Welcome to theMolecular Medicine

course!

Registration• General information• Over-arching goals• Roll call• Course contents• Information about KS library• Coffee • Course evaluation HT 2012• Study design (research application)• Seminar assignments• Teacher exchange• Final examination• Molecular Medicine - from bed to bench

Course leader: Rachel Fisher08-517 732 45 rachel.fisher@ki.se

Deputy course leader: Ewa Ehrenborg08-517 761 91 ewa.ehrenborg@ki.se

Teaching assistant: Louisa Cheung08-517 732 21 louisa.cheung@ki.se

Department of Medicine, Center for Molecular Medicine,Karolinska University Hospital, L8:02

Course administrator: Sofia Asp (Laila Leidersten) 073 744 19 21 sofia.asp@ki.seCourse office:Department of Medicine, Unit for Internal Medicine,Karolinska University Hospital, A3:02Office hours daily 8.00am - 3.00pm

KS main entrance

Nanna Svartz

Lifts

D1Lifts

Up to floor 2

A3:02

Course office(marked in yellow)

Over-arching goals

• To integrate previously gained knowledge

• To stimulate team work

• To analyse, evaluate and interpret raw data

• To design a study and write a research application

• To provide “real life” experience

Roll call

Course set up

• Lectures, usually 9am – 3pm (check venue!)• Labs/demonstrations/work shops• Group work (+ preparation time)• Seminar assignments (+ preparation time)• Revision• Final written examination: 13th January• Presentation of group work (research application)

at end of course

Course contents (15 hp/ECTS)

Specific areas• Circulation, ischemia, metabolic syndrome, diabetes • Respiration, asthma, allergy • Endocrinology• Gastroenterology• Pathology• Clinical immunology / Clinical chemistry

Assignments etc.• Molecular biology lab• Research application• Seminar assignments• Workshops• Revision

Course literature

• Text books from previous courses:

physiology, pharmacology, biochemistry,

molecular genetics, immunology

• Hand outs

• Lecture summary points (from lecturers)

• Selected articles

Does everyone want a paper copy of the hand outs?

Information about KS libraryMarie Källberg

Lab “Methods in Molecular Biology”

Lectures, demos, labs, exam

Research plan

Seminar assignments

Workshops

Labs and Demonstrations • Lab: “Methods in Molecular Biology –

Theory and Practice”12/11 (introduction)26-28/11, 3-5/12 (lab)9-11/12 (analysis + statistics)17/12 (discussion + review)

• Blood grouping lab (14-15/11)

• Lung/allergy demonstration (19/11)not compulsory

• Angiography demonstration (22/11)

Labs • You must bring your own lab coat

Compulsory to have a lab coat to perform the labs

• If you have lost the lab coat you were given when you started the Biomedicine Programme, you can buy a new one (380kr):http://www.g-ess.se/ Tel: 08-449 85 70 (Stuvsta + Bromma)

• Some labs and demonstrations will be performed in active research labs/clinics- show consideration for those who work there

Course evaluation HT 2012Good

• Research application• Lab “Methods in Molecular Biology”• Seminar assignment• Work shops• Examination relevant• Course leaders/administration

Mixed• Clinical emphasis• Lung/asthma/allergy demonstration• Lecturers

Bad• Lack of a course text book/absent summary points• Work load too light

New for HT 2013

• Two seminar assignments• Teacher exchange• New workshop• Revision of lab “Methods in Molecular Biology”• Modification of research application• Lung/asthma/allergy demonstration voluntary

Workshops • 3 workshops: Atherosclerosis (7/11)

Endocrinology (2/12)Clinical immunology

(16/12)

• Questions/discussion topics handed out in connection with relevant lectures

• Self-study/discussion + review with teacher

• Preparation for the exam

Evaluation of the course

• We rely on your feedback to improve the course

• Please give constructive feedback

• Evaluation forms (online)• Cinema ticket voucher if all evaluation forms

completed + submitted!

• With class representativesThursday 21st November, 12 noon

• With whole classWednesday 15th January, 1 pm

Who are the class representatives?

Course councils

Forms of feedback

feedforward assignments

Research

application

whole-class feedback

Workshops

Research application

feedback on seminar assignment & exam

Pre-submission guidance and feedback

Research application

Workshops

Peer-to-peer to edit and

redraft

Methods in mol biol

reviewing progress with

students

Informing about feedback

Course councils and evaluations

Round-table feedback

Methods in mol biol

Course language

• All literature in English

• Lectures in English

• All assignments must be examined in English

(written + verbal)

Research application• Group assignment

• Choose a specific issue to focus on

• Design a research project

• Write a research application

• Present the project orally

• Answer questions

• Team work

• Realistic exercise

Research application:groups and topics

• Groups 1-6 each split in 2

• 12 “subgroups” of 3-4 people

• Each subgroup allocated a broad topic

• Detailed project chosen by the subgroup

• Discussions with and feed back from topic “mentor” and from Ewa E

Research application – broad topics

• MicroRNA and vascular disease

• Aneurysm

• Thyroid diseases

• Coagulation

• Inflammatory lung diseases

• Cell death in metabolism

• Immunological aspects of gastric disease

• Regenerative cardiology

• Allergy

• Diabetes and co-morbidities

• Vascular remodelling

• Inflammation in cardiovascular disease

2 topics/group, 3-4 people/research application

Research applicationtopic lottery

Research application:new for HT2013

• Include writing a “popular science” project

summary

• Early discussions/feed back - start with groups

with topics relating to lectures at start of course

→ timetable issues regarding groups

Groups will be announced today/tomorrow

Seminar assignments

• Two assignments

• Handed out at in advance

• Group or individual work / individual assessment

• Research based aspects, requires independent work

• Obtain appropriate information- lectures, discussions, web, articles ..…

• Time scheduled to prepare answers

• Examination in seminar format, in groups:No. 1 27th/29th NovemberNo. 2 5th/6th December

• Grading = pass / fail

Teacher exchange

• Terhi Heino – University of Turku, Finland

• Seminar Assignment 2

Examination

• Final examination: Monday 13th January Grades A-F

Questions testing knowledge + understanding

Grading of the examination• F, Fx, E, D, C, B, A

• Goal-based assessment

• Evaluating the level of knowledge obtained not the amount of knowledge

• F, Fx = fail

• E = basic pass: identify, describe, list

• C, D = pass with merit: compare, explain connections, analyse, apply

• B, A = pass with distinction: theorise, hypothesise, reflect

PrestructuralF

UnistructuralFx

MultistructuralE

RelationalC, D

Extended abstractB, A

One relevantaspect

Several relevantindependent aspects

Integrated intoa structure

Generalized tonew domain

To pass the course …

• The student must obtain a grade of at least E for the written examination (5 hp)

• The student must also pass

– the seminar assignments (3 hp)

– the research application (3 hp)

– all compulsory labs and demonstrations (4 hp)

Replacement assignments

• When compulsory parts of the course are missed, there are replacement exercises

• If written, these must be handed in by the last day of the course (17 January 2013)

• Next opportunity for submission = next course (HT2014)

Use the web page!

We will communicate with you via the web page

Molecular Medicine:from bed to bench

• Important clinical contact

• Translational research

• Cross-disciplinary

• “From bench to bed and back again”