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Warts Pharmacology IV (PHL 425) Dr. Abdulaziz Saeedan PhD, Pharmacology Email: [email protected]

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Page 1: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

WartsPharmacology IV (PHL 425)

Dr. Abdulaziz SaeedanPhD, Pharmacology

Email: [email protected]

Page 2: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Background Information Warts are small harmless lesions of the skin caused by a

DNA-containing human papillomavirus (HPV).

The appearance of warts can differ based on the type of wartand where it is located on the body.

Warts are common in children. Most cases occur betweenages 12-16 years.

Up to 30% of warts disappear by themselves within 6 months.Most will disappear without any treatment within 3 years.

The virus enters the skin after direct contact with recentlyshed viruses kept alive in warm, moist environments such asa locker room, or by direct contact with an infected person.

The entry site is often an area of recent injury. The incubationtime—from when the virus is contracted until a wart appears—can be 1-8 months.

Contrary to popular mythology, touching a frog will not giveyou warts.

Page 3: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Types of warts

Common warts (Verrucae vulgaris): Typically

develop on the hand, especially around the nail.

They are gray to flesh colored, raised from the skin

surface, and covered with rough, hornlike

projections.

Page 4: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Types of warts (cont.) Plantar warts (Verrucae plantaris): Occur on the plantar

surface, or bottom, of the foot.

They usually occur in high pressure areas such as the heeland the metatarsal heads (just behind the toes).

They usually grow into the skin, not outward like commonwarts.

This growing into the skin makes them more difficult to treat.

Page 5: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Flat warts (Verrucae plana): Flat warts are mostcommonly seen on the face, the back of the hands,and lower legs.

They usually appear as small individual bumpsabout 1/4 inch across.

Flat warts may spread rapidly on the face and lowerlegs from the activities involved in shaving.

Types of warts (cont.)

Page 6: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Treatment Home care is effective in making the wart or warts

go away. No matter what technique you use,

warts will disappear 60-70% of the time.

Techniques may be done with and without

medication.

The ultimate goal of the medical therapies (not the

surgical treatments) is to get your body to

recognize the wart as something foreign and to

destroy it, much like the body destroys a cold

virus.

Page 7: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Adhesive tape therapy

Place several layers of waterproof adhesive tape

over the wart region (even duct tape).

Do not remove the tape for 6-12 days. Then take

off the tape and open the area to the air for 12

hours.

Re-apply tape for another 6-12 days.

The tape works best in the region around the

fingernail.

Tape works because the air-tight, moist

environment under the tape does not allow the

virus to grow and reproduce

Page 8: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Salicylic acid therapy Salicylic acid is available by many different trade names at the drug store.

Dual Film

Wart-Off

Dr. Scholl’s Wart Medication

Medi-Plast

It comes either as a liquid to paint on the wart or as a plaster to be cut out

and placed on the wart tissue.

slowly destroys virus-infected epidermis and may cause an immune

response from the mild irritation caused by the salicylic acid

The area with the wart should be soaked in warm water for 5-10 minutes.

The wart should then be pared down with a razor. A simple razor works fine

for this, then throw it away.

Do not shave far enough to make the wart bleed.

Apply the salicylic acid preparation to the wart tissue.

Do not apply it to other skin because of salicylic acid's potential to injure

normal tissue.

Follow directions on the package for how long to apply the acid.

Page 9: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Cryosurgery Liquid nitrogen or dimethyl ether - propane mixture

is used to deep freeze the wart tissue.

With liquid nitrogen applied to the wart, the water inthe cells expands, thus exploding the infectedtissue.

The exploded cells can no longer hide the humanpapillomavirus from the body's immune system.

The immune system then works to destroy thevirus particles.

Periungual area may scar if cryotherapy with liquid

nitrogen is used improperly.

Scarring could lead to permanent nail disfiguration.

Page 10: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance
Page 11: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Laser Therapy

Lasers are simply very intense light

sources.

This light has an enormous amount of

energy that heats the tissue enough that it

vaporizes.

Page 12: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Shave Removal Shave removal and electrodessication of the base may be

necessary when other treatment methods fail.

This would involve numbing the region around the wartand shaving the wart flat with the surface and lightelectrodessication of the base.

Page 13: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Others Treatments Imiquimod, a topical cream that helps the body's immune

system fight the wart virus by encouraging interferonproduction. Approved by the U.S. Food and DrugAdministration (FDA) for genital warts. The drug is veryexpensive.

Dinitrochlorobenzene (DNCB), like salicylic acid, this isapplied directly to the wart. Studies showed this method waseffective with a cure rate of 80%. But DNCB must be usedmuch more cautiously than salicylic acid; the chemical isknown to cause genetic mutations, so it must beadministered by a physician. This drug induces an allergicimmune response resulting in inflammation that wards off thewart-causing virus.

Flurouracil, which inhibits DNA synthesis, is being used asan experimental treatment. It is applied directly to the wart(especially plantar warts) and covered (for example: withtape).

Page 14: Warts Diagnosis and Treatment › filedownload › doc-13... · Warts are small harmless lesions of the skin caused by a DNA-containing human papillomavirus (HPV). The appearance

Prognosis Most warts will disappear without treatment anywhere from

6 months to 3 years.

Warts may recur after treatment and require additional

treatments.

Prevention Avoid touching warts on others or touching them on

yourself (refrain from rubbing a warty finger across your

face).

Children needs to avoid biting or chewing warts.

Wear shower shoes in the gym locker room to lower your

risk of picking up the virus that causes plantar warts from

the moist environment.