wednesday 06 may 2015 - embl heidelberg · dna methylation profile of sporadic and melanoma-prone...

Programme

Wednesday 06 May 2015 15:00 - 17:15 Arrival and Registration

ATC Reception

17:15 - 17:30 Opening remarks ATC Auditorium

17:30 - 20:10 Session 1: Transgenerational inheritance Chairs: Asifa Akhtar and Renato Paro ATC Auditorium

17:30 - 17:55 Propagating transcription patterns through mitosis 1Gerd Blobel Children's Hospital of Philadelphia, United States of America

17:55 - 18:10 Transmission and accurate deployment of human Chromosome 21 through the mouse male germline

2

Christina Ernst Cancer Research UK - Cambridge Institute, United Kingdom

18:10 - 18:35 Demystifying trans-generational epigenetics 3Vincent Colot École Normale Supérieure, France

18:35 - 19:05 Coffee Break ATC Foyer

19:05 - 19:30 Spatial distribution of H3K9 methylated chromatin in worm embryos: fate decisions in development

4

Susan M. Gasser Friedrich Miescher Institute for Biomedical Research, Switzerland

19:30 - 19:45 Sperm is epigenetically programmed to regulate gene transcription in embryos

5

Jerome Jullien Cambridge University, United Kingdom

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EMBO Conference: Chromatin and Epigenetics

19:45 - 20:10 Chromatin replication and epigenome maintenance 6Anja Groth BRIC, University of Copenhagen, Denmark

20:10 - 22:00 Welcome Reception in the ATC Foyer and Rooftop Lounge

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Programme

Thursday 07 May 2015 09:00 - 12:10 Session 2: Systems biology in epigenetics

Chairs: Sarah Teichmann and Vincent Colot ATC Auditorium

09:00 - 09:25 Genome regulation during embryonic development 7Eileen Furlong EMBL Heidelberg, Germany

09:25 - 09:40 Genomic and epigenomic determinants of mammalian DNA methylation patterns

8

Tuncay BaubecFriedrich Miescher Institute for Biomedical Research, Switzerland

09:40 - 09:55 High resolution chromatin dynamics during a yeast stress response

9

Nir Friedman The Hebrew University of Jerusalem, Israel

09:55 - 10:20 Toward physical principles of chromatin (re)organization 10

Leonid Mirny

Massachusetts Institute of Technology, United States of America


10:50 - 11:15 Unraveling principles of chromatin regulation using massively parallel measurements of designed sequences

11

Eran Segal

Weizmann Institute of Science, Israel

11:15 - 11:30 Enhancer – core-promoter specificity separates developmental and housekeeping gene regulation

12

Cosmas ArnoldIMP, Austria

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11:30 - 11:45 Proteins that bind regulatory regions in the embryonic stem cell genome, identified by histone-modification chromatin immunoprecipitations and mass spectrometry

13

Raymond Poot Erasmus MC, The Netherlands

11:45 - 12:10 To be presented onsite 14John Stamatoyannopoulos University of Washington, United States of America

12:10 - 13:30 Lunch ATC Foyer

13:30 - 16:00 Poster Session I

ATC Helices

16:00 - 18:55 Session 3: The chromatin proteomeChairs: Susan Gasser and Michiel Vermeulen ATC Auditorium

16:00 - 16:25 Quantitative interaction proteomics for epigenetics 15Michiel VermeulenRadboud University Nijmegen, The Netherlands

16:25 - 16:40 Posttranslational modifications on the histone variant CENP-A/ Cse4 from S. cerevisiae

16

Ann Ehrenhofer-MurrayHumboldt-Universität zu Berlin, Germany

16:40 - 17:25 Coffee Break & Meet the SpeakersATC Foyer

17:25 - 17:50 Dynamics and regulation of DNA methylation in mouse development

17

Michaël Weber University of Strasbourg/CNRS, France

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Programme

17:50 - 18:15 Chromatin architecture and dynamics of histone variant H2A.Z at yeast promoters

18

Carl Wu HHMI, Janelia Research Campus, United States of America

18:15 - 18:30 CRISPR/Cas9 deletion shows that HBO1 is essential for H3K14 acetylation in human cells

19

Anne Voss Walter and Eliza Hall Institute of Medical Research, Australia

18:30 - 18:55 Integrative structural analysis of the INO80 chromatin remodeler

20

Karl-Peter HopfnerLMU Munich, Germany

18:55 - 21:00 Dinner ATC Canteen

21:00 - 22:30 After dinner drinks in the ATC Foyer and Rooftop Lounge

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Friday 08 May 2015 09:00 - 12:05 Session 4: Chromatin dynamics, signalling and disease

Chairs: Geneviève Almouzni and Paolo Sassone-Corsi ATC Auditorium

09:00 - 09:25 Non-coding upstream anti-sense promoters are distinct hubs of transcription factor binding and enhancer-like histone modifications

21

Karen Adelman NIEHS/ NIH, United States of America

09:25 - 09:40 Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions

22

Darío G. Lupiáñez MPI for Molecular Genetics, Germany

09:40 - 09:55 Programmed reorganization of telomeres triggered by mitochondrial activity in long-lived quiescent cells

23

Angela Taddei Institut Curie, France

09:55 - 10:20 Parental origin effects and the epigenetic control of developmental processes

24

Anne Ferguson-Smith University of Cambridge, United Kingdom


11:00 - 11:25 Common threads: epigenetics, metabolism and the clock 25

Paolo Sassone-Corsi

University of California, Irvine, United States of America

11:25 - 11:40 Epigenetic regulation and chromatin dynamics in embryonic stem cells and cancer

26

Raffaella SantoroUniversity of Zurich, Switzerland

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Programme

11:40 - 12:05 Actin-related proteins and regulatory domains enable nucleosome ejection by RSC/Sth1

27

Bradley Cairns University of Utah, United States of America

12:05 - 13:30 Lunch ATC Foyer

13:30 - 16:00 Poster Session II ATC Helices

16:00 - 17:00 Session 5: Keynote lecture: Renato Paro Chair: Robert Kingston ATC Auditorium

16:00 - 17:00 Cellular memory in regeneration and cancer 28Renato Paro ETH Zurich, Switzerland

17:00 Free Evening

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Saturday 09 May 2015 09:00 - 11:45 Session 6: RNA and epigenetics

Chairs: Anne Ferguson-Smith and Edith Heard ATC Auditorium

09:00 - 09:15 Systematic characterization of the KRAB zinc finger proteins family using high-resolution ChIP-Seq 154Michael Imbeault EPFL, Switzerland

09:15 - 09:30 Disentangling the Xist regulatory network 30Edda Schulz MPI for Molecular Genetics, Germany

09:30 - 09:45 Single-cell mass cytometry of gene regulatory networks in highly complex samples

31

Andreas Frei Stanford University, United States of America

09:45 - 10:10 Epigenetic regulation by MOF containing complexes 32Asifa Akhtar MPI of Immunobiology and Epigenetics, Germany


10:50 - 11:15 Chromatin determinants of centromeric identity and their deregulation in cancer

33

Geneviève AlmouzniInstitut Curie/CNRS, France

11:15 - 11:30 A new epigenetic twist: LncRNAs target chromatin by triple helix formation

34

Holger Bierhoff German Cancer Research Center, DKFZ-ZMBH Alliance, Germany

11:30 - 11:45 Global chromatin regulation effects molecular features of totipotent cells

35

Maria-Elena Torres-Padilla IGBMC, France

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Programme

11:45 - 13:30 Lunch ATC Canteen

13:30 - 16:00 Poster Session III ATC Helices

16:00 - 19:10 Session 7: Nuclear architecture and chromatin structure Chairs: Bas van Steensel and Bradley Cairns

ATC Auditorium

16:00 - 16:25 X-chromosome inactivation: exploring the relationship between chromosome structure and gene activity

36

Edith Heard Institut Curie, France

16:25 - 16:40 In vitro reconstitution of NFR-array nucleosome patterns across the yeast genome with purified remodelers and barrier factors

37

Philipp Korber University of Munich, Germany

16:40 - 16:55 Chromatin dynamics during mouse oogenesis 38Petra Hajkova MRC Clinical Sciences Centre, United Kingdom

16:55 - 17:20 Polycomb-Group function: compaction of nucleosomes and regulation by lncRNAs

39

Robert Kingston Massachusetts General Hospital, United States of America


18:05 - 18:30 Novel, ligation-free method for identifying chromatin interactions genome-wide

40

Ana Pombo Max-Delbrück-Centre for Molecular Medicine, Germany

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18:30 - 18:45 Histone H2B methylation – a novel guardian of transposable elements

41

Robert Schneider IGBMC, France

18:45 - 19:10 Function and regulation of long-distance chromosomal interactions

42

Francois Spitz EMBL Heidelberg, Germany

19:10 - 19:15 Poster Prize AnnouncementATC Auditorium

19:15 - 00:30 Banquet Dinner and Party ATC Canteen and ATC Foyer

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Programme

Sunday 10 May 2015 09:00 - 11:45 Session 8: New technologies in epigenomics

Chairs: Ana Pombo and Davide Corona ATC Auditorium

09:00 - 09:25 Expression homeostasis during DNA replication 43Naama Barkai Weizmann Institute of Science, Israel

09:25 - 09:50 Chromatin status and stochasticity in gene expression 44Sarah Teichmann EMBL-EBI and Wellcome Trust Sanger Institute, United Kingdom

09:50 - 10:05 Structure and Dynamics of Replication Domains in Single Chromosome Territories of Interphase Nuclei

45

Wanqing XiangEMBL Heidelberg, Germany

10:05 - 10:20 Poster prize talk 1ATC Auditorium


10:50 - 11:05 Poster prize talk 2 ATC Auditorium

11:05 - 11:20 Poster prize talk 3 ATC Auditorium

11:20 - 11:45 Mapping of genome – nuclear lamina interactions in single cells

46

Bas van Steensel Netherlands Cancer Institute, The Netherlands

11:45 - 12:00 Closing remarks ATC Auditorium

12:00 - 12:30 Packed lunch and departureATC Foyer

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Poster removal (Please remember to collect your poster. Posters which have not been collected will be disposed of after the meeting.)

Feedback Questionnaire - Check your inbox when the meeting ends! You will find an email with the link to the online feedback questionnaire. Please take time to complete it!

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Posters A-Z

Agresti, Alessandra Nucleosomal landscapes in nucleosome-rich and nucleosome-poor cells

47

Ahmad Zabidi, Muhammad Mamduh binEnhancer–core-promoter specificity in housekeeping and developmental transcriptional regulation

48

Alabert, ConstanceTwo distinct modes for propagation of histone PTMs across the cell cycle

49

Alex, Tina Poly ADP-ribose polymerase1 ortholog in Dictyostelium discoideum regulates its growth and development

50

Amort, Thomas Identification and characterization of cytosine methylation in mammalian lncRNAs

51

Andersson, AnneliH2O2-induced chromatin-associated poly-ADP-ribosylation is dependent on PKCa mediated phosphorylation of HMGB1

52

Araújo, Érica Sara Souza de DNA methylation profile of sporadic and melanoma-prone patients 53

Arner, Erik Enhancers lead waves of coordinated transcription in transitioning mammalian cells

54

Artemov, Artem Single-cell gene expression pattern might reflect topological organization of the genome

55

Attig, Jan The splicing regulator Matr3 suppresses alternative exons in long introns marked by H3K36 tri-methylation

56

Auclair, Ghislain Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse

57

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Azami, Sina Study of expression and methylation of SFRP4 gene in 30 colorectal cancer patients

58

Babl, Virginia Chromatin dynamics at the yeast rDNA locus upon transition to and exit from stationary phase

59

Ballarino, Monica Presenter: Cipriano, Andrea The long non-coding RNA lnc-405 is a nuclear transcript which promotes myoblasts differentiation

60

Bardet, Anaïs F. Transcription factor sensitivity to DNA methylation 61

Basson, Albert The chromatin remodeller CHD7 controls cerebellar growth via Reelin 62

Bauer, Fanelie Functional analysis of H3K79 methylation 63

Begni, Veronica Telomere length: Role of the effect of stress on psychiatric disorders vulnerability and on its transgenerational transmission

64

Beira, Jorge V. Interplay between signaling and chromatin during regeneration and tumourigenesis

65

Belikov, Sergey Quantitative analysis of transcription factor-DNA interactions in vivo 66

Bellvis, Pablo Role of histone mutations in brain tumors 67

Bender, Ambre Deciphering the role of DNA methylation in the ontogeny of hematopoietic stem cells in the mouse embryo

68

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Posters A-Z

Bengtsen, Mads Identification of c-Myb binding sites by DNase I footprinting in six hematopoietic cell types

69

Bernhart, Stephan H. Does disturbance of poised chromatin cause cancer? 70

Bhattacharya, Saikat A structural and functional study of the role of H2A isoforms H2A.1 and H2A.2 in cancer

71

Bodega, Beatrice Epigenetic control of L1 retrotransposition in skeletal muscle differentiation

72

Boeckmann, Lars Novel role of Dbf4-Dependent Kinase in ubiquitin-dependent proteolysis of Cse4/CENPA in S. cerevisiae

73

Borgel, Julie Presenter: Bartke, Till A function for the lysine demethylase KDM2A in histone modification-independent HP1 recruitment and cell proliferation

74

Borggrefe, Tilman Presenter: Giaimo, Benedetto DanieleA phospho-dependent mechanism controls a committed chromatin state at Notch target genes

75

Bou Dargham, Daria Genome-wide analysis of ATP-dependent chromatin remodeling factors functions in embryonic stem cells and during differentiation

76

Bracken, Adrian Identification of a novel protein, ‘BIG’, which links Polycomb gene repression and nuclear receptor signalling

77

Brauchle, Eva Molecular epigenetic signature of pluripotent embryonic stem cells 78

Brauns-Schubert, Prisca The histone acetyl transferase Tip60 is regulated by phosphorylation 79

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Breiling, Achim Tet1 and Tet2 protect DNA methylation canyons against hypermethylation

80

Bright David, Starling Emerald Early indicators of altered metabolic function 81

Bystricky, Kerstin macroH2A1.1, an actor in the maintenance of a transient cellular state in EMT progress towards metastatic development of breast tumors

82

Bystricky, Kerstin Chromatin folding in estrogen regulated transcription 83

Cardoso-Júnior, Carlos Evidence of epigenetic modifications in DNA and histones of the stingless bee Melipona scutellaris and implications in caste differentiation

84

Cebrià Costa, Joan Pau Characterization of oxidized H3 as a new histone modification 85

Chabbert, Christophe Presenter: Pelechano, Vicent; Chabbert, Christophe; Adjalley, Sophie H.

A high-throughput ChIP-Seq for large-scale chromatin studies 86

Chao, Yu-Chan Baculovirus IE2, a master viral factor to locate the invading viral genome, manage gene activation, and result viral genome replication

87

Chatterjee, Anamika Does cryopreservation alter the epigenetic properties of stem cells? 88

Chen, Chun-ChangDNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases

89

Chen, Shuting The functional role of RAI1 in retinoic acid signaling 90

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Posters A-Z

Chen, Xi Enhancer commissioning by the transcription factor complex IRF-BATF during CD4+ T cell differentiation

91

Chung, Ho-Ryun The tale of two tails 92

Coda, Davide Martino Signalling to the epigenome: how TGF-ß superfamily ligands regulate gene expression via chromatin

93

Cortesi, Alice D4Z4 repeat regulates transcriptional units in trans via chromosome looping

94

Dalcher, Damian The role of the epigenetic factor TIP5 in embryonic stem cells 95

Darr, Jonatan A novel mechanism for Swi/Snf mediated transformation in Ewing's Sarcoma

96

Declerck, Ken Epigenetic control of cardiovascular health by diet or cocoa flavanol metabolites involves multiple chromatin writer-eraser enzymes

97

Defossez, Pierre-Antoine A histone mimic within DNA Ligase 1 recruits UHRF1 to sites of DNA replication: implications for DNA remethylation

98

Denizot, Jeremy Presenter: Petrini, Edoardo Chromatin-remodeling factor SMARCAD1 regulates tissue-specific and innate-immunity linked gene expression by organizing chromatin over CpG islands in intestinal cells

99

Dillinger, Stefan Molecular mapping of nucleolus-associated chromosomal domain dynamics during cellular senescence

100

Dimond, Andrew Developmental gene promoters establish poised enhancer loops in embryonic stem cells

101

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Ding, Pingtao Transcriptional regulation in effector-triggered immunity via NB-LRR resistance genes RPS4 and RRS1

102

Domke, Tanja O-GlcNAc: an evolving role in transcriptional regulation in mouse embryonic stem cells

103

Droog, Marjolein Comparative genomics identifies a distinct DNA-binding signature of ERa in tamoxifen-associated endometrial cancers

104

Du, Chunguang Integrated network analysis of maize endosperm epigenomics 105

Duffy, Michael F. A novel Plasmodium Falciparum bromodomain protein regulates invasion gene expression

106

Elizar'ev, Pavel Studying PREs/TREs activity switch in Drosophila 107

El-Osta, Assam Presenter: Khurana, Ishant Methylome sequencing identifies CTCF regulated genes implicated in diabetic complications

108

Eom, Gwang Hyeon Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy

109

Eom, Gwang Hyeon PP2A/HSP70 dynamically regulates HDAC2 phosphorylation and its activity in cardiac hypertrophy

110

Falcao, Ana Peptidylarginine deiminases as regulators of the epigenetic state of oligodendrocyte precursor cells

111

Feng, Weijun The chromatin remodeller CHD7 is essential for neurogenesis and tumorigenesis

112

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Posters A-Z

Fennessy, Ross T. Genome-wide mapping of nascent chromatin provides evidence for distinct replication and transcription coupled pathways for nucleosome organisation

113

Festenstein, Richard Presenter: Law, Pui-Pik Interplay between histone variant H3.3 and Heterochromatin protein 1 gamma (HP1?) in gene regulation genome wide in mice

114

Festenstein, Richard Position Effect Variegation as a model for DNA-repeat diseases and epigenetic memory: a novel therapy for an incurable disease?

115

Fischer, Johanna Investigating the role of conserved non-coding elements in determining DNA toplogy

116

Förderer, Alexander The functional divergence of plant SET domain histone methyltransferases

117

Frommel, Sandra C. BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence

118

Gaarenstroom, Tessa Gene expression dynamics in response to TGF-ß signalling through Smad2-mediated transcription

119

Gagliardi, Miriam ICF-specific DNMT3B mutations affect the intragenic epigenetic signature interfering with the control of splicing events

120

Gaillard, Marie-Cécile 3D nuclear topology dynamics of the 4q35 subtelomeric region linked to Facio-Scapulo-Humeral Dystrophy in skeletal muscle cells and hIPSC

121

Gainetdinov, Ildar Epigenetic regulation of PIWIL2 in testicular germ cell tumors and its diagnostic implications

122

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Galle, Joerg Presenter: Rother, Karen Hypomethylating agent-based therapy: Insights from in silico simulations

123

Garding, Angela Identifying Novel Transcription Factors Underlying Neurogenesis 124

Georgieva, Angelina Linking high order chromatin reorganization to stem cell homeostasis by H3K56ac and Sirt6

125

Ghosh, Shrestha Regulation of SIRT6 activities by the Lamins 126

Giorgetti, Luca Polymer modeling of Hi-C data reveals genome-wide correlations between chromosome structure and local chromatin state

127

Givaty Rapp, Yemima Open chromatin conformation in dedifferentiating cells is associated with activation of S1 type endonucleases

128

Gnani, Daniela Possible functional cross-talk between FAK and EZH2 in intra-hepatic lipid accumulation

129

Gómez Velázquez, Melisa Regulation of genome architecture during heart development 130

Grimaldi, Alexis Chromatin type comparison at differential TADs 131

Grimm, Christina Epigenetic alterations in intestinal tumor formation in men and the Apc(Min/+) mouse model

132

Griñán-Ferré, Christian Time course screening of miRNAs in female SAMP8: Implications in senescence process

133

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Posters A-Z

Groth, Martin Synergistic roles of SU(VAR)3-9-RELATED2 and SNF2 family proteins FRG1 and 2 in RNA-directed DNA methylation in Arabidopsis

134

Groves-Kirkby, Nick Parent of origin effects on gene expression in human twins 135

Grundström, Thomas Signal regulated localisation of a mutagenic protein complex at the Igh locus

136

Gu, Namjin Analysis of transcriptome and epi-genomic data for endothelial progenitor cell differentiation

137

Halsall, John Histone deacetylase inhibitors initiate a transcriptional and Polycomb-mediated, chromatin-based response that promotes cell survival

138

Hansel-Hertsch, Robert G-quadruplex structure formation is prevalent in chromatin regulatory elements and is elevated during oncogenesis

139

Hayano, Motoshi Evidence for an epigenetic cause of aging in mice 140

Heery, David M. A twist in the tail for chromatin modification: Molecular basis of MOZ/KAT6A function as a histone PTM reader/writer

141

Heinz, Helena Presenter: Horsthemke, Bernhard Development of an inducible cell culture model for transcriptional interference at the Angelman syndrome gene UBE3A

142

Hennion, Magali Decoding the engram: A deep look into the epigenetics of learning and memory

143

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Hernando Herraez, Irene A genome-wide comparative study of DNA methylation in Great Apes 144

Hoeijmakers, Wieteke Dissecting the Plasmodium falciparum epigenome by Mass-Spectrometry-based Proteomics

145

Hoelper, Dominik Role of the histone chaperone Daxx in proviral silencing via interaction with SETDB1

146

Hoffman, Michael M. Transcription factor motif discovery and prediction in an expanded epigenetic alphabet

147

Hoffmann, Christian Presenter: Neumann, Heinz In vivo mapping of FACT-histone interactions identifies a role of Pob3 C-terminal domain in DNA replication

148

Hore, Tim Presenter: Iurlaro, Mario Epiblast stem cells as a system for the study of DNA demethylation function in reprogramming

149

Hottiger, Michael O. ADP-ribosylation of histones: A reversible modification of specific amino acid residues

150

Hur, Man-Wook ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65

151

Hussong, MichelleThe bromodomain protein BRD4 regulates splicing during the heat shock response

152

Ievolella, Monica Investigating KRAB/KAP1-mediated epigenetic control of differentiation and function of the adaptive immune system

153

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Posters A-Z

Imbeault, Michael Systematic characterization of the KRAB zinc finger proteins family using high-resolution ChIP-Seq

154

Iturbide Martínez de Albéniz, Ane LOXL2 oxidizes methylated TAF10 and controls neural progenitor differentiation

155

Jägle, Sabine Silencing of the EPHB3 tumor suppressor involves multimodal decommissioning of a transcriptional enhancer by defective Notch signaling and the EMT inducer SNAIL1

156

Jang, Suk Min Role of KAP1 during DNA replication 157

Javierre, Biola M. High-resolution analysis of genomic regulatory architecture in multiple human cell types with Promoter-Capture HiC

158

Jeon, Bu-Nam KR-POK has tumor progressive activity and regulates cancer cell proliferation through glutamine metabolism

159

Jha, Sudhakar Investigating TIP60’s role in regulating cancer metastasis 160

Jost, Daniel Modeling epigenetic regulation: implications to development, proliferation and diseases

161

Jost, Daniel Interactions between chromatin states shape the epigenome nuclear organization

162

Kalasova, Ilona Nuclear phosphatidylinositol 4-phosphate affects the activity of lysine-specific histone demethylase 1

163

Kamminga, Leonie M. Normal formation of the vertebrate body plan and loss of cardiac integrity in the absence of ezh2

164

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Kanki, Yasuharu Angiogenesis is regulated by trithorax complex in solid tumor 165

Kar, Gozde Deciphering the relationship between chromatin status and stochasticity in gene expression from single-cell RNA-seq data

166

Katou, Yuki RNA dependent protein binding revealed by ChIP-seq 167

Khurana, Ishant Methylome sequencing identifies CTCF regulated genes implicated in diabetic complications

168

Kleinmanns, Julia Anna Functional characterization of BLISTER - A Polycomb group associated protein in Arabidopsis

169

Koh, Dong-In c-Myc decides cell fate through ZBTB5 170

Kokkalis, Antonis Genome-wide characterization of the role of macroH2A histone variants in cellular differentiation and reprogramming

171

Kook, Hyun Presenter: Joung, Hosouk Ret finger protein mediates Pax7-induced ubiquitination of MyoD in skeletal muscle atrophy

172

Krasikova, Alla Endoreplication and selective elimination of parental genomes during oogenesis in hybrid European water frogs

173

Kretzmer, Helene Fast and memory efficient DMR calling 174

Kriukiene, Edita Methyltransferase-directed enzymatic exchange and genomic mapping of cytosine-5 modification at single base resolution

175

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Posters A-Z

Kruse, Kai Changes in the network of chromatin contacts during the P. falciparum infection cycle

176

Kumar, Mukesh Presenter: Vastenhouw, Nadine L. Histone level determines the timing of zygotic genome activation in zebrafish

177

Kungulovski, Goran Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained

178

Laktionov, Petr Hierarchic model for selective activation of testis-specific genes in D. melanogaster

179

Lan, Wanwen Involvement of novel non-coding RNA in pterygium cell proliferation 180

Lanzuolo, Chiara The epigenetic role of Lamin A in muscle differentiation 181

Lee, Jong-Soo A novel mitotic role of HP1 182

Leone, Sergio RNA helicases are implicated in lncRNA-mediated epigenetic silencing 183

Lerdrup, Mads An interactive environment for agile mining and visualization of ChIP-sequencing data

184

Lesniak, Wieslawa Analysis of cytosine methylation within selected regions of the Epidermal Differentiation Complex (EDC) during keratinocyte differentiation

185

Li, Jinghua Analysis of chromatin states at Notch regulated genes reveals large scale changes in H3K56 acetylation accompany enhancer activation

186

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Lim, Ji Hyae Identification of Fetal-Specific Epigenetic Markers on Chromosome 21 for non-invasive prenatal testing of fetal trisomy 21

187

Liokatis, Stamatios Independent observation of sister histones and readout of asymmetric post-translational modification (PTM) patterns in nucleosomes by high-resolution Nuclear Magnetic Resonance (NMR) spectroscopy

188

Lopizzo, Nicola GR and GR-target genes: epigenetic modulation in response to gene-environment interaction in psychiatric disorders

189

Lüscher, Bernhard Ash2l, a core component of MLL histone methyltransferase complexes, is essential for histone H3 lysine 4 methylation and cell proliferation

190

MacCarthy, CaitlinDissecting Oct4's DNA contacts in establishing and maintenance of pluripotency

191

Mahé, Elise Understanding the role of 5-hydroxymethylcytosine at active enhancers during cell differentiation

192

Maksimenko, Oksana Domain organization of CTCF protein in Drosophila melanogaster 193

Maqbool, Muhammad Ahmad Combinatorial Enhancer usage influences tuning of gene expression and isoform selection during T-cell differentiation

194

Marasca, Federica A dynamic switch of Ezh1 isoforms controls PRC2 mediated adaptive epigenetic response in post-mitotic cells

195

Marasek, Pavel Paxillin interacts with cohesin and regulates the expression of IGF2/H19 gene cluster

196

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Posters A-Z

Markozashvili, Diana Study of HDAC Inhibitor Abexinostat in Mantle Cell Lymphoma 197

Marsman, Judith Cohesin and CTCF contact regulatory elements to control runx1 expression

198

Marullo, Fabrizia Role of LaminA/C-PcG proteins crosstalk in Hutchinson-Gilford Progeria syndrome

199

Mayer, Andreas Visualizing human transcription with nucleotide resolution by native elongating transcript sequencing

200

McMurchy, Alicia N. The role of nucleosome remodeler MI-2/LET-418 in the germline-soma distinction in C. elegans

201

Meister, Peter Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans

202

Miklik, Dalibor Epigenetic environment in the integration site-specific regulation of retroviral transcription

203

Miron Sardiello, Ezequiel J. Novel CRISPR modality for versatile super-resolution chromatin imaging 204

Moissiard, Guillaume Presenter: Yen, Linda Arabidopsis thaliana microrchidia homologues regulate gene silencing 205

Mokhtari, Zakia Internal dynamics of a living cell nucleus: Study by Dynamic light scattering

206

Möller, Mareike The impact of histone methylation on genome stability in experimental evolution in Zymoseptoria tritici

207

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Mondin, Mateus Chromatin dynamics of the 45S rDNA arrays and their relationship to epigenetic indexing

208

Montes, Matias In vivo and in vitro complex formation analysis on Schizosaccharomyces pombe HomolD box-containing promoters

209

Montibus, Bertille Bivalent chromatin signature is the default state of imprinting control regions (ICRs)

210

Muchardt, Christian A role for HP1 proteins in normal and pathological control of inflammation

211

Mueller, Britta MNase titration reveals changes in chromatin accessibility during the unfolded protein response

212

Müller, Sebastian HJURP, a histone chaperone bridging the nucleosomal scale to a chromosome landmark

213

Mushunje, Annals T. Epigenetic regulation of transcription of the stevor multigene family of Plasmodium falciparum

214

Mutazono, Masatoshi Regulation of RNAi-mediated formation of centromeric heterochromatin through ncRNA and the splicing machinery in fission yeast

215

Namdeo, Suryesh K. A long non coding RNA acts as a potential regulator of mouth form developmental plasticity of Pristionchus pacificus.

216

Nardocci, Gino Epigenetic control of osteoblast lineage commitment through regulating Runx2/p57 gene transcription

217

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Posters A-Z

Nashun, Buhe Continuous histone H3.3/H4 replacement by Hira is essential for normal transcriptional regulation and efficient de novo DNA methylation during mouse oogenesis

218

Navratilova, Pavla Complex epigenomes of endocycling ovaries vs. mitotic testis in the closest living relative of vertebrates

219

Neri, Francesco Single-base resolution analysis of 5-formyl and 5-carboxyl cytosine reveals DNA methylation/demethylation dynamics in the mammalian genome

220

Nicodemi, Mario Presenter: Fraser, James Hierarchical organization of chromosome folding during mammalian cell differentiation

221

Nishibuchi, Gohei Phosphorylation of HP1alpha regulates its function in chromatin organization

222

Nowak, Theresa Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors

223

Ori, Alessandro Histone deacetylase inhibitors cause the selective depletion of bromodomain containing proteins

224

Ozturk, Nail Can Early Cranial Irradiation Alters Epigenetic Profile of Hippocampal Neurogenesis

225

Palacios, Daniela Presenter: Brancaccio, Arianna Post-translational control of EZH2 stability via phospho-ubiquitination regulates skeletal myogenesis

226

Pan, Leslie Role of topological domains in organizing remote regulatory interactions 227

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Papamichos-Chronakis, Manolis INO80 remodeler facilitates release of RNA Polymerase II from chromatin for ubiquitin-proteasomal degradation

228

Park, Seongjin Prometheus: Omics portal for comparative genomics 229

Pasumarthy, Kalyan Kumar Methylation dynamics at genic and non-genic functional elements across the genome in Mesenchymal stem cells

230

Petrini, Edoardo Transcriptional regulation during phosphate starvation requires Myosin I in fission yeast

231

Picchi, Gisele Chromatin-modifying enzymes in T. cruzi 232

Pieters, Bas Exploration of the chemical basis behind the recognition of the epigenetic H3K4me3 mark

233

Piwko, Pawel Gypsy insulator containing transgenes display transvection 234

Popov, Sergej The Epstein-Barr virus nuclear antigen 1 – a link between chromatin organization and genomic instability in viral oncogenesis

235

Popp, Christian Role of histone variants H3.3 and H2A.Z in epigenetic memory in induced pluripotent stem cells

236

Porter, Keith The role of chromatin remodeling factor SMARCAD1 in intestinal intraepithelial lymphocyte homeostasis

237

Postepska-Igielska, Anna Functional interplay between sense and antisense RNA: lncRNA Khps1 mediates changes of the chromatin structure and regulates expression of the proto-oncogene SPHK1

238

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Posters A-Z

Prasad, Punit CAGE deep-sequencing identifies epigenetic regulators in human blood cell types

239

Qi, Hui Epigenetic control of cardiopulmonary development and congenital heart disease

240

Radman-Livaja, Marta Nucleosome repositioning during DNA replication 241

Ramírez, Fidel Topologically associating domain boundaries serve as recruitment platforms for the Drosophila dosage compensation complex

242

Rezsohazy, Rene Ogt and Prdm14 are direct interactors of the Hoxa1 homeoprotein 243

Ricci, Barbara A novel Polycomb feed forward loop in glioblastoma multiforme 244

Roche, Stephane DNA Methylation-based diagnosis of Facio Scapulo Humeral Dystrophy 245

Rokach, Ori Epigenetic changes as a common trigger of muscle weakness in congenital myopathies

246

Sadeghi, Laia Paf1 complex factor Leo1 promotes local nucleosome turnover to alter chromatin state in fission yeast

247

Sahlen, Pelin Akan Genome-wide mapping of promoter-anchored interactions at a single enhancer resolution

248

Schumacher, Eva Epigenetic changes during in vitro activation of hepatic stellate cells 249

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Schunter, Sarah The impact of MOF ubiquitylation on Drosophila Dosage Compensation 250

Schutkowski, Mike Presenter: Eckey, Maren Advanced characterization of histone-code directed antibodies 251

Schutkowski, Mike A direct and continuous Sirtuin activity assay 252

Seiser, Christian H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress

253

SeongHui, Eo De-methylation Inducer, 5’-azacytidine Regulates Dedifferentiation and Inflammation via p38 kinase in Rabbit Articular Chondrocytes

254

Serobyan, Vahan Epigenetic regulation of a developmental switch gene 255

Shaik, Tajith Baba Study of Schistosoma mansoni HDAC8, a key epigenetic player in the treatment of Schistosomiasis

256

Shekariesfahlan, Azam S-nitrosylation of arabidopsis nuclear proteins, specially its plant specific histone deacetylases (HD2 like proteins)

257

Shliaha, Pavel Towards top-down proteomics: Sequencing intact histones by mass spectrometry for precision mapping of co-occurring post-translational modifications

258

Shlyueva, Daria Genome-wide maps of enhancers downstream of WNT and hormone signaling

259

Shumskaya, Valeria Influence of osmotic stress on the epigenetic changes during the induction of pluripotent stem cells from somatic cells

260

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Posters A-Z

Sigurdsson, Stefan Promoter methylation of DNA repair genes in cancer 261

Singh, Vijender The encounter of RNA polymerase with stable nucleosomes facilitates transitions in elongation coupled processes

262

Smigova, Jana Structural basis of the Polycomb body 263

Sobol, Margarita A.PIP2 islets – a novel compartment of the cell nucleus 264

Sokolov, Alexey SVMOneClAS: pipeline for efficient splicing events calling 265

Soldi, Monica Dynamic profiling of chromatome at enhancers of inflammatory genes 266

Soupsana, Aikaterini Chromatin remodelling during stem cell differentiation proceeds through a process resembling a "shifting mosaic steady-state"

267

Stanley, Alice The dynamics of cohesin-mediated cis-regulatory modules reveal interplay with transcription factors

268

Stelloo, Suzan Androgen Receptor profiling in tumor specimens yields hallmarks of prostate cancer outcome

269

Stempor, Przemyslaw SeqPlots - a fast interactive web tool for visualizing next generation sequencing signals along genomic features

270

Stewart, KathleenDNA Methylation-Histone Modification Crosstalk During de novo DNA Methylation

271

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Stratigi, Kalliopi Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression

272

Strømme, Caroline B. Structure-function insights into MCM2 chaperoning of H3/H4 tetramers and, with ASF1, H3/H4 dimers

273

Taddei, Angela Presenter: Tadeo, Xavier Replicative stress links to heterochromatic silencing 274

Tercan Avci, Sanem A novel mechanism for the regulation of H3K27me3 modification in hepatocellular carcinoma cell line Huh7

275

Thomas, Tim Moz (Kat6a) haploinsufficiency dramatically retards MYC-induced lymphoma development

276

Timmermans, Steven Finding new miR-target relationships using the SPRET/Ei mouse strain 277

Tolic, Anja Regulation of Cxcl12 gene transcription by DNA methylation 278

Tu, WenJuan Characterizing epigenetic signatures that mark transcriptional memory responsive genes in human T lymphocytes

279

Tzerpos, Petros Convergent roles of transcription factors BACH1 and SATB1 in murine Tcells

280

Ugarte, Fernando Presenter: Krietsch, Jana Progressive chromatin condensation and H3K9 methylation regulate the differentiation of hematopoietic stem cells

281

Ulicna, Livia PHF8 histone demethylase interacts directly with nuclear phosphatidylinositol-4,5-bisphosphate

282

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Posters A-Z

Vaillant, Isabelle Bivalency is a key component of the regulation of imprinted genes expression during neural differentiation

283

van den Berg, Debbie LC A novel Ascl1-interacting factor regulates cortical neurogenesis 284

van Zundert, Brigitte AJ Bi-directional transcriptional and epigenetic modulation of endogenous PSD95 gene expression to regulate neuronal refinement

285

Villa, Raffaella Targeting of the Drosophila dosage compensation complex relies on specific DNA recognition by MSL2

286

Vollenweider, Eva PARP1-mediated parylation orchestrates the dynamics of heterochromatin assembly during replication

287

Wang, Sai Dependence of chromatin structure on histone modification, linker histone, and nucleosome repeat length

288

Ward, Aoife Global identification of genomic loci bound by epigenetic protein complexes

289

Westermark, Pål Characterization of the circadian core promoter 290

Whongsiri, Patcharawalai Oxidative stress and RUNX3 hypermethylation in chronic hepatitis B-associated hepatocellular carcinoma in Thailand

291

Wiechens, Nicola The chromatin remodelling ATPase SNF2H positions nucleosomes adjacent to a subset of transcription factors including CTCF

292

Wille, Alexandra Chromatin remodeling factor expression during extinction of fear 293

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Wu, Liling Novel substrates for protein arginine methyltransferase PRMT5 294

Xu, Guoliang Tet-catalyzed DNA Oxidation in Mouse Zygotes 295

Yang, Xi Novel Post Translational Modification of UHRF1 and Its Biological Relevance

296

Yu, Seon-Mi Azacytidine (AzaC) regulates migration by inducing matrix metalloproteinase (MMP)-9 expression and COX-2 expression via PI3-kinase and ERK-1/2 pathways in HT1080 human fibrosarcoma cell line

297

Zhang, Jingchao Interactions between Otx2 and Nanog Regulate the ES Cell Self-Renewal Network

298

Zhang, Tianyi Interplay between Polycomb and Trithorax proteins 299

Zhao, Xinghui Anthrax edema toxin down regulates MIP-1a expression in macrophages by decreasing histone H3K4 trimethylation

300

Ziadlou, Reihane Epigenetic Comparison of Mesenchymal Stem Cells derived from Human Bone Marrow and Chorion

301

Ziane, Rahima Presenter: Ziane, Rahima; Radman-Livaja, Marta

Tracking maternal nucleosomes at targeted genomic loci during replication 302

Zippo, Alessio Myc-driven self-reinforcing regulatory network maintains Embryonic Stem cell identity

303

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