VU ir FTMC Chemijos krypties Doktoranturos komitetui

Paraiska doktoranturos temi| konkursui

Temos vadovas (pedagoginis vardas, mokslinis laipsnis, vardas, pavarde)

Docentas, flziniq mokslq srities chemijos krypties daktaras EVALDAS NAUJALIS

Disertacinio darbo (temos) pavadinimas (lietuviij iranglij kalbomis)

Lakiqji} organiniq junginii} kaip potencialiq biozymenq ligij diagnostikai ir monitoringui tyrimas

Study on volatile organic compounds (VOC's) as potential biomarkers for disease diagnosis and monitoring.

Temos apraSas (Rekomenduojama apimtis - ne daugiau kaip 1000 spaudos zenklij. Atskleiskite temos aktualum% mokslinj naujum^, perspektyvumq.)

Every living organism has a specific volatile organic compounds (VOCs) fingerprint. Identifying certain VOCs, or monitoring their changes could be used to detect diseases in early stages. Specific emissions from fungi could be detected to treat fungal invasions. Recent studies show that human diseases such as Alzheimer, liver disease, or even cancer could cause higher levels of some VOCs. Variations of the levels of some VOCs could be a sign of hypoglycaemic changes in diabetic people. Nowadays still there is not any fast methodology to detect diseases like Alzheimer, cancer or invasive fungal infections. To diagnose those diseases several tests are necessary, and sometimes it is even to late to be treated when they are diagnosed. Understanding which volatiles compounds are emitted from the living organisms wi l l improve early stage diagnosis and could be a potential online monitoring tool. Once we find which VOC are related to every disease we could develop specific sensors that wi l l allow us a fast detection and treatment. This research wil l open possibilities for closer collaboration between scientists working in different fields.

Disertacinio darbo S^kmingo atliltimo prielaidos (Rekomenduojama apimtis - ne daugiau kaip 1000 spaudos fenkli). Nurodykite turimq aparaturin? !rang% jvaldytas metodikas, patirtj sprendziant panaSius uMavinius, atliktus preliminarius tyrimus. Jei esate numat̂ s kandidatq teikiamai doktoranturos temai, nurodykite kandidat^ ir bendro mokslinio darbo su juo patirtj.)

Numatyta, kad sj disertacinj darb^ atliks musij laboratorijoje jau kelet^ metq dirbantis jaunesnysis mokslo darbuotojas Adrian Vicent Claramunt. Planuojamas doktorantas yra puikiai jvald^s laboratorijoje turim^ chromatografin^ bei masiij spektrometrin^ jrang^. Jj galima charakterizuoti kaip savarankiskai mokslines uzduotis sprendziantj ir kruopsciai atliekantj visus darbus laboratorijoje darbuotoj^. Tiriamajam darbui vykdyti musvj laboratorijoje yra visa reikalinga patirtis ir bandiniq paruosimo bei chromatografine -masiij spektrometrine jranga. Jau siuo metu A. Vicent Claramunt, besiruosdamas stoti j doktorantur^ atliko literaturos saltiniq analiz^ ir pradejo tyrimus sioje siulomoje tematikoje. Pirminiai rezultatai buvo pristatyti 60-oje tarptautineje konferencijoje "Open Readings 2017" (tezes Adrian Vicent Claramunt^ Algimantas Paskevicius^,

Jurgita Svediene , Egle GudeliUnaite^, Silvija Kiveryte^, Roberta Petrauskaite^, Laimonas

Griskevicius^, Audrius Zolumskis', Evaldas Naujalis' "Thermal desorption methodology for volatile organic compounds (VOCs) identification: possible application in invasive fungal infections , p. 173.) Pradzi^ idejai ir darbams sioje tematikoje dave atsirad^s sekmingas bendradarbiavimas su Gamtos tyrimij centro (GTC) mikrobiologijos laboratorijomis bei VUL Santariskii| klinikij Hematologijos, onkologijos ir transfuziologijos centru (HOTC). Tai uztikrina laboratorijoje atliekamij mokslo tiriamiyi} darbij tarpdiscipliniskum^ ir galimai praktinj taikym^ ateityje.

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Vadovo einamos pareigos.

(nurodykite ir pareigas kitose darbovietese)

VMTI Fiziniij ir technologijos moksli} centro vyresnysis mokslo darbuotojas, Metrologijos skyriaus vadovas VU Chemijos ir geomokslij fakulteto Analizines ir aplinkos chemijos katedros docentas

Svarbiausios pastarijji} 5 metij mokslines publikacijos 1. A. Linkeviciute, R. Butkiene, E . Naujalis. Optimization of matrix solid-phase dispertion

extraction for the chromatographic analysis of flavones in cranberries. Chemija. 24, No.3 (2013), 217-222.

2. Marcelle Archer, Maria Femandes-Whaley, Ria Visser, Jayne de Vos, Sara Prins, Adriana Rosso, Mariana Ruiz de Arechavaleta, Ibrahim Tahoun, Ellas Kakoulides, Caleb Luvonga, Geoffrey Muriira, Evaldas Naujalis, Osman Bin Zakaria, Mirella Buzoianu, Jelena Bebic, Ben Achour Mounir and Ngo Huy Thanh. Final report on AFRIMETS.QM-K27 : Determination of ethanol in aqueous matrix. Metrologia, 50 (2013), 08020

3. D. Plausinaitis, E . Naujalis, A. Prokopchik, A. Budreika. Method for detection of Cs and Sr isotopes avoiding interferences of Ba and Rb in radioactive samples using ion chromatography coupled with ICP-MS. Current Analytical Chemistry, 10 (2014), 140-148.

4. A. Linkeviciute, J. Barauskas, A. Misiunas, E . Naujalis. Preparation and characterization of quercetin-loaded lipid liquid crystalline systems. Proceedings of the international conference Chemistry and Chemical Technology, (2014) p.30-33.

5. R. Druteikiene, J . Sapolaite, Z. Ezerinskis, E . Naujalis, A. Puzas. Immobilization of radioactive waste in cement: iodine binding by cementitious materials under highly alkaline conditions. Lithuanian Journal of Physics, 55, No. I (2015), 54-62.

6. A. Linkeviciute, A. Misiunas, E . Naujalis, J . Barauskas. Preparation and characterization of quercetin-loaded lipid liquid crystalline systems. Colloids and Surfaces B: Biointerfaces, 128 (2015), 296-303.

7. A. Budreika, D. Plausinaitis, E . Naujalis, B. Knasiene, A. Prokopchik. Chromatographic separation and on-line detection of long life alkali, alkaline earth and transition metal radionuclides by ICP-MS. Technical Report by the EC Joint Research Centre, (2015), ISBN 978-92-79-49495-6, p.507-513.

8. A. Zolumskis, E . Naujalis, S. Sakirzanovas. Research on behavior of N-alkanes in programmable temperature injector range from C8 to C40. Nanochemistry and nanomaterials 2015, Proceedings of the international conference, (2015), ISBN 9786094595912, p.58

9. R. Godliauskiene, V. Tamosiunas, E . Naujalis. Polychlorinated dibenzo-p-dioxins/furans and dioxin-like polychlorinated biphenyls in food and feed in the Lithuanian market, Toxicological & Environmental Chemistry, Vol.99, No. I (2017), 65-77,

{DOE 10.1080/02772248.2016.1174704)

10. A. Linkeviciute, J. Budiene, E . Naujalis, A. Katelnikovas, J. Barauskas . Characterisation and stability study of cranberry flavonoids in lipid liquid crystalline systems. European Journal of Lipid Science and Technology, 118 (2017), 1600373 {DOI: 10.1002/ejlt.201600373)

Esu sekmingai vadovav^s 2 doktorantams: 1) Ausra Linkeviciute (2015 m. apginta disertacija: "Lipidij savitvarkiq skystakristaliij sistemq su jterptais flavonoidais kurimas ir charakterizavimas")

2) Rasa Godliauskiene (2016 m. apginta disertacija: "Patvariq organiniij tersali} PCDD/PCDF, DT-PCB, ne DT-PCB ir P B D E tyrimas maisto produktuose ir pasaruose, naudojant dujq chromatografij^ su dideles skiriamosios gebos masiij spektrometrija")

Evaldas Naujalis Vardas, pavarde, paraSas

Data: 2017 m. kovo 20 d.

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Pritarimas siulomai temai

Teikiamai konkursui doktoranturos temai pritariu. FTMC Metrologijos skyriaus vadovas E.Naujalis (VU ar FTMC akadeniinio padalinio, fakulteto, institute, skyriaus, katedros, laboratorijos, kuriame bus vykdomas disertacinis darbas, vadovas)

Data: 2017 m. kovo 20 d. ParaSas

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