we’re not crazy! 6.25.14
TRANSCRIPT
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We’re Not Crazy, We’re Just a Little Unwell
Recognizing Abnormal Behavior in Laboratory Animals
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But first…
• Certification Training• Training on MSDS Sheets• Basic Biotechniques such as gavaging, blood
draws, ear notching• How to operate the anesthesia and CO2 machines
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What is Abnormal?
ab·nor·mal
adjective
Deviating from what is normal or usual, typically in a way that is undesirable or worrying
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Abnormal Behavior
• Unusual/Strange• Not ordinary• Unexpected• Not Accepted• Disturbing• Deviant
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Abnormal Animal Behavior
• Two Categories– Maladaptive– Malfunctional
Maladaptive
Malfunctional
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Why Care?
• Not necessarily a ‘normal’ organism– Brain chemistry may be different– Issues with metabolism could be present– Blood parameters may be altered
• Unnatural behavior• Scientific data may be skewed• Data may be considered invalid
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STRESS / DISTRESS
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Comes in ALL Varieties
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No more! Please!!
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Anxiety
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Anger
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So, What’s a Lab Critter To Do?
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Maladaptive Behavior
• Responsive behavior to the environment• Individual is not dealing with environment well• Humans– Turning to substance abuse– Avoidance behavior
• Animals– Infanticide– Avoidance behavior
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Maladaptive
• Cannot adapt to environment• Exhibit inappropriate behavior
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Fearful
• Due to current environment• Due to previous experiences• Two types– Aggressive Fear– Paralytic Fear
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Aggressive Fear
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Aggressive Fear
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Paralytic Fear
United Kingdom Metro News
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Self Directed Display
• Mouthing of limb– Does not break skin– Causes no injury
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Malfunctional Behaviors• Abnormal brain chemistry or development
brought on by the environment• Humans– Stereotypic behavior– Compulsive disorders
• Animals– Stereotypic behaviors– Compulsive behaviors
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Stereotypic Behavior
• Definition:– Unvarying inappropriate repetition
•Lacks a goal
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The Classic Circle
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Let’s Jump!
• And spin, and dig, and bar chew…
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Salute
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Compulsive Behavior
• Repetition of an inappropriate goal• THIS is where it gets UGLY
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Overgrooming• Self explanatory• Varying degrees of severity
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Barbering
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Classic Hair Pullers
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Classic Self Overgrooming
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Itchy Mouse Syndrome
• To the point of irritation/infection!
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Self Injurious Behavior (SIB)
• Self explanatory• Varying degrees of severity• Really really ugly…
“Bailey in bandages” – c. Susan Cleghorn
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SIB
BAD
WORSE
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Floating Limb
• While sitting passively, a limb performs an involuntary, upward movement
• Activity may last from a few seconds to several minutes
• Really Really REALLY ugly…
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Floating Limb
Non-aggressive Aggressive (with bite)
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Active Floating Limb With Bite
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No Rest for the Weary…
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When is Abnormal Normal?
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Innate Behaviors
• Protection of young• Imprinting in baby birds
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Transgenic & Knockout Phenotypes
• Grooming and appearance• Home cage behaviors– Nesting/huddling– Fighting– Stereotypical behaviors– Altered sleep patters
• Reaction to handling• Motor insufficenies
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Wiley-Liss, 2000
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Quick Example
University of Kansas Medical University of Kansas Medical CenterCenter
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Even Hairloss!
Dr. Gabriel DiMattia – University of Western Ontario Dept. of OncologyDr. Gabriel DiMattia – University of Western Ontario Dept. of Oncology
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Love
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Additional Photo Credits
• Viktor Reinhardt, DVM, PhD• Kathy Benson, PhD• Jim Weed, PhD• Dawn Abney• Hanno Wurbel, PhD• Joe Garner, PhD• Online Elephant Encyclopedia
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FIN
ANY QUESTIONS??