vuos partner for cooperation 2 where you can find us
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VUOS PARTNER FOR COOPERATION2
Where you can find usWhere you can find us
VUOS PARTNER FOR COOPERATION3
VUOS VUOS ownershipownership
AGROFERT HOLDING,a.s..
SYNTHESIA, a.s.
VÝZKUMNÝ ÚSTAVORGANICKÝCH
SYNTÉZ a.s.
(VUOS
100%
100%
VUOS PARTNER FOR COOPERATION4
HistoryHistory
1941 1952 1992 1997 2004 2009
Foundation of Research Laboratories
Voucher Privatisation
New name – VUOS
Affiliation of Synthesia´s R&D 100% daughter
company of Synthesia a.s.
VUOS PARTNER FOR COOPERATION5
VUOS VUOS main businessesmain businesses
1. R&D and Production of Fine Chemicals
2. Toxicology and Analytics
Employees Sales in %
VUOS PARTNER FOR COOPERATION6
The Certificates of VUOSThe Certificates of VUOS
• ISO 9001:2008
• Certificates of Good Laboratory Practice
• Certificate of Accreditation for Certification of Products No. 229/2002 (EN 45011:1998)
• Certificate of Accreditation No. 230/2002 Testing Laboratory No. 1057 (EN ISO/IEC 17025:2005)
• Certificate on Compliance with Principles of Good Manufacturing Practice in laboratory
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• Education structure of employees
•VUOS is located in area of long-lasting . chemical tradition with complete infrastructure
•Cooperation with University of Pardubice
Strong PointsStrong Points
VUOS PARTNER FOR COOPERATION8
R&D, up scalingR&D, up scaling
• pharmaceutical intermediates
• intermediates for microelectronics
• custom syntheses of chemical specialities
• dyes and pigments for special application
VUOS PARTNER FOR COOPERATION9
R&D, up scalingR&D, up scaling
Wide range of quantities
Grams – in laboratory
Kilograms – in kilolab unit
Metric tons – in VUOS production plant
Hundreds of MT –
VUOS PARTNER FOR COOPERATION10
VUOS's key chemistry
VUOS's key technology
Adamantane derivates
N-Heterocycles
Hydrogenation Phosgenation
API Building Blocks
VUOS PARTNER FOR COOPERATION11
VUOS's technology/manufacture expertise includes:
acetylationaldolisationamidation alkylationaminationamoxidationalkali fusionarylhydrazines synthesesazocoupling benzoylationchiral synthesischlorinationchlorosulfonationcyclisationClaisen condensationdecarboxylation
dehydrohalogenationdiazotisationeliminationesterificationFriedel-Crafts reactionheterocyclic synthesishydrolysis reactionsneutralisationnitrationnitriles synthesesoxidation – catalytic/chemical oxidation in liquid phase rearrangementreduction with hydrazine and sodium borohydridesulfonation
VUOS PARTNER FOR COOPERATION12
Kilolab UnitKilolab Unit
Phosgenation
2x reactors, 250 and 650 l
2x High performance rectification columns
Laboratory phosgenation units from 1 to 30 litres
VUOS PARTNER FOR COOPERATION13
Kilolab UnitKilolab Unit
Hydrogenation
3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200˚C, Hastelloy C clad
1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad
1x autoclave 700 l, 100 bar,
200oC, stainless steel
1x autoclave 1,000 l, 10 bar, 140˚C, stainless steel
many autoclaves up to 10 l
VUOS PARTNER FOR COOPERATION14
Kilolab UnitKilolab Unit
Low temperature, RLi, RMgX, NaH
1 x glass reactor 50 l cooled down to – 80˚C
1x glasslined reactor for NaH reactions (250 l)
3x glass reactors 100l for RLi, Grignard reactions
VUOS PARTNER FOR COOPERATION15
Kilolab UnitKilolab Unit
20x glass reactors, 100 l each
6x glass lined reactors (200 – 1,500 l)
2x evaporators 50 l / h
4x stainless steel reactors (300 – 1,500 l)
sufficient filtration and distillation capacity
Multipurpose chemistry
VUOS PARTNER FOR COOPERATION16
Production Unit
Production EquipmentProduction Equipment
45x glass lined reactors, total vol. 70,000 l (500 – 5,000 l)
13x stainless steel reactors, total vol. 22,000 l (1,000 – 3,000 l)
8x High performance rectification columns
sufficient filtration capacity (nutsches, centrifuges)
computer controlled
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Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics
VUOS PARTNER FOR COOPERATION18
• Toxicology / ecotoxicology testing
• Sampling, analysing, evaluation of production waste streams (air pollution, effluents, solid
wastes hazards)
• Environmental Impact Assessment
• Development/validation of new specialised analytical methods
Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics
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Analytical techniques:• NMR Spectroscopy• Mass Spectrometry (LC/GC-MS)• ICP-AES• IR Spectroscopy• Chromatography (HPLC, GC)• UV-Vis
Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics
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Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics
Toxicology:
In vivo and in vitro testing according to the OECD or EU methods:
• Acute toxicity test• Skin and eye irritation• Sensibilization• Repeated dose tests• Reproduction toxicity tests• Carcinogenicity• Mutagenicicty
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Toxicology, Ecology and Toxicology, Ecology and AnalyticsAnalytics
Ecotoxicological testing:
In vivo and in vitro testing according to the OECD or EU methods:
• Aquatic toxicity• Biotic degradation – Ready biodegradability• Inherent biodegradability• Abiotic degradation
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Complete Offer of Services
by VUOS
CONSULTING
TESTING
EXPERT WORKS
REGISTRATION
REACHREACHand other legislative provisions and other legislative provisions
VUOS PARTNER FOR COOPERATION23
ContactContactss
General Manager: Dr. Karel NovákPhone: +420 46 682 2550 fax:+420 46 682 2976 e-mail:
Sales Manager: Miloš Jesenský,Ph.D.Phone: +420 46 682 3300 fax:+420 46 682 2976 e-mail:[email protected]
R&D : Alois Koloničný, Ph.D.Phone:+420 46 682 3156 fax: +420 46 682 3900 e-mail:[email protected]
Toxicology and Analytics: Viktor Mejstřík,Ph.D.Phone:+420 46 682 3127 fax:+420 46 682 2975 e-mail:[email protected]
Process Engineering: Luboš Víšek Phone:+420 46 682 5790 fax:+420 46 682 3900 e-mail:[email protected]