weber et al (1998). cell 92: 759mbklab/courses/bi113/lecture 4.pdf · rizo & sudhof (1998) nat...

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Page 1: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347
Page 2: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347
Page 3: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Weber et al (1998). Cell 92: 759

SNARE complex formation can mix lipids

Protein free vesicles

Page 4: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Rizo & Sudhof (1998) Nat Struct Biol 5, 839

Crystal structure of SNARE complex

Page 5: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Sutton et al (1998) Nature 395:347

Crystal structure of SNARE complex

Page 6: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Clostridial neurotoxins: botulinum toxins and tetanus toxin

Page 7: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Model of SNARE complex in membrane fusion

Sutton et al (1998) Nature 395:347

Page 8: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Weber et al (1998). Cell 92: 759

Pre-assembled SNARE complexes areresistant to inhibitors

Page 9: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Calcium controls regulated exocytosis in nerve cells

Lodish et al, 2000

Page 10: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Sudhof & Rizo (1998)

Cycles of SNARE assembly and disassembly

Page 11: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Carr (2001). Nat Struct Biol 8:186

Distinct conformations of a t-SNAREin crystal structures

Page 12: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347

Sudhof & Rizo (1998)

Cycles of SNARE assembly and disassembly