water soluble vitamins lecture 1 thiamin & riboflavin ppt biochemistry
TRANSCRIPT
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WATER SOLUBLE VITAMINS
Dr Vijay Marakala M.B.B.S.,M.D
Assistant ProfessorBiochemistry
SIMS&RC
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Their common properties are
1. Water solubility.2. Except Vitamin B12 others are not stored.3. Unstable to normal cooking conditions.4. Excreted in urine.
WATER SOLUBLE VITAMINS
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• Thiamine [B1]• Riboflavin [B2]• Niacin [B3]• Pantothenic acid [B5] • Pyridoxine [B6]• Biotin • Folic acid• Cobalamine [B12]
Vitamin B complex
WATER SOLUBLE VITAMINS
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WATER SOLUBLE VITAMINS
Thiamine Riboflavin
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Heat labile sulfur containing vitamin
Contains pyrimidine and thiazole ring
Joined by methylene bridge
It is highly alkaline sensitive
Thiamine
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Pyrimidine ring Methylene bridge Thiazole ring
VITAMIN B1 - THIAMINE
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Sources
Rich Sources
Good sources
Fair sources
• Outer coatings of food grains like rice, wheat and yeast.
• Whole cereals, pulses, oilseeds and nuts.
• Meat, liver and egg and fish.
Vitamin B1 - Thiamine
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VITAMIN B1 - THIAMINE
Thiamine Sources
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THIAMINE -RDA
1mg/day
Requirement increases with energy expenditure
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Absorption and Transport
It is absorbed in small intestine by active transport mechanism and simple diffusion. Then it reaches liver through circulation.
Ethanol inhibits active transport
VITAMIN B1 - THIAMINE
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THIAMINE-ACTIVE FORM
Thiamin pyrophosphate (TPP or TDP) is the active form of
thiamine.
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VITAMIN B1 - THIAMINE
Thiamin pyrophosphate (TPP or TDP) is the active form of thiamine.
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Functions
VITAMIN B1 - THIAMINE
Essential for release of
energy from carbohydrates
Necessary branched
chain amino acid
metabolism
Needed for normal
functioning of nervous system
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In carbohydrate metabolismOxidative decarboxylationTransketolase reactions
VITAMIN B1 - THIAMINE
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Pyruvate Acetyl - CoA
NAD+ NADH+H+
Lipoate, CoA-SH, FAD
CO2
Oxidative decarboxylation
VITAMIN B1 - THIAMINE
TPP
PDH
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α ketoglutarate Succinyl - CoA
NAD+ NADH+H+
Lipoate, CoA-SH, FAD
CO2
Oxidative decarboxylation
VITAMIN B1 - THIAMINE
TPP
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VITAMIN B1 - THIAMINE
Xylose-5 phosphate Ribose-5 phosphate
Glyceraldehyde-3 phosphate Sedoheptulose-7 phosphate
Transketolase TPP
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VITAMIN B1 - THIAMINE
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VITAMIN B1 - THIAMINE
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Thiamine Deficiency:
Failure of carbohydrate metabolism
↓ATP production
Impaired cellular
functions
VITAMIN B1 - THIAMINE
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Thiamine Deficiency:
Impaired cellular functions
Neurological symptoms, Edema,
Indigestion,Constipation
VITAMIN B1 - THIAMINE
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Thiamine Deficiency:
Neurological symptoms, Edema,
Indigestion,Constipation
BERIBERI
VITAMIN B1 - THIAMINE
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Thiamine Deficiency:
Types of BERIBERIDry beriberi
Wet beriberi
Cerebral beriberi
Infantile beriberi
VITAMIN B1 - THIAMINE
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WATER SOLUBLE VITAMINS
RIBOFLAVIN
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RIBOFLAVIN - CHEMISTRY
It contains heterocyclic isoalloxazine ring and ribitol a sugar alcohol
It is sensitive to light.
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RIBOFLAVIN - SOURCES
SourcesMilkCheeseEggsMeat Yeast extractsGreen vegetables
27
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VITAMIN B2 -RIBOFLAVIN
RDA
1.3 – 1.7mg/day
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VITAMIN B2 -RIBOFLAVIN
Absorption and Transport
Absorbed in small intestine and distributed to all tissues by circulation.
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RIBOFLAVIN – ACTIVE FORMS
FMNFAD
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RIBOFLAVIN – ACTIVE FORMS
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VITAMIN B2 -RIBOFLAVIN
Active forms of riboflavin are FMN and FAD.
They act as prosthetic groups of several enzymes.
Catalyzes oxidation-reduction reactions.
Growth, repair, development of body tissues - healthy skin, eyes and tongue
Functions
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VITAMIN B2 -RIBOFLAVIN
Co-enzyme activity
FMN - dependent enzymes
FAD - dependent enzymes
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RIBOFLAVIN - DEFICIENCY
Oral
• Angular Stomatitis
• Cheliosis• Glossitis
Facial • Dermatitis of
nasolabial region.
Ocular • Vascularization
of cornea
Riboflavin Deficiency
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WATER SOLUBLE VITAMINS
NIACIN
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Nicotinic acid Nicotinamide
NIACIN [B3]-CHEMISTRY
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NIACIN [B3]- SOURCE
LegumesYeastLiverFish
Meat
Niacin can also be obtained from Tryptophan •
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Daily Requirement (RDA):
Niacin [B3]
15-20 mg/day
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Absorbed in small intestine and reach various tissues through circulation where they are converted to NAD
and NADP.
Niacin [B3]
Absorption and transport
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Niacin [B3]-ACTIVE FORM
NAD+ NADP+
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NIACIN [B3]
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FUN
CTIO
NS NAD+, NADP+ are involved in oxidation and
reduction reactions
NAD in oxidative pathways- TCA cycle, Glycolysis
NADP in reductive pathways- PPP, Synthesis of cholesterol, FA
NIACIN [B3]
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PELLAGRA
Dermatitis
Diarrhoea
Dementia
Death
NIACIN [B3]- DEFICIENCY
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CAUSES Dietary deficiency
Deficient synthesis
Isoniazid
Hartnup disease
Carcinoid syndrome
NIACIN [B3]
Niacin Deficiency
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WATER SOLUBLE VITAMINS
Pantothenic acid Pyridoxine
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Combination of pantoic acid and β-alanine
PANTOTHENIC ACID [B5]-CHEMISTRY
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EggLiverMeatYeastMilk
Cereals
PANTOTHENIC ACID [B5]-SOURCES
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Daily requirement (RDA)
PANTOTHENIC ACID [B5]
5-10 mg/day.
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Absorption and transport
Freely absorbed in the intestine and reach various tissues through circulation.
PANTOTHENIC ACID [B5]
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ACTIVE FORMS
Coenzyme-A[CoA-SH]
Acyl carrier protein[ACP]
PANTOTHENIC ACID [B5]
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PANTOTHENIC ACID [B5]
Coenzyme A
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PANTOTHENIC ACID [B5]
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Coenzyme-A
TCA cycle
Fatty acid synthesis
Cholesterol synthesis
ACP
Fatty acid synthesis
PANTOTHENIC ACID [B5]-FUNCTIONS
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Rare in humans Burning Foot Syndrome
Experimental animals
AnemiaDermatitisFatty liver
PANTOTHENIC ACID [B5]-Deficiency
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:
Time fora short break
1009080706050403020100
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••••••••••••••••••••••••••••••••••
PYRIDOXINE [B6]
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Pyridoxine
Pyridoxal
Pyridoxamine
PYRIDOXINE [B6]- CHEMISTRY
• Three compounds derived from pyridine show vitamin B6 activity.
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PYRIDOXINE [B6]
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Whole grainsLegumes
LiverYeastMeat
VegetablesFruits
PYRIDOXINE [B6]
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Daily requirement (RDA)
2-2.5 mg/day
PYRIDOXINE [B6]
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Pyridoxine is easily absorbed and reaches
various tissues through circulation.
In the tissues pyridoxine is converted to pyridoxal and
pyridoxamine.
Absorption and Transport
PYRIDOXINE [B6]
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Active form of vitamin B6
Pyridoxal phosphate
PYRIDOXINE [B6]
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PYRIDOXINE [B6]
Protein metabolism
Heme synthesis
Glycogenolysis
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PYRIDOXINE [B6]
Transamination
Deamination Decarboxylation
Heme synthesis
Production of Niacin
Glycogenolysis
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PYRIDOXINE [B6]
Reaction type Example
Transamination Oxaloacetate + glutamate aspartate + ⇔ α-ketoglutarate
Deamination Serine → pyruvate + NH3
Decarboxylation Histidine → histamine + CO2
Condensation Glycine + succinyl CoA → δ-aminolevulinic acid
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PYRIDOXINE [B6]-DEFICIENCY
Microcytic hypochromic anaemia Peripheral neuropathy Convulsions
It is rare in human adults.
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Drug induced pyridoxine deficiency
Isoniazid or isonicotinic acid hydrazine (INH)
Pencillamine
Oral contraceptives and excessive alcohol consumption
PYRIDOXINE [B6]
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