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Educational Resources

Center for Clinical and Translational Science

WelcomeMaster’s Program Orientation

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Agenda• Introductions• CCaTS Program Overview• Master’s Requirements• Research Proposal• Scholar/Mentor Relationships• Competencies• Program Evaluations & Outcomes• Questions

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Communications

ResearchResources

Sundeep Khosla, MDPI and Director

CommunityEngagement

Victor Montori, MDCo-PI and Director

EducationResources

David Warner, MDCo-PI and Director

Consultative, Regulatory and

Informatics ServicesRickey Carter, PhD

Christopher Chute, MDRichard Sharp, PhD

Internal Advisory Committee External Advisory Committee

Mayo Clinic Center for Clinical and Translational Science (CCaTS)

Intramural Awards Program

Translational Technology

Cores

Pre-doctoral Programs

Post-doctoral Programs

Research Team Education

Practice-Based

Research Networks

TranslatingComparative Effectiveness Research into

Practice

Office for Community

Engaged Research

Study Design and Biostatistics

Research Subject Advocacy Services

Clinical Research

Units

Biomedical Informatics

Research Ethics Program

Research Information

Center

Regulatory Support

Consortia DevelopmentRobert Rizza, MD

Co-PI and Director

Sundeep Khosla, MDCCaTS Director and Principal Investigator

Scott Kaese, MBACCaTS Director of Administration

Laura Meiners, MBACCaTS Operations Manager

Drug Discovery and Development

Andrew Badley, MDCo-PI and Director

SpecializedPhenotyping

Facilities

Midwest Area Research

Consortium for Health (MARCH)

University of Minnesota CTSI

Sanford Burnham Medical Research

Institute

Jane Welter, MBACCaTS Associate Director of Administration

Late Stage Translational

ResearchVictor Montori, MDCo-PI and Director

University of Mississippi

Medical Center

Dartmouth-Synergy CCTS

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Mayo ClinicCenter for Clinical and Translational

Science (CCaTS)

• CCaTS Research Resources (CRU)

• CCaTS Community Engagement

• CCaTS Consultative, Regulatory and Informatics Services

• CCaTS Education Resources – David O. Warner, MD, DirectorGlenn E. Smith, PhD, LP, Associate Director

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• Prasad Iyer, M.D.• Director, Postdoctoral Programs

• Shawna L. Ehlers, Ph.D., L.P.• Associate Director, Postdoctoral Programs

• Katrin Frimannsdottir, Ph.D.• Director of Program Evaluation

• Karen Weavers – Operations Manager• Tauna Juenger – Operations Coordinator• Jesse Welch– Education Specialist Curriculum• Linda Wenner –Education Specialist Master’s• Ashley Noelke– Administrative Assistant

Postdoctoral Administrative Staff

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CCaTS Postdoctoral Program

Goal:To train clinicians to participate in intramurally- and extramurally-funded patient-based research.

The Social Contract of Medical Research (discovering and applying knowledge to improve health) is a privilege.

AAMC-GREAT Group

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CCaTS Master’s Degree Program

Goal:To train independent investigators to perform outstanding extramurally-funded patient-based research.

The Social Contract of Medical Research (discovering and applying knowledge to improve health) is a privilege.

AAMC-GREAT Group

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Master’s Program Expectations• Find time for coursework:

• 1 hour lecture = 2-4 hours outside work• 1 credit = 48 hours/qtr or 4 hours/week• 3 credit/quarter ~ 12 hours/week• Aligned with research goals

• Accept feedback from mentors/tutors/peers• Learn to identify the important questions• Take charge of your destiny• Submit by deadlines indicated

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Master’s Program Requirements• 24 didactic credits – GPA 3.0

• 16 required, 8 electives• “Writing for Biomedical Publications” workshop• “Writing Winning Grants” workshop• Written Comprehensive Examination• Research resulting in thesis with 2-3 possible

publications• Final Oral Examination

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Required Coursework• CTSC 5300, 5310 and

5390 Clinical Epidemiology (4 cr total)

• CTSC 5600, 5601 and 5610 Statistics in Clinical Research (6 cr total)

• CTSC 5010 Clinical Research Protocol Development (2 cr)

• CORE 6000 Responsible Conduct of Research (1 cr)

• CTSC 5020 Regulatory Issues (1 cr)

• CTSC 5690 Critical Appraisal (1 cr)

• CTSC 5720 Clinical Trials (1 cr)

• Mayo Graduate School Course Information

• CCaTS Annual Course Schedule

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Potential Elective Courses• CTSC 5640 Logistic Regression• CTSC 5650 Survival Analysis• CTSC 5720 Clinical Trials: Design & Conduct• MPET 6820 Regenerative Medicine

• CTSC 5080 Eliminating Health Disparities• CTSC 5810 Qualitative Research Design• CTSC 5860 Behavioral Interventions in Clinic Research• CTSC 5870 Social & Behavioral Foundations of Health in HSR

• BMB 8350 Intro to Bioinformatics• CTSC 5140 Epigenetics and Epigenomics• CTSC 5660 Design analysis & App of Bioinformatics

• CTSC 5960 Medical Informatics• CTSC 5760 Medical Decision Making• CTSC 5761 Evidence Based Medicine for Clinical Researchers• CTSC 5910 Economic Evaluation in Health Care• CTSC 5940 Secondary Data Analysis

Clinical Trials

Behavioral

Individualized Medicine

Healthcare Delivery

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Workshops Required Workshop:

• Writing for Biomedical Publications• March ~ offered once per year only• Available at all three sites (MCR, MCA, MCF)• Registration Fee - $275 (fee waived)

Optional Workshop:• Write Winning Grants

• November ~ offered once per year only• Available at all three sites (MCR, MCA, MCF)• Registration Fee - $275 (fee waived)

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Research Proposal• Utilize CTSC 5010 Clinical Research Protocol Development

• If you take course in the fall, submit proposal in January• If you take course in the spring, submit proposal in July

• Research Proposal Format• Reviewed using the Research Proposal Review Criteria• Research Proposal Packet Includes:

• Cover page• Cover letter signed by your mentor• Research proposal• Division research committee approval• IRB approval

• Submission cycle to CCaTS review is twice each year• January or July only• Early submissions are accepted

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Thesis Advisory Committee (TAC)(due with proposal, January or July 1)

• Minimum of 4 members – 1) Thesis Advisory Committee (TAC) Form

2) Recommended Action on Thesis Protocol Form • TAC and scholar have defined roles and expectations

• Chair - usually primary mentor – only member who can also be co-investigator (exception for statistician)

• Members - need MGS Faculty Privileges (check Catalog)• Oversees progress and quality of research project• Meet every 6 months to review progress of scholar

• Submit summary of Progress Report Meetings to CCaTS• Becomes Examining Committee at Thesis Defense

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Master’s Degree Program Form (DPF)(due with proposal, January or July 1)

• Include courses you propose to take to fulfill degree requirements (24 credits total; 17 required)

• Can transfer in up to 6 credits (25%) and may require taking a test

• Master’s Degree Program Form on Mayo Graduate School Web site

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Comprehensive Written Exam

• Taken after completion of (14 cr):• Protocol Development• Epi I & II• Advanced Applied Epi (III)• Stats I & II• Critical App of Stat Methods (III)• Clinical Trials Design

• Full day exam• 3rd Thursday of January, April or August

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Final Oral Examination –Thesis Defense

• After completion of all course work, approval of DPF, research proposal and TAC and Comprehensive Written Exam

• Follow CCaTS and MGS Thesis Guidelines

• Six weeks prior to your anticipated defense date – • Submit thesis draft for CCaTS review (allow 1 week)• Find a date/time all TAC members will be present• Allow 3 weeks for TAC to review final draft and prepare

examination questions

• After successful defense, submit Verification of Thesis Corrections and Final thesis to Mayo Graduate School

• Complete Evaluations

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Program Timeline

• Research Proposal Packet – July or January 1• Writing Workshop – March 2015• Publishing Workshop – November 2014• Progress Report – 6 months after research proposal

approval and every 6 months thereafter• Coursework complete (3.0 GPA) • Written Comprehensive Exam – 3rd Thursday of January,

April and August only• Thesis submission to CCaTS• Final Oral Examination

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Scholar and Mentor RelationshipsExpectationsThese are meant as a guide to help facilitate optimal scholar/mentor relationships. Contact CCaTS if issues arise.

1) Initial Agreement – at time of application2) Progress Report – submit 6 months after research

proposal is approved and every 6 months thereafter3) Mentoring Effectiveness Assessment (Scholar &

Mentor) – will be requested annually, spring quarter.

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Competencies• Critically evaluate clinical/translational research in the

medical literature• Articulate the ethical & legal responsibilities of an

investigator• Develop feasible and testable hypotheses• Design and conduct a clinical/translational research

project• Write competitive grant proposals• Effectively communicate research results through

publications and presentation

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Competencies (cont.)• Articulate and apply appropriate study designs

• Use appropriate bio-statistical methods

• Understand the peer-review process

• Ability to navigate the peer-review process for grants and papers

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Program Evaluations & Outcomes

Program Evaluation Activities• Clinical Translational Research Appraisal

(CTRAI) Pre/Post self-assessment – completed in CTSC 5300 Epi I and at end of program

• Mentor Assessments – annual• Course Evaluations• Graduate tracking – annual CVs

Publications, grants, promotions, awards, patents, leadership and professional activities, etc.

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Websites to knowCCaTS Education Resourceshttp://ctsa.mayo.edu/education/index.html

• Quarterly Course Schedule• Program Milestones• New course listings• This presentation

Mayo Graduate School http://mayoweb.mayo.edu/mgs/

• Quarterly course listing• Course Registration • Other required forms

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“The research we do today will determine the type of medical and surgical practice

we carry on at the Clinic tomorrow.”

-William J. Mayo, M.D.

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QUESTIONS