeptides and hypoxic pulmonary vasoconstriction in the rat D G McCormack, R G Rees, D Crawley,PJ Barnes, T WEvans

558 Central venous catheter associated thrombosis of major veins: thrombolytic treatment with recombinant tissueplasminogen activator S Rodenhuis, L G FM van't Hek, L T Vlasveld, R Kroger, R Dubbelman, R G L van Tol

Review series560 New perspectives on basic mechanisms in lung disease 6-Proteinase imbalance: its role in lung disease

TD Tedey

Short reports566 Effect of preservative on the efficacy of terbutaline nebuliser solution in atopic asthma C K W Lai, C H S Chan568 Mediastinal mass caused by syphilitic aortitis R Hofmann-Wellenhof, WDomej, C Schmid, D Rossmann-Moore,

P KuUnig, M Annelli-Monti570 Association of cadmium exposure with rapidly progressive emphysema in a smoker D Leduc, P de Francquen,

DJ7acobovitz, R Vandeweyer, R Lauwerys, P De Vuyst572 Multiple recurrent intrapulmonary and endobronchial mesenchymomas (hamartomas) CM Laroche, S Stewart,

F WeUs, J Shneerson574 Prolonged hypoxaemia after nebulised salbutamol G Connett, WLenney576 Reversal of hypoxia in a patient with chronic obstructive pulmonary disease, pulmonary hypertension and oedema

during treatment with long term domiciliary oxygen KM Skwarski, D Morrison, WMacNee578 Pneumatoceles and pneumothoraces complicating staphylococcal pneumonia: treatment by synchronous

independent lung ventilation A W Lohse, 0 Klein, E Hermann, H Ldhr, KF Kreitner, H Steppling,K-H Meyer zum Buschenfelde, M Staritz

580 Pulmonary and cutaneous vasculitis following hepatitis B vaccination MB Allen, P CockweUl, R L Page

Letters to the editor582 Effect of aminophylline on brain tissue oxygenation in patients with chronic obstructive lung disease G J Addis;

M Nishimura * Concentrations of the domestic house dust mite allergen Der p I after treatment with solidifiedbenzyl benzoate (Acarosan) or liquid nitrogen TK Ninan, G Russell, M Omran; A A Woodcock, S Kalra *Notification of tuberculosis: how many cases are never reported? L P Ornerod;N C Barnes, C D Sheldon -

Diagnosis of Pneumocystis carinii pneumonia in HIV antibody positive patients by simple outpatient assessmentsR B Nieman, RJ Coker, D M Mitchell; B G Gazzard, D E Smith *Pathological assessment of mediastinal lymphnodes in lung cancer: implications for non-invasive mediastinal staging S-H Ren, S-J Xu;KM Kerr, NJ Douglas.Guidelines for care during bronchoscopy B D WHarrisonMiscellaneous

584 Notices

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No 6 JUNE 1993 Editordals585 Osteoporosis and cystic fibrosis T C B Stamp, D M Geddes587 Role of thoracic radiotherapy in small cell lung cancer J S Tobias

Original articles589 Bone mineral density and body composition in adult patients with cystic fibrosis A B Grey, R WAmes,

R D Matthews, I R Reid594 Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses

A Freitag, R M Watson, G Matsos, C Eastwood, PM O'Byrne599 Effects of high doses of inhaled corticosteroids on adrenal function in children with severe persistent asthma

TKNinan, I WReid, PE Carter, PJ Smail, G Russell603 Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate

inhalation, and avoiding multiple actuations of drug C O'Callaghan, J Lynch, M Cant, C Robertson607 Investigations of an optimal inhaler technique with the use of urinary salbutamol excretion as a measure of

relative bioavailability to the lung M Hindle, D A G Newton, H Chrystyn611 Time course and duration of bronchodilatation with formoterol dry powder in patients with stable asthma

A Wallin, T Sandstrim, L Rosenhall, B Melander615 Effect of inhaled procaterol on cough receptor sensitivity to capsaicin in patients with asthma or chronic

bronchitis and in normal subjectsM Fujimura, S Sakamoto, Y Kamio, T Bando, K Kurashima, T Matsuda619 Serum titres of Pneumocystis carinii antibody in health care workers caring for patients with AIDS TR Leigh,

MI Millett, B Jameson, J V Collins622 Enhanced type III collagen gene expression during bleomycin induced lung fibrosis S Shahzeidi, B Mulier,

B de Crombrugghe, PK3Jeffery, RJ McAnulty, GJ Laurent629 Ciliary beat frequency in transplanted lungs D Veale, PN Glasper, A Gascoigne, J H Dark, G J Gibson,

PA Cornis632 Percutaneous needle biopsy of the mediastinum: review of 94 procedures B Morrissey, HAdams, A R Gibbs,

M D Crane638 Effects of recombinant GM-CSF and IgA opsonisation on neutrophil phagocytosis of latex beads coated

with P6 outer membrane protein from Haemophilus influenzae D Burnett, A Chamba, R A Stockley, TF Murphy,S L Hill

643 Use of a combined oxygen and carbon dioxide transcutaneous electrode in the estimation of gas exchangeduring exerciseMK Sridhar, R Carter, F Moran, S WBanham

648 Effect of seasonal allergic rhinitis on airway mucosal absorption of chromium-51 labelled EDTA L Greiff,P Wollmer, C Svensson, M Andersson, C G A Persson

651 Effects of nicotine on the human nasal mucosa L Greiff, P Wollmer, I Erjefdlt, M Andersson, U Pipkorn,C GA Persson

656 Single dosing comparison of the relative cardiac fi1/f, activity of inhaled fenoterol and salbutamol in normalsubjects DM Newnham, NM Wheeldon, B J Lipworth, D G McDevitt

Review series659 Cytokines: Introduction R M du Bois660 Cytokines: 1-Overview L P Nicod

Short reports668 Age related increase in the intra-alveolar macrophage population of non-smokers WA H Wallace, M GiUooly,

D Lamb670 Mucosa associated lymphoma of the lung PH B Bolton-Maggs, A Colman, G R Dixon, M WMyskow,

_' G Williams, RI Donnelly, C R K Hind672 Culture ofMycobacterium kansasii in the blood of an HIV negative patient D Veale, D Fishwick, J'E S White,

A D Gascoigne, K Gould, PA Corns674 Lung abscess: a neglected cause of life threatening haemoptysis NJ Philpott,MA Woodhead, A G Wilson,

FJI C Millard676 Mitral valve replacement for an annular submitral aneurysm of the left ventricle A G K Gokhale, N Lal, B Ashok,

_Jacob, S Krishnaswami, P S airaj

Letters to the editor678 Cohabiting with domestic mites 0 Linna; I H Feather, _A Warner, S THolgate, PJ Thompson, GA Stewart

Tuberculin positive children L 0 Larsson, B-E Skoogh, A Lind;K Citron * Estimating age, sex and periodspecific constant tar cigarette consumption in the UK PN Lee, J S Fry, B A Forey * Alveolar atypicalhyperplasia in association with primary pulmonary adenocarcinoma: a clinicopathological study of 10 casesR R Miller; FA Carey, D Lamb

Miscellaneous680 Book notices * Notice

No 7 JULY 1993 Editorials681 Primary tracheal tumours H C Grilo683 Respiratory muscle strength after upper abdominal surgery B Celli685 To help patients control asthma the clinician must be a good listener and teacher D Evans

Original articles688 Primary tracheal tumours: a national survey C M Gelder, M R Hetzel693 Effect of aminophylline on respiratory muscle strength after upper abdominal surgery: a double blind study

NM Siafakas, A Stoubou,M Stathopoulou, VHaviaras, N Tzanakis, D Bouros698 Lung volume restriction in patients with chronic respiratory muscle weakness: the role of microatelectasisM

Estenne, PA Gevenois, WKinnear, P Soudon, A Heilporn, A De Troyer702 Recruitiment of some respiratory muscles during three maximal inspiratory manoeuvres S Nava, NAmbrosino,

P Crotti, C Fracchia, C Rampulla

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708 Assessment and follow up of patients prescribed long term oxygen treatment LJ Restrck, EA Paul, GM Braid,P Cullinan, Jf Moore-Gillon, IA Wedzicha

714 Effect of alterations of dietary sodium on the severity of asthma in men OJ Carey, C Locke, J B Cookson719 Is the sleep apnoea/hypopnoea syndrome inherited? NJ Douglas,M Luke, R Mathur722 Variability of bronchodilator response and effects of inhaled corticosteroid treatment in obstructive airways

disease HA M Kers4ens, P L P Brand, PH Quanjer, B A HA van der Bruggen-Bogaarts, G H Koeter, D S Postmaon behalf of the Dutch CNSLD Study Group

730 Atrial natriuretic peptide in stable and decompensated chronic obstructive pulmonary disease K Skwarski, M Lee,L Tumbull, WMacNee

736 Fibroblast chemotactic response elicited by native bronchoalveolar lavage fluid from patients with fibrosingalveolitis J Behr, B C Adelmann-Grill, F Krombach, T Beinert, M Schwaiblmair, G Fruhmann

743 Arachnoid nodules in the lungs of high altitude Indians D Heath, D Williams746 Association of silicosis, lung dysfunction, and emphysema in gold miners R L Cowie,M Hay, R G Thomas

Technical note

750 Normal range for transdiaphragmatic pressures during sniffs with catheter mounted transducers S A Evans,L Watson, A J Cowley, I D A Johnston, WJM KinnearOccasional review

754 Obstructive sleep apnoea S G McNamara, R R Grunstein, C E Sullivan

Review series765 Cytokines: 2-Cytokines and lung inflammation: mechanisms of neutrophil recruitment to the lung R M Strieter,

N WLukacs, TJ Standiford, S L Kunkel

Short reports770 Ciliary disorientation: a possible variant of primary ciliary dyskinesia A Rutman, P Cullinan, M Woodhead, PJ Cole,

R Wilson

772 Oesophageal tuberculosis mimicking a tumour during treatment for nodal tuberculosis U Kaur, S Katarnya,S R Bhusnurmath, P Bambery, J B Dilawari

774 Asthma following occupational exposure to Lycopodium clavatum in condom manufacturers P Cullinan, J Cannon,D Sheril, A Newman TaylorLetters to the editor

776 Sex differences in hypokalaemic and electrocardiographic effects of inhaled terbutaline D R Taylor, G P Herbison,MR Sears; B J Lipworth - Inhalation trauma due to overheating in a microwave oven D S C Rose

Miscellaneous776 Notices

No 8 AUGUST 1993 Editorials777 After pneumoniaM Woodhead779 Management of malignant pleural effusion P T Reid, RM Rudd781 Chronic respiratory failure in COPD: is there a place for a respiratory stimulant? PA Bardsley

Original articles785 Factors of importance for the long term prognosis after hospital treated pneumonia J U Hedlund, A B 6rtqvist,

ME Kalin, F Granath

790 Chemical pleurodesis in malignant pleural effusions: a randomised prospective study of mepacrine versusbleomycin S Koldsland, J L Svennevig, G Lehne, EJohnson

794 Lung function in white children aged 4-19 years: I-Spirometry M Rosenthal, S H Bain, D Cramer, P Helms,D Denison, A Bush, J 0 Warner

803 Lung function in white children aged 4-19 years: II-Single breath analysis and plethysmography M Rosenthal,D Cramer, SH Bain, D Denison, A Bush, J 0 Warner

809 Pattern of lung volumes in patients with sighing breathing G Aliadeff, M Molho, I Katz, S Benzaray, Z Yemini,R Jf Shiner

812 Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normalsubjects P G Middleton, D M Geddes, E WF WAlton

817 Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated forone year L Fabbri, P S Burge, L Croonenborgh, F Warlies, B Weeke, A Ciaccia, C Parker on behalfof an InternationalStudy Group

824 Decrease of histamine induced bronchoconstriction by caffeine in mild asthma J C Henderson, F O'Connell,R WFuller

827 Predicting patient attitudes to asthma medication L M Osman, I T Russell, JA R Friend, J S Legge, J G Douglas831 Tine testing in HIV positive patients S P Higgins, C S Bradbeer, N T Bateman835 Relationship between plasma cell levels and profile of bronchoalveolar lavage fluid in patients with subacute

extrinsic allergic alveolitis M Drent, SjSc Wagenaar, H van Velzen-Blad, P G HMulder, H C Hoogsteden,J MM van den Bosch

840 Phospholipid content of bronchoalveolar lavage fluid in granite workers with silicosis in Quebec R Bigin, 0 Lesur,TBouhadiba, L Guojian, P Larivee,B Melloni, M Martel, A CantinReview series

845 Cytokines: 3-Cytokines in asthma D S Robinson, SR Durham, A B Kay854 Pulmonary rehabilitation in chronic respiratory insufficiency: Introduction J-F Muir, D JTPierson855 Pulmonary rehabilitation in chronic respiratory insufficiency: 1-Pulmonary rehabilitation in perspective: historical

roots, present status, and future projections T L PettyTechnical note

863 Standardisation of gas mixtures for estimating carbon monoxide transfer factor A H Kendrick, G Laszlo

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Short reports866 Tracheal paraganglioma A P Gaflimore, P Goldstraw867 Pleural effusions associated with pancreaticopleural fistula S G J Williams, A Bhupalan, N Zureikat, PJ Thuluvath,

G Santis, N Theodorou, D Westaby869 Upper zone cystic lung disease in HIV related Pneumocystis carinii pneumonia N C Cowan, J Moxham

Letters to the editor871 Regular inhaled ,B agonist in asthma: effects on exacerbations and lung function E EM Van Essen-Zandvliet,

KF Kerrebijn; D R Taylor,M R Sears - Respiratory symptoms questionnaire for asthma epidemiology: validityand reproducibility A M Donoghue * Chlamydia pneumoniae H Kawane

Miscellaneous872 Book notices * Notice

No 9 SEPTEMBER 1993

No 10 OCTOBER 1993

Editorials873 European standards for lung function testing: 1993 update G Laszlo877 flAgonists and ventilation A E Tatersfield, P Wilding879 Effect of air pollution on the prevalence of asthma and allergy: lessons from the German reunification

H Magnussen, R Jorres, D Nowak

Original articles882 Acute effects of inhaled salbutamol on the metabolic rate of normal subjects P Amoroso, S R Wilson, J Moxham,

J Ponte886 Modification of the thermogenic effect of acutely inhaled salbutamol by chronic inhalation in normal subjects

S R Wilson, P Amoroso, J Moxham, I Ponte890 Effect of orally administered beclomethasone dipropionate on calcium absorption from the gut in normal subjects

B J Smith, PJ Phillips, PR Pannafl, HI Cain, WJH Leckie894 Reproducibility of incremental maximal cycle ergometer testing in patients with restrictive lung disease

D D Marciniuk, R E Watts, C G Gallagher899 Factors affecting peak expiratory flow variability and bronchial reactivity in a random population sample

B G Higgins, R Britton, S Chinn, KK Lai, P GI Burney, A E Tattersfield906 Ethnic differences in lung function in Israeli children H Roizin, A Szeinberg, E Tabachnik, M Molho, S Benzaray,

A Augarten, D Har-Even, Z Barzilay, J Yahav911 Daytime sleepiness, cognitive performance and mood after continuous positive airway pressure for the sleep

apnoea/hypopnoea syndrome HM Engleman, KE Cheshire, IJf Deary, NJ Douglas915 Expandable Wallstent for the treatment of obstruction of the superior vena cava A F Watkinson, DM Hansell921 Thoracoscopy assisted pulmonary lobectomy WS Walker, FM Carnochan, M Tin925 Empyema thoracis: a problem with late referral? C W Cham, SM Haq, I Rahamim928 Treatment of symptomatic pulmonary aspergillomas with intracavitary instillation of amphotericin B through an

indwelling catheter MJackson, C D R Flower, JM Shneerson

Review series931 Cytokines: 4-Cytokines and pulmonary fibrosis J Gauldie, MJordana, G Cox936 Pulmonary rehabilitation in chronic respiratory insufficiency: 2-Exercise in patients with chronic obstructive

pulmonary disease M J Belman

Short reports947 Successful treatment of diffuse lipoid pneumonitis with whole lung lavage H-Y Chang, C-W Chen, C-Y Chen,

T-R Hsuie, C-R Chen, W-WLei, M-H Wu, Y-TJin949 Amyloidosis complicating cystic fibrosis K Gaffney, D Gibbons, B Keogh,MX FitzGerald951 Unusual presentation of a large tension bronchogenic cyst in an adult S P Tarpy, H Kornfeld, KMoroz, H L Lazar

953955957

EditorialsTGF-fl antibodies: a novel treatment for pulmonary fibrosis? GJ Laurent, R K Coker, R J McAnultySystemic effects of inhaled corticosteroids J P MonsonDrug resistant tuberculosis: problems on the horizon L P Ornerod

Origal articles959 Effect of antibody to transforming growth factor, on bleomycin induced accumulation of lung collagen in mice

SN Gin, D M Hyde, MA Hollinger967 Systemic effects of high dose inhaled steroids: comparison of beclomethasone dipropionate and budesonide in

healthy subjects PH Brown, S P Matusiewcz, C Shearing, L Tibi, A P Greening, G K Crompton974 Effect of eight months of inhaled beclomethasone dipropionate and budesonide on carbohydrate metabolism in

adults with asthma KKiviranta, M Turpeinen979 Stemomastoid muscle fatigue and twitch maximum relaxation rate in patients with steroid dependent asthma

VHF Mak, Jf R Bugler, S G Spiro985 Correction of glutathione deficiency in the lower respiratory tract of HIV seropositive individuals by glutathione

aerosol treatment KJ Holroyd, R Buhl, Z Borok, J H Roum, A D Bokser, G J Grimes, D Czerski, A M Cantin,R G Crystal

990 Isolation of mycobacteria from patients seropositive for the human immunodeficiency virus (HIV) in south east

England: 1984-92 M D Yates, A Pozniak, YM Grange996 Histologically atypical Pneumocystis carinii pneumonia NM Foley, M H Griffiths, R F Miller

1002 Adult cystic fibrosis: association. of acute pulmonary exacerbations and increasing severity of lung disease withauxotrophic mutants of Pseudomonas aenrginosa R FH Taylor, M E Hodson, T L Pitt

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1006 In vitro bioelectric properties of bronchial epithelium from transplanted lungs in recipients with cystic fibrosisV T Tsang, E WF WAlton, ME Hodson, M Yacoub

1012 Relation between distal airspace size, bronchiolar attachments, and lung function D Lamb, A McLean, M Gilooly,PM Warren, GA Gould, WMacNee

1018 Variability in ciliary beat frequency in normal subjects and in patients with bronchiectasis D Veale, A D Rodgers,CJGriffiths, TAshcroft, GJ Gibson

1021 Lower respiratory tract symptoms in Queensland schoolchildren: risk factors for wheeze, cough and diminishedventilatory function D L Duffy, CA MitchellReview series

1025 Pulmonary rehabilitation in chronic respiratory insufficiency: 3-Ventilatory muscle training R S Goldstein

Occasional review1034 Nitric oxide and lung disease PJ Barnes, M G Belvisi

Short reports1044 Massive haemoptysis caused by congenital absence of a segment of inferior vena cavaM HAshour, S KJain,

KM Kattan, A KEI-Bakry, M Khoshim, FM Mesahel1045 Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation

M L Everard, J G Hardy, A D Milner1047 Case of spontaneous haemothorax associated with an endodermal sinus tumourM Karabocuoglu, S Ugur,

N Uzel, E Dayioglu, D Yilmazbayhan, R fihan1048 Catamenial haemoptysis: a rare cause D J Wood, K Krishnan, P Stocks, E Morgan, MJ Ward

Letters to the editor1050 Guidelines on the management of asthma KPJones;M G Pearson, MR Partridge, B D WHarnson

Miscellaneous1050 Book notices * Notices

Proceedings1052 British Thoracic Society summer meeting 1993

No 1 1 NOVEMBER 1993 Editorials1093 Use of near fatal asthma for investigating asthma deaths R Beasley, N Pearce, J Crane1095 Airway hyperresponsiveness: relation to asthma and inflammation? D F Rogers, B J O'Connor1097 Development of bronchus associated lymphoid tissue (BALT) in human lung disease: a normal host defence

mechanism awaiting therapeutic exploitation? P G Holt

Original articles1099 Near fatal asthma attacks: the reliability of descriptive information collected from close acquaintances

D A Campbell, G McLennan, J R Coates, PA Frith, PA Gluyas, KM Latimer, A J Martin, DM Roder,R E Ruffin, D Scarce, PM Yelwlees

1105 Demographic characteristics of patients with severe life threatening asthma: comparison with asthma deathsG N Richards, J Kolbe, J Fenwick, HH Rea

1110 Controlled trial evaluation of an asthma education programme for adults R Yoon, D K McKenzie, A Bauman,D A Miles

1117 A district confidential enquiry into deaths due to asthma NJ Wareham, B D WHarrison, P FJenkins, J NichoUls,D E Stableforth

1121 Changes in methacholine induced bronchoconstriction with the long acting fl2 agonist salmeterol in mild tomoderate asthmatic patients H Booth, K Fishwick, R Harkawat, G Devereux, D J Hendrick, E H Walters

1125 Distribution of immunocompetent cells in the bronchial wall of clinically healthy subjects showing bronchialhyperresponsiveness C Power, S Sreenan, B Hurson, C Burke, L WPoulter

1130 Bronchus associated lymphoid tissue (BALT) in human lung: its distribution in smokers and non-smokersI Richmond, G E Pritchard, TAshcroft, A Avery, PA Corms, EH Walters

1135 How reliable is the diagnosis of lung cancer using small biopsy specimens? Report of a UKCCCR Lung CancerWorling Party J StJ Thomas, D Lamb, TAshcroft, B Comnn, C WEdwards, A R Gibbs, WE Kenyon, RJ Stephens,WF Whimster

1140 Intercellular adhesion molecule 1 (ICAM-1) in the pathogenesis of mononuclear cell alveolitis in pulmonarysarcoidosis K Dalhoff, S Bohnet, J Braun, B Kreft, KJ Wiessmann

1145 Oxygen desaturation and breathlessness during corridor walking in chronic obstructive pulmonary disease: effect ofoxitropium bromide D PS Spence, J G Hay, J Carter, M G Pearson, PMA Calverley

1151 Bronchodilator reversibility to low and high doses of terbutaline and ipratropium bromide in patients with chronicobstructive pulmonary disease D M Newnham, D P Dhillon, J H Winter, CMJackson, R A Clark, B J Lipworth

1156 Bronchoscopic diatherny resection and stent insertion: a cost effective treatment for tracheobronchial obstructionM Petrou, D Kaplan, P Goldstraw

1160 Measurement of exhaled nitric oxide in man C Borland, Y Cox, T Higenbottam1163 Prevalence of chronic cough and phlegm among male cigar and pipe smokers: results of the Scottish Heart Health

Study CA Brown,M Woodward, H Tunstal-Pedoe1168 Time trends and seasonal variation in hospital admissions for childhood asthma in the Athens region of Greece:

1978-88 K Priftis, JAnagnostakis, E Harokopos, I Orfanou,M Petraki, P Saxoni-PapageorgiouReview series

1170 Pulmonary rehabilitation in chronic respiratory insufficiency: 4-Long term domiciliary oxygen therapy in chronicobstructive pulmonary disease MI Walters, PR Edwards, JfC Waterhouse, P Howard

Technical note1178 Thoracoscopic pericardial fenestration: diagnostic and therapeutic aspects A Cana6, R Guijarro, A Arnau,

A Fernaindez-Centeno, MA Ciscar, JfGalbis, A Garcia-Vilanova

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Short reports1181 Mediastinal paraganglioma presenting as an intracardiac mass with superior vena caval obstruction S K Sharma,

S Sharma, S Mukhopadhyay1183 Spontaneous sternal fractures in four patients with chronic airflow obstruction taking corticosteroids K Hameed,

G E Packe, J S Legge, YA R Friend1185 Spontaneous haemothorax: an unusual presentation of primary lung cancer S-H Chou, Y-J Cheng, E-L Kao,

C-Y Chai1186 Need for a comparative performance standard for dry powder inhalers R Richards, M Saunders

Miscellaneous1188 Book notices * Notices * Correction

No 12 DECEMBER 1993 Editorials1189 Leukotrienes and aspirin induced asthma TH Lee, P E Christie1191 HIV in the lung: guilty or not guilty? C Mayaud, J Cadranel1196 Vasodilators in pulmonary hypertension A J Peacock

Altounyan address1200 Out of the mouths ofbabes and sucklings: lessons from early childhood asthmaM Silverman

Original articles1205 Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive

asthmatic subjects B Dahlen, D J Margolskee, 0 Zetterstrom, S-E Dahlen1211 How many times per day should peak expiratory flow rates be assessed when investigating occupational asthma?

J-L Malo, J Coti, A Cartier, L-P Boulet, J L'Archev&que,M Chan-Yeung1218 Is exercise testing useful in a community based asthma survey? TK Ninian, G Russell1222 Relation of HIV-I in bronchoalveolar lavage cells to abnormalities of lung function and to the presence of

Pneumocystis pneumonia in HIV-I seropositive patients J R Clarke, I K Taylor, J Fleming, J D Williamson,DM Mitchell

1227 Value of bacterial antigen detection in the diagnostic yield of transthoracic needle aspiration in severe communityacquired pneumonia F Bella, J Tort, M-A Morera, Y EspauleUa, YArmengol

1230 Correlation ofGM-CSF mRNA in bronchoalveolar fluid with indices of clinical activity in sarcoidosis A Itoh,E Yamaguchi, K Furuya, N Hizawa, N Ohnuma, YKawakami, N Kuzumaki

1235 Kinetics and cellular localisation of putrescine uptake in human lung tissue PHM Hoet, D Dinsdale, C P L Lewis,EK Verbeken, YM Lauweryns, B Nemeiy

1242 Identificationwof sleep disruption and sleep disordered breathing from the systolic blood pressure profileR 0O Davies, K Vardi-Visy, M Clarke, J R Stradling

1248 Investigation and management of pulmonary infiltrates following bone marrow transplantation: an eight yearreviewYH Campbell, N Blessing, A K Burnett, R D Stevenson

1252 Endocrine cells in diffuse pulmonary fibrosis NJ E Wilson, J R Gosney, F MayaUl1257 Tuberculin testing in residential homes for the elderlyM Nisar, C SD Williams, D Ashby, PD 0 Davies1261 Chlamydia pneumoniae seroprevalence in immunocompetent and immunocompromised populations in Milan

F Blasi, R Cosentini, M Clerici Schoeller, A Lupo, L AlegraReview series

1264 Pulmonary rehabilitation in chronic respiratory insufficiency: 5-home mechanical ventilation J-F Muir

Technical note1274 Respiratory gas exchange using a triaxial alveolar gas diagramY F Fuster, T Pages, L Palacios

Short reports1276 Long term survival in non-encapsulated primary liposarcoma of the mediastinum R G Grewal, K Prager,

J HM Austin, H Rotterdam1278 Gastropleural fistula following pulmonary resection PA O'Keefe, P Goldstraw1280 Use of continuous positive airway pressure in the management of community acquired pneumonia A Brett,

D G Sinclair1281 Endobronchial nocardial infectionKD McNeil, D WJohnson, WA Oliver1283 Mycobacterial contamination of fibreoptic bronchoscopes NM Brown, EA HeUyar, J E Harvey, D S Reeves

1285 Unilateral wheeze caused by pseudomembranous aspergillus tracheobronchitis in the immunocompromised patientR C Tait, B R O'Driscoll, D WDenning

1287 Pulmonary nodules due to systemic amyloidosis (AA) in Crohn's disease T WBeer, C WEdwards

Letters to the editor1289 Accuracy of the typical computed tomographic apppearances of fibrosing alveolitis P Brown, C Selby * Respiratory

symptoms questionnaire for asthma epidemiology: validity and reproducibility KPMcKinley, KM VenablesDiagnostic rigid and flexible oesophagoscopy in carcinoma of the oesophagus: a comparison L R Murmu

Miscellaneous1288 Book notice1289 Notices1290 Annual report1292 Indexes for 1993

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