weber et al (1998). cell 92: 759mbklab/courses/bi113/lecture 4.pdf · rizo & sudhof (1998) nat...
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![Page 1: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347](https://reader033.vdocuments.net/reader033/viewer/2022060601/6054c5fb215fd7093710ee3e/html5/thumbnails/1.jpg)
![Page 2: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347](https://reader033.vdocuments.net/reader033/viewer/2022060601/6054c5fb215fd7093710ee3e/html5/thumbnails/2.jpg)
![Page 3: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347](https://reader033.vdocuments.net/reader033/viewer/2022060601/6054c5fb215fd7093710ee3e/html5/thumbnails/3.jpg)
Weber et al (1998). Cell 92: 759
SNARE complex formation can mix lipids
Protein free vesicles
![Page 4: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347](https://reader033.vdocuments.net/reader033/viewer/2022060601/6054c5fb215fd7093710ee3e/html5/thumbnails/4.jpg)
Rizo & Sudhof (1998) Nat Struct Biol 5, 839
Crystal structure of SNARE complex
![Page 5: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347](https://reader033.vdocuments.net/reader033/viewer/2022060601/6054c5fb215fd7093710ee3e/html5/thumbnails/5.jpg)
Sutton et al (1998) Nature 395:347
Crystal structure of SNARE complex
![Page 6: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347](https://reader033.vdocuments.net/reader033/viewer/2022060601/6054c5fb215fd7093710ee3e/html5/thumbnails/6.jpg)
Clostridial neurotoxins: botulinum toxins and tetanus toxin
![Page 7: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347](https://reader033.vdocuments.net/reader033/viewer/2022060601/6054c5fb215fd7093710ee3e/html5/thumbnails/7.jpg)
Model of SNARE complex in membrane fusion
Sutton et al (1998) Nature 395:347
![Page 8: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347](https://reader033.vdocuments.net/reader033/viewer/2022060601/6054c5fb215fd7093710ee3e/html5/thumbnails/8.jpg)
Weber et al (1998). Cell 92: 759
Pre-assembled SNARE complexes areresistant to inhibitors
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Calcium controls regulated exocytosis in nerve cells
Lodish et al, 2000
![Page 10: Weber et al (1998). Cell 92: 759mbklab/courses/bi113/Lecture 4.pdf · Rizo & Sudhof (1998) Nat Struct Biol 5, 839 Crystal structure of SNARE complex. Sutton et al (1998) Nature 395:347](https://reader033.vdocuments.net/reader033/viewer/2022060601/6054c5fb215fd7093710ee3e/html5/thumbnails/10.jpg)
Sudhof & Rizo (1998)
Cycles of SNARE assembly and disassembly
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Carr (2001). Nat Struct Biol 8:186
Distinct conformations of a t-SNAREin crystal structures
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Sudhof & Rizo (1998)
Cycles of SNARE assembly and disassembly