welcome to lewa process technologies, inc. · version sept. 2014 rev. 6 welcome to lewa process...

Version Sept. 2014 Rev. 6

Welcome toLEWA Process Technologies, Inc.

LEWA Center Of Excellence for High Purity– Devens, MA

LEWA Process Technologies; LEWA PT Business Overview. .


Agenda

– Corporate Structure – Main Groups: Nikkiso – LEWA – LEWA PT

– LEWA Group – Global Look at LEWA Products

– LEWA Process Technologies, Inc. “Clean Market”

– Example Systems Produced by LPT

– Example Systems Produced by LEWA GmbH for Clean Market

LEWA Process Technologies; Introduction to our company 2

Nikkiso Factsheet

9/17/2014© LEWA GmbH, LEWA Imagepresentation, v1.0 3

NIKKISO CO., LTD.

Executive Management

Headquarters

Date of Establishment

Registered Capital

Net Sales (cons.) March 2013

No. of employees

Stock Exchange Listing

Core business

Toshihiko Kai, President & CEO

Yebisu Garden Place Tower

Tokyo 150-6022, Japan

December 26, 1953

6,544 million yen

104,000 million yen (consolidated)

5,411 (consolidated)

First Section of Tokyo Stock

Exchange

80,286,464 issued shares

Industrial Division

Aerospace Division

Precision Equipment

Medical Division

LEWA-Nikkiso Industrial Division (pumps + systems) – Factsheet

9/17/2014© LEWA GmbH 4

LEWA-Nikkiso Industrial Division


Naota Shikano (CEO),

Dr.-Ing. Martin Fiedler (COO)

Stefan Glasmeyer (CMO)

HeadquartersLEWA GmbH,

Leonberg / Germany

Net Sales (cons.)

March/2013

Thereof LEWA USD 280 m

Add. LPT USD 10 m

No. of employees

2,088 in total

560 in Germany of LEWA

520 in Japan of NIKKISO

768 Intl. of LEWA & NIKKISO

75 LEWA Process

Technologies

Core business

Chromatography Systems

Reciprocating pumps

Canned motor pumps

Cryogenic pumps

Metering & conditioning

systems Services

Geveke

IPT >> LEWA Process Technologies affiliates Nikkiso

LEWA

affiliates

Original

Manufacturers,

system integrators,

sales / service

engineers

Places

Reciprocating

Pumps

Systems &

Packages

Canned Motor

Pumps

Cryogenic

Pumps

Partner

Products

Services &

Aftersales

LEWA-Nikkiso Business

9/17/2014© LEWA GmbH. 5

Core Business Strategic Business

Clean

MarketsOil & Gas

Upstream

Process Industry

& Downstream Utilities

Package

Diversification

LNG supply chain

markets

LEWA-Nikkiso Industrial Division – Overview

9/17/2014© LEWA GmbH, LEWA 6

Customer Solutions

Various Applications of

– Pharmaceutical

– Personal Care

– Food

– Beverages

– Oil & Gas

– Chemicals

– Petrochemicals

– Plastics

– Cleaning

– Detergents

– Energy

– Environment

– Other IndustriesWater Treatment

LEWA ecoflowNikkiso Non-

Seal Pump

LEWA diaphragm

process pump

Geveke N2 generation

Exclusive rights in

many regions for

Partner Products

Nikkiso Cryogenic

EcoPrime LPLC

affiliates

Original

Manufacturers,

system integrators,

sales / service

engineers

Products

LEWA Process Technologies – Factsheet(Former Integrated Process Technologies)

9/17/2014© LEWA Process Technologies, Inc. 7

Jim Banks (CEO)

Christopher Sandusky (CTO)

Gerard Gach (CMO)

US Devens, MA

2000

100% subsidiary of LEWA-

Nikkiso America, Inc.

EUR 7.6 m ($10.4 m)

75

Bio / pharmaceutical

Personal Care

Fine Chemical

Systems engineering and

services integrating

– Process expertise

– Fabrication

– Automation

– Installation Services

LEWA Process Technologies, Inc.


Headquarters in

Date of Establishment

Ownership

Net Sales (cons.) 2013

No. of employees

Target markets

Core business


Agenda


– LEWA Group – A Global Look at LEWA Products

– LEWA Process Technologies “Clean Market”




LEWA Group

LEWA Milestones – from Family Business to International Group


1952

First ACHEMA G4T – biggest process

diaphragm pump

Company

Foundation

Integration LEWA-

NikkisoAcquisition of

Integrated

Process

Technologies,

Inc.

First Patent LEWA ecoflow DBAG and Quadriga

Capital acuire LEWAStrategic Business

Diversification in

„Clean Markets“

New Management for

Strategy 2018+

1953 1954 1955 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013…

Record Project

USD 40 m

Integrated

Process Technologies,

Inc. Founded 2000

LEWA; System Integrator and Engineering Services

9/17/2014

© LEWA Process Technologies, Inc.

10

LEWA Systems

LEWA-Nikkiso acts as a system integrator and global packager for Industrial and Clean Markets

LEWA Process Technologies acts as a system integrator and engineering services specializing in the Life

Sciences and Regulated Industries globally leveraging LEWA- Nikkiso companies

We combine mechanical engineering, fluid dynamics, electrical control, large-scale fabrication, and project

management know-how.

LEWA Systems Capability

9/17/2014© LEWA Process Technologies, Inc.

11

LEWA ecofoam®

System for metering various blowing

agents in plastic manufacture in

combination with extruders

LEWA EcoPrime®

Chromatography system with innovative,

mechatronic drive and hygienic

diaphragm metering pumps

LEWA odorizing system

LEWA has built odorizing systems for over

40 years, e.g., for natural gas, oxygen,

nitrogen and carbon dioxide

Buffer Inline Dilution

System to mix all ingoing fluids, e.g. prior

to a chromatography system

Nitrogen Generation

Industry-scale, custom-designed

membrane-type package with very low

lifecycle costs

LEWA production unit

Customer specific batch/continuous

systems for production processes

Chemical Injection Package

Customer specific packages for

chemical injection in the oil and gas

industry

OEM Systems

Systems designed and fabricated for OEM

clients in Clean Process Industry

LEWA Process

Technologies Products

LEWA Process


LEWA Process


LEWA Group:Industrial Division – Order Bookings Split 2013 by Industry in %


Oil & Gas

39

Refinery,

Petrochemicals,

Chemicals

32

Clean

Markets*

10

Plastic,

Ceramic,

Textiles

11

Power Plants

& Nuclear

5

Others

6

* Does not reflect full Clean Market supply; OEM business not fully recognized.

„Number 1 in ‘Creating Fluid Solutions’

for all customers in our target markets.“

LEWA Group Vision: “No. 1 in Creating Fluid Solutions”


...Solutions

We understand customer’s

processes and identify their

respective “pain points”.

Therefore we offer complete

systems backed by high-

quality life-cycle services.

Creating...

“Creating” suits the brand

personality of LEWA as an

ambitious maker and

creative manufacturer, who

goes beyond (technological)

boundaries.

...Fluid...

“Fluid” designates the core

business. LEWA doses,

injects, conveys, mixes, fills,

separates and heats or

cools liquids and knows how

to handle critical fluids in all

states as well as their

interactions with materials.

LEWA: Focus on own Research & Development


Structured Innovation Management

– Internal R&D department works independently

of our daily business

– Structured process for innovation management in place

– Various patents in place

– Knowledge network with universities

– Test stand - process pumps:

max. ca. 350kW hydraulic power

– Latest software tools in use

– CAD solid edge

– Electrical design

– Finite element analysis (FEM): ANSYS

– Computational fluid dynamics (CFD): CFX

– Computer aided measurement

LEWA Group Hub Subsidiaries


LEWA Process Technologies

– Engineering

– Fabrication

LEWA-Nikkiso

America, Inc.

– Sales

– Engineering

– Fabrication

LEWA Bombas, Brazil

– Sales

– Engineering

– Fabrication

LEWA S.R.L.

– Sales

– Engineering

– Fabrication

LEWA Middle East FZE

– Sales

– Engineering

– Fabrication

Nikkiso Pumps

Korea Ltd.

– Sales

LEWA China

– Sales

– Engineering

– Pump production

– Fabrication

LEWA GmbH

Headquarters

Industrial Division

– Sales

– Engineering

– Pump production

– Fabrication

Nikkiso Co., Ltd.

Group

Headquarters

LEWA PTE LTD

– Sales

– Engineering

– Fabrication

Geveke

– Sales

– Engineering

– Fabrication

LEWA Group Service – Worldwide


Service Portfolio

– Customer service

– Repairs

– Commissioning

of equipment

– Health checks

– Spare parts

– Fast and worldwide

– Maintenance contracts

– Revamping of

entire systems

– Fluid evaluation

– Internal and external seminars

for users

Certificates, Memberships, Standards within LEWA Corporation


Member of VDMA

e.V. (Association

of German

Machine and Plant

Engineering)

Member of ISPE

International

Society for

Pharmaceutical

Engineering

Member of the

Europump

Organization

Member of the

VDMA e-market

Member of

the Hydraulic

Institute

Member of

network of

competence

process

engineering

Pro3 e.V.

Material ac-

cording to U.S.

Food and Drug

Administration

GOST-R

Export-certificate

for Russia

Pumps according

to guidelines:

API 674 and

API 675

Registered at

FPAL First Point

Assessment

Certified

according to

DIN EN ISO 9001

TÜV SÜD

Member of

DIN e.V. (German

Institute for

Standardization)

Partner of the

Engineering

Industry

Sustainability

Initiative

Member of

Cleaning

Excellence

Center

Pumps according

to guidelines of

the European

Hygienic

Engineering &

Design Group


Agenda








More information at www.lewapt.com

“LPT”

• New name,

• New brand,

• New website

www.lewapt.com

September 2014

http://www.lewapt.com/

The Product Structure of LEWA Process Technologies, Inc.


LEWA Process Technologies, Inc. - Products & Services

Our Offerings

Professional

Services /

Design – Build

Engineering

LPLC, HPLC

Chromatography

Systems

Batch to

Continuous

Processing

Systems

OEM &

Custom

Engineered

Products

Automation

Field Piping &

Installation

Example of our work: Purification Systems


LEWA EcoPrime® LPLC

– Custom-designed

chromatography system

– Pressure: 0.04 l/min

up to 33.1 l/min

(EcoPrime 500)

– Flow rate: up to 10 bar

– Precise flow rate with

minimum pulsation

– Dynamic flow range 1:150

– Low holdup volume

– 0.5 to 99.5% step and linear

gradient capability

– Low shear to process

biomolecules

– Target markets:

pharmaceutical

and biopharmaceutical


Our Purpose

To become the world’s leading

innovator of systems that reinvent the

downstream processing of critical

fluids.

Our Value Proposition

LEWA Process Technologies is the

only company that combines deep

expertise in fluid dynamics with

proven pump technology to engineer

advanced systems that move fluids

with unmatched precision,

reproducibility, flexibility and

efficiency.

We work with you…

…to provide them with the industry’s most

advanced and well-engineered fluid processing

platforms so they can create products with

unmatched precision and efficiency.

Processing

Brilliance.

We are:

Innovative

End-to-end

Nimble

Precise

Reproducible

Flexible

Accurate

Experienced

Processing Brilliance

Customer Base & Industry Requirements

9/17/2014LEWA Process Technologies CONFIDENTIAL Use of logo or name does not imply endorsement. Logo‘s are property of respective companies. 23

Industry Requirements

– Software with ease of

validation.

– High metering accuracy

(recipe consistency)

– Good repeatability (HACCP)

– High reliability

– Gentle to the product

– Good cleanability to ensure

food safety, CIP, SIP

– Use of approved material

and lubricants (FDA, NSF)

– Hygienic pump selection

for critical application

(EHEDG)

Representative List of Customer Base

Work Flow For LEWA Process Technologies - our Strength, Your Benefit

LPT maintains a full compliment of departments that ensure the project has the right resources


A clear differientiator from

other ”suppliers”.

– Complete array of expertise

to ensure comprehensive

management of the design

– Process experts at each

step.

Process Engineering

Mechanical/Design/CAD Engineering

Automation Engineering

Manufacturing / Fabrication

1

2

3

Project Mangement

QA/QC

Constant Customer Interface

Field

Installation /

Service

4

Subject

Matter

Experts

The Well Defined Project Work

Flow at LEWA Process

Technologies Assures a Quality

End Product.

Full workflow charts available for

review within on site audit meetings© LEWA Process Technologies, Inc. Confidential - Non Controlled Copy

On Spec.

On Budget.

On Time.

Custom Specialists.

9/17/2014© LEWA GmbH, v1.0 26

Getting you what you want –


understands the best system is designed

to your standard.

We are experts in custom design

systems.

Engineering Services.


LEWA Process Technologies is long

known for unique insights into high purity

processes.

A comprehensive staff of process

engineers, project manages, automation

engineers, world class fabrication and on

site installation sets LEWA Process

Technologies apart from others.

Downstream Expertise.



understands downstream and creates

value through reduction in footprint,

batch to batch reproducibility and

precision that results in yield

improvement.

Ingenuity with process integrity is our

commitment.


Agenda







Application Example: Bulk Filling Station

9/17/2014© LEWA Process Technologies, Inc. 2014 30

USA (Pharma Production

facilities), multiple units

delivered since 2011

Location

Application

Filling intermediate and bulk liquid

drug substances from 0.2 to 5.0L

in microbial controlled semi

automated portable station with

built in weighing.


original design in concert with

major biopharmaceutical

company.

LEWA solution

Application Example: Continuous Processing


USA (Biopharma Process

Development facilities).

Delivered 2014

Location

Application

Multiple purification processes

linked to performed continuous

processing of protein based

therapies under development.


original design in concert with

major biopharmaceutical

company. LPT automation,

system design and manufacture.

LEWA solution

Application Example: Chromatography Systems Processing

9/17/2014© LEWA Process Technologies, Inc. - Confidential 32

Asia

Delivered 2014

Location

Application

Low Pressure Chromatography

skids for monoclonal antibody

production for GMP production.

LEWA original design in concert

with major biopharmaceutical

company. Employed LEWA

Intellidrive EcoDos pumps with

system design and manufacture

by LPT.

LEWA solution

Application Example: Ultrafiltration Processing System

9/17/2014© LEWA Process Technologies, Inc. - Confidential33

EU, USA, Asia (Multiple

Biopharma Facilities).

Delivered series of units starting

2008

Location

Application

Hollow Fiber Membrane

production skid for GMP

production.

LEWA OEM design for major life

sciences technology supply

company. LEWA Process

Technologies design and

manufacture based on OEM

supplied concept.

LEWA solution

Application Example: Membrane Purification System


USA (Biopharma Facilitiy).

Delivered 2011

Location

Application

Hollow Fiber Membrane

production skid for GMP

production.

LEWA original design for major

biopharmaceutical company.

Employed LEWA EcoDos pumps

with system design and

manufacture by LPT.

LEWA solution

Application Example: Centrifuge System


USA (Biopharma Facilitiy).

Delivered 2014

Location

Application

Clarification of biologic in a GMP

production plant.

OEM centrifuge complimented

by LEWA design and

manufacture for a

biopharmaceutical company.

Employed LEWA pumps.

LEWA solution

Application Example: Buffer Dilution System


USA (GMP Bio/pharma Facility).

Delivered 2009

Location

Application

Buffer preparation for

pharmaceutical manufacturing

processing


design and manufacture purpose

built to meet A&E design.

Manufactured, FAT and

disassembled for shipping and

re-assembly on customer site.

LEWA solution

~60 ft (19 m)

~10 ft

(3 m

)

Application Example: Hydrogen Storage; Utility Support


Installation in Germany (Clean

Energy Site) in 2015

Manufactured in USA at LPT in

2014

Location

Application

Storage of wind energy in form of

hydrogen.

LEWA Process

Technologies design and

manufacture purpose built

to meet customer design.

Fabricated in the mobile

container for shipping and

operation with at the

customer site.

LEWA solution


Agenda





– Example Systems Produced by LEWA GmbH for “Clean" Market


Application Example: Production of Powder

9/17/2014© LEWA GmbH, LEWA v1.0 39

Germany (R&D facilities),

delivered in 2006

Location

Application

Production of powder by spray

drying system with hot food or

plastic melts, supercritical CO2

160 l/h, 320 l/h @ 350 bar

Temperature controlled pumps,

LEWA ecoflow LDE3

LEWA solution

Application Example: Production of aromatized water


France, delivered in 2007

Location

Dosing of aroma for the production

of aromatized water

15 l/h @ 10 bar

– LEWA ecodos metering pump

– Mass flow meter

and pressure gauge

– SPS-controlled dosing system

Application

LEWA solution

Application Example: Continuous Blending

9/17/2014© LEWA GmbH, LEWA v1.0 41

Germany, delivered in 2001

Location

Continuous blending of gelatine,

aroma, colorant and citric acid

2.5 t/h @ 6 bar

– LEWA plunger pump

– Vessels

– Mass flow meters

– Electrical control

Application

LEWA solution

Application Example: Liquid Metering for Pharma Extruder

9/17/2014© LEWA GmbH, LEWA, v1.0 42

Germany, Puerto Rico, USA,

delivered in 2006, 2007

Location

Application

Liquid metering for pharma

extruder application

– Complete system with

impeller type mixer, control

system, LEWA ecoflow LDB

– Designed according all

qualification and validation

steps (cGMP, GAMP)

LEWA solution

Application Example: Production of Buffer for Protein Purification

9/17/2014© LEWA GmbH, LEWA v1.0 43

Germany, delivered 2008

Location

Application

Production of buffer and protein

solution, water for injection

15 – 800 l/h, 60 – 2,100 l/h

@ 6 bar

Entire system, LEWA ecodos

hygienic with multiplex heads,

frequency converter, multiphase

motor and control system

LEWA solution

LEWA Process Technologies, Inc. benefits:

9/17/2014© LEWA GmbH, filename, purpose 44

– Global strength, financial security of LEWA-Nikkiso

– History of ingenuity and execution in GMP

environments

– Full service design – engineering – fabrication –

installation; not just a supplier or A&E but a single

point vertical supplier from concept to on-site

implementation

– Automation, Process Engineering, Mechanical

Design, Fabrication all under one roof assures

commercial and technical project certainty

– Our customer auditing successes illustrate an

environment of attention to quality and an

environment in tune with GMP customer expectations

– Your partner of choice for programs that demand high

precision, reliable performance using the best in class

engineering experience and practice

Version 2014 Rev. 6

Thank you!

Visit www.lewapt.com for more information on


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LEWA Process Technologies; Introduction to our company


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Addenda Slides

The following slides may enhance your understanding of LEWA

Process Technologies.

These are supplied for additional information.


Mission


LEWA Process Technologies – Processing Brilliance

LEWA Process Technologies draws on its deep expertise in fluid

dynamics to conceive, construct and install advanced downstream

processing platforms.

Our solutions combine years of research in manipulating the

movement of critical fluids with proven pump technology to deliver

systems with unmatched precision, reproducibility, flexibility and

efficiency.

We help customers in clean industries such as biotechnology and

pharmaceuticals gain competitive advantage by giving them tools to

create the next generation of breakthrough products.

More at www.lewapt.com


Reliable and Safe.

Consistent and Precise.

9/17/2014© LEWA GmbH 48

LEWA Process Technologies systems do

not compromise on process integrity. We

employ our leading sanitary and hygienic

pumps known for exceptional precision

and long life with low maintenance.

Ingenuity coupled with leading pump

technology. That is the no compromise

promise from LEWA Process

Technologies.

Flow Purity.

System Integrity.

9/17/2014© LEWA GmbH, v1.0 49

LEWA Process Technologies systems

are centered on leading sanitary and

hygienic pumps known for exceptional

precision and long life with low

maintenance.

Ingenuity coupled with leading pump

technology. That sets LEWA Process

Technologies apart from others.

Precise. Repeatable.

Formulation Consistency

9/17/2014© LEWA GmbH, v1.0 50

Making your process repeatable and the

quality spot on batch to batch is a

strength of LEWA. We employ our

leading sanitary and hygienic pumps

known for exceptional precision and our

automation package simplifies control

and quality documentation.

Ingenuity coupled with leading pump &

dispensing technology. That is the no

compromise promise from LEWA.

welcome to lewa process technologies, inc. · version sept. 2014 rev. 6 welcome to lewa process...

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