vypro mesh presentation today
DESCRIPTION
incisional hernia repairTRANSCRIPT
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VENTRAL INCISIONAL
HERNIA REPAIR
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Evaluatation of the Sublay retromuscular technique using light-weight "Vypro"mesh versus prolene
mesh
THESISSubmitted for partial fulfillment of the M.D degree in general
surgery
By
Dr.MOUSTAFA MOHAMED HEGAZY
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Supervised by PROF. Dr. AHMED MOHAMED LOTFY
Professor of General SurgeryFaculty of Medicine - Ain-Shams UniversityPROF. Dr. OSAMA FOUAD MOHAMED
ABD ELGAWADProfessor of General Surgery
Faculty of Medicine - Ain-Shams UniversityDr. MOHAMED ALI MOHAMED NADA
Lecture of General SurgeryFaculty of Medicine - Ain-Shams University
2010
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Incisional hernias remain one of the most Incisional hernias remain one of the most
common surgical complications with a long-term common surgical complications with a long-term
incidence of 10-20% incidence of 10-20% (Schumpelick, et al., 2006).(Schumpelick, et al., 2006).
Primary suture repair of incisional hernia results Primary suture repair of incisional hernia results
in 31-58% recurrence in 31-58% recurrence (Clark et al., 2006).(Clark et al., 2006).
With a move to the tension-free repair following
the introduction of the meshes, results improved,
with a dramatic decrease in the rate of recurrence
to approximately 10% (Millikan, 2003).
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Several techniques have been advocated to Several techniques have been advocated to implant the meshimplant the mesh
or epifascialor epifascial
underlay or retromuscularunderlay or retromuscular
within the defectwithin the defect
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The onlay method may be complicated by: The onlay method may be complicated by:
seroma and wound infections, while seroma and wound infections, while
intraperitoneal mesh leaves the potential for intraperitoneal mesh leaves the potential for
development of enteric fistula or small development of enteric fistula or small
bowel obstructions bowel obstructions (Hamilton et al., (Hamilton et al.,
20052005)
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Within recent decades, the sublay prosthetic Within recent decades, the sublay prosthetic
herniorrhaphy, which was introduced in the 1970 herniorrhaphy, which was introduced in the 1970
by the French surgeons Stoppa and Rives, became by the French surgeons Stoppa and Rives, became
one of the widely accepted procedures for one of the widely accepted procedures for
incisional hernia repair. This technique is incisional hernia repair. This technique is
basically characterized by mesh implantation in basically characterized by mesh implantation in
the "sublay"position below the rectus muscle the "sublay"position below the rectus muscle
and fixation of the mesh by transfascial sutures at and fixation of the mesh by transfascial sutures at
the edges of the mesh the edges of the mesh (Petresen et al., 2004 )(Petresen et al., 2004 )
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Increasing evidence of impaired wound healing Increasing evidence of impaired wound healing
in incisional hernia patients supports routine use in incisional hernia patients supports routine use
of an open prefascial, retromuscular mesh repair. of an open prefascial, retromuscular mesh repair.
Basic pathophysiologic principles dictate that for Basic pathophysiologic principles dictate that for
a successful long-term outcome and prevention of a successful long-term outcome and prevention of
recurrence, a wide overlap underneath healthy recurrence, a wide overlap underneath healthy
tissue is required ,only retromuscular placement tissue is required ,only retromuscular placement
allows sufficient subduction of the mesh by allows sufficient subduction of the mesh by
healthy tissue healthy tissue (schumpelick, et al; 2007)(schumpelick, et al; 2007).
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Polypropylene is the material widely used for Polypropylene is the material widely used for
open mesh repair. New developments have led to open mesh repair. New developments have led to
light-weight meshe e.g`Vypro and Ultrapro``meshes, light-weight meshe e.g`Vypro and Ultrapro``meshes,
which are adjusted to the physiological requirements which are adjusted to the physiological requirements
of the abdominal wall and permit proper tissue of the abdominal wall and permit proper tissue
integration. These meshes provide the possibility of integration. These meshes provide the possibility of
forming a scar net instead of a stiff scar plate , forming a scar net instead of a stiff scar plate ,
therefore help to avoid theformer known therefore help to avoid theformer known
complicationscomplications (schumpelick, et al; 2009).
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In our study we try to evaluate the: In our study we try to evaluate the:
*challenge of the sublay retromuscular *challenge of the sublay retromuscular
technique of ventral incisional hernia repair, with technique of ventral incisional hernia repair, with
the advent of some new technical points in a trial the advent of some new technical points in a trial
to reduce recurrence. to reduce recurrence.
**compare results of using light-weight **compare results of using light-weight
``Vypro``mesh versus the standard heavy-weight ``Vypro``mesh versus the standard heavy-weight
prolene mesh in respect of post-operative prolene mesh in respect of post-operative
complications, chronic pain and recurrence.complications, chronic pain and recurrence.
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REVIEW OF HERNIA
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No disease of the human body, belonging No disease of the human body, belonging
to the province of the surgeon, requires in its to the province of the surgeon, requires in its
treatment a better combination of accurate treatment a better combination of accurate
anatomical knowledge with surgical skill anatomical knowledge with surgical skill
than hernia in all its varietiesthan hernia in all its varieties(Sir Astley (Sir Astley
Paston copoer, 1804) Paston copoer, 1804)
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Incidence of Incisional Hernia:
An incisional hernia is represented by the escape of
organs from their physiologic position through an
area of weakness in the surgical scar. The frequency
for incisional hernias (IH) after laparotomy is 2-11%
Incisional hernias make up about 80% of the ventral
hernias that surgeons encounter (Voeller, 2007).
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Factors affecting incisional hernia incidencFactors affecting incisional hernia incidenc
A- Patient factors: A- Patient factors: Many patient-related risk Many patient-related risk
factors have been implicated in the development of factors have been implicated in the development of
incisional hernias, including obesity, smoking, incisional hernias, including obesity, smoking,
aneurismal disease, chronic obstructive aneurismal disease, chronic obstructive
pulmonary disease, male gender, malnourishment, pulmonary disease, male gender, malnourishment,
corticosteroid dependency, renal failure, corticosteroid dependency, renal failure,
malignancy, and prostatismmalignancy, and prostatism (Millikan, 2003).
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B- Surgical factors: B- Surgical factors: Like emergency surgery, Like emergency surgery,
bowel surgery, suture type and technique, bowel surgery, suture type and technique,
chest infection, abdominal distension and chest infection, abdominal distension and
wound infection. There is evidence that in wound infection. There is evidence that in
many cases wound failure after abdominal many cases wound failure after abdominal
wall closure is dependent on the surgeon wall closure is dependent on the surgeon
(Yahchouchy-Chouillard et al., 2003).(Yahchouchy-Chouillard et al., 2003).
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Recently, molecular biologic investigations Recently, molecular biologic investigations
have proven the theory of disturbed have proven the theory of disturbed
composition of the extracellular matrix in composition of the extracellular matrix in
patients with recurrent hernia. In particular, patients with recurrent hernia. In particular,
there is a decreased ratio of collagen types I there is a decreased ratio of collagen types I
and III and III (Jansen et al., 2004 ). (Jansen et al., 2004 ). .…
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Treatment of Incisional Hernia
Once an IH occurs, the natural history of Once an IH occurs, the natural history of
it is to grow. Delay in repair complicates it is to grow. Delay in repair complicates
every single aspect of the surgery and leads every single aspect of the surgery and leads
to increased morbidity; so repair should be to increased morbidity; so repair should be
done as soon as possibledone as soon as possible
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Suture Repair
Many suture techniques have been described, Many suture techniques have been described,
but none has proven to be superior to the other in but none has proven to be superior to the other in
well-performed clinical trials. However well-performed clinical trials. However (Jenkin's (Jenkin's
rule):rule): mass closure with a non-absorbable or mass closure with a non-absorbable or
slowly absorbable monofilament suture (e.g. slowly absorbable monofilament suture (e.g.
PDS) good bites (>1cm), using a suture length : PDS) good bites (>1cm), using a suture length :
wound length ratio of 4:1,is good,insmall sized wound length ratio of 4:1,is good,insmall sized
hernia less than 4 cm.hernia less than 4 cm.
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Inlay Repair:
In this repair, the mesh is sutured to the fascial In this repair, the mesh is sutured to the fascial
edges without initially closing the defect. The edges without initially closing the defect. The
mesh lies in contact with the viscera. This mesh lies in contact with the viscera. This
technique has a high recurrence rate and may technique has a high recurrence rate and may
lead to bowel adhesions and development of lead to bowel adhesions and development of
enterocutaneous fistulas, so it is not enterocutaneous fistulas, so it is not
recommended unless the substantial defect recommended unless the substantial defect
cannot be closed with other technique . cannot be closed with other technique .
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Onlay Repair :
After dissection of the hernial sac, the fascial After dissection of the hernial sac, the fascial
edges are brought together and the mesh is edges are brought together and the mesh is
placed over the suture line making an overlap of placed over the suture line making an overlap of
5 cm.and fixed with stiches to the anterior fascia 5 cm.and fixed with stiches to the anterior fascia
The skin is closed over the mesh.The skin is closed over the mesh.
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Sublay Repair (Rives-Stoppa-Retrorectus Repair)
The mesh is placed beneath the rectus muscle in The mesh is placed beneath the rectus muscle in
front of the closed posterior rectus sheath and front of the closed posterior rectus sheath and
peritoneum. The anterior rectus sheath is closed. peritoneum. The anterior rectus sheath is closed.
The advantage of this technique is that if the mesh The advantage of this technique is that if the mesh
is much larger in surface area than the hernia is much larger in surface area than the hernia
defect, intra-abdominal forces hold the prosthesis defect, intra-abdominal forces hold the prosthesis
against the muscles. The forces that created the against the muscles. The forces that created the
hernia now are used to prevent its recurrence. hernia now are used to prevent its recurrence.
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In contrast to a mesh in front of the fascia in In contrast to a mesh in front of the fascia in
onlay position, the sublay mesh position onlay position, the sublay mesh position
facilitates a sufficient subduction of intact linea facilitates a sufficient subduction of intact linea
alba. It is the retromuscular mesh with a fascia alba. It is the retromuscular mesh with a fascia
closure in front, which is kept in position just by closure in front, which is kept in position just by
tissue ingrowth and intra-abdominal pressure, tissue ingrowth and intra-abdominal pressure,
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whereas the onlay mesh has to be fixed whereas the onlay mesh has to be fixed
additionally by permanent sutures. The mesh in additionally by permanent sutures. The mesh in
the space behind the rectus muscle can be the space behind the rectus muscle can be
easily dissected, whereas the extended easily dissected, whereas the extended
preparation of the subcutaneous space in the preparation of the subcutaneous space in the
case of the onlay position frequently is case of the onlay position frequently is
accompanied by hematoma, seroma, or wound accompanied by hematoma, seroma, or wound
infection. infection. (Schumpelick et al., 2007).(Schumpelick et al., 2007).
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Laparoscopic Repair of the Incisional Hernia
In 1991 LeBlanc reported the first successful In 1991 LeBlanc reported the first successful
series of laparoscopic ventral hernia repair series of laparoscopic ventral hernia repair
(LeBlanc et al., 2001). (LeBlanc et al., 2001).
After creation of the pneumoperitoneum and After creation of the pneumoperitoneum and
port placement, the hernial contents are reduced port placement, the hernial contents are reduced
intraperitoneally and the mesh is placed to intraperitoneally and the mesh is placed to
overlap the defect and fixed with clips and overlap the defect and fixed with clips and
suturessutures(Goodney et al., 2002).(Goodney et al., 2002).
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The Ideal Mesh The Ideal Mesh
There is no ‘‘best’’ mesh, so the decision of There is no ‘‘best’’ mesh, so the decision of
which mesh to use is based on several factors: which mesh to use is based on several factors:
the type of procedure being done, the clinical the type of procedure being done, the clinical
situation, the desired handling characteristics, situation, the desired handling characteristics,
and the products available to the surgeon based and the products available to the surgeon based
upon hospital materials contracts and costs. upon hospital materials contracts and costs.
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The most commonly used meshes
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l
Biological Meshes Biological Meshes
Recently, a number of biological meshes have Recently, a number of biological meshes have
become available. These are Surgisis?, which is become available. These are Surgisis?, which is
made from porcine gut submucosa, Alloderm?, made from porcine gut submucosa, Alloderm?,
which is made from cadaver dermis and Permacol? which is made from cadaver dermis and Permacol?
made from porcine dermis. They are expensive and made from porcine dermis. They are expensive and
can be used in contaminated situations. Long-term can be used in contaminated situations. Long-term
evaluation is neededevaluation is needed(Voeller 2007).(Voeller 2007).
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Postoperative complications
Postoperative complications of mesh repair are:Postoperative complications of mesh repair are:
**seroma formation,seroma formation,
**wound haematoma, wound haematoma,
**superficial and deep wound infection,superficial and deep wound infection,
**mesh rejection and mesh rejection and
**Abdominal discomfort,chronic pain and restriction Abdominal discomfort,chronic pain and restriction
of abdominal wall mobility (stiff abdomen), of abdominal wall mobility (stiff abdomen),
**recurrence.recurrence.
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SUBLAY SUBLAY RETROMUSCULR RETROMUSCULR
MESH REPAIRMESH REPAIRPrinciple of Principle of
RepairRepair
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SUBLAY RETROMUSCULR MESH REPAIR
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PatientsPatients::
*30 patients complaining of moderate *30 patients complaining of moderate
sized ventral incisional hernia ,i.e size of sized ventral incisional hernia ,i.e size of
hernia ranging from 5-11cm.hernia ranging from 5-11cm.
*Larg and huge sized hernia are *Larg and huge sized hernia are
excluded as it well need additional excluded as it well need additional
methods of repair.methods of repair.
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The patients classified into two groups:Group A: 15 patients treated by using the Heavy-weight prolene mesh using the sublay technique.
Group B: 15 patients treated by the same sublay technique but using the Light-weight`` vypro`` mesh in their repair.
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“MMETHODES OF REPAIR
Sublay "mesh repair; Sublay "mesh repair; retromuscular technique retromuscular technique i.e. mesh implanted behind the rectus abdominis muscle infront of the closed posterior rectus sheath and peritoneum.
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Operative detai
OPERATIVE DETAILS:OPERATIVE DETAILS:
The steps of operation sublay retromuscular
mesh repair published by Schumpelick et al.,
(2007),stressing on the following technical points:
*The different layers of the abdominal wall were
reconstructed with mesh placed behind the rectus
muscle.
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*The mesh was sized to give an overlap of at least
5 cm in all directions from the aponeurotic edges
i.e. wide overlap of the implanted mesh at least
5cm in all directions surrounding the hernia
defect.
*The posterior rectus sheath and the peritoneum
were closed to prevent direct contact between
mesh and intestine.
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*The anterior fascia of the rectus sheath was then
closed to reconstruct the linea alba i.e.
reconstruction of the linea alba by closure of
anterior rectus sheath over the mesh is
mandatory.
*Suction drain left in the retromuscular plane
before wound closure is essential .
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pic.(1)moderate size incisional hernia pic.(2)moderate size incisional hernia
pic.(3)huge size incisional herni
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pic.(4) skin incision
pic(5) scar excision
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pic(6)opening of hernia sac
pic(7) adhenlysis
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pic(8) peritoneal cavity
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pic(9) the posterior rectus sheath
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pic(10) incision of the posterior rectus sheath
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pic(11) dissection of the posterior rectus sheath
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pic(12)closure of the posterior rectus sheath
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pic(13) Prolene mesh
pic(14) Vypro mesh
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pic(15) mesh placement(Prolene mesh)
pic(16) mesh placement(Prolene mesh)
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pic(17) mesh placement( Vypro mesh)
pic(18) mesh placement( Vypro mesh)
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pic(19) mesh placement( Vypro mesh)
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pic(20)Anterior fascia closure with submuscular suction drainage
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pic(21) Anterior fascia closure( Prolene mesh)
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pic(22) fascia closure( Vypro mesh)
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pic(23) skin closure
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Duration of suction
Group
Duration (day)P value
MeanSDValueComment
Group (A)4– 7 days
(5.8)0.94
0.000
Significant
Group (B)3–5 days
(4.4 )0.73
Table 7: Duration of suction
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Group
Group (A) Group (B)
Mea
n±
SE
du
rati
on o
d s
uct
ion
(d
ay.)
0
1
2
3
4
5
6
7
Chart 1: Duration of Suction
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Table 8: Amount of Suction
Amount of suction
Group
Amount (mL)P value
MeanSDValueComment
Group (A)70 - 150
(102.0 )ml per day
23.05
0.032Significant
Group (B)50 -110
(85.3 )ml per day
16.85
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Group
Group (A) Group (B)
Mea
n±
SE
am
ou
nt
od
su
cti
on
(m
L.)
0
20
40
60
80
100
120
Chart 2: Amount of Suction
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Table 14: Incidence of seroma
Group
Compli.
Group (A)(n= 15)
Group (B)(n= 15)
Total(n= 30)
P value
no%no%no%ValueComment
Seroma426.7%213.3%620.0%0.013Significant
Chart 6: Seroma
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Table 16: Abdominal discomfort
Group
Complications
Group (A)(n= 15)
Group (B)(n= 15)
Total(n= 30)
P value
no%no%no%ValueComment
Ab
dom
inal d
iscomfort
First month
746.7%426.7%1136.7%0.003Signif.
Third month
320.0%16.7%413.3%0.007Signif.
Sixth month
16.7%00.0%13.3%0.007Signif.
Ninth month
00.0%00.0%00.0%--
First year00.0%00.0%00.0%--
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Chart 8: Abdominal Discomfor
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Table 15: Incidence of Wound Infection
GroupCompli.
Group (A)(n= 15)
Group (B)(n= 15)
Total(n= 30)
P value
no%no%no%ValueComment
Wound infection
320.0%16.7%413.3%0.007Significant
Chart 7: Wound Infection
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Table 17: Incidence of Recurrence (End of First Year)
Group
Recurrence
Group (A) )n=15(
Group (B) (n=15)
P- value
no%no%Valuecommen
t
Lost Patients16.7%16.7%1.00Not
significant
Recurrence 00.0%00.0%--
Chart 9: Incidence of Recurrence (End of First Year)
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Between Aug. 2007 and March 2010, Patients
were randomized to receive lightweight composite
(Vypro) mesh, or standard polypropylene
(Prolene) mesh. The clinical course of all
patients was registered during the hospital stay as
well as 3 ,6,9, and 12 months after surgery. The
follow up of all patients was regular for at least
one year after surgery and we observed that :
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*No significant differences concerning age,
gender,operative time.
*Duratin and amount of suction, length of
hospital stay were lower in the low-weight
(Vypro)mesh.
*Minor complications; seroma and wound
infection appeared frequently more in the heavy-
weight (Prolene)mesh group
.
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*Patients of the heavy-weight mesh
complained significantly and more frequently
about chronic pain and abdominal wall
discomfort than those of the low-weight (Vypro)
mesh group,but non of both groups complain of
"stiff abdomen“.
* No hernia recurrences observed in both
groups ,this may be due to short follow up also
the hernias were selected of moderate size (5-
11cm in length).
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To conclude:
Incisional hernia is a biologic problem due to Incisional hernia is a biologic problem due to
unstable scar formation with a defective collagen unstable scar formation with a defective collagen
metabolism.metabolism.
*Due to the disappointing results of primary *Due to the disappointing results of primary
suture repair, mesh repair is strongly suggested. suture repair, mesh repair is strongly suggested.
Prosthetic meshes are used for augmentation of Prosthetic meshes are used for augmentation of
the abdominal wall, and thus require a wide the abdominal wall, and thus require a wide
overlap of at least 5–6 cm.overlap of at least 5–6 cm.
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*Mesh prosthesis should be developed ideally for *Mesh prosthesis should be developed ideally for
the physiologic parameters of the abdominal wall to the physiologic parameters of the abdominal wall to
provide tensile strength, yet maintain elasticity. provide tensile strength, yet maintain elasticity.
**Retromuscular mesh repair offers the Retromuscular mesh repair offers the
advantage of an extraperitoneal mesh position advantage of an extraperitoneal mesh position
(avoiding the potential complications of an (avoiding the potential complications of an
intraperitoneal prosthesis) and a wide stable intraperitoneal prosthesis) and a wide stable
fixation by its position within the abdominal wall.fixation by its position within the abdominal wall.
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*Important steps in repair of incisional *Important steps in repair of incisional
hernias include complete excision of the fascial hernias include complete excision of the fascial
scar, use of a large enough mesh to provide a 5–scar, use of a large enough mesh to provide a 5–
6 cm overlap in all directions, closure of the 6 cm overlap in all directions, closure of the
posterior rectus sheath to prevent intraperitoneal posterior rectus sheath to prevent intraperitoneal
contact with the mesh, and closure of the contact with the mesh, and closure of the
anterior fascia in front of the mesh (thrust anterior fascia in front of the mesh (thrust
bearing resistance) whenever possible.bearing resistance) whenever possible.
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**DeficienciesDeficiencies in repair of incisional hernias in repair of incisional hernias
include insufficient scar excision, insufficient include insufficient scar excision, insufficient
preparation of the space for the mesh prosthesis, preparation of the space for the mesh prosthesis,
too small a piece of mesh, and inadequate closure too small a piece of mesh, and inadequate closure
of the anterior fascia. of the anterior fascia. **The introduction of retromuscular, sublay The introduction of retromuscular, sublay
technique using polypropylene meshes had technique using polypropylene meshes had significantly decreased the recurrence rates after significantly decreased the recurrence rates after open incisional hernia repair.This technique is open incisional hernia repair.This technique is very simple can be easly done and learned. very simple can be easly done and learned.
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Also the use of the lightweight composite Also the use of the lightweight composite
(Vypro,Ultrapro) mesh for incisional hernia (Vypro,Ultrapro) mesh for incisional hernia
repair had similar outcomes to heavyweight repair had similar outcomes to heavyweight
polypropylene mesh, but lightweight mesh polypropylene mesh, but lightweight mesh
resulted in a better abdominal wall compliance resulted in a better abdominal wall compliance
and less chronic pain, lower incidences of and less chronic pain, lower incidences of
postoperative seroma and infections with postoperative seroma and infections with
accepted recurrence rate.accepted recurrence rate.
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As compared to the heavyweight meshes, the As compared to the heavyweight meshes, the
lighter-weight meshes show a decrease in lighter-weight meshes show a decrease in
inflammatory response decreased stiffness, less inflammatory response decreased stiffness, less
shrinkage, and fewer post operative complaints. shrinkage, and fewer post operative complaints.
We thus now have evidence that if the surgeon We thus now have evidence that if the surgeon
chooses a polypropylene mesh for ventral chooses a polypropylene mesh for ventral
incisional hernia repair, it should be a incisional hernia repair, it should be a
lightweight mesh if possible.lightweight mesh if possible.
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Thank you
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الأمامي البطن لجدار الجراحي الفتق علاجالأماميةلجدارالبطن العضلات تحت برولين شبكه وضع طريق عن
من مقدم بحثحجازي/ محمد مصطفى الطبيب
العامة الجراحة ماجستيرالعامة الجراحة في الدكتوراه درجه على للحصول توطئه
إشراف تحت / لطفي محمد أحمد الدكتور الأستاذ
العامة الجراحة أستاذشمس – عين طب كليه
الجواد / عبد فؤادمحمد أسامه الدكتور الأستاذالعامة الجراحة أستاذ
- شمس عين طب كليهندا / محمد علي محمد الدكتور
العامة الجراحة مدرسشمس - عين طب كليه