Cairo University

Faculty of PharmacyCurriculum Vitae

Education Academic DegreesChoose an item.

Bachelor Degree: Pharmacy and Pharmaceutical Science, Faculty of Pharmacy, Cairo University, Excellent honor, 1991.

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Master Degree/ Pharmaceutical Chemistry/Thesis title: "Synthesis of Certain Acridine Derivatives of Anticipated Anti-tumor and Anti-HIV-I Activities. Faculty of Pharmacy, Cairo University 1997.

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Choose DegreePh. D.: Pharmaceutical Chemistry/ Thesis title: Synthesis of Certain Acridine Derivatives of Anticipated Anti-cancer Activity. 2002, Faculty of Pharmacy, Cairo University.

Research interestMedicinal chemist capable of executing chemical reactions employing new innovative methodologies, solid background about computer aided drug design (CADD) with an experience of modeling software such as (MOE and Discovery studio) and elucidating structural activity relationship (SAR). Solid background and experience structure elucidation using UV, NMR, IR and Mass. Of particular interest is the design and synthesis of small molecule inhibitors for some kinases like PI3K, EGFR, VEGFR-2, in addition to carbonic anhydrase inhibitors, COX- inhibitors and anticancer agents with pro-apoptotic activity.

Teaching

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Name: Sahar Mahmoud Abou-Seri

Title: Associate Professor Dr.

Department:

Pharmaceutical Chemistry

E-mail: Sahar.shaarawy@pharma.cu.edu.eg

Website: http://scholar.cu.edu.eg/?q=dr_sahar_abou_seri/

Mobile: +2 01227059742

Phone: +202 25591683

Cairo University

Faculty of PharmacyCurriculum Vitae

Course TitleUndergraduate Courses

(General Program)801 Pharmaceutical Chemistry I

802 Pharmaceutical Chemistry II

803 Pharmaceutical Chemistry III

Undergraduate Courses (Clinical Program)

PC 509 Medicinal Chemistry-1

Choose an item.PC 610 Medicinal Chemistry-2

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Postgraduate Courses 1- (Molecular modeling in Drug Design) for master students 2003-2010

2- ( Biotransformation reaction mechanism 2808) for master students2011- 2015

3- Diploma of Drug Discovery (principles of drug discovery and development 1801) 2015-2016

Career History and Professional Experience

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Cairo University

Faculty of PharmacyCurriculum Vitae

Titles 1-Active member of the molecular modeling center, Cairo University, 2009-2012. 2-Postgraduate Vice dean Assistant, Cairo University, 2010-2013.

3-Supervisor of the library, Faculty of pharmacy, Cairo University, 2010-2013.4-Director of the molecular modeling of unit, Cairo University, 2014-2015

Awards 1-Best international publication in medicinal chemistry, Faculty of pharmacy at the 5th scientific conference of Faculty of Pharmacy, Cairo University (2015).

2-Cairo University award for international publications 2010-2015.

3-Outstanging contribution reviewing from the European Journal of Medicinal Chemistry, 2015

Projects Design, Synthesis and Evaluation of Cardiovascular Activity of Novel Substituted Coumarin Derivatives".(1 Jan 2009- 31 Dec 2010). Funded by Cairo university

Publications and Presentations1. Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase

isoforms IX and XII. Hany S. Ibrahim, Sahar M. Abou-Seri, Muhammet Tanc, Mahmoud M. Elaasser, Hatem A. Abdel-Aziz, Claudiu T. Supuran. European Journal of Medicinal Chemistry 2015, 103, 583-593.

2. Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking

Wagdy M. Eldehna, Mohamed Fares, Hany S. Ibrahim , Mohamed H. Aly, Suher Zada, Mamdouh M. Ali, Sahar M. Abou-Seri, Hatem A. Abdel-Aziz Dalal A. Abou El Ella. European Journal of Medicinal Chemistry 2015, 100, 89-97.

3. Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kα inhibitors

Marwa A. Ibrahim, Sahar M. Abou-Seri, Mona M. Hanna, Mohamed M. Abdalla, Nehad A. El Sayed. European Journal of Medicinal Chemistry 2015, 99, 1-13.

4. Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38aMAPK and ERK1/2 inhibitory activity

Fadi M. Awadallah, Sahar M. Abou-Seri, Mohamed M. Abdulla, Hanan H. Georgey European Journal of Medicinal Chemistry 2015, 94, 397-404.

5. Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells

Kamilia M. Amin, Sahar M. Abou-Seri, Fadi M. Awadallah, Amal A.M. Eissa, Ghaneya S. Hassan, Mohamed M. Abdulla.European Journal of Medicinal Chemistry 2015, 90, 221-231.

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Cairo University

Faculty of PharmacyCurriculum Vitae

6. Design, synthesis and in Vitro antiproliferative activity of novel isatin-quinazoline hybrid. Mohamed Fares, Wagdy M. Eldehna, Sahar M. Abou-Seri, Hatem A. Abdel- Aziz, Mohamed H. Aly and Mai F. TolbaArch. Pharm. Chem. Life Sci. 2015, 348, 144–154.

7. Synthesis and antitumor activity of pyrido[2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest

Mohamed Fares, Sahar M. Abou-Seri, Hatem A. Abdel-Aziz, Safinaz E.-S. Abbas b, Mohieldin Magdy Youssef , Radwa Ahmed EladwyEuropean Journal of Medicinal Chemistry 2014, 83, 155-166.**This publication received the Cairo University award for international publications.

8. Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: Design, synthesis and evaluation as potential anti-inflammatory agents

Ghaneya S. Hassan , Sahar M. Abou-Seri, Gehan Kamel , Mamdouh M. AliEuropean Journal of Medicinal Chemistry 2014, 76, 482-493**This publication received the Cairo University award for international publications and best international publication in medicinal chemistry, Faculty of pharmacy at the 5th scientific conference of Faculty of Pharmacy, Cairo University.

9. Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents

Kamilia M. Amin, Amal A.M. Eissa, Sahar M. Abou-Seri, Fadi M. Awadallah, Ghaneya S. HassanEuropean Journal of Medicinal Chemistry 2013, 60, 187-198.

**This publication received the Cairo University award for international publications.10. Synthesis and Bioactivity Evaluation of New 6-Aryl-5-cyano Thiouracils as Potential

Antimicrobial and Anticancer Agents.Azza Taher Taher and Sahar M. Abou-Seri Molecules 2012, 17, 9868-9886.

**This publication received the Cairo University award for international publications.11. Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450

enzymes inhibitors.Ashraf H. Abadi, Sahar M. Abou-Seri, Qingzhong Hu, Matthias Negri, Rolf W. Hartmann.Medicinal Chemistry Communication, 2012, 3, 663-666.**This publication received the Cairo University award for international publications.

12. Synthesis and In Vitro Cytotoxic Activity of Novel Pyrazolo[3,4-d]pyrimidines and Related Pyrazole Hydrazones Toward Breast Adenocarcinoma MCF-7 Cell Line.

Ghaneya S. Hassan, Hanan H. Kadry, Sahar M. Abou-Seri, Mamdouh M. Ali, Abeer E. E-D. Mahmoud.Bioorganic and Medicinal Chemistry 2011, 19, 6808–6817.**This publication received the Cairo University award for international publications.

13. Design, synthesis and vasorelaxant evaluation of novel coumarin–pyrimidine hybrids.Kamilia M. Amin, Fadi M. Awadalla, Amal A. M. Eissa, Sahar M. Abou-Seri, Ghaneya S. Hassan.Bioorganic and Medicinal Chemistry 2011, 19, 6087-6097.

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Cairo University

Faculty of PharmacyCurriculum Vitae

**This publication received the Cairo University award for international publications.14. Novel diphenylamine 2,4'-dicarboxamide based azoles as potential epidermal growth factor

receptor inhibitors: synthesis and biological activity.Sahar M. Abou-Seri, Nahla A. Farag, Ghaneya S. Hassan.Chemical and Pharmaceutical Bulletin 2011, 59, 1124—1132.**This publication received the Cairo University award for international publications.

15. Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as α1-adrenoreceptor antagonists. Sahar M. Abou-Seri, Khaled Abouzid, Dalal A. Abou El Ella. European Journal of Medicinal Chemistry 2011, 46, 647-658.**This publication received the Cairo University award for international publications.

16. Synthesis and biological evaluation of novel 2,4'-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors.Sahar M. Abou-SeriEuropean Journal of Medicinal Chemistry 2010, 45, 4113-4121.**This publication received the Cairo University award for international publications and best poster presentation award at the 2nd scientific conference of Faculty of Pharmacy, Cairo University.

17. Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents.Ashraf H. Abadi, Sahar M. Abou-Seri, Doaa E. Abdel-Rahman, Christian Klein, Olivier Lozach, Laurent Meijer. European Journal of Medicinal Chemistry 2006, 41, 296–305.**This publication received the Cairo University award for international publications.

18. Synthesis, molecular modeling and anticancer activity of certain acridine derivatives. Samir M. El-moghazy Aly, Dalal A. Abou El-Ella, Sahar M. Abou-Seri, Mohammed Y. Ebeid. Egypt. J. pharm. Sci., 2002, 43, 73-103.

19. -Synthesis and Anti-HIV-1Activity of some N substituted 9-(4-sulfonylphenyl-amino)acridin-2-yl-9-oxo-9,10-dihdroacridin-2-yl- and 9-aminoacridin-2-yl]N-(4-sulfamoylphenyl)carboxamide derivatives.

Samir M. El-moghazy Aly , Mohammed Y. Ebeid, Enaya l. Aly, Sahar M. Abou-Seri. Bull. Fac. pharm., Cairo Univ.; 1997, 35,185.

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